Antipsychotic polypharmacy increases metabolic dysregulation in female rats.

abstract：:Smoking-related cues tend to produce urges and cardiac responses in smokers. This reactivity has been assumed to reflect prior classical conditioning. However, little direct evidence exists supporting the notion that environmental cues can be classically conditioned to cigarette smoking. In this study, 8 smokers recei...

journal_title：Experimental and clinical psychopharmacology

authors： Lazev AB,Herzog TA,Brandon TH

更新日期：1999-02-01 00:00:00

abstract：:This report describes a novel procedure for computer-controlled drug-dose determination for IV drug self-administration studies. By modifying the duration of each infusion of a single concentration of a drug solution, five or more unit doses (mg/kg/inj) can be dispensed from the same syringe. The advantages of this pr...

journal_title：Experimental and clinical psychopharmacology

authors： Fivel PA

更新日期：2011-04-01 00:00:00

abstract：:Smokers are highly reactive to smoking-related cues that are directly linked, or most proximal, to actual smoking behavior (e.g., lit cigarettes). However, over the course of smoking, proximal cues may not be the only stimuli to become strongly associated with smoking. Distal cues, such as the environments in which sm...

journal_title：Experimental and clinical psychopharmacology

authors： Conklin CA,Robin N,Perkins KA,Salkeld RP,McClernon FJ

更新日期：2008-06-01 00:00:00

abstract：:Estrogen increases and progesterone decreases the acquisition and reinstatement of cocaine-seeking behavior in female rats. Here estrogen and progesterone were studied for their effects on the escalation of cocaine self-administration in female rats. The rats received ovariectomy (OVX) or sham (SH) surgery and were tr...

journal_title：Experimental and clinical psychopharmacology

authors： Larson EB,Anker JJ,Gliddon LA,Fons KS,Carroll ME

更新日期：2007-10-01 00:00:00

abstract：:Oxytocin has been shown to decrease cocaine taking and seeking in male rats, suggesting potential treatment efficacy for drug addiction. In the present study, we extended these findings to the assessment of cocaine seeking and taking in female rats. Further, we made direct comparisons of oxytocin's impact on cocaine i...

journal_title：Experimental and clinical psychopharmacology

authors： Leong KC,Zhou L,Ghee SM,See RE,Reichel CM

更新日期：2016-02-01 00:00:00

abstract：:This study examined prevalence and patterns of co-use of opioids and cocaine in regular users of illicit opioids (N = 729) recruited from 5 Canadian cities. Fifty-seven percent (n = 417) reported having used both opioids and cocaine in the month and week preceding the interview; of these, 73% (n = 304) were able to id...

journal_title：Experimental and clinical psychopharmacology

authors： Leri F,Stewart J,Fischer B,Jürgen R,Marsh DC,Brissette S,Bruneau J,El-Guebaly N,Noël L,Tyndall MW,Wild TC

更新日期：2005-11-01 00:00:00

abstract：:Increased discounting (devaluing) of delayed rewards is associated with nearly all types of substance use disorders (SUDs) and is also present in individuals with family histories of SUDs. Early life adversity (ELA) likely contributes to these findings as it is common in both individuals with SUDs and their children a...

journal_title：Experimental and clinical psychopharmacology

authors： Acheson A,Vincent AS,Cohoon A,Lovallo WR

更新日期：2019-04-01 00:00:00

abstract：:Benzodiazepines and alcohol are widely used psychoactive substances that have performance-impairing effects. Research suggests that the impairment profiles for benzodiazepines and alcohol differ, although few cognitive psychopharmacological studies have directly compared these drugs. This double-blind, double-dummy, p...

journal_title：Experimental and clinical psychopharmacology

authors： Kleykamp BA,Griffiths RR,Mintzer MZ

更新日期：2010-02-01 00:00:00

abstract：:Heavy smokers (N = 408, smoking more than 25 cigarettes/day) were randomized to receive high-dose (25 mg) or standard-dose (15 mg) nicotine patch therapy delivered during the daytime only (16 hr) for a period of 6 weeks. Treatment effects of each dose were similar. The percentages of participants not smoking at 2-, 6-...

journal_title：Experimental and clinical psychopharmacology

authors： Killen JD,Fortmann SP,Davis L,Strausberg L,Varady A

更新日期：1999-08-01 00:00:00

abstract：:Despite depressive symptoms being very common among patients seeking treatment for cocaine dependence, few studies have examined the effects of depressive symptoms on cocaine outpatient treatment outcomes, and there is even less research in the context of Contingency Management (CM). The purpose of this study was to a...

