The gastric precancerous cascade.

Abstract:

:Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade. The following steps are: intestinal metaplasia (first "complete" and then "incomplete"); dysplasia, first low grade and then high grade (equivalent to "carcinoma in situ"). The following step is invasive carcinoma, which is thought to be associated with degradation of the intercellular matrix.

journal_name

J Dig Dis

authors

Correa P,Piazuelo MB

doi

10.1111/j.1751-2980.2011.00550.x

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

2-9

issue

1

eissn

1751-2972

issn

1751-2980

journal_volume

13

pub_type

杂志文章
  • Sending family history questionnaires to patients before a colonoscopy improves genetic counseling for hereditary colorectal cancer.

    abstract:OBJECTIVES:To investigate whether sending a family history questionnaire to patients prior to undergoing colonoscopy results in an increased availability of family history and better genetic counseling. METHODS:A questionnaire was mailed to patients before they underwent outpatient colonoscopy at a university hospital...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12491

    authors: Kessels K,Eisinger JD,Letteboer TG,Offerhaus GJA,Siersema PD,Moons LMG

    更新日期:2017-06-01 00:00:00

  • Insulin-like growth factor binding protein-related protein 1 contributes to hepatic fibrogenesis.

    abstract:OBJECTIVE:The aim of this study was to investigate the role of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) in the development of hepatic fibrogenesis in experimental disease models and human liver samples. METHODS:Cellular distribution patterns of IGFBP-rP1 were assessed by immunohistochem...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12126

    authors: Guo XH,Liu LX,Zhang HY,Zhang QQ,Li Y,Tian XX,Qiu ZH

    更新日期:2014-04-01 00:00:00

  • A novel approach for the detection of early gastric cancer: fluorescence spectroscopy of gastric juice.

    abstract:OBJECTIVE:This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening. METHODS:Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were ...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12040

    authors: Deng K,Zhou LY,Lin SR,Li Y,Chen M,Geng QM,Li YW

    更新日期:2013-06-01 00:00:00

  • Columnar-lined esophagus in Chinese patients with proximal gastric carcinomas.

    abstract:OBJECTIVE:To investigate the clinicopathological features of columnar-lined esophagus (CLE) in Chinese patients. METHODS:Among 182 consecutive resections of proximal gastric cancer with residual esophageal tissue, 114 were eligible for the study. The maximal lengths of CLE and superficial esophageal glands (SEG) and t...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12007

    authors: Sun Q,Huang Q,Feng AN,Fan XS,Wu HY,Mashimo H,Zhou Q,Chen J,Lauwers GY

    更新日期:2013-01-01 00:00:00

  • Hypoxia/IL-1α axis promotes gastric cancer progression and drug resistance.

    abstract:OBJECTIVE:The microenvironment of tumors constitutes a unique niche that promotes cancer metastasis and resistance. Two remarkable characteristics of this microenvironment are hypoxia and inflammation. Interleukin-1α (IL-1α), an important inflammatory factor, is frequently upregulated in a variety of cancers. This stud...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12496

    authors: Xuan Y,Wang YN

    更新日期:2017-09-01 00:00:00

  • Follow-up study on a high risk population of gastric cancer in north China by serum pepsinogen assay.

    abstract:OBJECTIVE:To explore the features and clinical significance of serum pepsinogen (PG) assay in a follow-up study on a high-risk gastric cancer (GC) population. METHODS:A total of 444 participants from a high-risk area of GC in north China were enrolled in this follow-up study from April 1997 to December 1999. Serum PG ...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/j.1443-9573.2007.00321.x

    authors: Sun LP,Gong YH,Wang L,Gong W,Yuan Y

    更新日期:2008-02-01 00:00:00

  • Tuberculosis screening using IGRA and chest computed tomography in patients with inflammatory bowel disease: A retrospective study.

    abstract:OBJECTIVES:To assess the prevalence and potential risk factors of latent tuberculosis infection (LTBI) in Chinese patients with inflammatory bowel disease (IBD) and to evaluate the role of chest computed tomography (CT) in the screening of LTBI. METHODS:A single-center retrospective study was conducted and all IBD pat...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12437

    authors: Song DJ,Tong JL,Peng JC,Cai CW,Xu XT,Zhu MM,Ran ZH,Zheng Q

    更新日期:2017-01-01 00:00:00

  • Chronic alcoholics retain dyspeptic symptoms, pan-enteric dysmotility, and autonomic neuropathy before and after abstinence.

