Chronic alcoholics retain dyspeptic symptoms, pan-enteric dysmotility, and autonomic neuropathy before and after abstinence.

abstract：OBJECTIVE:This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening. METHODS:Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were ...

journal_title：Journal of digestive diseases

authors： Deng K,Zhou LY,Lin SR,Li Y,Chen M,Geng QM,Li YW

更新日期：2013-06-01 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection causes peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphomas and gastric adenocarcinomas, for which the pathogenesis of chronic gastric inflammation prevails and provides the pathogenic basis. Since the role of H. pylori infection is promoting carcinogenesis...

journal_title：Journal of digestive diseases

authors： Lee SY,Shin YW,Hahm KB

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Currently the screening and diagnosis of gastric cancer and atrophic gastritis are mainly made by endoscopy and biopsy. The aim of this study was to evaluate the use of serum tests: serum pepsinogen I (PGI pepsinogen I/II ratio (PGR), gastrin-17 (G-17) and H. pylori-immunoglobulin G (IgG) antibodies to screen...

journal_title：Journal of digestive diseases

authors： Cao Q,Ran ZH,Xiao SD

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:We aimed to identify the features of microRNA (miRNA) at different fibrotic stages in patients with hepatitis B virus (HBV)-related liver fibrosis. METHODS:Liver tissues were collected from 40 chronic hepatitis B (CHB) patients at fibrotic stages S0-4. Microarrays of miRNAs and genomic informatics analysis w...

journal_title：Journal of digestive diseases

authors： Chen R,Wu JC,Liu T,Qu Y,Lu LG,Xu MY

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) in the development of hepatic fibrogenesis in experimental disease models and human liver samples. METHODS:Cellular distribution patterns of IGFBP-rP1 were assessed by immunohistochem...

journal_title：Journal of digestive diseases

authors： Guo XH,Liu LX,Zhang HY,Zhang QQ,Li Y,Tian XX,Qiu ZH

更新日期：2014-04-01 00:00:00

abstract：:Fibroblast infiltration and collagen deposition result in structural changes in the bowel wall, and lead to strictures in intestinal inflammatory disease. While strictures can also occur in other contexts, such as malignancy, this review focuses on the surgical treatment of stricture secondary to inflammatory bowel di...

journal_title：Journal of digestive diseases

authors： Mohan HM,Coffey JC

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:To investigate the alterations and functions of intrahepatic B (IHB) cells in non-alcoholic fatty liver disease (NAFLD) model induced by high-fat diet (HFD). METHODS:C57BL/6 J mice were fed with HFD for 16 weeks to induce NAFLD. Flow cytometry was used to analyze lymphocytes from liver, spleen and peripheral...

journal_title：Journal of digestive diseases

authors： Zhang F,Jiang WW,Li X,Qiu XY,Wu Z,Chi YJ,Cong X,Liu YL

更新日期：2016-07-01 00:00:00

abstract：:The incidence of early esophageal adenocarcinoma has been increasing significantly in recent decades. Prognosis depends greatly on the choice of treatment. Early cancers can be treated by endoscopic resection, whereas advanced carcinomas have to be sent for surgery. Esophageal resection is associated with high periope...

journal_title：Journal of digestive diseases

authors： Knabe M,May A,Ell C

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) is a valuable device to diagnose and determine the malignant potential of gastrointestinal stromal tumors (GIST) as early as possible when making clinical therapeutic decisions. This study aimed to estimate the ability of CH-EUS to discriminate be...

journal_title：Journal of digestive diseases

authors： Tang JY,Tao KG,Zhang LY,Wu KM,Shi J,Zeng X,Lin Y

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To gain insight into the molecular events of lymph node metastasis of human gastric carcinoma. METHODS:The gene expression profile of five matched primary gastric carcinomas and their lymph node metastases was analyzed by complementary DNA (cDNA) microarray. Differential genes were identified in the metastat...

journal_title：Journal of digestive diseases

authors： Xie HL,Li ZY,Gan RL,Li XJ,Zhang QL,Hui M,Zhou XT

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate the expression of peroxisome proliferator-activated receptors (PPAR)gamma and the effects of PPARgamma ligands on cells growth in colorectal cancer (CRC) cell line HT-29, and to explore whether the activation of PPARgamma by its selective ligand can induce apoptosis and the arrest of the cell c...

