Abstract:
:The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that have been implicated in both receptor and store-operated channel functions. The family of the classical TRPs (TRPCs) consists of seven members (TRPC1-7). The presence of TRPC1 and TRPC5 mRNA in the brain has previously been demonstrated by real-time polymerase chain reaction. However, the distribution of these receptors within different brain areas of mice has not been investigated in detail. We have used antibodies directed against TRPC1 and TRPC5 to study the distribution and localization of these channels in murine medial temporal lobe structures. Both TRPC1 and TRPC5 channels are present in the various nuclei of the amygdala, in the hippocampus, and in the subiculum and the entorhinal cortex. We have found that TRPC1 channels are primarily expressed on cell somata and on dendrites, whereas TRPC5 channels are exclusively located on cell bodies. Moreover, TRPC1 channels are selectively expressed by neurons, whereas TRPC5 channels are mainly expressed by neurons, but also by non-neuronal cells. The expression of TRPC1 and TRPC5 channels in mammalian temporal lobe structures suggests their involvement in neuronal plasticity, learning and memory.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
von Bohlen Und Halbach O,Hinz U,Unsicker K,Egorov AVdoi
10.1007/s00441-005-0004-4keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
201-6issue
2eissn
0302-766Xissn
1432-0878journal_volume
322pub_type
杂志文章abstract::The extracellular matrix is involved in various morphogenetic processes which are accompanied by changes in its physicochemical properties and spatial organization. In the adult brain it contributes to cellular communication and the regulation of neuronal activity. The present study deals with the postnatal appearance...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050790
更新日期:1997-04-01 00:00:00
abstract::Using specimens of human submandibular glands, we have investigated in vitro the morphological modifications induced by clozapine, a dibenzodiazepine derivative that is used in psychotic patients and that provokes hypersalivation, a side-effect of therapy. The effects of the drug, used alone or in combination with car...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-0149-1
更新日期:2006-05-01 00:00:00
abstract::Osteoarthritis (OA) is the most common joint disease with an unsatisfactory therapy outcome and characterized by the degradation of articular cartilage and synovial inflammation. Here, we isolated bone marrow mesenchymal stem cells (BMSCs) from rat's bone marrow and BMSC-derived exosome (BMSCs-Exo) from BMSCs successf...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03319-1
更新日期:2021-01-06 00:00:00
abstract::We describe the histological basis of color metamorphosis in the polychromatic Midas cichlid, Cichlasoma citrinellum. Eight percent of the individuals in a natural population transform from gray with black markings to orange, simultaneously losing their ability to adjust coloration in response to background and social...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221733
更新日期:1988-07-01 00:00:00
abstract::Steroid hormones intervene in the structural and functional regulation of neuronal processes during development and thus determine brain differentiation. The effects of estrogens are mediated by two transcription factors, namely estrogen receptor α (ER-α) and estrogen receptor β (ER-β), that regulate the expression of...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-2023-5
更新日期:2015-02-01 00:00:00
abstract::To obtain more information concerning the origin of dendritic reticulum cells, the development of germinal centers in the spleens of rabbits was investigated by conventional light microscopy, enzyme histochemistry, and electron microscopy. Washed sheep erythrocytes were used as antigen. Splenic tissue was examined on ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00237632
更新日期:1980-01-01 00:00:00
abstract::Gill lamellae of a bivalve Anodonta woodiana lauta (v. Martens) were observed by electron microscopy. The Anodonta gill wall consists of a single layer of epithelial cells, its basal lamina and the underlying connective tissue layer. It was confirmed that there is no true endothelium in the vessels and that the connec...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222069
更新日期:1975-01-01 00:00:00
abstract::By use of the indirect immunofluorescence technique a small group of large somatostatin-positive neurons is described in the subependymal area of the anterior paraventricular thalamus of the male rat. Retrograde-tracing experiments suggest that they project to areas outside the blood-brain barrier. ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215212
更新日期:1986-01-01 00:00:00
abstract::The spatial and temporal distribution of three peptides, DSK I, DSK II, and DSK 0, encoded by the Drosophila melanogaster drosulfakinin (Dsk) gene, have been examined in the central nervous system. DSK I and DSK II have a -RFamide C-terminus and are structurally similar to sulfakinin peptides; in contrast, DSK 0 conta...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050518
更新日期:1996-01-01 00:00:00
abstract::Nematocysts are characteristic organelles of the phylum Cnidaria. The free-living Platyhelminth Microstomum lineare preys on Hydra oligactis and sequesters nematocysts. All nematocyst types become phagocytosed without adherent cytoplasm by intestinal cnidophagocytes. Desmoneme and isorhiza nematocysts disappear within...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-019-03149-w
更新日期:2020-01-01 00:00:00
abstract::Type-A spermatogonia can be found in different locations throughout the germinal epithelium of human seminiferous tubules. Generally they represent the population of germ cells adjacent to the basal lamina, but under special conditions they may be located in the adluminal compartment. This aberrant location is found n...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216510
更新日期:1984-01-01 00:00:00
abstract::We have recently reported that Sox2-expressing pituitary stem/progenitor cells contact each other via a tight-junction protein CAR to form stem/progenitor cell niches in the marginal cell layer facing the lumen and in the clusters scattered in the parenchyma of the anterior lobe. However, the microenvironment of the n...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-2054-y
更新日期:2015-03-01 00:00:00
abstract::The fine structure of the pore cells in pre- and post-hatched Deroceras reticulatum is described. The cells have been divided into three main types on morphological grounds, one type being particulary rich in glycogen. Certain pore cells contain haemocyanin granules in grooves below cytoplasmic tongues, and in charact...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234637
