Abstract:
OBJECTIVE:We conducted a randomized trial aiming at improving patients' informed consent for undergoing endoscopic retrograde cholangiopancreatography (ERCP) in clinical care by comparing the efficacy of an additional educational video to written informed consent with that of written informed consent alone. METHODS:This was a single-center, randomized controlled trial. Consecutive patients undergoing ERCP were randomized to a video education or a control group. An educational video detailing ERCP procedure plus standard written informed consent was administered to the video education group, while the control group reviewed standard written informed consent only. The primary outcome was the patients' perception of the risk or possibility of ERCP complications. Their perception of the benefits of ERCP, alternative treatments and overall satisfaction with the process of informed consent were also compared. RESULTS:In total 205 patients were included in the study (104 in the control group and 101 in the video education group). Patients' comprehension of ERCP-related complications in the video education group was significantly increased (P < 0.001), and these patients were more likely to correctly identify the incidence of such complications. Significantly more patients in the video education group were very satisfied with informed consent process (87.1% vs 76.0%, P = 0.040) and fewer patients needed additional explanations (31.7% vs 47.1%, P = 0.024). CONCLUSIONS:A supplementary educational video could greatly improve patient's understanding of ERCP procedure, in particular, its potential risks and complications, as well as their overall satisfaction with the process of informed consent (ClinicalTrials.gov no. NCT02810379).
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Xia T,Zhu YB,Zeng YB,Chen C,Wang SL,Zhao SB,Su XJ,Wang D,Yao J,Li ZS,Bai Ydoi
10.1111/1751-2980.12824subject
Has Abstractpub_date
2019-12-01 00:00:00pages
656-662issue
12eissn
1751-2972issn
1751-2980journal_volume
20pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:MicroRNAs (miRNAs) have recently emerged as novel regulators in liver fibrosis. miR-30c and miR-193 are involved in fibrotic remodeling processes and cancer development, respectively. This study aimed to explore the role of miR-30c and miR-193 in liver fibrosis. METHODS:The regulation of miRNAs in carbon tet...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12266
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:The monocyte chemoattractant protein-1 (MCP-1) -A2518G gene polymorphism has been found to be involved in the susceptibility to inflammatory bowel disease (IBD); however, the results of existing studies are controversial. The aim of this meta-analysis was to assess the relationship between the MCP-1 -A2518G p...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1751-2980.12232
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:The best cure for colorectal cancer (CRC) lies on its early diagnosis and treatment. We aimed to provide the epidemiological features of advanced colorectal adenoma (A-CRA) and CRC in symptomatic patients and to determine whether the incidences of A-CRA and CRC increased simultaneously in China between 1990 a...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00531.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Currently the screening and diagnosis of gastric cancer and atrophic gastritis are mainly made by endoscopy and biopsy. The aim of this study was to evaluate the use of serum tests: serum pepsinogen I (PGI pepsinogen I/II ratio (PGR), gastrin-17 (G-17) and H. pylori-immunoglobulin G (IgG) antibodies to screen...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1443-9573.2007.00271.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening. METHODS:Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12040
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Ursodeoxycholic acid (UDCA) is widely used to treat chronic liver diseases, and its cytoprotective effect on normal hepatocytes has been shown. This study aimed to investigate the apoptotic effects of UDCA on hepatocellular carcinoma (HCC) cells and the underlying molecular events in vitro. METHODS:HCC cells...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12191
更新日期:2014-12-01 00:00:00
abstract::Aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) gene polymorphisms associating with enhanced acetaldehyde exposure and markedly increased cancer risk in alcohol drinkers provide undisputable evidence for acetaldehyde being a local carcinogen not only in esophageal but also in gastric cancer. Accordingly...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2011.00480.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:Preoperative biliary drainage (PBD) can relieve symptoms of cholestasis, but carries risk of procedural complications. Metal stents have wider lumens and longer patency, although plastic stents (PS) remain in use. We reviewed the outcomes after PBD in patients with cholestasis. METHODS:Patients with symptom...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12455
更新日期:2017-03-01 00:00:00
abstract::Drug-induced liver injury (DILI), which is caused by drugs and herbal or dietary supplements, remains a serious concern for drug developers, regulators, and clinicians; however, serum biomarkers utilized to detect and monitor DILI have not changed in decades and have limitations. Data-driven mathematical modeling that...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12684
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To analyze the prognostic effect of E-cadherin expression, the growth pattern of the tumor and the regression grade in a rectal cancer cohort treated with neoadjuvant radiochemotherapy (RCT). METHODS:A total of 223 patients with rectal cancer treated with neoadjuvant RCT followed by surgery were included. Al...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12471
更新日期:2017-05-01 00:00:00
abstract::Cytomegalovirus, regarded as a trigger of several autoimmune diseases, is an opportunistic pathogen. Patients with ulcerative colitis (UC) undergoing steroid treatment are susceptible to this infection. In the presence of cytomegalovirus, inflammation becomes more complex. Patients with active UC who are infected with...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12037
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Data on the association between the antioxidant capacity of a diet and the risk of ulcerative colitis (UC) are scarce. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of UC in Iranian adults. METHODS:In this case-control study, patients w...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12823
