Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment.


:Gut microbiota constitute the largest reservoir of the human microbiome and are an abundant and stable ecosystem-based on its diversity, complexity, redundancy, and host interactions This ecosystem is indispensable for human development and health. The integrity of the intestinal mucosal barrier depends on its interactions with gut microbiota. The commensal bacterial community is implicated in the pathogenesis of inflammatory bowel disease (IBD), including ulcerative colitis (UC). The dysbiosis of microbes is characterized by reduced biodiversity, abnormal composition of gut microbiota, altered spatial distribution, as well as interactions among microbiota, between different strains of microbiota, and with the host. The defects in microecology, with the related metabolic pathways and molecular mechanisms, play a critical role in the innate immunity of the intestinal mucosa in UC. Fecal microbiota transplantation (FMT) has been used to treat many diseases related to gut microbiota, with the most promising outcome reported in antibiotic-associated diarrhea, followed by IBD. This review evaluated the results of various reports of FMT in UC. The efficacy of FMT remains highly controversial, and needs to be regularized by integrated management, standardization of procedures, and individualization of treatment.


J Dig Dis


Guo XY,Liu XJ,Hao JY




Has Abstract


2020-03-01 00:00:00












  • Epidemiological study of colorectal adenoma and cancer in symptomatic patients in China between 1990 and 2009.

    abstract:OBJECTIVE:The best cure for colorectal cancer (CRC) lies on its early diagnosis and treatment. We aimed to provide the epidemiological features of advanced colorectal adenoma (A-CRA) and CRC in symptomatic patients and to determine whether the incidences of A-CRA and CRC increased simultaneously in China between 1990 a...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Chen HM,Weng YR,Jiang B,Sheng JQ,Zheng P,Yu CG,Fang JY

    更新日期:2011-10-01 00:00:00

  • Follow-up study on a high risk population of gastric cancer in north China by serum pepsinogen assay.

    abstract:OBJECTIVE:To explore the features and clinical significance of serum pepsinogen (PG) assay in a follow-up study on a high-risk gastric cancer (GC) population. METHODS:A total of 444 participants from a high-risk area of GC in north China were enrolled in this follow-up study from April 1997 to December 1999. Serum PG ...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Sun LP,Gong YH,Wang L,Gong W,Yuan Y

    更新日期:2008-02-01 00:00:00

  • Insulin-like growth factor binding protein-related protein 1 contributes to hepatic fibrogenesis.

    abstract:OBJECTIVE:The aim of this study was to investigate the role of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) in the development of hepatic fibrogenesis in experimental disease models and human liver samples. METHODS:Cellular distribution patterns of IGFBP-rP1 were assessed by immunohistochem...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Guo XH,Liu LX,Zhang HY,Zhang QQ,Li Y,Tian XX,Qiu ZH

    更新日期:2014-04-01 00:00:00

  • Video education can improve awareness of risks for patients undergoing endoscopic retrograde cholangiopancreatography: A randomized trial.

    abstract:OBJECTIVE:We conducted a randomized trial aiming at improving patients' informed consent for undergoing endoscopic retrograde cholangiopancreatography (ERCP) in clinical care by comparing the efficacy of an additional educational video to written informed consent with that of written informed consent alone. METHODS:Th...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,随机对照试验


    authors: Xia T,Zhu YB,Zeng YB,Chen C,Wang SL,Zhao SB,Su XJ,Wang D,Yao J,Li ZS,Bai Y

    更新日期:2019-12-01 00:00:00

  • Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies.

    abstract:OBJECTIVE:Currently the screening and diagnosis of gastric cancer and atrophic gastritis are mainly made by endoscopy and biopsy. The aim of this study was to evaluate the use of serum tests: serum pepsinogen I (PGI pepsinogen I/II ratio (PGR), gastrin-17 (G-17) and H. pylori-immunoglobulin G (IgG) antibodies to screen...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Cao Q,Ran ZH,Xiao SD

    更新日期:2007-02-01 00:00:00

  • Therapeutic benefits of combined sorafenib for intermediate hepatocellular carcinoma unresponsive to transarterial chemoembolization in a Chinese population.