    abstract:OBJECTIVE:To carry out a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathy in chronic alcoholics before and one year after abstinence. METHODS:Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lact...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12415

    authors: Di Ciaula A,Grattagliano I,Portincasa P

    更新日期:2016-11-01 00:00:00

  • Epidemiological study of colorectal adenoma and cancer in symptomatic patients in China between 1990 and 2009.

    abstract:OBJECTIVE:The best cure for colorectal cancer (CRC) lies on its early diagnosis and treatment. We aimed to provide the epidemiological features of advanced colorectal adenoma (A-CRA) and CRC in symptomatic patients and to determine whether the incidences of A-CRA and CRC increased simultaneously in China between 1990 a...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/j.1751-2980.2011.00531.x

    authors: Chen HM,Weng YR,Jiang B,Sheng JQ,Zheng P,Yu CG,Fang JY

    更新日期:2011-10-01 00:00:00

  • Serum biomarkers of drug-induced liver injury: Current status and future directions.

    abstract::Drug-induced liver injury (DILI), which is caused by drugs and herbal or dietary supplements, remains a serious concern for drug developers, regulators, and clinicians; however, serum biomarkers utilized to detect and monitor DILI have not changed in decades and have limitations. Data-driven mathematical modeling that...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1751-2980.12684

    authors: Church RJ,Watkins PB

    更新日期:2019-01-01 00:00:00

  • Dietary total antioxidant capacity and risk of ulcerative colitis: A case-control study.

    abstract:OBJECTIVE:Data on the association between the antioxidant capacity of a diet and the risk of ulcerative colitis (UC) are scarce. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of UC in Iranian adults. METHODS:In this case-control study, patients w...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12823

    authors: Rahmani J,Kord-Varkaneh H,Ryan PM,Rashvand S,Clark C,Day AS,Hekmatdoost A

    更新日期:2019-12-01 00:00:00

  • Acid inhibition effect of ilaprazole on Helicobacter pylori-negative healthy volunteers: an open randomized cross-over study.

    abstract:OBJECTIVE:The aim of this study was to evaluate the effects and safety of different doses of ilaprazole on healthy volunteers without a Helicobacter pylori infection. METHODS:A total of 12 healthy Chinese volunteers were enrolled and divided into four groups randomly, with a 5-day treatment of oral ilaprazole 5mg, 10m...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1751-2980.2011.00557.x

    authors: DU YQ,Guo WY,Zou DW,Zhan XB,Li Z,Hu JH,Gong YF,He J,Lu JP,Li ZS

    更新日期:2012-02-01 00:00:00

  • Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma.

    abstract:OBJECTIVE:Given the rarity of the disease, the post-resection clinical course of localized pancreatic acinar cell carcinoma (ACC) is largely unknown. Therefore, we aimed to analyze the outcomes of patients with localized pancreatic ACC who underwent curative surgical resection. METHODS:We retrospectively analyzed the ...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12505

    authors: Seo S,Yoo C,Kim KP,Ryoo BY,Chang HM,Hong SM,Lee JH,Song KB,Hwang DW,Kim KH,Hwang S,Kim SC

    更新日期:2017-08-01 00:00:00

  • Gastroesophageal and laryngopharyngeal reflux detected by 24-hour combined impedance and pH monitoring in healthy Chinese volunteers.

    abstract:OBJECTIVE:To define the normative data of gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) in healthy Chinese volunteers. METHODS:Healthy volunteers without gastrointestinal and throat disease and symptoms were enrolled and underwent 24-hour impedance-pH monitoring. RESULTS:A total of 37 healthy volun...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/j.1751-2980.2011.00502.x

    authors: Wang AJ,Liang MJ,Jiang AY,Lin JK,Xiao YL,Peng S,Chen J,Wen WP,Chen MH

    更新日期:2011-06-01 00:00:00

  • Involvement of VDAC1 and Bcl-2 family of proteins in VacA-induced cytochrome c release and apoptosis of gastric epithelial carcinoma cells.

    abstract:OBJECTIVE:It is known that the vacuolating cytotoxin (VacA) could induce apoptosis. However, the mechanism remained to be elucidated. The aim of this study is to investigate the role of Bcl family of proteins (Bcl-2 and Bax) and the mitochondrial voltage-dependent anion channel (VDAC) in VacA-induced apoptosis of AGS c...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/j.1751-2980.2009.00412.x

    authors: Lan CH,Sheng JQ,Fang DC,Meng QZ,Fan LL,Huang ZR

    更新日期:2010-02-01 00:00:00

  • Epidemiology of inflammatory bowel diseases from west to east.

