Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.

Abstract:

:Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity that has been consistently associated with addiction. It has also been identified as a promising addiction endophenotype, linking specific sources of genetic variation to individual risk. A challenge in the studies to date is that levels of DRD are often confounded with prior drug use, and previous studies have also had limited genomic scope. The current investigation sought to address these issues by studying DRD in healthy young adults with low levels of substance use (N = 986; 62% female, 100% European ancestry) and investigating genetic variation genome-wide. The genome-wide approach used a prioritized subset design, organizing the tests into theoretically and empirically informed categories and apportioning power accordingly. Three subsets were used: (a) a priori loci implicated by previous studies; (b) high-value addiction (HVA) markers from the recently developed SmokeScreen array; and (c) an atheoretical genome-wide scan. Among a priori loci, a nominally significant association was present between DRD and rs521674 in ADRA2A. No significant HVA loci were detected. One statistically significant genome-wide association was detected (rs13395777, p = 2.8 × 10-8), albeit in an intergenic region of unknown function. These findings are generally not supportive of the previous candidate gene studies and suggest that DRD has a complex genetic architecture that will require considerably larger samples to identify genetic associations more definitively. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

authors

MacKillop J,Gray JC,Weafer J,Sanchez-Roige S,Palmer AA,de Wit H

doi

10.1037/pha0000227

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

29-37

issue

1

eissn

1064-1297

issn

1936-2293

pii

2018-47961-001

journal_volume

27

pub_type

杂志文章
  • Analytic complexities associated with group therapy in substance abuse treatment research: problems, recommendations, and future directions.

    abstract::In community-based alcoholism and drug abuse treatment programs, the vast majority of interventions are delivered in a group therapy context. In turn, treatment providers and funding agencies have called for more research on interventions delivered in groups in an effort to make the emerging empirical literature on th...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037/1064-1297.14.2.265

    authors: Morgan-Lopez AA,Fals-Stewart W

    更新日期:2006-05-01 00:00:00

  • The effects of cadmium contamination on the discriminative stimulus properties of cocaine and related drugs.

    abstract::Rats were exposed to a diet containing 100 ppm cadmium chloride or a control diet. At 52 days of exposure, rats were trained to discriminate between saline and 5 mg/kg cocaine injections. After acquisition training, successive substitution tests were conducted using cocaine, the indirect dopamine agonist d-amphetamine...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.7.2.90

    authors: Nation JR,Miller DK

    更新日期:1999-05-01 00:00:00

  • "Buzzwords": Crowd-sourcing and quantifying U.S. young adult terminology for subjective effects of alcohol and marijuana use.

    abstract::Prevalence of heavy alcohol use remain high, and daily marijuana use is at an all-time high in young adults. As perceptions of drug effects may guide risky decision making, understanding subjective feelings for alcohol and marijuana use is critical. Existing laboratory-based and diary metrics (0-100 rating of "how dru...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000344

    authors: Linden-Carmichael AN,Masters LD,Lanza ST

    更新日期:2020-12-01 00:00:00

  • The discriminative stimulus effects of cocaine in a pavlovian sexual approach paradigm in male Japanese quail.

    abstract::Two groups of male Japanese quail (Coturnix japonica) were trained [corrected] to discriminate cocaine from saline in a conditioned approach procedure maintained by sexual reinforcement. For 1 group, cocaine (10 mg/kg ip) was administered prior to a conditioned stimulus (CS) that predicted copulation; saline followed ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.12.4.237

    authors: Troisi JR 2nd,Akins C

    更新日期:2004-11-01 00:00:00

  • Do heavy smokers benefit from higher dose nicotine patch therapy?

    abstract::Heavy smokers (N = 408, smoking more than 25 cigarettes/day) were randomized to receive high-dose (25 mg) or standard-dose (15 mg) nicotine patch therapy delivered during the daytime only (16 hr) for a period of 6 weeks. Treatment effects of each dose were similar. The percentages of participants not smoking at 2-, 6-...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//1064-1297.7.3.226

    authors: Killen JD,Fortmann SP,Davis L,Strausberg L,Varady A

    更新日期:1999-08-01 00:00:00

  • Early life adversity and increased delay discounting: Findings from the Family Health Patterns project.

