Spatial and temporal immunocytochemical analysis of drosulfakinin (Dsk) gene products in the Drosophila melanogaster central nervous system.


:The spatial and temporal distribution of three peptides, DSK I, DSK II, and DSK 0, encoded by the Drosophila melanogaster drosulfakinin (Dsk) gene, have been examined in the central nervous system. DSK I and DSK II have a -RFamide C-terminus and are structurally similar to sulfakinin peptides; in contrast, DSK 0 contains -SFamide and is not structurally similar to sulfakinins. Antisera specificities were determined by the design of the antigens and confirmed by dot blot analysis and preincubation with peptides prior to their use in immunocytochemistry. The distribution of immunoreactivity suggests that all three DSK peptides are processed from the polypeptide precursor and expressed in many of the same cells. Expression was observed at all developmental stages with an increase in the level of staining and the number of immunoreactive cells as development progresses. Cells in the brain lobe, optic lobe, subesophageal ganglion, thoracic ganglia, and the eighth abdominal neuromere contain DSK-immunoreactive materials. Immunoreactive fibers project from some cells and extend into the brain and ventral ganglion with regions of extensive arborization. DSK 0 immunoreactivity provides initial evidence for the presence of a -SFamide peptide in neural tissue. The observed expression of DSK-immunoreactive materials throughout development in numerous cells of the central nervous system suggests that DSK peptides may serve as hormones, modulators, or transmitters involved in several functions.


Cell Tissue Res


Cell and tissue research


Nichols R,Lim IA




Has Abstract


1996-01-01 00:00:00












  • Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease.

    abstract::Fibroblast growth factors (Fgfs) are proteins with diverse functions in development, repair, and metabolism. The human Fgf gene family with 22 members can be classified into three groups, canonical, intracellular, and hormone-like Fgf genes. In contrast to canonical and intracellular Fgfs identified in invertebrates a...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Itoh N

    更新日期:2010-10-01 00:00:00

  • ChAT and NOS in human myenteric neurons: co-existence and co-absence.

    abstract::Most myenteric neurons contain one of the two generating enzymes for major excitatory and inhibitory neurotransmitters: choline acetyltransferase (ChAT) or neuronal nitric oxide synthase (NOS). Two minor groups of myenteric neurons contain either both enzymes or neither. Our study had two aims: (1) to compare the prop...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Beck M,Schlabrakowski A,Schrödl F,Neuhuber W,Brehmer A

    更新日期:2009-10-01 00:00:00

  • From immune to olfactory expression: neofunctionalization of formyl peptide receptors.

    abstract::Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an immune pathogen sen...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Boillat M,Carleton A,Rodriguez I

    更新日期:2021-01-16 00:00:00

  • Sympathectomy causes increased root resorption after orthodontic tooth movement in rats: immunohistochemical study.

    abstract::Accumulating evidence suggests that the sympathetic nervous system modulates inflammatory responses and bone remodeling. We have studied the effects of sympathectomy and orthodontic tooth movement (OTM) on root resorption, immunocompetent cell recruitment, neuropeptide, neurokinin-1 receptor (NK1-R), and interleukin 6...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Haug SR,Brudvik P,Fristad I,Heyeraas KJ

    更新日期:2003-08-01 00:00:00

  • Development of cell-to-cell relationships in the thyroid gland of the chick embryo.

    abstract::Thyroid glands of 7 to 21 day-old chick embryos were examined by electron microscopy using freeze-fracture and thin-section preparations. The primitive follicle lumen first appears between two adjacent epithelial cells in 8 day-old embryos, and is formed in the region of a focal tight junction (macula occludens). The ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Ishimura K,Fujita H

    更新日期:1979-04-30 00:00:00

  • Tetrodotoxin suppresses morphological enhancement of the metastatic MAT-LyLu rat prostate cancer cell line.

    abstract::Voltage-gated Na+ channels are expressed by highly metastatic MAT-LyLu cells, but not by poorly metastatic AT-2 cells, derived from the rodent Dunning model of prostatic cancer. We have investigated the possible involvement of these channels in the morphological development of the cells. Incubation of both the MAT-LyL...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Fraser SP,Ding Y,Liu A,Foster CS,Djamgoz MB

    更新日期:1999-03-01 00:00:00

  • Catestatin regulates vesicular quanta through modulation of cholinergic and peptidergic (PACAPergic) stimulation in PC12 cells.

    abstract::We have previously shown that the chromogranin A (CgA)-derived peptide catestatin (CST: hCgA352-372) inhibits nicotine-induced secretion of catecholamines from the adrenal medulla and chromaffin cells. In the present study, we seek to determine whether CST regulates dense core (DC) vesicle (DCV) quanta (catecholamine ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Sahu BS,Mahata S,Bandyopadhyay K,Mahata M,Avolio E,Pasqua T,Sahu C,Bandyopadhyay GK,Bartolomucci A,Webster NJG,Van Den Bogaart G,Fischer-Colbrie R,Corti A,Eiden LE,Mahata SK

    更新日期:2019-04-01 00:00:00

  • Extrarenal determinants of kidney filter function.

    abstract::The kidney is an organ involved in cross talk with many human organs. The link between the immune system and the kidney has been studied in some detail, although data precisely elucidating their interaction are sparse, in particular with regard to the function of the kidney filter apparatus. Current research suggests ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Hahm E,Peev V,Reiser J

    更新日期:2017-07-01 00:00:00

  • Putative epithelial stem cell loss corresponds with mammary growth senescence.

    abstract::Since the advent of transmission electron microscopy of tissues capable of growth and regeneration, cell and developmental biologists have postulated that the undifferentiated cells observed within these tissues represent tissue-specific stem or progenitor cells. However, no studies have addressed the issue of whether...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Smith GH,Strickland P,Daniel CW

