Abstract：
OBJECTIVE:To gain insight into the molecular events of lymph node metastasis of human gastric carcinoma. METHODS:The gene expression profile of five matched primary gastric carcinomas and their lymph node metastases was analyzed by complementary DNA (cDNA) microarray. Differential genes were identified in the metastatic and corresponding primary tumor pairs. Among the differentially expressed genes, carbonic anhydrase II (CAII) and insulin-like growth factor binding protein 4 (IGFBP 4) genes were detected by RT-PCR. CTTN protein expression was examined by tissue microarray. RESULTS:There was a high expression (over twofold) of 44 genes and a low expression (under twofold) of 32 genes in lymph node metastasis compared with primary gastric carcinoma, respectively. CAII mRNA was downregulated and IGFBP 4 mRNA was upregulated in paired lymph node metastases of gastric carcinomas. The overexpression of CTTN protein was related to the lymph node metastasis and the clinical stage of gastric carcinomas. CONCLUSION:This study showed that there is a low expression of genes relative to growth signal and immune response in lymph node metastases, and a high expression of genes relative to growth factor, cell cycle, cell motility and adhesion in lymph node metastases compared with primary gastric carcinomas. The expression of CTTN was related to the invasion and metastasis of gastric cancer.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Xie HL,Li ZY,Gan RL,Li XJ,Zhang QL,Hui M,Zhou XTdoi
10.1111/j.1751-2980.2010.00432.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
167-75issue
3eissn
1751-2972issn
1751-2980pii
CDD432journal_volume
11pub_type
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journal_title：Journal of digestive diseases
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journal_title：Journal of digestive diseases
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doi：10.1111/1751-2980.12694
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abstract：OBJECTIVE:The best cure for colorectal cancer (CRC) lies on its early diagnosis and treatment. We aimed to provide the epidemiological features of advanced colorectal adenoma (A-CRA) and CRC in symptomatic patients and to determine whether the incidences of A-CRA and CRC increased simultaneously in China between 1990 a...
journal_title：Journal of digestive diseases
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doi：10.1111/1751-2980.12040
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pub_type： 杂志文章,评审
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journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12037
更新日期：2013-04-01 00:00:00
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journal_title：Journal of digestive diseases
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journal_title：Journal of digestive diseases
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pub_type： 杂志文章,meta分析,评审
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更新日期：2015-04-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2011.00502.x
更新日期：2011-06-01 00:00:00
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doi：10.1111/j.1751-2980.2012.00616.x
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doi：10.1111/1751-2980.12243
更新日期：2015-05-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2007.00309.x
更新日期：2007-11-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12039
更新日期：2013-05-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12437
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/1751-2980.12334
更新日期：2016-04-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2008.00326.x
更新日期：2008-05-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12656
更新日期：2018-10-01 00:00:00
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journal_title：Journal of digestive diseases
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
