Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides.

abstract：:Serum corticosterone levels were determined at intervals after i.p. injection of 1.8 mg cadmium (Cd)/kg body weight. Thymus weight decreased significantly 3 days after injection. The effect of Cd injection on serum corticosterone levels was almost indistinguishable from that of saline injection. Further, Cd-induced th...

journal_title：Toxicology letters

authors： Yamada YK,Murakami N,Shimizu F,Kubota K

更新日期：1982-08-01 00:00:00

abstract：:Methoxetamine is one of the constantly growing group of novel psychoactive substances that has emerged in recent years. The compound belongs to the arylcyclohexylamine class, which is used for its recreational and psychedelic effects. Methoxetamine is a structural analogue of ketamine, with a much longer duration of a...

journal_title：Toxicology letters

authors： Zawilska JB

更新日期：2014-11-04 00:00:00

abstract：:Long-term (20 days) treatment with methyl mercury (MeHg) increases the total number of benzodiazepine binding sites and decreases essentially the content of cyclic GMP in the cerebellar cortex. In contrast, this treatment fails to modify the content of GABA and cyclic AMP, GAD activity and GABA binding sites in the sa...

journal_title：Toxicology letters

authors： Concas A,Corda MG,Salis M,Mulas ML,Milia A,Corongiu FP,Biggio G

更新日期：1983-08-01 00:00:00

abstract：:Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated ra...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1984-10-01 00:00:00

abstract：:Alternaria spp. are ubiquitous molds that are able to produce toxic secondary metabolites which may contaminate food globally. One of those is the mycotoxin altertoxin II (ATX-II), a genotoxic and mutagenic compound. In recent years, different flavonoids that may co-occur with mycotoxins in food were demonstrated to t...

journal_title：Toxicology letters

authors： Aichinger G,Puntscher H,Beisl J,Kütt ML,Warth B,Marko D

更新日期：2018-03-01 00:00:00

abstract：:Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the s...

journal_title：Toxicology letters

authors： Murakami T,Nagamura Y,Hirano K

更新日期：1998-01-31 00:00:00

abstract：:Protein S-glutathionation has been demonstrated to be one of the cellular responses under oxidative stress and may be involved in many cellular metabolisms. In this study, the effect of redox cycling bipyridylium compounds, paraquat and diquat, on this protein modification was investigated. Male Sprague-Dawley rats we...

journal_title：Toxicology letters

authors： Lii CK,Wang ST,Chen HW

更新日期：1996-02-01 00:00:00

abstract：:Results of health survey and biological monitoring in pesticide formulators exposed to a combination of pesticides, an organophosphorus (OP) insecticide (phorate) and a persistent chlorinated insecticide (technical hexachlorocyclohexane; HCH; BHC) are reported. Exposure of 160 workers to a combination of pesticides (m...

journal_title：Toxicology letters

authors： Kashyap SK

更新日期：1986-10-01 00:00:00

abstract：:This objective of this study was to investigate the toxicogenomics and the spatial regulation of global gene expression profiles elicited by endoplasmic reticulum (ER) stress inducer tunicamycin (TM) in mouse small intestine and liver as well as to identify TM-modulated nuclear factor-E2-related factor 2 (Nrf2)-depend...

journal_title：Toxicology letters

authors： Nair S,Xu C,Shen G,Hebbar V,Gopalakrishnan A,Hu R,Jain MR,Liew C,Chan JY,Kong AN

更新日期：2007-01-10 00:00:00

abstract：:Aim of this pilot study was to correlate the human exposure to formaldehyde (F) with N-methylenvaline, a molecular adduct formed by addiction of F to the N-terminal valine in hemoglobin. A group of 21 subjects employed in a plywood factory and a laminate factory, and occupationally exposed to F, together with a group ...

journal_title：Toxicology letters

authors： Bono R,Vincenti M,Schiliro' T,Scursatone E,Pignata C,Gilli G

更新日期：2006-02-08 00:00:00

abstract：:A multi-unit, dynamic flow, inhalation exposure system which is capable of accommodating 12 mice per unit has been described. Components of the system include a mixing board, one or more glass distributing tubes, and detachable glass chamber tubes. The flow of a specified concentration of test gas exits from the mixin...

journal_title：Toxicology letters

authors： Kapeghian JC,Waters IW,Jones AB

更新日期：1985-02-01 00:00:00

abstract：:The polychlorinated biphenyls (PCBs) have been demonstrated to be inducers of hepatic microsomal enzymes and some of their effects such as hormonal imbalance, and alteration of lipid and porphyrin metabolism could be ascribed to this mechanism. For this reason, the urinary excretion of D-glucaric acid (DGA), an indire...

journal_title：Toxicology letters

authors： Apostoli P,Mangili A,Carasi S,Manno M

更新日期：2003-09-15 00:00:00

abstract：:Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholi...

journal_title：Toxicology letters

authors： Baños G,Lopez-Zetina P,Franco M

更新日期：1995-02-01 00:00:00

abstract：:The toxicity of diethylene glycol butyl ether (DGBE), and its principal metabolite, butoxyethoxyacetic acid (BEAA), were assessed in vitro for rat and human red blood cells. Rat erythrocytes showed evidence of mild hemolysis when exposed to BEAA at concentrations of 5 or 10 mM for 4 h. BEAA treated rat red blood cells...

journal_title：Toxicology letters

authors： Udden MM

更新日期：2005-03-28 00:00:00

abstract：:The birth of the twenty first century has provoked a substantial rise in the use of designer drugs, such as synthetic cathinones, because of a decrease in the availability and purity of other drugs of abuse. The khat plant or Catha edulis, contains cathinone, the parent compound. Synthetic cathinones are sold under th...