journal_title：Experimental and clinical psychopharmacology

authors： García-Fernández G,Secades-Villa R,García-Rodríguez O,Peña-Suárez E,Sánchez-Hervás E

更新日期：2013-12-01 00:00:00

abstract：:Alcohol and cannabis couse is highly prevalent and associated with various negative consequences. The likelihood of same day couse is high, especially among men, however, underlying mechanisms to their couse and its sex-dependent nature remain poorly understood. This study aims to elucidate the effects of controlled a...

journal_title：Experimental and clinical psychopharmacology

authors： Venegas A,Meredith LR,Green R,Cooper ZD,Ray LA

更新日期：2020-07-13 00:00:00

abstract：:This study analyzed whether a contingency management (CM) for shaping cessation period implemented prior to an abstinence-only period (CMS) improves outcomes relative to CM that reinforces only a fixed abstinence criteria (CMA) among treatment-seeking patients in a community setting. A total of 110 patients were rando...

journal_title：Experimental and clinical psychopharmacology

authors： Secades-Villa R,López-Núñez C,Weidberg S,González-Roz A,Alonso-Pérez F

更新日期：2019-12-01 00:00:00

abstract：:Two groups of male Japanese quail (Coturnix japonica) were trained [corrected] to discriminate cocaine from saline in a conditioned approach procedure maintained by sexual reinforcement. For 1 group, cocaine (10 mg/kg ip) was administered prior to a conditioned stimulus (CS) that predicted copulation; saline followed ...

journal_title：Experimental and clinical psychopharmacology

authors： Troisi JR 2nd,Akins C

更新日期：2004-11-01 00:00:00

abstract：:Binge drinking is frequently reported by young adults, despite being associated with a number of negative consequences. This type of heavy drinking is associated with deficits in many executive functions, including working memory. Poor working memory may contribute to increased alcohol use by limiting one's ability to...

journal_title：Experimental and clinical psychopharmacology

authors： Looby A,Norton-Baker M,Russell TD

更新日期：2018-08-01 00:00:00

abstract：:Habitual substance use is associated with attentional bias for stimuli related to the use. The current study tested whether individuals' substance use can be predicted from their attentional bias for concern-related and substance-related stimuli. Participants (N = 71; 54% male) were selected among university students ...

journal_title：Experimental and clinical psychopharmacology

authors： Fadardi JS,Ziaee S,Shamloo ZS

更新日期：2009-12-01 00:00:00

abstract：:Cocaine dependence constitutes a significant public health concern. This randomized, double-blind, placebo-controlled trial tested a novel approach to reducing cocaine use among cocaine-dependent individuals with d-cycloserine, a drug known to enhance learning and some learning-based therapies. Urine samples and cocai...

journal_title：Experimental and clinical psychopharmacology

authors： Johnson MW,Bruner NR,Johnson PS,Silverman K,Berry MS

更新日期：2020-04-01 00:00:00

abstract：:The authors investigated several features of polydrug use in rats. Heroin and cocaine were self-administered following responses on different levers, with only 1 drug and 1 lever available on alternate days of training. Four doses of each drug (heroin: 25, 50, 100, and 200 microg/kg/infusion; cocaine: 0.25, 0.5, 1, an...

journal_title：Experimental and clinical psychopharmacology

authors： Leri F,Stewart J

更新日期：2001-08-01 00:00:00

abstract：:Children's alcohol expectancies shift in late childhood/early adolescence in ways thought to lead to increased risk for adolescent alcohol use. The precise nature of this shift and the maturational processes that may influence it remain to be clarified. To these ends, we compared expectancy endorsement by grade across...

journal_title：Experimental and clinical psychopharmacology

authors： Bekman NM,Goldman MS,Worley MJ,Anderson KG

更新日期：2011-12-01 00:00:00

abstract：:Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels ...

journal_title：Experimental and clinical psychopharmacology

authors： MacKillop J,Gray JC,Weafer J,Sanchez-Roige S,Palmer AA,de Wit H

更新日期：2019-02-01 00:00:00

abstract：:In the United States, marijuana is the most commonly used illicit drug. Its prevalence is growing, particularly among young adults. Behavioral economic indices of the relative reinforcing efficacy (RRE) of substances have been used to examine the appeal of licit (e.g., alcohol) and illicit (e.g., heroin) drugs. The pr...

journal_title：Experimental and clinical psychopharmacology

authors： Collins RL,Vincent PC,Yu J,Liu L,Epstein LH

更新日期：2014-06-01 00:00:00

abstract：:Discounting is a behavioral phenomenon in which the value of an outcome diminishes as a function of its increased delay or decreased probability and is related to substance abuse research because of its theoretical ties with behavioral models of impulsive choice. Research to date suggests that hypothetical outcomes us...