    abstract::Increased discounting (devaluing) of delayed rewards is associated with nearly all types of substance use disorders (SUDs) and is also present in individuals with family histories of SUDs. Early life adversity (ELA) likely contributes to these findings as it is common in both individuals with SUDs and their children a...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000241

    authors: Acheson A,Vincent AS,Cohoon A,Lovallo WR

    更新日期:2019-04-01 00:00:00

  • Effects of energy drinks mixed with alcohol on information processing, motor coordination and subjective reports of intoxication.

    abstract::The consumption of alcohol mixed with energy drinks (AmED) has become a popular and controversial practice among young people. Increased rates of impaired driving and injuries have been associated with AmED consumption. The purpose of this study was to examine if the consumption of AmED alters cognitive processing and...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/a0026136

    authors: Marczinski CA,Fillmore MT,Henges AL,Ramsey MA,Young CR

    更新日期:2012-04-01 00:00:00

  • Substance use and the paradox of good and bad attentional bias.

    abstract::Habitual substance use is associated with attentional bias for stimuli related to the use. The current study tested whether individuals' substance use can be predicted from their attentional bias for concern-related and substance-related stimuli. Participants (N = 71; 54% male) were selected among university students ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0017294

    authors: Fadardi JS,Ziaee S,Shamloo ZS

    更新日期:2009-12-01 00:00:00

  • The effects of cigarette smoking on negative priming.

    abstract::Nicotine administration has been found to enhance performance on tasks of selective attention. It has been proposed that efficient attentional filtering depends on the successful inhibition of distracting information. In the work reported here, a negative priming paradigm was adopted to test whether smoking enhanced t...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1037//1064-1297.8.1.104

    authors: Rodway P,Dienes Z,Schepman A

    更新日期:2000-02-01 00:00:00

  • Allocating under the influence: Effects of alcohol intoxication and social identification on in-group favoritism.

    abstract::The "social lubrication" function of alcohol during interpersonal interactions is well documented. However, less is known about the effects of alcohol consumption on group-level behavior. Empirical findings from social psychological literature suggest that individuals tend to favor those who are considered as members ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000186

    authors: Zhou J,Heim D,Monk R,Levy A,Pollard P

    更新日期:2018-06-01 00:00:00

  • The efficacy and tolerability of paliperidone in mania of bipolar disorder: A preliminary meta-analysis.

    abstract::Paliperidone may be effective for the treatment of bipolar disorder (BD); however, the evidence has been mixed. This is the first meta-analysis to evaluate the efficacy, safety, and tolerability of paliperidone for the treatment of BD. We performed a systematic search of the literature using major electronic databases...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1037/pha0000148

    authors: Chang HY,Tseng PT,Stubbs B,Chu CS,Li DJ,Fornaro M,Carvalho A,Solmi M,Veronese N,Vieta E,Chen TY,Chen YW,Lin PY,Chow PC

    更新日期:2017-10-01 00:00:00

  • The language of subjective alcohol effects: Do young adults vary in their feelings of intoxication?

    abstract::Among young adults, subjective feelings of alcohol's effects often guide risky decision making. The majority of studies measuring subjective effects have used singular indices ("How drunk do you feel?") which limits our understanding of young adults' full range of subjective states and their individual differences in ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000416

    authors: Linden-Carmichael AN,Allen HK,Lanza ST

    更新日期:2020-07-16 00:00:00

  • Drunk personality: reports from drinkers and knowledgeable informants.

    abstract::Existing literature supports the five-factor model (FFM) of personality (i.e., Extraversion, Agreeableness, Conscientiousness, Emotional Stability, and Intellect or Openness) as a comprehensive representation of stable aspects of mood, affect, and behavior. This study evaluated the FFM as a framework for both self-per...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0036607

    authors: Winograd RP,Steinley DL,Sher KJ

    更新日期:2014-06-01 00:00:00

  • Effects of acute pramipexole on male rats' preference for gambling-like rewards II.

    abstract::Pramipexole (PPX) is a dopamine agonist medication that has been implicated in the development of pathological gambling and other impulse control disorders. Johnson, Madden, Brewer, Pinkston, and Fowler (2011) reported that PPX increased male rats' preference for gambling-like rewards (those arranged according to a va...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0027117

    authors: Johnson PS,Madden GJ,Stein JS

    更新日期:2012-06-01 00:00:00

  • Development and validation of the Wisconsin Smoking Withdrawal Scale.

