Abstract：
:Helicobacter pylori (H. pylori) infection causes peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphomas and gastric adenocarcinomas, for which the pathogenesis of chronic gastric inflammation prevails and provides the pathogenic basis. Since the role of H. pylori infection is promoting carcinogenesis rather than acting as a direct carcinogen, as several publications show, eradication alone cannot be the right answer for preventing H. pylori-associated gastric cancer. Therefore, a non-antimicrobial approach has been suggested to attain microbe-associated cancer prevention through controlling H. pylori-related chronic inflammatory processes and mediators responsible for carcinogenesis. Phytoceutical is a term for plant products that are active on biological systems. Phytoceuticals such as Korean red ginseng, green tea, red wine, flavonoids, broccoli sprouts, garlic, probiotics and flavonoids are known to inhibit H. pylori colonization, decrease gastric inflammation by inhibiting cytokine and chemokine release, and repress precancerous changes by inhibiting nuclear factor-kappa B DNA binding, inducing profuse levels of apoptosis and inhibiting mutagenesis. Even though further unsolved issues are awaited before phytoceuticals are accepted as a standard treatment for H. pylori infection, phytoceuticals can be a mighty weapon for either suppressing or modulating the disease-associated footprints of H. pylori infection.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Lee SY,Shin YW,Hahm KBdoi
10.1111/j.1751-2980.2008.00334.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
129-39issue
3eissn
1751-2972issn
1751-2980journal_volume
9pub_type
杂志文章,评审abstract：OBJECTIVE:To evaluate whether patients with malignant biliary obstruction (MBO) benefit from balloon dilation before the placement of a self-expanding metal stent (SEMS) for palliative biliary drainage. METHODS:Consecutive patients who underwent endoscopic retrograde cholangiopancreatography with SEMS placement for pa...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12864
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:The aim of our study was to document our 6-year experiences in identifying the clinical characteristics, laboratory findings, risk factors and the outcomes of patients with ischemic colitis (IC) in a community hospital setting. METHODS:The medical records of patients who were diagnosed with IC from 2007 to 2...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12182
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:There is currently little information on the medical economic outcomes of endoscopic submucosal dissection (ESD) for gastric cancer (GC) in elderly patients. This study therefore aimed to investigate the medical economic outcomes of ESD in elderly patients with GC using a national administrative database. ME...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1751-2980.12106
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease, the natural course of which has not been well documented. This study aimed to perform a prospective cohort study to investigate NAFLD in a Chinese population. METHODS:Using our previous epidemiological survey, 3543 patients were foll...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2011.00571.x
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:Our aim was to investigate the expression of cytotoxic T lymphocyte-associated molecule 4 (CTLA-4) in ulcerative colitis (UC) and to evaluate the effect of CTLA-4 gene -1661A/G polymorphism on CTLA-4 expression and transcription. METHODS:A total of 20 UC patients and 22 healthy controls matched by age and se...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2010.00462.x
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVE:To investigate whether the ultrastructure and hydrogen potassium adenosine triphosphate (H+ /K+ ATPase) expression of human parietal cells were associated with aging. METHODS:In all, 50 participants who underwent gastroscopy due to dyspepsia were divided into two age groups, with 19 in the younger group (YG,...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12055
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:Currently the screening and diagnosis of gastric cancer and atrophic gastritis are mainly made by endoscopy and biopsy. The aim of this study was to evaluate the use of serum tests: serum pepsinogen I (PGI pepsinogen I/II ratio (PGR), gastrin-17 (G-17) and H. pylori-immunoglobulin G (IgG) antibodies to screen...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1443-9573.2007.00271.x
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVES:Peptest is a new non-invasive reflux diagnostic test based on lateral flow technology that containing two highly specific human pepsin monoclonal antibodies for detecting pepsin, a biomarker for reflux disease. The primary aim of this multicenter clinical study was to validate the efficacy of Peptest in pati...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1751-2980.12783
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:Probiotics are increasingly advocated in the management of various gastrointestinal disorders. The aim of this study was to investigate the current attitudes and prescribing practices of surgeons and gastroenterologists for probiotics in the treatment of gastrointestinal disorders. METHODS:A questionnaire wa...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2011.00534.x
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To carry out a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathy in chronic alcoholics before and one year after abstinence. METHODS:Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lact...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12415
更新日期：2016-11-01 00:00:00
abstract：:Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous casca...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2011.00550.x
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To investigate the role of ghrelin in the gastric cancer cell line AGS and its probable mechanism. METHODS:Cell proliferation was detected by MTT assay after treated with ghrelin or des-acyl ghrelin. The expression of growth hormone secretagogue receptor 1a (GHS-R1a) and 1b (GHS-R1b) mRNA was detected using ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2012.00616.x
更新日期：2012-09-01 00:00:00
abstract：:Barrett's esophagus (BE)-related esophageal adenocarcinoma (EAC) has shown the fastest rise in incidence in Western countries; however, research data on BE-related diseases from China are inconclusive. We aimed to review and analyze the published results on these diseases in China. We searched PubMed and Chinese medic...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/j.1751-2980.2011.00535.x
