Abstract:
OBJECTIVE:To investigate retrospectively the efficacy of steroids in patients with acute-on-chronic liver failure (ACLF) precipitated by hepatitis B. METHODS:Patients with ACLF precipitated by hepatitis B were included and categorized according to treatment modalities (steroid vs. control). Survival and clinical characteristics, including patients' age, baseline ACLF grade, the model for end-stage liver disease (MELD) score, and occurrence of infection were compared between the two groups. Survival analyses of subgroups classified by their age, ACLF grade and MELD score were performed. Cox regression analyses were conducted to identify factors associated with 60-day cumulative and transplant-free mortality. RESULTS:From 2007 to 2016, 293 patients with hepatitis B-precipitated ACLF were recruited, among whom 162 received at least five consecutive doses of corticosteroids. By day 60 transplant-free survival was 62.6% in the control group compared with 53.7% in the steroid group (P = 0.126). Steroid treatment failed to show a survival benefit in the survival analysis among the subgroup. Within 60 days, pulmonary and overall infections occurred with higher frequency in the steroid-treated group than in the controls (P = 0.003 and < 0.001, respectively). In the univariate analysis, age, baseline MELD score >20, CLIF consortium (CLIF-C) ACLF grade 2-3, pulmonary infection and overall infection were associated with 60-day mortality. In the multivariate analysis, older age, baseline MELD score >20 and CLIF-C ACLF grade 2-3 were independent risk factors of 60-day mortality. CONCLUSION:Steroid treatment did not improve transplant-free survival in patients with ACLF precipitated by hepatitis B.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Huang C,Yu KK,Zheng JM,Li Ndoi
10.1111/1751-2980.12691subject
Has Abstractpub_date
2019-01-01 00:00:00pages
38-44issue
1eissn
1751-2972issn
1751-2980journal_volume
20pub_type
杂志文章abstract::Gut microbiota constitute the largest reservoir of the human microbiome and are an abundant and stable ecosystem-based on its diversity, complexity, redundancy, and host interactions This ecosystem is indispensable for human development and health. The integrity of the intestinal mucosal barrier depends on its interac...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12849
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To explore the features and clinical significance of serum pepsinogen (PG) assay in a follow-up study on a high-risk gastric cancer (GC) population. METHODS:A total of 444 participants from a high-risk area of GC in north China were enrolled in this follow-up study from April 1997 to December 1999. Serum PG ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1443-9573.2007.00321.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Probiotics are increasingly advocated in the management of various gastrointestinal disorders. The aim of this study was to investigate the current attitudes and prescribing practices of surgeons and gastroenterologists for probiotics in the treatment of gastrointestinal disorders. METHODS:A questionnaire wa...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00534.x
更新日期:2011-12-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is now the most common etiology of chronic liver disease threatening global public health. However, the name "NAFLD" is no longer appropriate with the change of time. Recently, a new term, "metabolic dysfunction-associated fatty liver disease" has been proposed by an internati...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12944
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To investigate the role of ghrelin in the gastric cancer cell line AGS and its probable mechanism. METHODS:Cell proliferation was detected by MTT assay after treated with ghrelin or des-acyl ghrelin. The expression of growth hormone secretagogue receptor 1a (GHS-R1a) and 1b (GHS-R1b) mRNA was detected using ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2012.00616.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years) with CBD stones. METHODS:We retrospectively examined 65 patients who underwent complete CBD stone removal (the duct clearance group) and 40 patients who underwent biliary s...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12656
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:MicroRNA-1254 (miR-1254) has not been studied in colorectal cancer (CRC) to date. This study aimed to investigate the inhibitory mechanism of miR-1254 in CRC tumorigenesis. METHODS:MiR-1254 expression was examined using real-time polymerase chain reaction in CRC and adjacent non-tumorous tissues. The correla...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12463
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Peritoneal mesothelioma is a rare disease associated with poor prognosis. Acute abdomen as the first presentation is an extremely rare occurrence. We report an exceptional case of a patient who was found to have a jejunal perforation due to infiltration of peritoneal mesothelioma. METHODS:A 62-year-old man ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2007.00309.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:We conducted a randomized trial aiming at improving patients' informed consent for undergoing endoscopic retrograde cholangiopancreatography (ERCP) in clinical care by comparing the efficacy of an additional educational video to written informed consent with that of written informed consent alone. METHODS:Th...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1751-2980.12824
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:We aimed to determine the effect of antithrombotics on in-hospital mortality and morbidity in patients with peptic ulcer disease-related upper gastrointestinal bleeding (PUD-related UGIB). METHODS:The study cohort was retrospectively selected from a tertiary center database of patients with PUD-related UGIB,...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12140
更新日期:2014-06-01 00:00:00
abstract::Lgr5 marks stem cells in digestive epithelial tissues by lineage tracing, and in vitro ever-expansion of Lgr5 stem cells form organoids, which can be directed to differentiate into functional somatic cells. Organoids derived from gastrointestinal epithelium even recapitulate the morphologic features of their in vivo c...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12305
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To investigate the alterations and functions of intrahepatic B (IHB) cells in non-alcoholic fatty liver disease (NAFLD) model induced by high-fat diet (HFD). METHODS:C57BL/6 J mice were fed with HFD for 16 weeks to induce NAFLD. Flow cytometry was used to analyze lymphocytes from liver, spleen and peripheral...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12362