    abstract::The accurate assessment of nicotine withdrawal is important theoretically and clinically. A 28-item scale, the Wisconsin Smoking Withdrawal Scale, was developed that contains 7 reliable subscales tapping the major symptom elements of the nicotine withdrawal syndrome. Coefficients alpha for the subscales range from .75...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//1064-1297.7.4.354

    authors: Welsch SK,Smith SS,Wetter DW,Jorenby DE,Fiore MC,Baker TB

    更新日期:1999-11-01 00:00:00

  • Attentional bias is associated with incentive-related physiological and subjective measures.

    abstract::Drug cue reactivity is theoretically and clinically important. The modified Stroop task has been widely used to assess attention capture by drug cues (attentional bias). Attentional bias to drug cues is assumed to reflect the incentive value of those cues, but this has not been directly tested. The authors examined wh...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/a0016658

    authors: Waters AJ,Carter BL,Robinson JD,Wetter DW,Lam CY,Kerst W,Cinciripini PM

    更新日期:2009-08-01 00:00:00

  • Diazepam impairs temporal dynamics of visual attention.

    abstract::The effect of benzodiazepines on attention has been the object of few investigations. Studies using the spatial cueing paradigm (Posner's paradigm) have reported inconsistent results, which are likely due to methodological and/or dose differences but suggest impaired disengagement of attention from the cue to the targ...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/1064-1297.15.1.115

    authors: Boucart M,Waucquier N,Michael GA,Libersa C

    更新日期:2007-02-01 00:00:00

  • Motivation and readiness for tobacco cessation among nicotine dependent postmenopausal females: A pilot study.

    abstract::Despite considerable health risks due to lower levels of estrogen production and the compounding antiestrogenic effects of nicotine, postmenopausal females continue to smoke. These females face significant barriers to cessation, including negative affect, weight concerns, and menopausal symptom severity. The current p...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/pha0000191

    authors: Peltier MR,Roys MR,Waters AF,Vinci C,Waldo KM,Stewart SA,Toups RC,Jones L,Copeland AL

    更新日期:2018-04-01 00:00:00

  • Attentional and approach biases to alcohol cues among young adult drinkers: An ecological momentary assessment study.

    abstract::Alcohol-specific attentional biases (AttB) and approach biases (AppB) are postulated to play a role in alcohol use disorders but their association with drinking in young adults remains unknown. A subsample of young adults with risky alcohol use (N = 296) enrolled in a randomized trial, testing different text message i...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000343

    authors: Suffoletto B,Field M,Chung T

    更新日期:2020-12-01 00:00:00

  • Neural outcome processing of peer-influenced risk-taking behavior in late adolescence: Preliminary evidence for gene × environment interactions.

    abstract::Adolescent brains are particularly susceptible to the rewarding properties of risky decisions in social contexts. Individual differences in genetic influences on dopamine transmission moderate neural outcome processing of risky decisions and may exert pronounced effects on adolescent risk-taking behavior (RTB) and cor...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000105

    authors: Webber TA,Soder HE,Potts GF,Park JY,Bornovalova MA

    更新日期:2017-02-01 00:00:00

  • Predicting college student prescription stimulant misuse: An analysis from ecological momentary assessment.

    abstract::Prescription stimulant misuse (PSM) is common in young adult college students, at over 10% in the past year, and it is associated with other substance use and risk behaviors. Research focused on the real-time drivers of PSM is absent, impeding prevention and intervention. This research aimed to fill that gap by examin...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000386

    authors: Schepis TS,Buckner JD,Klare DL,Wade LR,Benedetto N

    更新日期:2020-05-28 00:00:00

  • Anxiety sensitivity and smoking outcome expectancies among Spanish-speaking Latinx adult smokers.

    abstract::Smoking is among the most important health behaviors linked to premature death and disability among the Latinx population. Yet there is limited understanding of whether transdiagnostic factors like anxiety sensitivity may help explain smoking expectancies among Spanish-speaking Latinx smokers. The present investigatio...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000270

    authors: Zvolensky MJ,Bakhshaie J,Shepherd JM,Garey L,Peraza N,Viana AG,Brown JT,Brown RA