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:The capacity of fundoplication to prevent esophageal adenocarcinoma is controversial. Development of cancer is associated with proliferation and anti-apoptosis, for which little data exist as to their response to fundoplication. Therefore, we wanted to clarify the effect of fundoplication on the magnitude of ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00508.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To summarize the clinical and spiral computed tomography (CT) features of undifferentiated embryonic liver sarcoma (UELS) in adults. METHODS:Clinical and CT findings of four adult patients with pathology-approved UELS were retrospectively analyzed with a literature review. All patients were examined using a ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2009.00400.x
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:There is currently little information on the medical economic outcomes of endoscopic submucosal dissection (ESD) for gastric cancer (GC) in elderly patients. This study therefore aimed to investigate the medical economic outcomes of ESD in elderly patients with GC using a national administrative database. ME...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/1751-2980.12106
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of peroxisome proliferator-activated receptors (PPAR)gamma and the effects of PPARgamma ligands on cells growth in colorectal cancer (CRC) cell line HT-29, and to explore whether the activation of PPARgamma by its selective ligand can induce apoptosis and the arrest of the cell c...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1443-9573.2007.00290.x
更新日期:2007-05-01 00:00:00
abstract::Fibroblast infiltration and collagen deposition result in structural changes in the bowel wall, and lead to strictures in intestinal inflammatory disease. While strictures can also occur in other contexts, such as malignancy, this review focuses on the surgical treatment of stricture secondary to inflammatory bowel di...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12880
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Non-steroidal anti-inflammatory drugs (NSAID) induce gastroduodenal mucosal injury and are metabolized by cytochrome P450 2C9 (CYP2C9). It is postulated that CYP2C9 genotype is associated with NSAID-induced gastropathy. This study aims to determine whether individuals with a CYP2C9 allele mutation are suscept...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2008.00326.x
更新日期:2008-05-01 00:00:00
abstract::The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographical regions. The first studies on the epidemiology of IBD were mainly from traditionally high-incidence areas, such as North America, and northern and western Europe. In the last two decades, more...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12449
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To explore the role of tagging single nucleotide polymorphisms (tagSNPs) in the adiponectin gene in the natural course of nonalcoholic fatty liver disease (NAFLD). METHODS:The participants were chosen from our previous survey containing 3543 individuals. Finally, a total of 696 participants who had been foll...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12288
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility and accuracy of confocal laser endomicroscopy (CLE) for the in vivo diagnosis of colorectal cancer (CRC) compared with conventional histology. METHODS:Consecutive patients who had undergone CLE examination for screening or surveillance colonoscopy were recruited. Suspected maligna...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12039
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the role of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) in the development of hepatic fibrogenesis in experimental disease models and human liver samples. METHODS:Cellular distribution patterns of IGFBP-rP1 were assessed by immunohistochem...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12126
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate the relationship between the number of involved organs or regions and serum immunoglobulin G (IgG) and immunoglobulin G4 (IgG4) levels. METHODS:The number of pancreatic and/or extrapancreatic lesions and serum IgG and IgG4 levels were examined by groups in 46 patients with IgG4-relate...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2012.00583.x
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of the non-cytotoxic drug (cyclooxygenase-2 (COX-2) inhibitor and octreotide) on growth of the multidrug-resistant human gastric carcinoma cell line SGC-7901/ADR. METHODS:The effects of non-cytotoxic drug on the growth of SGC-7901 and SGC-7901/ADR cells were evaluated by (3)H-thymi...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2009.00370.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:The efficacy of argon plasma coagulation (APC) on gastric antral vascular ectasia (GAVE) may be impaired over time and depends greatly on the application settings. Endoscopic band ligation (EBL) may be an alternative, but study on its efficacy is limited. This study aimed to evaluate and compare the clinical ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12958
更新日期:2021-01-01 00:00:00
abstract::Lgr5 marks stem cells in digestive epithelial tissues by lineage tracing, and in vitro ever-expansion of Lgr5 stem cells form organoids, which can be directed to differentiate into functional somatic cells. Organoids derived from gastrointestinal epithelium even recapitulate the morphologic features of their in vivo c...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12305
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Given the rarity of the disease, the post-resection clinical course of localized pancreatic acinar cell carcinoma (ACC) is largely unknown. Therefore, we aimed to analyze the outcomes of patients with localized pancreatic ACC who underwent curative surgical resection. METHODS:We retrospectively analyzed the ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12505
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the incidence and risk factors of de novo hepatitis B virus (HBV) infection from hepatitis B core antibody (anti-HBc)-positive donors in pediatric living donor liver transplantation (LDLT). METHODS:We retrospectively analyzed 46 recipients without pre-liver transplantatio...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12066
更新日期:2013-08-01 00:00:00
abstract::Gut microbiota constitute the largest reservoir of the human microbiome and are an abundant and stable ecosystem-based on its diversity, complexity, redundancy, and host interactions This ecosystem is indispensable for human development and health. The integrity of the intestinal mucosal barrier depends on its interac...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12849
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To carry out a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathy in chronic alcoholics before and one year after abstinence. METHODS:Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lact...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12415
更新日期:2016-11-01 00:00:00