Abstract:
OBJECTIVE:To analyze the prognostic effect of E-cadherin expression, the growth pattern of the tumor and the regression grade in a rectal cancer cohort treated with neoadjuvant radiochemotherapy (RCT). METHODS:A total of 223 patients with rectal cancer treated with neoadjuvant RCT followed by surgery were included. Altogether 88 biopsies prior to RCT and 213 tumor resections in an average of 55 days post-RCT were investigated. Protein expression of E-cadherin and tumor growth pattern (solid glandular vs single-cell pattern) was assessed by staining tissue microarrays. The regression grade at the invasion front was determined according to the Dworak scale. RESULTS:There was a significant decrease of E-cadherin expression (P = 0.002) and a significant increased single-cell growth (P < 0.001) at the invasion front in tumor samples after RCT compared with primary biopsies of the tumor. A low E-cadherin expression in the biopsy was related to a longer metastasis-free survival (P = 0.033) and tumor-specific survival (P = 0.030). Post-RCT single-cell growth at the tumor invasion front was a prognostic factor for longer tumor-specific survival (P = 0.021). A combination of growth pattern and the Dworak regression grade was an independent prognostic parameter for tumor-specific survival (P = 0.015). CONCLUSIONS:Loss of E-cadherin protein expression in the pretreatment biopsy of rectal cancer is associated with fewer metastases and improved survival. Furthermore, the growth pattern in the post-RCT resection specimen has a prognostic value for survival. A combination of growth pattern and tumor regression score (the RegPat score) showed the highest discriminatory power to identify high-risk patients.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Jessberger J,Erlenbach-Wünsch K,Posselt R,Haderlein M,Agaimy A,Fietkau R,Hartmann A,Distel Ldoi
10.1111/1751-2980.12471subject
Has Abstractpub_date
2017-05-01 00:00:00pages
283-291issue
5eissn
1751-2972issn
1751-2980journal_volume
18pub_type
杂志文章abstract:OBJECTIVE:We aimed to identify the differences in symptoms, high-resolution manometry (HRM) characteristics, and the efficacy of peroral endoscopic myotomy (POEM) regarding patients' sex in achalasia. METHODS:All patients diagnosed with achalasia by HRM who underwent POEM and were followed up for more than 6 months we...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12922
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Methotrexate (MTX) can be used as an alternative for patients with Crohn's disease (CD) who are intolerant of thiopurine. This retrospective study aimed to provide some clues about MTX treatment in Chinese patients with CD. METHODS:Medical records of 27 adult patients with CD who were treated with MTX betwee...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12694
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Data on the association between the antioxidant capacity of a diet and the risk of ulcerative colitis (UC) are scarce. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of UC in Iranian adults. METHODS:In this case-control study, patients w...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12823
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To explore the role of tagging single nucleotide polymorphisms (tagSNPs) in the adiponectin gene in the natural course of nonalcoholic fatty liver disease (NAFLD). METHODS:The participants were chosen from our previous survey containing 3543 individuals. Finally, a total of 696 participants who had been foll...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12288
更新日期:2015-10-01 00:00:00
abstract::Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous casca...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00550.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To investigate the role of ghrelin in the gastric cancer cell line AGS and its probable mechanism. METHODS:Cell proliferation was detected by MTT assay after treated with ghrelin or des-acyl ghrelin. The expression of growth hormone secretagogue receptor 1a (GHS-R1a) and 1b (GHS-R1b) mRNA was detected using ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2012.00616.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To carry out a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathy in chronic alcoholics before and one year after abstinence. METHODS:Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lact...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12415
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Transarterial chemoembolization (TACE) is the treatment modality for intermediate, or Barcelona Clinic Liver Cancer stage B, hepatocellular carcinoma (HCC), but its beneficial effect on outcomes is still unsatisfactory. This study aimed to assess the outcomes of combined TACE and sorafenib for patients with i...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12911
更新日期:2020-08-01 00:00:00
abstract::Aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) gene polymorphisms associating with enhanced acetaldehyde exposure and markedly increased cancer risk in alcohol drinkers provide undisputable evidence for acetaldehyde being a local carcinogen not only in esophageal but also in gastric cancer. Accordingly...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2011.00480.x
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Peritoneal mesothelioma is a rare disease associated with poor prognosis. Acute abdomen as the first presentation is an extremely rare occurrence. We report an exceptional case of a patient who was found to have a jejunal perforation due to infiltration of peritoneal mesothelioma. METHODS:A 62-year-old man ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2007.00309.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:Whether minocycline can replace tetracycline in Helicobacter pylori (H. pylori) eradication remains unclear. The aim of this study was to determine the efficacy, safety, patient compliance and risk factors of a combination regimen of esomeprazole, minocycline, metronidazole and bismuth (EMMB) for H. pylori er...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12334
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) is a valuable device to diagnose and determine the malignant potential of gastrointestinal stromal tumors (GIST) as early as possible when making clinical therapeutic decisions. This study aimed to estimate the ability of CH-EUS to discriminate be...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,meta分析
doi:10.1111/1751-2980.12710
更新日期:2019-03-01 00:00:00
abstract::Cytomegalovirus, regarded as a trigger of several autoimmune diseases, is an opportunistic pathogen. Patients with ulcerative colitis (UC) undergoing steroid treatment are susceptible to this infection. In the presence of cytomegalovirus, inflammation becomes more complex. Patients with active UC who are infected with...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12037
