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The -A2518G polymorphism in the MCP-1 gene and inflammatory bowel disease risk: A meta-analysis.

Abstract：

OBJECTIVE:The monocyte chemoattractant protein-1 (MCP-1) -A2518G gene polymorphism has been found to be involved in the susceptibility to inflammatory bowel disease (IBD); however, the results of existing studies are controversial. The aim of this meta-analysis was to assess the relationship between the MCP-1 -A2518G polymorphism and the risk of IBD. METHODS:PubMed, EMBASE and MEDLINE were searched for studies assessing the relationship between the -A2518G polymorphism in MCP-1 gene and the risk of IBD. Available data were extracted and statistically analyzed using STATA 12.0. RESULTS:A total of five publications involving 3137 individuals (1818 IBD cases and 1319 controls) were included in the meta-analysis. A combined analysis revealed that the MCP-1 -A2518G polymorphism in was a protective factor for GG + AG vs AA (OR 0.76, 95% CI 0.67-0.87, P = 0.000). Subgroup analysis by ethnicity showed that among European patients the AG + GG homozygote, unlike the AA homozygote, had a protective effect against IBD (OR 0.73, 95% CI 0.63-0.84, P = 0.000), but did not do so among Asian and African patients. Subgroup analysis by disease subtype suggested the -A2518G polymorphism in MCP-1 had a protective effect against Crohn's disease (OR 0.69, 95% CI 0.58-0.81, P = 0.000), but not against ulcerative colitis. CONCLUSIONS:Our meta-analysis suggested that the -A2518G polymorphism in MCP-1 may be a protective factor for IBD in European populations. Further studies are required to confirm these findings.

journal_name

J Dig Dis

journal_title

Journal of digestive diseases

authors

Li YW,Yang CQ,Xiao YL,Li J,Xie CX,Zhang SH,Yu Q,Wang HL,Lu WM,Chen MH

doi

10.1111/1751-2980.12232

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

177-85

issue

4

eissn

1751-2972

issn

1751-2980

journal_volume

16

pub_type

杂志文章,meta分析,评审

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