journal_title：Experimental and clinical psychopharmacology

authors： Lawyer SR,Schoepflin F,Green R,Jenks C

更新日期：2011-08-01 00:00:00

abstract：:Using data from 4 smoking cessation trials conducted from 1988 to 2000, the authors investigated whether men are more successful than women in quitting smoking. Odds ratios indicated that the abstinence rates were not significantly different for men and women. Thus, there may be little value to diverting research fund...

journal_title：Experimental and clinical psychopharmacology

authors： Killen JD,Fortmann SP,Varady A,Kraemer HC

更新日期：2002-08-01 00:00:00

abstract：:Insulin receptors are present in brain areas that are involved in the control of hunger and satiety, and intranasal insulin is assumed to have an anorexigenic effect. This known influence of insulin on satiety encouraged us to investigate the effect of intranasal insulin on feeding-related behaviors. The aim of the cu...

journal_title：Experimental and clinical psychopharmacology

authors： Rodriguez-Raecke R,Sommer M,Brünner YF,Müschenich FS,Sijben R

更新日期：2020-08-01 00:00:00

abstract：:Difficulty monitoring and inhibiting impulsive behaviors has been reported in marijuana (MJ) smokers; neuroimaging studies, which examined frontal systems in chronic MJ smokers, have reported alterations during inhibitory tasks. Diffusion tensor imaging (DTI) provides a quantitative estimate of white matter integrity ...

journal_title：Experimental and clinical psychopharmacology

authors： Gruber SA,Silveri MM,Dahlgren MK,Yurgelun-Todd D

更新日期：2011-06-01 00:00:00

abstract：:Nonpharmacological cues associated with drug intake may influence subjective and reinforcing effects of those drugs. Social drinkers (N = 80) participated in 2 sessions in which they rated and then consumed ad lib their preferred beer (with participants blind to brand). Visual and olfactory stimuli were obscured durin...

journal_title：Experimental and clinical psychopharmacology

authors： Perkins KA,Ciccocioppo M,Jacobs L,Doyle T,Caggiula A

更新日期：2003-11-01 00:00:00

abstract：:The purpose of this study was to examine the acute effects of alcohol on aggressive behavior in men and women in a laboratory setting. Participants were 526 (261 men and 265 women) healthy social drinkers between 21 and 35 years of age. They were randomly assigned to either an alcohol or a placebo group. Aggression wa...

journal_title：Experimental and clinical psychopharmacology

authors： Giancola PR,Levinson CA,Corman MD,Godlaski AJ,Morris DH,Phillips JP,Holt JC

更新日期：2009-06-01 00:00:00

abstract：:Substantial evidence links greater impulsivity and stress exposure to poorer smoking cessation outcomes. Results from adolescents also indicate that stress-related change in risk taking can impede cessation attempts. We investigated the effects of stress-related change in impulsivity, risk taking, attention and nicoti...

journal_title：Experimental and clinical psychopharmacology

authors： Schepis TS,Tapscott BE,Krishnan-Sarin S

更新日期：2016-04-01 00:00:00

abstract：:In this experiment, the observing-response procedure was adapted for use with drug self-administration. Rats' responding for oral ethanol was sometimes reinforced on a random-ratio schedule, whereas at other times it had no effect (i.e., extinction). Behavior producing stimuli associated with the otherwise unsignaled ...

journal_title：Experimental and clinical psychopharmacology

authors： Shahan TA

更新日期：2002-02-01 00:00:00

abstract：:Two studies were conducted to determine the anger-attenuating effects of nicotine as a function of trait hostility. The 1st study examined the effects of nicotine on diary ratings of anger during a 24-hr period in a natural setting in 30 smokers and 30 nonsmokers. Participants took part in 2 monitoring sessions involv...

journal_title：Experimental and clinical psychopharmacology

authors： Jamner LD,Shapiro D,Jarvik ME

更新日期：1999-11-01 00:00:00

abstract：:In Experiment 1, the effect of repeated injections of 2.5, 5.0, or 10.0 mg/kg of chlordiazepoxide (CDP) on food intake and body weight was studied in rats on an activity anorexia (AA) regimen. For several days before CDP testing began, rats lived in activity wheels and had one 60-min meal per day. During CDP testing, ...

journal_title：Experimental and clinical psychopharmacology

authors： Lett BT,Grant VL,Koh MT,Parsons JF

更新日期：1998-11-01 00:00:00