Abstract:
:Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade. The following steps are: intestinal metaplasia (first "complete" and then "incomplete"); dysplasia, first low grade and then high grade (equivalent to "carcinoma in situ"). The following step is invasive carcinoma, which is thought to be associated with degradation of the intercellular matrix.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Correa P,Piazuelo MBdoi
10.1111/j.1751-2980.2011.00550.xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
2-9issue
1eissn
1751-2972issn
1751-2980journal_volume
13pub_type
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doi:10.1111/1751-2980.12007
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pub_type: 杂志文章,随机对照试验
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