    abstract:OBJECTIVE:Transarterial chemoembolization (TACE) is the treatment modality for intermediate, or Barcelona Clinic Liver Cancer stage B, hepatocellular carcinoma (HCC), but its beneficial effect on outcomes is still unsatisfactory. This study aimed to assess the outcomes of combined TACE and sorafenib for patients with i...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Lee SW,Tung CF,Peng YC,Lien HC,Chang CS

    更新日期:2020-08-01 00:00:00

  • Differential gene and protein expression in primary gastric carcinomas and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis.

    abstract:OBJECTIVE:To gain insight into the molecular events of lymph node metastasis of human gastric carcinoma. METHODS:The gene expression profile of five matched primary gastric carcinomas and their lymph node metastases was analyzed by complementary DNA (cDNA) microarray. Differential genes were identified in the metastat...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Xie HL,Li ZY,Gan RL,Li XJ,Zhang QL,Hui M,Zhou XT

    更新日期:2010-06-01 00:00:00

  • Non-alcoholic fatty liver disease to metabolic dysfunction-associated fatty liver disease: Conceptual changes for clinicians, researchers and patients.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is now the most common etiology of chronic liver disease threatening global public health. However, the name "NAFLD" is no longer appropriate with the change of time. Recently, a new term, "metabolic dysfunction-associated fatty liver disease" has been proposed by an internati...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Lin SZ,Chen YW,Fan JG

    更新日期:2020-11-01 00:00:00

  • Organoids derived from digestive tract, liver, and pancreas.

    abstract::Lgr5 marks stem cells in digestive epithelial tissues by lineage tracing, and in vitro ever-expansion of Lgr5 stem cells form organoids, which can be directed to differentiate into functional somatic cells. Organoids derived from gastrointestinal epithelium even recapitulate the morphologic features of their in vivo c...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审


    authors: Xu AT,Tong JL,Ran ZH

    更新日期:2016-01-01 00:00:00

  • Barrett's esophagus-related diseases remain uncommon in China.

    abstract::Barrett's esophagus (BE)-related esophageal adenocarcinoma (EAC) has shown the fastest rise in incidence in Western countries; however, research data on BE-related diseases from China are inconclusive. We aimed to review and analyze the published results on these diseases in China. We searched PubMed and Chinese medic...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审


    authors: Huang Q,Fang DC,Yu CG,Zhang J,Chen MH

    更新日期:2011-12-01 00:00:00

  • Effects of short RNA structural analogues against hepatitis C virus genotypes 2, 3 and 4 in replicon cells.

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    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Elshaffei IM,Gupta N,Wu CH,Wu DC,Hammad LN,Abo-Elmatty DM,Mesbah NM,Wu GY

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  • Surgical treatment of intestinal stricture in inflammatory bowel disease.

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    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审


    authors: Mohan HM,Coffey JC

    更新日期:2020-06-01 00:00:00

  • High-definition magnifying endoscopy with i-scan in the diagnosis of Helicobacter pylori infection: a pilot study.

    abstract:OBJECTIVE:This study aimed to compare the diagnostic value and image quality of high-definition magnifying white light endoscopy (M-WLE) and high-definition magnifying endoscopy with i-scan (M-i-scan) for Helicobacter pylori (H.pylori) infection. METHODS:Patients complaining of dyspepsia who underwent esophagogastrodu...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Qi QQ,Zuo XL,Li CQ,Ji R,Li Z,Zhou CJ,Li YQ

    更新日期:2013-11-01 00:00:00

  • Clinical utility of retrograde terminal ileum intubation in the evaluation of chronic non-bloody diarrhea.

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    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Makkar R,Lopez R,Shen B

    更新日期:2013-10-01 00:00:00

  • Cytomegalovirus: a probable cause of steroid-refractory ulcerative colitis.

    abstract::Cytomegalovirus, regarded as a trigger of several autoimmune diseases, is an opportunistic pathogen. Patients with ulcerative colitis (UC) undergoing steroid treatment are susceptible to this infection. In the presence of cytomegalovirus, inflammation becomes more complex. Patients with active UC who are infected with...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审


    authors: Xue M,Chen SJ,Wang LJ,Du Y,Si JM

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  • Sending family history questionnaires to patients before a colonoscopy improves genetic counseling for hereditary colorectal cancer.

