Bacillus subtilis ccpA gene mutants specifically defective in activation of acetoin biosynthesis.

Abstract:

:A large number of carbon source utilization pathways are repressed in Bacillus subtilis by the global regulator CcpA, which also acts as an activator of carbon excretion pathways during growth in media containing glucose. In this study, CcpA mutants defective in transcriptional activation of the alsSD operon, which is involved in acetoin biosynthesis, were identified. These mutants retained normal glucose repression of amyE, encoding alpha-amylase, and acsA, encoding acetyl-coenzyme A synthetase, and normal activation of ackA, which is involved in acetate excretion; in these ccpA mutants the CcpA functions of activation of the acetate and acetoin excretion pathways appear to be separated.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Turinsky AJ,Moir-Blais TR,Grundy FJ,Henkin TM

doi

10.1128/jb.182.19.5611-5614.2000

keywords:

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

5611-4

issue

19

eissn

0021-9193

issn

1098-5530

journal_volume

182

pub_type

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