journal_title：Toxicology letters

authors： Katz DP,Bhattacharya D,Bhattacharya S,Deruiter J,Clark CR,Suppiramaniam V,Dhanasekaran M

更新日期：2014-09-02 00:00:00

abstract：:The clinical use of gentamicin (G) is limited because of its nephrotoxic potential. The administration of G (50 mg/kg) to rats in a 10-day daily treatment gave a biphasic pattern of lactate dehydrogenase (LDH) and N-acetyl-beta-D-glucosaminidase (NAG) excretion. Alkaline phosphatase (ALP) was highly elevated during th...

journal_title：Toxicology letters

authors： Obatomi DK,Plummer DT

更新日期：1995-01-01 00:00:00

abstract：:EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...

journal_title：Toxicology letters

authors： Kaur G,Srivastava UC,Dwivedi RS,Srivastava RC

更新日期：1984-07-01 00:00:00

abstract：:Small molecular weight chemicals may irritate tissues via the induction of the production of various proinflammatory and chemotactic molecules. The structure of these irritants is heterogenous, as is the pattern of their effects. Chemicals are potentially allergenic (i.e. haptens) when they are able to bind proteins s...

journal_title：Toxicology letters

authors： Kapsenberg ML

更新日期：1996-08-01 00:00:00

abstract：:Single doses of primaquine did not produce methemoglobinemia in beagle bitches. Repeated daily administration for 12 days produced a gradually rising level of methemoglobin over that time period, unaccompanied by depletion of erythrocytic reduced glutathione. Primaquine was mutagenic in the Ames test in Salmonella typ...

journal_title：Toxicology letters

authors： Marrs TC,Bright JE,Morris BC

更新日期：1987-05-01 00:00:00

abstract：:Effects of intestinal damage on thyroid carcinogenesis due to amitrole (AT) were examined in F344 male rats initiated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). In experiment 1, rats were provided with diet containing 0.03% AT for 20 weeks after a single subcutaneous injection of DHPN (2800 mg/kg body weight), and...

journal_title：Toxicology letters

authors： Imai T,Onose J,Hasumura M,Takizawa T,Hirose M

更新日期：2006-06-20 00:00:00

abstract：:By the gas plant at Schwaan (a small city near Rostock), tar and other by-products were released into the river Warnow which supplies Rostock with drinking water 20 km downstream. The tar-contaminated river sediment contained phenols and polycyclic aromatic hydrocarbons (PAH), indicating a mutagenic potential. Investi...

journal_title：Toxicology letters

authors： Randow FF,Hübener T,Merkel G

更新日期：1996-11-01 00:00:00

abstract：:This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroe...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2018-01-05 00:00:00

abstract：:The biomedical application of single-walled carbon nanotubes (SWCNTs), such as drug delivery and cancer treatment, requires a clear understanding of their fate and toxicological profile after intravenous administration. In this study, the long-term accumulation and toxicity of intravenously injected SWCNTs in the main...

journal_title：Toxicology letters

authors： Yang ST,Wang X,Jia G,Gu Y,Wang T,Nie H,Ge C,Wang H,Liu Y

更新日期：2008-10-01 00:00:00

abstract：:The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of the individual co...

journal_title：Toxicology letters

authors： Scotti TM,Chernoff N,Linder R,McElroy WK

更新日期：1981-11-01 00:00:00

abstract：:Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and...

journal_title：Toxicology letters

authors： Bolden AL,Rochester JR,Kwiatkowski CF

更新日期：2017-10-05 00:00:00

abstract：:The mutagenicity of four chemical compounds to strain TA100 of S. typhimurium was affected differently by liver S-9 preparations from untreated Sprague-Dawley rats and from rainbow trout (Salmogairdneri). These two species were equally effective in decreasing the direct mutagenicity of sodium dichromate. Rat preparati...

journal_title：Toxicology letters

authors： de Flora S,Zanacchi P,Bennicelli C,Arillo A

更新日期：1982-03-01 00:00:00

abstract：:Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTX-like compounds....

journal_title：Toxicology letters

authors： Del Favero G,Sosa S,Poli M,Tubaro A,Sbaizero O,Lorenzon P

更新日期：2014-03-03 00:00:00

abstract：:Xenobiotic exposure is a risk factor in the etiology of neurodegenerative disease. It was recently hypothesized that restricted exposure during brain development could predispose for a neurodegenerative disease later in life. As neuroinflammation contributes to progressive neurodegeneration, it is suspected that neuro...

journal_title：Toxicology letters

authors： Sandström von Tobel J,Zoia D,Althaus J,Antinori P,Mermoud J,Pak HS,Scherl A,Monnet-Tschudi F

更新日期：2014-10-15 00:00:00

abstract：:Localization of specific mRNA and protein molecules within cells and tissues can provide important information on the effects of a drug within a biological test system and help elucidate mechanisms of drug-induced toxicity and organ dysfunction. The most widely used techniques for measuring the cellular and tissue dis...

journal_title：Toxicology letters

authors： Kind CN

更新日期：2000-03-15 00:00:00

abstract：:Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic activity in estrogen-receptor positive human breast cancer cells. However, there is limited in vivo experimentation regarding the estrogenicity of acetaminophen. Therefore, the present study examined the in vivo estrogenic potential o...

journal_title：Toxicology letters

authors： Patel R,Rosengren RJ

更新日期：2001-05-31 00:00:00