Abstract：
OBJECTIVE:To investigate the clinicopathological features of columnar-lined esophagus (CLE) in Chinese patients. METHODS:Among 182 consecutive resections of proximal gastric cancer with residual esophageal tissue, 114 were eligible for the study. The maximal lengths of CLE and superficial esophageal glands (SEG) and the presence or absence of chronic inflammation (CI), lymphoid follicles (LF), Helicobacter pylori (H. pylori) infection, intestinal metaplasia (IM), pancreatic metaplasia (PM) and dysplasia were analyzed and compared with those in the adjacent proximal gastric mucosa. RESULTS:SEG were present in 110 cases with a mean length of 5.4 mm (range 1-16 mm, 90% equal to or under 10 mm and 10% between 11-16 mm). These glands were associated with CI (95%), LF (85%), H. pylori infection (42%), IM (25%), PM (36%) and dysplasia (10%). CLE was found in 65% of the cases and was associated with SEG (mean length of 4.0 mm, range 1-13 mm, 97% within 10 mm and 3% between 11-13 mm). The frequencies of CI (97%), LF (86%), H. pylori infection (65%) and PM (46%) in CLE were similar to those in the proximal stomach (CI 90%, LF 54%, H. pylori infection 58%, PM 39%). In contrast, the frequencies of IM (37%) and dysplasia (15%) in CLE were significantly lower than those in the proximal stomach (66% and 31%, respectively; P < 0.01). CONCLUSIONS:CLE in Chinese patients was within 10 mm in length in 97% of cases, and with SEG and H. pylori infection-related changes similar to those in the proximal stomach.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Sun Q,Huang Q,Feng AN,Fan XS,Wu HY,Mashimo H,Zhou Q,Chen J,Lauwers GYdoi
10.1111/1751-2980.12007subject
Has Abstractpub_date
2013-01-01 00:00:00pages
22-8issue
1eissn
1751-2972issn
1751-2980journal_volume
14pub_type
杂志文章abstract：OBJECTIVE:The aim of this study was to investigate the role of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) in the development of hepatic fibrogenesis in experimental disease models and human liver samples. METHODS:Cellular distribution patterns of IGFBP-rP1 were assessed by immunohistochem...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12126
更新日期：2014-04-01 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is now the most common etiology of chronic liver disease threatening global public health. However, the name "NAFLD" is no longer appropriate with the change of time. Recently, a new term, "metabolic dysfunction-associated fatty liver disease" has been proposed by an internati...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12944
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:The aims of this study were to investigate the frequency and factors involved in the terminal ileum intubation of patients with chronic, non-bloody diarrhea and to compare diagnostic yields of colonoscopy and ileocolonoscopy. METHODS:The medical records of 945 patients undergoing colonoscopy for chronic, non...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12082
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:MicroRNAs (miRNAs) have recently emerged as novel regulators in liver fibrosis. miR-30c and miR-193 are involved in fibrotic remodeling processes and cancer development, respectively. This study aimed to explore the role of miR-30c and miR-193 in liver fibrosis. METHODS:The regulation of miRNAs in carbon tet...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12266
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of the non-cytotoxic drug (cyclooxygenase-2 (COX-2) inhibitor and octreotide) on growth of the multidrug-resistant human gastric carcinoma cell line SGC-7901/ADR. METHODS:The effects of non-cytotoxic drug on the growth of SGC-7901 and SGC-7901/ADR cells were evaluated by (3)H-thymi...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2009.00370.x
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To explore the role of tagging single nucleotide polymorphisms (tagSNPs) in the adiponectin gene in the natural course of nonalcoholic fatty liver disease (NAFLD). METHODS:The participants were chosen from our previous survey containing 3543 individuals. Finally, a total of 696 participants who had been foll...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12288
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:Transarterial chemoembolization (TACE) is the treatment modality for intermediate, or Barcelona Clinic Liver Cancer stage B, hepatocellular carcinoma (HCC), but its beneficial effect on outcomes is still unsatisfactory. This study aimed to assess the outcomes of combined TACE and sorafenib for patients with i...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12911
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the prevalence of colorectal neoplasms in patients coronary artery disease (CAD) with or without a family history of colorectal cancer (CRC). METHODS:In this cross-sectional study, individuals with suspected CAD in the absence of cancer-related symptoms underwent coro...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12243
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:Systematic reports on acute upper gastrointestinal bleeding in children/adolescents are scanty. The aim of this study is to analyze its presentation, pathology and outcome in Hong Kong. METHODS:A retrospective review of the hospital database for admissions up to the age of 18 years with signs of acute upper ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2008.00346.x
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:We aimed to investigate the clinical features, precipitating factors, bowel habits, bothersome symptoms and treatment strategies of individuals in China with self-reported constipation. METHODS:An internet-based survey was conducted in China. The participants had self-reported chronic constipation (≥1 sympto...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12792
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:Hypomethylation within the body of the p53 gene, which is normally methylated, has been found in neoplasms. Also, the CG → TA transition was not detected in the CpG codons of the p53 gene in gastritis lesions in Iranian patients. Therefore, an evaluation of the probable correlation between global genome methy...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12053
更新日期：2013-06-01 00:00:00
abstract：:Cytomegalovirus, regarded as a trigger of several autoimmune diseases, is an opportunistic pathogen. Patients with ulcerative colitis (UC) undergoing steroid treatment are susceptible to this infection. In the presence of cytomegalovirus, inflammation becomes more complex. Patients with active UC who are infected with...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12037
更新日期：2013-04-01 00:00:00
abstract：:Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is one of the most common medical emergencies in China and worldwide. In 2009, we published the "Guidelines for the diagnosis and treatment of acute non-variceal upper gastrointestinal bleeding" for the patients in China; however, during the past years numer...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,实务指引
doi：10.1111/1751-2980.12319