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    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Kessels K,Eisinger JD,Letteboer TG,Offerhaus GJA,Siersema PD,Moons LMG

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  • Endoscopic submucosal dissection for gastric cancer in elderly Japanese patients: an observational study of financial costs of treatment based on a national administrative database.

    abstract:OBJECTIVE:There is currently little information on the medical economic outcomes of endoscopic submucosal dissection (ESD) for gastric cancer (GC) in elderly patients. This study therefore aimed to investigate the medical economic outcomes of ESD in elderly patients with GC using a national administrative database. ME...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,多中心研究


    authors: Murata A,Muramatsu K,Ichimiya Y,Kubo T,Fujino Y,Matsuda S

    更新日期:2014-02-01 00:00:00

  • Inflammatory bowel disease: a survey of the epidemiology in Asia.

    abstract::Inflammatory bowel disease (IBD) has long been considered a disease that affects predominantly a Western population. The incidence and prevalence rates from Asian populations are much lower in comparison. More recent data, however, have shown significantly higher rates in Asians and time trend studies have shown an in...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审


    authors: Goh K,Xiao SD

    更新日期:2009-02-01 00:00:00

  • Guidelines for the diagnosis and treatment of acute non-variceal upper gastrointestinal bleeding (2015, Nanchang, China).

    abstract::Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is one of the most common medical emergencies in China and worldwide. In 2009, we published the "Guidelines for the diagnosis and treatment of acute non-variceal upper gastrointestinal bleeding" for the patients in China; however, during the past years numer...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,实务指引


    authors: Bai Y,Li ZS

    更新日期:2016-02-01 00:00:00

  • Esomeprazole, minocycline, metronidazole and bismuth as first-line and second-line regimens for Helicobacter pylori eradication.

    abstract:OBJECTIVE:Whether minocycline can replace tetracycline in Helicobacter pylori (H. pylori) eradication remains unclear. The aim of this study was to determine the efficacy, safety, patient compliance and risk factors of a combination regimen of esomeprazole, minocycline, metronidazole and bismuth (EMMB) for H. pylori er...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Song ZQ,Zhou LY

    更新日期:2016-04-01 00:00:00

  • Acetaldehyde and gastric cancer.

    abstract::Aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) gene polymorphisms associating with enhanced acetaldehyde exposure and markedly increased cancer risk in alcohol drinkers provide undisputable evidence for acetaldehyde being a local carcinogen not only in esophageal but also in gastric cancer. Accordingly...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审


    authors: Salaspuro M

    更新日期:2011-04-01 00:00:00

  • Risk factors for small bowel bleeding in chronic nonsteroidal anti-inflammatory drug users.

    abstract:OBJECTIVE:The incidence of nonsteroidal anti-inflammatory drugs (NSAIDs)-induced enteropathy is currently increasing. However, the predictors of small bowel bleeding (SBB) associated with NSAIDs are unknown. This study aimed to assess the risk factors of SBB in chronic NSAIDs users. METHODS:We retrospectively compared...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Cho KM,Park SY,Chung JO,Jun CH,Kim TJ,Son DJ,Kim BS,Park CH,Kim HS,Choi SK,Rew JS

    更新日期:2015-09-01 00:00:00

  • Effects of non-cytotoxic drugs on the growth of multidrug-resistance human gastric carcinoma cell line.

    abstract:OBJECTIVE:To investigate the effects of the non-cytotoxic drug (cyclooxygenase-2 (COX-2) inhibitor and octreotide) on growth of the multidrug-resistant human gastric carcinoma cell line SGC-7901/ADR. METHODS:The effects of non-cytotoxic drug on the growth of SGC-7901 and SGC-7901/ADR cells were evaluated by (3)H-thymi...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Wang CH,Zheng WB,Qiang O,Tang CW

    更新日期:2009-05-01 00:00:00

  • H+ /K+ ATPase expression in human parietal cells and gastric acid secretion in elderly individuals.