journal_title：Journal of digestive diseases

authors： Lin MS,Chen WC,Bai X,Wang YD

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to document our 6-year experiences in identifying the clinical characteristics, laboratory findings, risk factors and the outcomes of patients with ischemic colitis (IC) in a community hospital setting. METHODS:The medical records of patients who were diagnosed with IC from 2007 to 2...

journal_title：Journal of digestive diseases

authors： Sherid M,Sifuentes H,Samo S,Sulaiman S,Husein H,Tupper R,Sethuraman SN,Spurr C,Vainder JA,Sridhar S

更新日期：2014-11-01 00:00:00

abstract：:Gastric cancer (GC) is one of the inflammation-associated cancers. Helicobacter pylori is now thought to be responsible for more than 95% of all GCs, and its development is associated with at least four mechanisms that lead to genetic instability of the gastric mucosa. The risk of developing GC can be predicted by ass...

journal_title：Journal of digestive diseases

authors： Lu H,Xiao SD

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility and accuracy of confocal laser endomicroscopy (CLE) for the in vivo diagnosis of colorectal cancer (CRC) compared with conventional histology. METHODS:Consecutive patients who had undergone CLE examination for screening or surveillance colonoscopy were recruited. Suspected maligna...

journal_title：Journal of digestive diseases

authors： Liu C,Li CQ,Zuo XL,Ji R,Xie XJ,Yang YS,Li YQ

更新日期：2013-05-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is now the most common etiology of chronic liver disease threatening global public health. However, the name "NAFLD" is no longer appropriate with the change of time. Recently, a new term, "metabolic dysfunction-associated fatty liver disease" has been proposed by an internati...

journal_title：Journal of digestive diseases

authors： Lin SZ,Chen YW,Fan JG

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease, the natural course of which has not been well documented. This study aimed to perform a prospective cohort study to investigate NAFLD in a Chinese population. METHODS:Using our previous epidemiological survey, 3543 patients were foll...

journal_title：Journal of digestive diseases

authors： Zhou YJ,Li YY,Nie YQ,Huang CM,Cao CY

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To explore the features and clinical significance of serum pepsinogen (PG) assay in a follow-up study on a high-risk gastric cancer (GC) population. METHODS:A total of 444 participants from a high-risk area of GC in north China were enrolled in this follow-up study from April 1997 to December 1999. Serum PG ...

journal_title：Journal of digestive diseases

authors： Sun LP,Gong YH,Wang L,Gong W,Yuan Y

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of endoscopic drainage and endoscopic necrosectomy in the management of symptomatic pancreatic fluid collection. METHODS:The clinical data of patients with symptomatic pancreatic fluid collection referred for endoscopic drainage were captured prospectively and analyzed. Pancreatic duct d...

journal_title：Journal of digestive diseases

authors： Ang TL,Teo EK,Fock KM

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years) with CBD stones. METHODS:We retrospectively examined 65 patients who underwent complete CBD stone removal (the duct clearance group) and 40 patients who underwent biliary s...

journal_title：Journal of digestive diseases

authors： Akazawa Y,Ohtani M,Nosaka T,Saito Y,Takahashi K,Naito T,Ofuji K,Matsuda H,Hiramatsu K,Nemoto T,Nakamoto Y

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Our aim was to investigate the expression of cytotoxic T lymphocyte-associated molecule 4 (CTLA-4) in ulcerative colitis (UC) and to evaluate the effect of CTLA-4 gene -1661A/G polymorphism on CTLA-4 expression and transcription. METHODS:A total of 20 UC patients and 22 healthy controls matched by age and se...

journal_title：Journal of digestive diseases

authors： Jiang T,Ge LQ,Chen ZT,Li C,Zhou F,Luo Y,Xia B

更新日期：2010-12-01 00:00:00

abstract：:Cytomegalovirus, regarded as a trigger of several autoimmune diseases, is an opportunistic pathogen. Patients with ulcerative colitis (UC) undergoing steroid treatment are susceptible to this infection. In the presence of cytomegalovirus, inflammation becomes more complex. Patients with active UC who are infected with...