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:The monocyte chemoattractant protein-1 (MCP-1) -A2518G gene polymorphism has been found to be involved in the susceptibility to inflammatory bowel disease (IBD); however, the results of existing studies are controversial. The aim of this meta-analysis was to assess the relationship between the MCP-1 -A2518G p...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,meta分析,评审
doi：10.1111/1751-2980.12232
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:With an age-standardized incidence rate of 2 per 100 000, esophageal cancer is not common among Malaysians, but they are nevertheless important due to its poor prognosis. The study is to clarify whether the human papillomavirus (HPV) is associated with esophageal cancer in Malaysians as there has been no repo...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12605
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To explore the features and clinical significance of serum pepsinogen (PG) assay in a follow-up study on a high-risk gastric cancer (GC) population. METHODS:A total of 444 participants from a high-risk area of GC in north China were enrolled in this follow-up study from April 1997 to December 1999. Serum PG ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1443-9573.2007.00321.x
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:It is known that the vacuolating cytotoxin (VacA) could induce apoptosis. However, the mechanism remained to be elucidated. The aim of this study is to investigate the role of Bcl family of proteins (Bcl-2 and Bax) and the mitochondrial voltage-dependent anion channel (VDAC) in VacA-induced apoptosis of AGS c...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2009.00412.x
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to analyze the incidence and risk factors of de novo hepatitis B virus (HBV) infection from hepatitis B core antibody (anti-HBc)-positive donors in pediatric living donor liver transplantation (LDLT). METHODS:We retrospectively analyzed 46 recipients without pre-liver transplantatio...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12066
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:Transarterial chemoembolization (TACE) is the treatment modality for intermediate, or Barcelona Clinic Liver Cancer stage B, hepatocellular carcinoma (HCC), but its beneficial effect on outcomes is still unsatisfactory. This study aimed to assess the outcomes of combined TACE and sorafenib for patients with i...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12911
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:To investigate the clinicopathological features of columnar-lined esophagus (CLE) in Chinese patients. METHODS:Among 182 consecutive resections of proximal gastric cancer with residual esophageal tissue, 114 were eligible for the study. The maximal lengths of CLE and superficial esophageal glands (SEG) and t...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12007
更新日期：2013-01-01 00:00:00
abstract：:The incidence of early esophageal adenocarcinoma has been increasing significantly in recent decades. Prognosis depends greatly on the choice of treatment. Early cancers can be treated by endoscopic resection, whereas advanced carcinomas have to be sent for surgery. Esophageal resection is associated with high periope...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12264
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:Ursodeoxycholic acid (UDCA) is widely used to treat chronic liver diseases, and its cytoprotective effect on normal hepatocytes has been shown. This study aimed to investigate the apoptotic effects of UDCA on hepatocellular carcinoma (HCC) cells and the underlying molecular events in vitro. METHODS:HCC cells...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12191
更新日期：2014-12-01 00:00:00
abstract：:Fibroblast infiltration and collagen deposition result in structural changes in the bowel wall, and lead to strictures in intestinal inflammatory disease. While strictures can also occur in other contexts, such as malignancy, this review focuses on the surgical treatment of stricture secondary to inflammatory bowel di...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12880
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening. METHODS:Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12040
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effects and safety of different doses of ilaprazole on healthy volunteers without a Helicobacter pylori infection. METHODS:A total of 12 healthy Chinese volunteers were enrolled and divided into four groups randomly, with a 5-day treatment of oral ilaprazole 5mg, 10m...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1751-2980.2011.00557.x
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To analyze the prognostic effect of E-cadherin expression, the growth pattern of the tumor and the regression grade in a rectal cancer cohort treated with neoadjuvant radiochemotherapy (RCT). METHODS:A total of 223 patients with rectal cancer treated with neoadjuvant RCT followed by surgery were included. Al...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12471
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:We aimed to determine the effect of antithrombotics on in-hospital mortality and morbidity in patients with peptic ulcer disease-related upper gastrointestinal bleeding (PUD-related UGIB). METHODS:The study cohort was retrospectively selected from a tertiary center database of patients with PUD-related UGIB,...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12140
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:We aimed to identify the differences in symptoms, high-resolution manometry (HRM) characteristics, and the efficacy of peroral endoscopic myotomy (POEM) regarding patients' sex in achalasia. METHODS:All patients diagnosed with achalasia by HRM who underwent POEM and were followed up for more than 6 months we...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12922
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:Systematic reports on acute upper gastrointestinal bleeding in children/adolescents are scanty. The aim of this study is to analyze its presentation, pathology and outcome in Hong Kong. METHODS:A retrospective review of the hospital database for admissions up to the age of 18 years with signs of acute upper ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2008.00346.x
更新日期：2008-11-01 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is now the most common etiology of chronic liver disease threatening global public health. However, the name "NAFLD" is no longer appropriate with the change of time. Recently, a new term, "metabolic dysfunction-associated fatty liver disease" has been proposed by an internati...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12944
更新日期：2020-11-01 00:00:00