    更新日期:2019-12-01 00:00:00

  • Stimulus compounding enhances conditioned suppression produced by cocaine-paired stimuli.

    abstract::When 2 stimuli that occasion cocaine self-administration are presented in compound, their ability to increase cocaine-reinforced operant responding is substantially enhanced. The goal of the present experiment was to determine whether stimulus compounding could produce analogous enhancements of a classically condition...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.8.1.6

    authors: Panlilio LV,Weiss SJ,Schindler CW

    更新日期:2000-02-01 00:00:00

  • Delay discounting of cocaine by rhesus monkeys.

    abstract::The present, subjective value of a reinforcer typically decreases as a function of the delay to its receipt, a phenomenon termed delay discounting. Delay discounting, which is assumed to reflect impulsivity, is hypothesized to play an important role in drug abuse. The present study examined delay discounting of cocain...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.15.3.238

    authors: Woolverton WL,Myerson J,Green L

    更新日期:2007-06-01 00:00:00

  • Recent-onset ecstasy use: association with deviant behaviors and psychiatric comorbidity.

    abstract:BACKGROUND:Despite increases in ecstasy (MDMA) use in the United States, little is known about characteristics linked with recent-onset ecstasy use, especially psychiatric symptoms and deviant behaviors. AIMS:To test whether individuals with high levels of other drug use are more likely to be recent-onset ecstasy user...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.14.3.275

    authors: Martins SS,Mazzotti G,Chilcoat HD

    更新日期:2006-08-01 00:00:00

  • State-dependent stimulus control: cuing attributes of acute cocaine rebound in rats.

    abstract::Sprague-Dawley (Rattus norvegicus) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivalent volumes of saline (SAL), subcutan...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037//1064-1297.6.3.264

    authors: Gauvin DV,Vanecek SA,Baird TJ,Briscoe RJ,Vallett M,Carl KL,Wasielewski JA,Holloway FA

    更新日期:1998-08-01 00:00:00

  • Impact of aerobic exercise intensity on craving and reactivity to smoking cues.

    abstract::Aerobic exercise can acutely reduce cigarette cravings during periods of nicotine deprivation. The primary aim of this study was to assess the differential effects of light and vigorous intensity aerobic exercise on cigarette cravings, subjective and physiological reactivity to smoking cues, and affect after overnight...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/a0032768

    authors: Janse Van Rensburg K,Elibero A,Kilpatrick M,Drobes DJ

    更新日期:2013-06-01 00:00:00

  • Placebo cigarettes in smoking research.

    abstract::This review outlines the development and use of placebo cigarettes in smoking research. Research on effects of smoking has been disadvantaged by the lack of an adequate placebo condition. Recently, tobacco-based denicotinized cigarettes have been used in smoking research to distinguish effects of smoking due to the de...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1037//1064-1297.8.3.326

    authors: Robinson ML,Houtsmuller EJ,Moolchan ET,Pickworth WB

    更新日期:2000-08-01 00:00:00

  • Past and future preference reversals are predicted by delay discounting in smokers and non-smokers.

    abstract::Delay discounting, the devaluation of delayed reinforcers, is one defining behavioral economic characteristic of cigarette smokers. Attempts at abstinence by smokers that result in relapse are conceptualized in this framework as preference reversals. Despite preference reversals being predicted by delay discounting mo...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/pha0000224

    authors: Pope DA,Poe L,Stein JS,Snider SE,Bianco AG,Bickel WK

    更新日期:2019-02-01 00:00:00

  • The subjective and reinforcing effects of visual and olfactory stimuli in alcohol drinking.

    abstract::Nonpharmacological cues associated with drug intake may influence subjective and reinforcing effects of those drugs. Social drinkers (N = 80) participated in 2 sessions in which they rated and then consumed ad lib their preferred beer (with participants blind to brand). Visual and olfactory stimuli were obscured durin...

    journal_title:Experimental and clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1037/1064-1297.11.4.269

    authors: Perkins KA,Ciccocioppo M,Jacobs L,Doyle T,Caggiula A

    更新日期:2003-11-01 00:00:00