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:Early diagnosis of colitis-associated cancer and dysplasia through surveillance endoscopy is vital for patients with ulcerative colitis (UC). This study aimed to evaluate the efficacy of autofluorescence endoscopy (AFE) using 5-aminolevulinic acid (ALA) and to investigate the fluorescence signal localization ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12923
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) is a valuable device to diagnose and determine the malignant potential of gastrointestinal stromal tumors (GIST) as early as possible when making clinical therapeutic decisions. This study aimed to estimate the ability of CH-EUS to discriminate be...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,meta分析
doi：10.1111/1751-2980.12710
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:We aimed to investigate the relationship between the number of involved organs or regions and serum immunoglobulin G (IgG) and immunoglobulin G4 (IgG4) levels. METHODS:The number of pancreatic and/or extrapancreatic lesions and serum IgG and IgG4 levels were examined by groups in 46 patients with IgG4-relate...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2012.00583.x
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:Given the rarity of the disease, the post-resection clinical course of localized pancreatic acinar cell carcinoma (ACC) is largely unknown. Therefore, we aimed to analyze the outcomes of patients with localized pancreatic ACC who underwent curative surgical resection. METHODS:We retrospectively analyzed the ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12505
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:This study aimed to systematically assess the relevant risk factors of positive lateral margin (LM) after en bloc resection of early gastric adenocarcinoma. METHODS:A total of 242 patients who had undergone endoscopic submucosal dissection (ESD) due to early gastric lesions from January 2009 to March 2015 we...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12342
更新日期：2016-04-01 00:00:00
abstract：:The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographical regions. The first studies on the epidemiology of IBD were mainly from traditionally high-incidence areas, such as North America, and northern and western Europe. In the last two decades, more...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,评审
doi：10.1111/1751-2980.12449
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:MicroRNA-1254 (miR-1254) has not been studied in colorectal cancer (CRC) to date. This study aimed to investigate the inhibitory mechanism of miR-1254 in CRC tumorigenesis. METHODS:MiR-1254 expression was examined using real-time polymerase chain reaction in CRC and adjacent non-tumorous tissues. The correla...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12463
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Peritoneal mesothelioma is a rare disease associated with poor prognosis. Acute abdomen as the first presentation is an extremely rare occurrence. We report an exceptional case of a patient who was found to have a jejunal perforation due to infiltration of peritoneal mesothelioma. METHODS:A 62-year-old man ...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/j.1751-2980.2007.00309.x
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to analyze the incidence and risk factors of de novo hepatitis B virus (HBV) infection from hepatitis B core antibody (anti-HBc)-positive donors in pediatric living donor liver transplantation (LDLT). METHODS:We retrospectively analyzed 46 recipients without pre-liver transplantatio...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12066
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:To assess the prevalence and potential risk factors of latent tuberculosis infection (LTBI) in Chinese patients with inflammatory bowel disease (IBD) and to evaluate the role of chest computed tomography (CT) in the screening of LTBI. METHODS:A single-center retrospective study was conducted and all IBD pat...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12437
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:Peptest is a new non-invasive reflux diagnostic test based on lateral flow technology that containing two highly specific human pepsin monoclonal antibodies for detecting pepsin, a biomarker for reflux disease. The primary aim of this multicenter clinical study was to validate the efficacy of Peptest in pati...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,多中心研究
doi：10.1111/1751-2980.12783
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:We conducted a randomized trial aiming at improving patients' informed consent for undergoing endoscopic retrograde cholangiopancreatography (ERCP) in clinical care by comparing the efficacy of an additional educational video to written informed consent with that of written informed consent alone. METHODS:Th...
journal_title：Journal of digestive diseases
pub_type： 杂志文章,随机对照试验
doi：10.1111/1751-2980.12824
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:With an age-standardized incidence rate of 2 per 100 000, esophageal cancer is not common among Malaysians, but they are nevertheless important due to its poor prognosis. The study is to clarify whether the human papillomavirus (HPV) is associated with esophageal cancer in Malaysians as there has been no repo...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12605
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:This study aimed to determine the prevalence of and risk factors associated with elevated alanine aminotransferase (ALT) levels among a sample of normal weight, overweight and obese youth from two urban populations in Central Mexico. METHODS:Baseline data from 1262 youth aged 8-19 years who participated in t...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12072
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:Data on the association between the antioxidant capacity of a diet and the risk of ulcerative colitis (UC) are scarce. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of UC in Iranian adults. METHODS:In this case-control study, patients w...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12823
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVES:The histone methylation and acetylation pathway genes regulate cell growth and survival. Aberrations in this pathway are implicated in a variety of cancers. This study aimed to identify germline genetic variants in histone methylation and acetylation pathway genes that may contribute to risk in eight types o...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12574
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:To determine whether computer-predicted short RNA structural analogues could inhibit hepatitis C virus (HCV) genotype 2a, 3a and 4a replication in cultured cells. METHODS:Short RNA sequences, X12, X12a and X12b, designed to be identical in secondary structure to the X region in the 3'-untranslated region (3'...
journal_title：Journal of digestive diseases
pub_type： 杂志文章
doi：10.1111/1751-2980.12250
更新日期：2015-08-01 00:00:00