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:The efficacy of argon plasma coagulation (APC) on gastric antral vascular ectasia (GAVE) may be impaired over time and depends greatly on the application settings. Endoscopic band ligation (EBL) may be an alternative, but study on its efficacy is limited. This study aimed to evaluate and compare the clinical ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12958
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:We conducted a randomized trial aiming at improving patients' informed consent for undergoing endoscopic retrograde cholangiopancreatography (ERCP) in clinical care by comparing the efficacy of an additional educational video to written informed consent with that of written informed consent alone. METHODS:Th...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1751-2980.12824
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to investigate the frequency and factors involved in the terminal ileum intubation of patients with chronic, non-bloody diarrhea and to compare diagnostic yields of colonoscopy and ileocolonoscopy. METHODS:The medical records of 945 patients undergoing colonoscopy for chronic, non...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12082
更新日期:2013-10-01 00:00:00
abstract::Helicobacter pylori (H. pylori) infection causes peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphomas and gastric adenocarcinomas, for which the pathogenesis of chronic gastric inflammation prevails and provides the pathogenic basis. Since the role of H. pylori infection is promoting carcinogenesis...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2008.00334.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the prevalence of and risk factors associated with elevated alanine aminotransferase (ALT) levels among a sample of normal weight, overweight and obese youth from two urban populations in Central Mexico. METHODS:Baseline data from 1262 youth aged 8-19 years who participated in t...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12072
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Non-steroidal anti-inflammatory drugs (NSAID) induce gastroduodenal mucosal injury and are metabolized by cytochrome P450 2C9 (CYP2C9). It is postulated that CYP2C9 genotype is associated with NSAID-induced gastropathy. This study aims to determine whether individuals with a CYP2C9 allele mutation are suscept...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2008.00326.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to systematically assess the relevant risk factors of positive lateral margin (LM) after en bloc resection of early gastric adenocarcinoma. METHODS:A total of 242 patients who had undergone endoscopic submucosal dissection (ESD) due to early gastric lesions from January 2009 to March 2015 we...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12342
更新日期:2016-04-01 00:00:00
abstract::Drug-induced liver injury (DILI), which is caused by drugs and herbal or dietary supplements, remains a serious concern for drug developers, regulators, and clinicians; however, serum biomarkers utilized to detect and monitor DILI have not changed in decades and have limitations. Data-driven mathematical modeling that...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12684
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Preoperative biliary drainage (PBD) can relieve symptoms of cholestasis, but carries risk of procedural complications. Metal stents have wider lumens and longer patency, although plastic stents (PS) remain in use. We reviewed the outcomes after PBD in patients with cholestasis. METHODS:Patients with symptom...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12455
更新日期:2017-03-01 00:00:00
abstract::The development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non-parenchymal cells in the liver. The impact of ethanol on hepatocytes can be characterized as a condition of organelle stress with multifactorial changes in hepatocellular function accumulating during ethanol ex...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2010.00468.x
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To gain insight into the molecular events of lymph node metastasis of human gastric carcinoma. METHODS:The gene expression profile of five matched primary gastric carcinomas and their lymph node metastases was analyzed by complementary DNA (cDNA) microarray. Differential genes were identified in the metastat...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2010.00432.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:This study aimed to compare the diagnostic value and image quality of high-definition magnifying white light endoscopy (M-WLE) and high-definition magnifying endoscopy with i-scan (M-i-scan) for Helicobacter pylori (H.pylori) infection. METHODS:Patients complaining of dyspepsia who underwent esophagogastrodu...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12086
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the role of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) in the development of hepatic fibrogenesis in experimental disease models and human liver samples. METHODS:Cellular distribution patterns of IGFBP-rP1 were assessed by immunohistochem...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12126
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:With an age-standardized incidence rate of 2 per 100 000, esophageal cancer is not common among Malaysians, but they are nevertheless important due to its poor prognosis. The study is to clarify whether the human papillomavirus (HPV) is associated with esophageal cancer in Malaysians as there has been no repo...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12605
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Systematic reports on acute upper gastrointestinal bleeding in children/adolescents are scanty. The aim of this study is to analyze its presentation, pathology and outcome in Hong Kong. METHODS:A retrospective review of the hospital database for admissions up to the age of 18 years with signs of acute upper ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2008.00346.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To investigate the clinicopathological features of columnar-lined esophagus (CLE) in Chinese patients. METHODS:Among 182 consecutive resections of proximal gastric cancer with residual esophageal tissue, 114 were eligible for the study. The maximal lengths of CLE and superficial esophageal glands (SEG) and t...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12007
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The monocyte chemoattractant protein-1 (MCP-1) -A2518G gene polymorphism has been found to be involved in the susceptibility to inflammatory bowel disease (IBD); however, the results of existing studies are controversial. The aim of this meta-analysis was to assess the relationship between the MCP-1 -A2518G p...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1751-2980.12232
更新日期:2015-04-01 00:00:00