    abstract:OBJECTIVE:To investigate whether the ultrastructure and hydrogen potassium adenosine triphosphate (H+ /K+ ATPase) expression of human parietal cells were associated with aging. METHODS:In all, 50 participants who underwent gastroscopy due to dyspepsia were divided into two age groups, with 19 in the younger group (YG,...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Zhang W,Zheng SB,Zhuang Y,Xiang P,Xiao L,Li B,Ji da N,Xia SJ,Yu Z,Shi DY

    更新日期:2013-07-01 00:00:00

  • Relationship between pancreatic and/or extrapancreatic lesions and serum IgG and IgG4 levels in IgG4-related diseases.

    abstract:OBJECTIVE:We aimed to investigate the relationship between the number of involved organs or regions and serum immunoglobulin G (IgG) and immunoglobulin G4 (IgG4) levels. METHODS:The number of pancreatic and/or extrapancreatic lesions and serum IgG and IgG4 levels were examined by groups in 46 patients with IgG4-relate...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Igarashi H,Ito T,Oono T,Nakamura T,Fujimori N,Niina Y,Hijioka M,Uchida M,Lee R,Iwao R,Nakamura K,Kotoh K,Takayanagi R

    更新日期:2012-05-01 00:00:00

  • A single-center experience with methotrexate in the treatment of Chinese Crohn's disease patients.

    abstract:OBJECTIVE:Methotrexate (MTX) can be used as an alternative for patients with Crohn's disease (CD) who are intolerant of thiopurine. This retrospective study aimed to provide some clues about MTX treatment in Chinese patients with CD. METHODS:Medical records of 27 adult patients with CD who were treated with MTX betwee...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Wang TR,Qiao YQ,Zou DW,Ran ZH

    更新日期:2018-12-01 00:00:00

  • New ideas for future studies of Helicobacter pylori.

    abstract::Gastric cancer (GC) is one of the inflammation-associated cancers. Helicobacter pylori is now thought to be responsible for more than 95% of all GCs, and its development is associated with at least four mechanisms that lead to genetic instability of the gastric mucosa. The risk of developing GC can be predicted by ass...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审


    authors: Lu H,Xiao SD

    更新日期:2014-01-01 00:00:00

  • Effect of cytotoxic T lymphocyte-associated molecule 4 1661 gene polymorphism on its expression and transcription in ulcerative colitis.

    abstract:OBJECTIVE:Our aim was to investigate the expression of cytotoxic T lymphocyte-associated molecule 4 (CTLA-4) in ulcerative colitis (UC) and to evaluate the effect of CTLA-4 gene -1661A/G polymorphism on CTLA-4 expression and transcription. METHODS:A total of 20 UC patients and 22 healthy controls matched by age and se...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Jiang T,Ge LQ,Chen ZT,Li C,Zhou F,Luo Y,Xia B

    更新日期:2010-12-01 00:00:00

  • Clinical features and treatment options among Chinese adults with self-reported constipation: An internet-based survey.

    abstract:OBJECTIVE:We aimed to investigate the clinical features, precipitating factors, bowel habits, bothersome symptoms and treatment strategies of individuals in China with self-reported constipation. METHODS:An internet-based survey was conducted in China. The participants had self-reported chronic constipation (≥1 sympto...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章


    authors: Song J,Bai T,Zhang L,Hou XH

    更新日期:2019-08-01 00:00:00

  • Validation in China of a non-invasive salivary pepsin biomarker containing two unique human pepsin monoclonal antibodies to diagnose gastroesophageal reflux disease.

    abstract:OBJECTIVES:Peptest is a new non-invasive reflux diagnostic test based on lateral flow technology that containing two highly specific human pepsin monoclonal antibodies for detecting pepsin, a biomarker for reflux disease. The primary aim of this multicenter clinical study was to validate the efficacy of Peptest in pati...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,多中心研究


    authors: Wang YF,Yang CQ,Chen YX,Cao AP,Yu XF,Yu Y,Zhang ZY,Shen XZ,Liu F,Zhong L,Wang YX,Liu ZJ,Shi YH,Zhong J,Li JN,Lan Y,Lenham RK,Woodcock AD,Dettmar PW,Fang JY

    更新日期:2019-06-01 00:00:00