A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein.

Abstract:

:The phoP-phoQ-regulated pagC locus is essential for full virulence and survival within macrophages of Salmonella typhimurium. The protein product, DNA sequence, and transcript of pagC were determined. The pagC locus encodes a single 188-amino-acid membrane protein that is similar to the ail-encoded eucaryotic cell invasion protein of Yersinia enterocolitica and the lom-encoded protein of bacteriophage lambda. The similarity of PagC and Ail to Lom leads us to hypothesize that Lom is a virulence protein and that bacteriophage gene transfer and lysogeny could have led to the development of proteins essential to survival within macrophages and eucaryotic cell invasion.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Pulkkinen WS,Miller SI

doi

10.1128/jb.173.1.86-93.1991

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

86-93

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

173

pub_type

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