    abstract::The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographical regions. The first studies on the epidemiology of IBD were mainly from traditionally high-incidence areas, such as North America, and northern and western Europe. In the last two decades, more...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1751-2980.12449

    authors: Vegh Z,Kurti Z,Lakatos PL

    更新日期:2017-02-01 00:00:00

  • Esomeprazole, minocycline, metronidazole and bismuth as first-line and second-line regimens for Helicobacter pylori eradication.

    abstract:OBJECTIVE:Whether minocycline can replace tetracycline in Helicobacter pylori (H. pylori) eradication remains unclear. The aim of this study was to determine the efficacy, safety, patient compliance and risk factors of a combination regimen of esomeprazole, minocycline, metronidazole and bismuth (EMMB) for H. pylori er...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12334

    authors: Song ZQ,Zhou LY

    更新日期:2016-04-01 00:00:00

  • Prevalence and predictors of alanine aminotransferase elevation among normal weight, overweight and obese youth in Mexico.

    abstract:OBJECTIVE:This study aimed to determine the prevalence of and risk factors associated with elevated alanine aminotransferase (ALT) levels among a sample of normal weight, overweight and obese youth from two urban populations in Central Mexico. METHODS:Baseline data from 1262 youth aged 8-19 years who participated in t...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12072

    authors: Purcell M,Flores YN,Zhang ZF,Denova-Gutiérrez E,Salmeron J

    更新日期:2013-09-01 00:00:00

  • A single-center experience with methotrexate in the treatment of Chinese Crohn's disease patients.

    abstract:OBJECTIVE:Methotrexate (MTX) can be used as an alternative for patients with Crohn's disease (CD) who are intolerant of thiopurine. This retrospective study aimed to provide some clues about MTX treatment in Chinese patients with CD. METHODS:Medical records of 27 adult patients with CD who were treated with MTX betwee...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12694

    authors: Wang TR,Qiao YQ,Zou DW,Ran ZH

    更新日期:2018-12-01 00:00:00

  • H+ /K+ ATPase expression in human parietal cells and gastric acid secretion in elderly individuals.

    abstract:OBJECTIVE:To investigate whether the ultrastructure and hydrogen potassium adenosine triphosphate (H+ /K+ ATPase) expression of human parietal cells were associated with aging. METHODS:In all, 50 participants who underwent gastroscopy due to dyspepsia were divided into two age groups, with 19 in the younger group (YG,...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12055

    authors: Zhang W,Zheng SB,Zhuang Y,Xiang P,Xiao L,Li B,Ji da N,Xia SJ,Yu Z,Shi DY

    更新日期:2013-07-01 00:00:00

  • Esophageal squamous cell carcinomas in a Malaysian cohort show a lack of association with human papillomavirus.

    abstract:OBJECTIVE:With an age-standardized incidence rate of 2 per 100 000, esophageal cancer is not common among Malaysians, but they are nevertheless important due to its poor prognosis. The study is to clarify whether the human papillomavirus (HPV) is associated with esophageal cancer in Malaysians as there has been no repo...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12605

    authors: Cheah PL,Koh CC,Khang TF,Goh KL,Lau PC,Chin KF,Teoh KH,Toh YF,Looi LM

    更新日期:2018-05-01 00:00:00

  • Differential gene and protein expression in primary gastric carcinomas and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis.

    abstract:OBJECTIVE:To gain insight into the molecular events of lymph node metastasis of human gastric carcinoma. METHODS:The gene expression profile of five matched primary gastric carcinomas and their lymph node metastases was analyzed by complementary DNA (cDNA) microarray. Differential genes were identified in the metastat...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/j.1751-2980.2010.00432.x

    authors: Xie HL,Li ZY,Gan RL,Li XJ,Zhang QL,Hui M,Zhou XT

    更新日期:2010-06-01 00:00:00

  • Endoscopic therapy in early adenocarcinomas (Barrett's cancer) of the esophagus.

    abstract::The incidence of early esophageal adenocarcinoma has been increasing significantly in recent decades. Prognosis depends greatly on the choice of treatment. Early cancers can be treated by endoscopic resection, whereas advanced carcinomas have to be sent for surgery. Esophageal resection is associated with high periope...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,评审

    doi:10.1111/1751-2980.12264

    authors: Knabe M,May A,Ell C

    更新日期:2015-07-01 00:00:00

  • High incidence and morbidity of Clostridium difficile infection among hospitalized patients with inflammatory bowel disease: A prospective observational cohort study.

