Abstract:
OBJECTIVE:To explore the features and clinical significance of serum pepsinogen (PG) assay in a follow-up study on a high-risk gastric cancer (GC) population. METHODS:A total of 444 participants from a high-risk area of GC in north China were enrolled in this follow-up study from April 1997 to December 1999. Serum PG was measured by enzyme-linked immunosorbent assay (ELISA), and the percentage changes in PG were calculated with 'PG( follow-up)/PG (first test)' thrice from the beginning to the end of these 30 months. Stomach diseases were diagnosed by a gastroscopy with biopsy examination. Helicobacter pylori (H. pylori) status was assessed by histopathological examination and serum H. pylori-immunoglobulin (Ig)G antibody assay with ELISA. RESULTS:In all groups except for the 51-60-year olds no significant differences of percentage changes in PGII and the PGI/II ratio were observed during 30-month follow-up period. In the superficial gastritis (SG) group the percentage change in PGI of group A (after 6 months' follow up) was significantly lower than that of group B (after 12 months' follow up) (0.69 vs 0.97, P = 0.002) in SG-->SG; while in SG-->normal (NOR), it was significantly higher than that in SG-->atrophic gastritis (AG) (0.94 vs 0.79, P = 0.022). In the AG group the percentage change in the PGI/II ratio of group A was significantly higher than that of group C (after 30 months' follow up) (1.13 vs 0.75, P = 0.042) in AG-->AG; and the percentage changes in PGI and PGII in AG-->NOR were significantly lower than those in AG-->SG (0.43 vs 0.87, P = 0.000; 0.60 vs 1.11, P = 0.010, respectively). In the H. pylori(-) (Hp(-)) group, the percentage change in PG of Hp(-)-->Hp(+) was significantly higher than that of Hp(-)-->Hp(-) (0.94 vs 0.81, P = 0.026). Percentage changes in PGI and PGII of Hp(+)-->Hp(-) were significantly lower than those of Hp(+)-->Hp(+) (0.74 vs 0.93, P = 0.000; 0.86 vs 1.15, P = 0.000, respectively), while the percentage change in the PGI/II ratio was higher than that the group of Hp(+)-->Hp(-) (0.90 vs 0.70, P = 0.022). CONCLUSION:The serum PG levels were influenced by the physiopathologic status of gastric mucosa and H. pylori infection, but they altered during the period of follow up. Serum PG assay might be a feasible and appropriate procedure to use in following up on a high-risk GC population.
journal_name
J Dig Disjournal_title
Journal of digestive diseasesauthors
Sun LP,Gong YH,Wang L,Gong W,Yuan Ydoi
10.1111/j.1443-9573.2007.00321.xsubject
Has Abstractpub_date
2008-02-01 00:00:00pages
20-6issue
1eissn
1751-2972issn
1751-2980pii
CDD321journal_volume
9pub_type
杂志文章abstract:OBJECTIVE:The best cure for colorectal cancer (CRC) lies on its early diagnosis and treatment. We aimed to provide the epidemiological features of advanced colorectal adenoma (A-CRA) and CRC in symptomatic patients and to determine whether the incidences of A-CRA and CRC increased simultaneously in China between 1990 a...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00531.x
更新日期:2011-10-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is now the most common etiology of chronic liver disease threatening global public health. However, the name "NAFLD" is no longer appropriate with the change of time. Recently, a new term, "metabolic dysfunction-associated fatty liver disease" has been proposed by an internati...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12944
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:We conducted a randomized trial aiming at improving patients' informed consent for undergoing endoscopic retrograde cholangiopancreatography (ERCP) in clinical care by comparing the efficacy of an additional educational video to written informed consent with that of written informed consent alone. METHODS:Th...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/1751-2980.12824
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether the ultrastructure and hydrogen potassium adenosine triphosphate (H+ /K+ ATPase) expression of human parietal cells were associated with aging. METHODS:In all, 50 participants who underwent gastroscopy due to dyspepsia were divided into two age groups, with 19 in the younger group (YG,...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12055
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence and potential risk factors of latent tuberculosis infection (LTBI) in Chinese patients with inflammatory bowel disease (IBD) and to evaluate the role of chest computed tomography (CT) in the screening of LTBI. METHODS:A single-center retrospective study was conducted and all IBD pat...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12437
更新日期:2017-01-01 00:00:00
abstract::The incidence of early esophageal adenocarcinoma has been increasing significantly in recent decades. Prognosis depends greatly on the choice of treatment. Early cancers can be treated by endoscopic resection, whereas advanced carcinomas have to be sent for surgery. Esophageal resection is associated with high periope...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12264