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:It is known that the vacuolating cytotoxin (VacA) could induce apoptosis. However, the mechanism remained to be elucidated. The aim of this study is to investigate the role of Bcl family of proteins (Bcl-2 and Bax) and the mitochondrial voltage-dependent anion channel (VDAC) in VacA-induced apoptosis of AGS c...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2009.00412.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:There is currently little information on the medical economic outcomes of endoscopic submucosal dissection (ESD) for gastric cancer (GC) in elderly patients. This study therefore aimed to investigate the medical economic outcomes of ESD in elderly patients with GC using a national administrative database. ME...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1751-2980.12106
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:Methotrexate (MTX) can be used as an alternative for patients with Crohn's disease (CD) who are intolerant of thiopurine. This retrospective study aimed to provide some clues about MTX treatment in Chinese patients with CD. METHODS:Medical records of 27 adult patients with CD who were treated with MTX betwee...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12694
更新日期:2018-12-01 00:00:00
abstract::Gastric cancer (GC) is one of the inflammation-associated cancers. Helicobacter pylori is now thought to be responsible for more than 95% of all GCs, and its development is associated with at least four mechanisms that lead to genetic instability of the gastric mucosa. The risk of developing GC can be predicted by ass...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12105
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To define the normative data of gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) in healthy Chinese volunteers. METHODS:Healthy volunteers without gastrointestinal and throat disease and symptoms were enrolled and underwent 24-hour impedance-pH monitoring. RESULTS:A total of 37 healthy volun...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00502.x
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:The microenvironment of tumors constitutes a unique niche that promotes cancer metastasis and resistance. Two remarkable characteristics of this microenvironment are hypoxia and inflammation. Interleukin-1α (IL-1α), an important inflammatory factor, is frequently upregulated in a variety of cancers. This stud...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12496
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To analyze the prognostic effect of E-cadherin expression, the growth pattern of the tumor and the regression grade in a rectal cancer cohort treated with neoadjuvant radiochemotherapy (RCT). METHODS:A total of 223 patients with rectal cancer treated with neoadjuvant RCT followed by surgery were included. Al...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12471
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Hypomethylation within the body of the p53 gene, which is normally methylated, has been found in neoplasms. Also, the CG → TA transition was not detected in the CpG codons of the p53 gene in gastritis lesions in Iranian patients. Therefore, an evaluation of the probable correlation between global genome methy...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12053
更新日期:2013-06-01 00:00:00
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journal_title:Journal of digestive diseases
pub_type: 杂志文章,meta分析
doi:10.1111/1751-2980.12710
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:Early diagnosis of colitis-associated cancer and dysplasia through surveillance endoscopy is vital for patients with ulcerative colitis (UC). This study aimed to evaluate the efficacy of autofluorescence endoscopy (AFE) using 5-aminolevulinic acid (ALA) and to investigate the fluorescence signal localization ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12923
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the role of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) in the development of hepatic fibrogenesis in experimental disease models and human liver samples. METHODS:Cellular distribution patterns of IGFBP-rP1 were assessed by immunohistochem...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12126
更新日期:2014-04-01 00:00:00
abstract::Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous casca...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00550.x
更新日期:2012-01-01 00:00:00
abstract::The development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non-parenchymal cells in the liver. The impact of ethanol on hepatocytes can be characterized as a condition of organelle stress with multifactorial changes in hepatocellular function accumulating during ethanol ex...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2010.00468.x
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To investigate the clinicopathological features of columnar-lined esophagus (CLE) in Chinese patients. METHODS:Among 182 consecutive resections of proximal gastric cancer with residual esophageal tissue, 114 were eligible for the study. The maximal lengths of CLE and superficial esophageal glands (SEG) and t...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12007
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Currently the screening and diagnosis of gastric cancer and atrophic gastritis are mainly made by endoscopy and biopsy. The aim of this study was to evaluate the use of serum tests: serum pepsinogen I (PGI pepsinogen I/II ratio (PGR), gastrin-17 (G-17) and H. pylori-immunoglobulin G (IgG) antibodies to screen...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1443-9573.2007.00271.x
更新日期:2007-02-01 00:00:00
abstract::The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographical regions. The first studies on the epidemiology of IBD were mainly from traditionally high-incidence areas, such as North America, and northern and western Europe. In the last two decades, more...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12449
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:Whether minocycline can replace tetracycline in Helicobacter pylori (H. pylori) eradication remains unclear. The aim of this study was to determine the efficacy, safety, patient compliance and risk factors of a combination regimen of esomeprazole, minocycline, metronidazole and bismuth (EMMB) for H. pylori er...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12334
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Our aim was to investigate the expression of cytotoxic T lymphocyte-associated molecule 4 (CTLA-4) in ulcerative colitis (UC) and to evaluate the effect of CTLA-4 gene -1661A/G polymorphism on CTLA-4 expression and transcription. METHODS:A total of 20 UC patients and 22 healthy controls matched by age and se...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2010.00462.x
更新日期:2010-12-01 00:00:00