更新日期:1979-12-01 00:00:00
abstract::The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotr...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-020-03260-3
更新日期:2020-10-01 00:00:00
abstract::The distribution of gap junctions (nexuses) in various parts of the small and large intestines of the guinea-pig was studied using the freeze-fracture technique and in thin sections. The percentage area of smooth muscle cell surface occupied by gap junctions varies from 0.50% in the circular muscle of the duodenum to ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209987
更新日期:1981-01-01 00:00:00
abstract::The structure of guppy (Poecilia reticulata) spermatogonia and spermatocytes has been studied using electron microscopy. The spermatogonia, situated at the apex of the seminiferous tubule, are almost all surrounded by a network of Sertoli cells; they have very diffuse chromatin and one or two large nucleoli. The cytop...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217139
更新日期:1984-01-01 00:00:00
abstract::This study aims to illustrate potential transport mechanisms behind the divergent approaches to nitrogen excretion seen in the ureotelic toadfish (Opsanus beta) and the ammoniotelic plainfin midshipman (Porichthys notatus). Specifically, we wish to confirm the expression of a urea transporter (UT), which is found in t...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1591-0
更新日期:2013-06-01 00:00:00
abstract::Neural stem and progenitor cells produce one of the most remarkable organs in nature, the human brain. Among neural stem cell progeny, post-mitotic neurons are likewise remarkably diverse. Single-cell transcriptomic approaches are now cataloging a long-sought-after molecular taxonomy of neuronal diversity in the brain...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-017-2728-3
更新日期:2018-01-01 00:00:00
abstract::The morphology and histology of the tibial auditory system of the New Zealand weta, Hemideina crassidens, are described. The groups of acoustic sensilla conform closely to the subgenual organ, intermediate organ and crista acoustica of the Tettigoniidae. Each prothoracic tibia bears two thick (40-100 micrometers) tymp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233584
更新日期:1981-01-01 00:00:00
abstract::Young rats were injected with 3H-fucose and killed at 10 min, 1, 4 and 24 h thereafter. Samples of the pancreas were processed for light- and electron-microscopic radioautography and then analyzed quantitatively. Fucose label was taken up in the supranuclear region of acinar pancreatic cells that were maximally labele...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222243
更新日期:1983-01-01 00:00:00
abstract::Transforming growth factor beta (TGF-beta) is a major member of a cytokine family with pluripotent biological activity. In the liver, TGF-beta has pathophysiological significance with respect to hepatic fibrogenesis, regulation of liver cell growth, tumor development, and induction of hepatocellular apoptosis. We show...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050740
更新日期:1997-01-01 00:00:00
abstract::The regeneration of the vallate papilla in the rat was studied by both light and electron microscopy. The papillae were excised and regeneration was studied at time intervals of 3 to 45 days. It was found that the vallate papilla is capable of regeneration after both partial and total papillectomies. The regenerated p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225338
更新日期:1978-10-30 00:00:00
abstract::The distribution of endocrine cells in the gastrointestinal tract of the house musk shrew, Suncus murinus (Family Soricidae, Order Insectivora) was studied immunohistochemically. The hormones investigated were gastrin, cholecystokinin (CCK), somatostatin, secretin, glucagon, gastric inhibitory polypeptide (GIP), motil...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00239456
更新日期:1989-11-01 00:00:00
abstract::The distribution pattern of adrenergic fibres innervating the ocular choroid membrane of the chicken was studied by means of fluorescence and electron microscopy. In addition, the origin of these fibres was investigated after superior cervical ganglionectomy. Adrenergic axons reach the choroid, partly forming the peri...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213222
更新日期:1982-01-01 00:00:00
abstract::Electron-dense granules (EDGs) are singular structures found in the tissues of several vertebrate and invertebrate organisms. Two types of EDGs were observed in hepatopancreatic cells of the crab Ucides cordatus: (1) a non-mineralized EDG, found mainly inside vacuoles, which reacted positively to acid phosphatase and ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0646-4
更新日期:2003-01-01 00:00:00
abstract::The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) comprise a group of four homologous and potent growth factors that includes GDNF, neurturin (NRTN), artemin (ARTN), and persephin (PSPN). The survival, growth, and mitotic activities of the GFLs are conveyed by a single receptor tyrosine kina...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03235-4
更新日期:2020-10-01 00:00:00
abstract::Previous studies have indicated that 19-day-old fetal long bones of the rat contain an adenylyl cyclase-stimulating activity antigenically related to parathyroid hormone-related peptide. To ascertain its origin, Northern blotting and in situ hybridization histochemistry were performed. Results demonstrate that mRNA of...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00645063
更新日期:1992-12-01 00:00:00
abstract::The alimentary system of Habrotrocha rosa is composed of the alimentary channel, five digestive glands and another gland which is in close relation to the intestinal syncytium. After the present investigation, the alimentary channel can be divided into sections which clearly differ from each other, these are: oral cav...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209138
更新日期:1978-06-08 00:00:00
abstract::A monoclonal antibody (Mab) developed against a partially purified bursal protein extract was found to bind specifically to a single cell type in the cortico-medullary border region of the chicken bursa of Fabricius. These cells were microscopically similar to the bursal secretory dendritic-like cells. A product with ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-004-0910-x
更新日期:2004-09-01 00:00:00
abstract::Two types of mammosomatotropes (MS), the small-granule and vesicle-granule MS, were detected in mouse adenohypophysis by electron microscopy and immunohistochemistry. Both cell-types were immunoreactive to prolactin (PRL) and growth hormone (GH) antisera. The small-granule MS contained small, round, solid secretory gr...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00225615
更新日期:1989-06-01 00:00:00