Abstract:
OBJECTIVE:The best cure for colorectal cancer (CRC) lies on its early diagnosis and treatment. We aimed to provide the epidemiological features of advanced colorectal adenoma (A-CRA) and CRC in symptomatic patients and to determine whether the incidences of A-CRA and CRC increased simultaneously in China between 1990 and 2009. METHODS:A total of 157,943 patients who had undergone a colonoscopy from 1990 to 2009 were enrolled, of which 6,777 patients had A-CRA and 3,503 had CRC. They were compared with controls in a stratified analysis. The detection rates of A-CRA and CRC in the 1990s and 2000s were also compared. RESULTS:The detection rate of A-CRA increased 1.88-fold over the two decades, while that of CRC increased 0.66-fold. The percentages of patients with A-CRA and CRC who were elder than 50 years were significantly higher in the 2000s than those in the 1990s (P = 0.000). The changes of location of A-CRA and CRC during the two decades indicated a shift of lesions from the distal colon to proximal colon. CONCLUSION:There was a significant increase in detection rate of A-CRA in the 2000s, but CRC did not increase at a similar speed. Our results indicated that the early detection and removal of colorectal adenoma in symptomatic patients might decrease the incidence of CRC.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Chen HM,Weng YR,Jiang B,Sheng JQ,Zheng P,Yu CG,Fang JYdoi
10.1111/j.1751-2980.2011.00531.xsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
371-8issue
5eissn
1751-2972issn
1751-2980journal_volume
12pub_type
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doi:10.1111/j.1751-2980.2008.00355.x
更新日期:2009-02-01 00:00:00
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journal_title:Journal of digestive diseases
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