Abstract：
:Along with epidemiological changes in tuberculosis (TB) and an increased incidence of Crohn's disease (CD), the differential diagnosis of intestinal TB (ITB) and CD is of vital importance and has become a clinical challenge because treatment based on misdiagnosis may lead to fatal outcomes. In this study, we reviewed the similarities and differences in clinical, endoscopic, radiological and histological features of these two diseases. Concomitant pulmonary TB, ascites, night sweats, involvement of fewer than four segments of the bowel, patulous ileocecal valve, transverse ulcers, scars or pseudopolyps strongly indicate ITB. Bloody stools, perianal signs, chronic diarrhea, extraintestinal manifestations, anorectal lesions, longitudinal ulcers and a cobblestone appearance are all suggestive of CD. Significant differences in the size, number, location and patterns of granulomas in ITB and CD with regard to their histopathologic features have been noted. Immune stain of cell surface markers is also helpful. Interferon-γ release assay and polymerase chain reaction analysis have achieved satisfactory sensitivity and specificity in the diagnosis of ITB. Computed tomography enterographic findings of segmental small bowel or left colon involvement, mural stratification, the comb sign and fibrofatty proliferation are significantly more common in CD, whereas mesenteric lymph node changes (calcification or central necrosis) and focal ileocecal lesions are more frequently seen in ITB. A diagnosis should be carefully established before the initiation of the therapy. In suspicious cases, short-term empirical anti-TB therapy is quite efficient to further confirm the diagnosis.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Ma JY,Tong JL,Ran ZHdoi
10.1111/1751-2980.12324subject
Has Abstractpub_date
2016-03-01 00:00:00pages
155-61issue
3eissn
1751-2972issn
1751-2980journal_volume
17pub_type
杂志文章,评审abstract：OBJECTIVE:The aim of our study was to document our 6-year experiences in identifying the clinical characteristics, laboratory findings, risk factors and the outcomes of patients with ischemic colitis (IC) in a community hospital setting. METHODS:The medical records of patients who were diagnosed with IC from 2007 to 2...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12182
更新日期：2014-11-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12250
更新日期：2015-08-01 00:00:00
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journal_title：Journal of digestive diseases
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doi：10.1111/1751-2980.12334
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) is a valuable device to diagnose and determine the malignant potential of gastrointestinal stromal tumors (GIST) as early as possible when making clinical therapeutic decisions. This study aimed to estimate the ability of CH-EUS to discriminate be...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,meta分析
doi：10.1111/1751-2980.12710
更新日期：2019-03-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1751-2980.12783
更新日期：2019-06-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12053
更新日期：2013-06-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12798
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years) with CBD stones. METHODS:We retrospectively examined 65 patients who underwent complete CBD stone removal (the duct clearance group) and 40 patients who underwent biliary s...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12656
更新日期：2018-10-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12415
更新日期：2016-11-01 00:00:00
abstract：:The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographical regions. The first studies on the epidemiology of IBD were mainly from traditionally high-incidence areas, such as North America, and northern and western Europe. In the last two decades, more...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12449
更新日期：2017-02-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12505
更新日期：2017-08-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2009.00370.x
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To explore the features and clinical significance of serum pepsinogen (PG) assay in a follow-up study on a high-risk gastric cancer (GC) population. METHODS:A total of 444 participants from a high-risk area of GC in north China were enrolled in this follow-up study from April 1997 to December 1999. Serum PG ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1443-9573.2007.00321.x
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:With an age-standardized incidence rate of 2 per 100 000, esophageal cancer is not common among Malaysians, but they are nevertheless important due to its poor prognosis. The study is to clarify whether the human papillomavirus (HPV) is associated with esophageal cancer in Malaysians as there has been no repo...
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pub_type： 杂志文章
doi：10.1111/1751-2980.12605
更新日期：2018-05-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12463
更新日期：2017-03-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章,meta分析,评审
doi：10.1111/1751-2980.12232
更新日期：2015-04-01 00:00:00
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journal_title：Journal of digestive diseases
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doi：10.1111/j.1443-9573.2007.00290.x
更新日期：2007-05-01 00:00:00
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更新日期：2017-02-01 00:00:00
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更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-08-01 00:00:00
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更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/1751-2980.12496
更新日期：2017-09-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12880
更新日期：2020-06-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/1751-2980.12362
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2010.00462.x
更新日期：2010-12-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1751-2980.12106
更新日期：2014-02-01 00:00:00
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journal_title：Journal of digestive diseases
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doi：10.1111/1751-2980.12491
更新日期：2017-06-01 00:00:00
