Abstract:
:Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels of DRD are often confounded with prior drug use, and previous studies have also had limited genomic scope. The current investigation sought to address these issues by studying DRD in healthy young adults with low levels of substance use (N = 986; 62% female, 100% European ancestry) and investigating genetic variation genome-wide. The genome-wide approach used a prioritized subset design, organizing the tests into theoretically and empirically informed categories and apportioning power accordingly. Three subsets were used: (a) a priori loci implicated by previous studies; (b) high-value addiction (HVA) markers from the recently developed SmokeScreen array; and (c) an atheoretical genome-wide scan. Among a priori loci, a nominally significant association was present between DRD and rs521674 in ADRA2A. No significant HVA loci were detected. One statistically significant genome-wide association was detected (rs13395777, p = 2.8 × 10-8), albeit in an intergenic region of unknown function. These findings are generally not supportive of the previous candidate gene studies and suggest that DRD has a complex genetic architecture that will require considerably larger samples to identify genetic associations more definitively. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
journal_name
Exp Clin Psychopharmacoljournal_title
Experimental and clinical psychopharmacologyauthors
MacKillop J,Gray JC,Weafer J,Sanchez-Roige S,Palmer AA,de Wit Hdoi
10.1037/pha0000227subject
Has Abstractpub_date
2019-02-01 00:00:00pages
29-37issue
1eissn
1064-1297issn
1936-2293pii
2018-47961-001journal_volume
27pub_type
杂志文章abstract::In community-based alcoholism and drug abuse treatment programs, the vast majority of interventions are delivered in a group therapy context. In turn, treatment providers and funding agencies have called for more research on interventions delivered in groups in an effort to make the emerging empirical literature on th...
journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2006-05-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
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doi:10.1037//1064-1297.7.2.90
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doi:10.1037/pha0000344
更新日期:2020-12-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
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doi:10.1037/1064-1297.12.4.237
更新日期:2004-11-01 00:00:00
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doi:10.1037/a0017294
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更新日期:2000-02-01 00:00:00
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更新日期:2018-06-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-10-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/pha0000416
更新日期:2020-07-16 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0036607
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章
doi:10.1037/a0027117
更新日期:2012-06-01 00:00:00
abstract::The accurate assessment of nicotine withdrawal is important theoretically and clinically. A 28-item scale, the Wisconsin Smoking Withdrawal Scale, was developed that contains 7 reliable subscales tapping the major symptom elements of the nicotine withdrawal syndrome. Coefficients alpha for the subscales range from .75...
journal_title:Experimental and clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037//1064-1297.7.4.354
更新日期:1999-11-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
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doi:10.1037/a0016658
更新日期:2009-08-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1037/1064-1297.15.1.115
更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1037/pha0000191
更新日期:2018-04-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
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更新日期:2017-02-01 00:00:00
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doi:10.1037/1064-1297.14.3.275
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更新日期:2000-08-01 00:00:00
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journal_title:Experimental and clinical psychopharmacology
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更新日期:2019-02-01 00:00:00
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