    abstract:OBJECTIVE:To investigate the clinical features of Clostridium difficile infection (CDI) in hospitalized patients with inflammatory bowel disease (IBD) and to analyze the impact of CDI on IBD. METHODS:A prospective study on patients newly diagnosed with IBD was conducted at the IBD center at Sir Run Run Shaw Hospital f...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12798

    authors: Chen XL,Deng J,Chen X,Wan SS,Wang Y,Cao Q

    更新日期:2019-09-01 00:00:00

  • Validation in China of a non-invasive salivary pepsin biomarker containing two unique human pepsin monoclonal antibodies to diagnose gastroesophageal reflux disease.

    abstract:OBJECTIVES:Peptest is a new non-invasive reflux diagnostic test based on lateral flow technology that containing two highly specific human pepsin monoclonal antibodies for detecting pepsin, a biomarker for reflux disease. The primary aim of this multicenter clinical study was to validate the efficacy of Peptest in pati...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1111/1751-2980.12783

    authors: Wang YF,Yang CQ,Chen YX,Cao AP,Yu XF,Yu Y,Zhang ZY,Shen XZ,Liu F,Zhong L,Wang YX,Liu ZJ,Shi YH,Zhong J,Li JN,Lan Y,Lenham RK,Woodcock AD,Dettmar PW,Fang JY

    更新日期:2019-06-01 00:00:00

  • Clinical utility of retrograde terminal ileum intubation in the evaluation of chronic non-bloody diarrhea.

    abstract:OBJECTIVE:The aims of this study were to investigate the frequency and factors involved in the terminal ileum intubation of patients with chronic, non-bloody diarrhea and to compare diagnostic yields of colonoscopy and ileocolonoscopy. METHODS:The medical records of 945 patients undergoing colonoscopy for chronic, non...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12082

    authors: Makkar R,Lopez R,Shen B

    更新日期:2013-10-01 00:00:00

  • MicroRNA-1254 inhibits the migration of colon adenocarcinoma cells by targeting PSMD10.

    abstract:OBJECTIVE:MicroRNA-1254 (miR-1254) has not been studied in colorectal cancer (CRC) to date. This study aimed to investigate the inhibitory mechanism of miR-1254 in CRC tumorigenesis. METHODS:MiR-1254 expression was examined using real-time polymerase chain reaction in CRC and adjacent non-tumorous tissues. The correla...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12463

    authors: Chu YM,Peng HX,Xu Y,Yang DM,Zhou FL,Li J,Kuai R,Lin Y

    更新日期:2017-03-01 00:00:00

  • Prevalence of colorectal neoplasm in Chinese patients with high-risk coronary artery disease classified by the Asia-Pacific Colorectal Screening score.

    abstract:OBJECTIVE:The aim of this study was to investigate the prevalence of colorectal neoplasms in patients coronary artery disease (CAD) with or without a family history of colorectal cancer (CRC). METHODS:In this cross-sectional study, individuals with suspected CAD in the absence of cancer-related symptoms underwent coro...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12243

    authors: Yang XB,Xu QL,Xu CY,Wu C,Yu LF

    更新日期:2015-05-01 00:00:00

  • Opposing effects of aspirin and anticoagulants on morbidity and mortality in patients with upper gastrointestinal bleeding.

    abstract:OBJECTIVE:We aimed to determine the effect of antithrombotics on in-hospital mortality and morbidity in patients with peptic ulcer disease-related upper gastrointestinal bleeding (PUD-related UGIB). METHODS:The study cohort was retrospectively selected from a tertiary center database of patients with PUD-related UGIB,...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12140

    authors: Abu Daya H,Eloubeidi M,Tamim H,Halawi H,Malli AH,Rockey DC,Barada K

    更新日期:2014-06-01 00:00:00

  • Relevant risk factors for positive lateral margin after en bloc endoscopic submucosal dissection for early gastric adenocarcinoma.

    abstract:OBJECTIVE:This study aimed to systematically assess the relevant risk factors of positive lateral margin (LM) after en bloc resection of early gastric adenocarcinoma. METHODS:A total of 242 patients who had undergone endoscopic submucosal dissection (ESD) due to early gastric lesions from January 2009 to March 2015 we...

    journal_title:Journal of digestive diseases

    pub_type: 杂志文章

    doi:10.1111/1751-2980.12342

    authors: Fu QY,Cui Y,Li XB,Chen P,Chen XY

    更新日期:2016-04-01 00:00:00