更新日期:2015-07-01 00:00:00
abstract::Lgr5 marks stem cells in digestive epithelial tissues by lineage tracing, and in vitro ever-expansion of Lgr5 stem cells form organoids, which can be directed to differentiate into functional somatic cells. Organoids derived from gastrointestinal epithelium even recapitulate the morphologic features of their in vivo c...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12305
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of endoscopic drainage and endoscopic necrosectomy in the management of symptomatic pancreatic fluid collection. METHODS:The clinical data of patients with symptomatic pancreatic fluid collection referred for endoscopic drainage were captured prospectively and analyzed. Pancreatic duct d...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2009.00388.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:Methotrexate (MTX) can be used as an alternative for patients with Crohn's disease (CD) who are intolerant of thiopurine. This retrospective study aimed to provide some clues about MTX treatment in Chinese patients with CD. METHODS:Medical records of 27 adult patients with CD who were treated with MTX betwee...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12694
更新日期:2018-12-01 00:00:00
abstract::Inflammatory bowel disease (IBD) has long been considered a disease that affects predominantly a Western population. The incidence and prevalence rates from Asian populations are much lower in comparison. More recent data, however, have shown significantly higher rates in Asians and time trend studies have shown an in...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2008.00355.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To investigate whether sending a family history questionnaire to patients prior to undergoing colonoscopy results in an increased availability of family history and better genetic counseling. METHODS:A questionnaire was mailed to patients before they underwent outpatient colonoscopy at a university hospital...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12491
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:This study aimed to compare the diagnostic value and image quality of high-definition magnifying white light endoscopy (M-WLE) and high-definition magnifying endoscopy with i-scan (M-i-scan) for Helicobacter pylori (H.pylori) infection. METHODS:Patients complaining of dyspepsia who underwent esophagogastrodu...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12086
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Data on the association between the antioxidant capacity of a diet and the risk of ulcerative colitis (UC) are scarce. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of UC in Iranian adults. METHODS:In this case-control study, patients w...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12823
更新日期:2019-12-01 00:00:00
abstract::Barrett's esophagus (BE)-related esophageal adenocarcinoma (EAC) has shown the fastest rise in incidence in Western countries; however, research data on BE-related diseases from China are inconclusive. We aimed to review and analyze the published results on these diseases in China. We searched PubMed and Chinese medic...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2011.00535.x
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years) with CBD stones. METHODS:We retrospectively examined 65 patients who underwent complete CBD stone removal (the duct clearance group) and 40 patients who underwent biliary s...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12656
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate the clinical features, precipitating factors, bowel habits, bothersome symptoms and treatment strategies of individuals in China with self-reported constipation. METHODS:An internet-based survey was conducted in China. The participants had self-reported chronic constipation (≥1 sympto...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12792
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:We aimed to identify the differences in symptoms, high-resolution manometry (HRM) characteristics, and the efficacy of peroral endoscopic myotomy (POEM) regarding patients' sex in achalasia. METHODS:All patients diagnosed with achalasia by HRM who underwent POEM and were followed up for more than 6 months we...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12922
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To investigate the alterations and functions of intrahepatic B (IHB) cells in non-alcoholic fatty liver disease (NAFLD) model induced by high-fat diet (HFD). METHODS:C57BL/6 J mice were fed with HFD for 16 weeks to induce NAFLD. Flow cytometry was used to analyze lymphocytes from liver, spleen and peripheral...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12362
