Abstract:
OBJECTIVE:The aim of this study was to evaluate the effects and safety of different doses of ilaprazole on healthy volunteers without a Helicobacter pylori infection. METHODS:A total of 12 healthy Chinese volunteers were enrolled and divided into four groups randomly, with a 5-day treatment of oral ilaprazole 5mg, 10mg and 20mg or omeprazole 20mg, respectively. After an interval of a 14-day washout phase, each was switched to another dose group and eventually completed all four regimens. The percentage time of intragastric pH>4 was the major index. The polymorphisms of the metabolic enzyme CYP2C19 in these volunteers were also detected. RESULTS:The percentage time of intragastric pH>4 in the ilaprazole 5, 10 and 20mg groups were 80.4%, 88.1% and 91.0%, respectively, during the first 24h, compared to that of the 20mg omeprazole group (76.6%, P>0.05). Ilaprazole 20mg provided a significant higher mean 24-h pH than that of the same dose of omeprazole both on Day 1 (7.78 vs 6.67, P<0.01) and Day 5 (7.95 vs 7.44, P<0.05). No CYP2C19-dependent difference or obvious adverse effect were found in any ilaprazole groups. CONCLUSION:Low dose ilaprazole offers a gastric acid inhibition comparable to a routine dose of omeprazole, and further investigations in patients with acid-associated diseases are needed.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
DU YQ,Guo WY,Zou DW,Zhan XB,Li Z,Hu JH,Gong YF,He J,Lu JP,Li ZSdoi
10.1111/j.1751-2980.2011.00557.xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
113-9issue
2eissn
1751-2972issn
1751-2980journal_volume
13pub_type
杂志文章,随机对照试验abstract::The incidence of early esophageal adenocarcinoma has been increasing significantly in recent decades. Prognosis depends greatly on the choice of treatment. Early cancers can be treated by endoscopic resection, whereas advanced carcinomas have to be sent for surgery. Esophageal resection is associated with high periope...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12264
更新日期:2015-07-01 00:00:00
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journal_title:Journal of digestive diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1751-2980.12106
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abstract::Helicobacter pylori (H. pylori) infection causes peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphomas and gastric adenocarcinomas, for which the pathogenesis of chronic gastric inflammation prevails and provides the pathogenic basis. Since the role of H. pylori infection is promoting carcinogenesis...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2008.00334.x
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abstract:OBJECTIVE:Currently the screening and diagnosis of gastric cancer and atrophic gastritis are mainly made by endoscopy and biopsy. The aim of this study was to evaluate the use of serum tests: serum pepsinogen I (PGI pepsinogen I/II ratio (PGR), gastrin-17 (G-17) and H. pylori-immunoglobulin G (IgG) antibodies to screen...
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pub_type: 杂志文章
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doi:10.1111/j.1751-2980.2007.00309.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To explore the features and clinical significance of serum pepsinogen (PG) assay in a follow-up study on a high-risk gastric cancer (GC) population. METHODS:A total of 444 participants from a high-risk area of GC in north China were enrolled in this follow-up study from April 1997 to December 1999. Serum PG ...
journal_title:Journal of digestive diseases
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abstract:OBJECTIVE:To evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years) with CBD stones. METHODS:We retrospectively examined 65 patients who underwent complete CBD stone removal (the duct clearance group) and 40 patients who underwent biliary s...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12324
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journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00550.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Methotrexate (MTX) can be used as an alternative for patients with Crohn's disease (CD) who are intolerant of thiopurine. This retrospective study aimed to provide some clues about MTX treatment in Chinese patients with CD. METHODS:Medical records of 27 adult patients with CD who were treated with MTX betwee...
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pub_type: 杂志文章
doi:10.1111/1751-2980.12694
更新日期:2018-12-01 00:00:00
abstract::Drug-induced liver injury (DILI), which is caused by drugs and herbal or dietary supplements, remains a serious concern for drug developers, regulators, and clinicians; however, serum biomarkers utilized to detect and monitor DILI have not changed in decades and have limitations. Data-driven mathematical modeling that...
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pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12798
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journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2011.00535.x
更新日期:2011-12-01 00:00:00
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journal_title:Journal of digestive diseases
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journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2008.00326.x
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pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of digestive diseases
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pub_type: 杂志文章
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journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:It is known that the vacuolating cytotoxin (VacA) could induce apoptosis. However, the mechanism remained to be elucidated. The aim of this study is to investigate the role of Bcl family of proteins (Bcl-2 and Bax) and the mitochondrial voltage-dependent anion channel (VDAC) in VacA-induced apoptosis of AGS c...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2009.00412.x
更新日期:2010-02-01 00:00:00
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更新日期:2018-02-01 00:00:00
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journal_title:Journal of digestive diseases
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journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00534.x
更新日期:2011-12-01 00:00:00
abstract::Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is one of the most common medical emergencies in China and worldwide. In 2009, we published the "Guidelines for the diagnosis and treatment of acute non-variceal upper gastrointestinal bleeding" for the patients in China; however, during the past years numer...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,实务指引
doi:10.1111/1751-2980.12319
更新日期:2016-02-01 00:00:00