journal_title：Journal of digestive diseases

authors： Xue M,Chen SJ,Wang LJ,Du Y,Si JM

更新日期：2013-04-01 00:00:00

abstract：:Along with epidemiological changes in tuberculosis (TB) and an increased incidence of Crohn's disease (CD), the differential diagnosis of intestinal TB (ITB) and CD is of vital importance and has become a clinical challenge because treatment based on misdiagnosis may lead to fatal outcomes. In this study, we reviewed ...

journal_title：Journal of digestive diseases

authors： Ma JY,Tong JL,Ran ZH

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:We aimed to determine the effect of antithrombotics on in-hospital mortality and morbidity in patients with peptic ulcer disease-related upper gastrointestinal bleeding (PUD-related UGIB). METHODS:The study cohort was retrospectively selected from a tertiary center database of patients with PUD-related UGIB,...

journal_title：Journal of digestive diseases

authors： Abu Daya H,Eloubeidi M,Tamim H,Halawi H,Malli AH,Rockey DC,Barada K

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:We conducted a randomized trial aiming at improving patients' informed consent for undergoing endoscopic retrograde cholangiopancreatography (ERCP) in clinical care by comparing the efficacy of an additional educational video to written informed consent with that of written informed consent alone. METHODS:Th...

journal_title：Journal of digestive diseases

authors： Xia T,Zhu YB,Zeng YB,Chen C,Wang SL,Zhao SB,Su XJ,Wang D,Yao J,Li ZS,Bai Y

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To determine whether computer-predicted short RNA structural analogues could inhibit hepatitis C virus (HCV) genotype 2a, 3a and 4a replication in cultured cells. METHODS:Short RNA sequences, X12, X12a and X12b, designed to be identical in secondary structure to the X region in the 3'-untranslated region (3'...

journal_title：Journal of digestive diseases

authors： Elshaffei IM,Gupta N,Wu CH,Wu DC,Hammad LN,Abo-Elmatty DM,Mesbah NM,Wu GY

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:To summarize the clinical and spiral computed tomography (CT) features of undifferentiated embryonic liver sarcoma (UELS) in adults. METHODS:Clinical and CT findings of four adult patients with pathology-approved UELS were retrospectively analyzed with a literature review. All patients were examined using a ...

journal_title：Journal of digestive diseases

authors： Yang L,Chen LB,Xiao J,Han P

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:The histone methylation and acetylation pathway genes regulate cell growth and survival. Aberrations in this pathway are implicated in a variety of cancers. This study aimed to identify germline genetic variants in histone methylation and acetylation pathway genes that may contribute to risk in eight types o...

journal_title：Journal of digestive diseases

authors： Fu LN,Tan J,Chen YX,Fang JY

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:This study aimed to determine the prevalence of and risk factors associated with elevated alanine aminotransferase (ALT) levels among a sample of normal weight, overweight and obese youth from two urban populations in Central Mexico. METHODS:Baseline data from 1262 youth aged 8-19 years who participated in t...

journal_title：Journal of digestive diseases

authors： Purcell M,Flores YN,Zhang ZF,Denova-Gutiérrez E,Salmeron J

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To investigate whether sending a family history questionnaire to patients prior to undergoing colonoscopy results in an increased availability of family history and better genetic counseling. METHODS:A questionnaire was mailed to patients before they underwent outpatient colonoscopy at a university hospital...

journal_title：Journal of digestive diseases

authors： Kessels K,Eisinger JD,Letteboer TG,Offerhaus GJA,Siersema PD,Moons LMG

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:The capacity of fundoplication to prevent esophageal adenocarcinoma is controversial. Development of cancer is associated with proliferation and anti-apoptosis, for which little data exist as to their response to fundoplication. Therefore, we wanted to clarify the effect of fundoplication on the magnitude of ...

journal_title：Journal of digestive diseases

authors： Rantanen T,Oksala N,Honkanen T,Räsänen J,Sihvo E,Mattila J,Paimela H,Paavonen T,Salo J

更新日期：2011-08-01 00:00:00