更新日期:2016-07-01 00:00:00
abstract::Fibroblast infiltration and collagen deposition result in structural changes in the bowel wall, and lead to strictures in intestinal inflammatory disease. While strictures can also occur in other contexts, such as malignancy, this review focuses on the surgical treatment of stricture secondary to inflammatory bowel di...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/1751-2980.12880
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To evaluate whether patients with malignant biliary obstruction (MBO) benefit from balloon dilation before the placement of a self-expanding metal stent (SEMS) for palliative biliary drainage. METHODS:Consecutive patients who underwent endoscopic retrograde cholangiopancreatography with SEMS placement for pa...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12864
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Early diagnosis of colitis-associated cancer and dysplasia through surveillance endoscopy is vital for patients with ulcerative colitis (UC). This study aimed to evaluate the efficacy of autofluorescence endoscopy (AFE) using 5-aminolevulinic acid (ALA) and to investigate the fluorescence signal localization ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12923
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Given the rarity of the disease, the post-resection clinical course of localized pancreatic acinar cell carcinoma (ACC) is largely unknown. Therefore, we aimed to analyze the outcomes of patients with localized pancreatic ACC who underwent curative surgical resection. METHODS:We retrospectively analyzed the ...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12505
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of peroxisome proliferator-activated receptors (PPAR)gamma and the effects of PPARgamma ligands on cells growth in colorectal cancer (CRC) cell line HT-29, and to explore whether the activation of PPARgamma by its selective ligand can induce apoptosis and the arrest of the cell c...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1443-9573.2007.00290.x
更新日期:2007-05-01 00:00:00
abstract::Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous casca...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2011.00550.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:We aimed to identify the features of microRNA (miRNA) at different fibrotic stages in patients with hepatitis B virus (HBV)-related liver fibrosis. METHODS:Liver tissues were collected from 40 chronic hepatitis B (CHB) patients at fibrotic stages S0-4. Microarrays of miRNAs and genomic informatics analysis w...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12452
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate the relationship between the number of involved organs or regions and serum immunoglobulin G (IgG) and immunoglobulin G4 (IgG4) levels. METHODS:The number of pancreatic and/or extrapancreatic lesions and serum IgG and IgG4 levels were examined by groups in 46 patients with IgG4-relate...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/j.1751-2980.2012.00583.x
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:The monocyte chemoattractant protein-1 (MCP-1) -A2518G gene polymorphism has been found to be involved in the susceptibility to inflammatory bowel disease (IBD); however, the results of existing studies are controversial. The aim of this meta-analysis was to assess the relationship between the MCP-1 -A2518G p...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1751-2980.12232
更新日期:2015-04-01 00:00:00
abstract::The development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non-parenchymal cells in the liver. The impact of ethanol on hepatocytes can be characterized as a condition of organelle stress with multifactorial changes in hepatocellular function accumulating during ethanol ex...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2010.00468.x
更新日期:2011-02-01 00:00:00
abstract::Aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) gene polymorphisms associating with enhanced acetaldehyde exposure and markedly increased cancer risk in alcohol drinkers provide undisputable evidence for acetaldehyde being a local carcinogen not only in esophageal but also in gastric cancer. Accordingly...
journal_title:Journal of digestive diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1751-2980.2011.00480.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Transarterial chemoembolization (TACE) is the treatment modality for intermediate, or Barcelona Clinic Liver Cancer stage B, hepatocellular carcinoma (HCC), but its beneficial effect on outcomes is still unsatisfactory. This study aimed to assess the outcomes of combined TACE and sorafenib for patients with i...
journal_title:Journal of digestive diseases
pub_type: 杂志文章
doi:10.1111/1751-2980.12911
更新日期:2020-08-01 00:00:00