    更新日期:2002-12-01 00:00:00

  • Molecular and cellular detection of expression of vitellogenin and zona radiata protein in liver and skin of juvenile salmon (Salmo salar) exposed to nonylphenol.

    abstract::In developing bioassays for estrogenic effects, vitellogenin (Vtg) induction and zona radiata protein (Zr-protein) induction in males and juveniles of oviparous vertebrates have been used as sensitive biomarkers for estrogenicity. Nonylphenol (NP) produces similar and parallel expression patterns of Vtg and Zr-protein...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Arukwe A,Røe K

    更新日期:2008-03-01 00:00:00

  • Trk neurotrophin receptor-like proteins in the teleost Dicentrarchus labrax.

    abstract::In recent years, data have accumulated suggesting that the role of neurotrophins and Trk receptors may not be limited to the nervous system, and the presence of these substances has been detected in a variety of vertebrate and invertebrate non-nervous tissues. This study was designed to map the expression of immunorea...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Hannestad J,Marino F,Germanà A,Catania S,Abbate F,Ciriaco E,Vega JA

    更新日期:2000-04-01 00:00:00

  • A pair of descending neurons with dendrites in the optic lobes projecting directly to thoracic ganglia of dipterous insects.

    abstract::The lobula descending neuron (LDN) of dipterous insects is a unique nerve cell (one on each side of the brain) that projects directly from the lobula complex of the optic lobes to neuropil in thoracic ganglia. In the supraoesophageal ganglia the LDN has two prominent groups of branches of which at least one is dendrit...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Nässel DR,Strausfeld NJ

    更新日期:1982-01-01 00:00:00

  • Angiotensin-converting enzyme 2 augments the effects of endothelial progenitor cells-exosomes on vascular smooth muscle cell phenotype transition.

    abstract::Phenotype transition of vascular smooth muscle cells (VSMCs) is implicated in vascular diseases. Angiotensin-converting enzyme 2 (ACE2) is a perspective cardiovascular target due to its ability of converting angiotensin (Ang II) to Ang (1-7). Our group recently showed that ACE2 can regulate the function of endothelial...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Wang J,Li J,Cheng C,Liu S

    更新日期:2020-12-01 00:00:00

  • Cyclophilin A is a new M cell marker of bovine intestinal epithelium.

    abstract::Microfold (M) cells in the follicle-associated epithelium (FAE) of Peyer's patches contribute to the mucosal immune response by the transcytosis of microorganisms. The mechanism by which M cells take up microorganisms, and the functional proteins by which they do this, are not clear. In order to explore one such prote...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Hondo T,Someya S,Nagasawa Y,Terada S,Watanabe H,Chen X,Watanabe K,Ohwada S,Kitazawa H,Rose MT,Nochi T,Aso H

    更新日期:2016-06-01 00:00:00

  • Photoreceptor membrane breakdown in the spider Dinopis: localisation of acid phosphatases.

    abstract::The ultrastructural localisation of acid phosphatases (AcPhs) during the normal daily breakdown of rhabdomere membrane in Dinopis has been examined using beta-glycerophosphate and p-nitrophenyl phosphate as substrates. Results are related to the classification of organelles in the receptors given by Blest, Powell and ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Blest AD,Price GD,Maples J

    更新日期:1979-07-17 00:00:00

  • Calcite in the statoconia of amphibians: a detailed analysis in the frog Rana esculenta.

    abstract::The otoconia of Amphibia, especially of the frog Rana esculenta, were studied by X-ray diffraction and scanning electron microscopy (SEM). The SEM studies showed that the membranous labyrinth of Amphibia contains two populations of crystals, which can easily be distinguished by their forms. The X-ray diffraction data ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Marmo F,Balsamo G,Franco E

    更新日期:1983-01-01 00:00:00

  • The effects of type 1 diabetes on the hypothalamic, pituitary and testes axis.

    abstract::Type 1 diabetes is an autoimmune disorder characterized by a lack of insulin production by the beta cells of the pancreas. This lack of insulin causes a variety of systemic effects on whole-body metabolism. Poorly managed type 1 diabetes can lead to cardiovascular disease, diabetic neuropathy, and diabetic retinopathy...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Schoeller EL,Schon S,Moley KH

    更新日期:2012-09-01 00:00:00

  • Phenotypic modulation of parietal epithelial cells of Bowman's capsule in culture.

    abstract::The origin of cobblestone-like polygonal cells (the most numerous in renal glomerular cell culture) remains controversial; they could be either dedifferentiated podocytes or parietal epithelial cells (PECs) of Bowman's capsule. Poor cellular outgrowth from glomeruli devoid of Bowman's capsule (decapsulated glomeruli) ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Yaoita E,Kurihara H,Sakai T,Ohshiro K,Yamamoto T

    更新日期:2001-06-01 00:00:00

  • Ultrastructure of the meninges at the site of penetration of veins through the dura mater, with particular reference to Pacchionian granulations. Investigations in the rat and two species of New-World monkeys (Cebus apella, Callitrix jacchus).

    abstract::At the sites where a vein penetrates through the dura mater, two aspects deserve particular attention: (i) The delineation of the perivascular cleft, a space belonging to the interstitial cerebrospinal fluid (CSF) compartment, toward the interior hemal milieu of the dura mater. (ii) The relationship between the periva...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Krisch B

    更新日期:1988-03-01 00:00:00

  • Effect of hypothyroidism on satellite cells and postnatal fiber development in the soleus muscle of rat.

    abstract::The effect of hypothyroidism, induced by 4-propyl-2-thiouracil, on muscle satellite cells in vivo and in vitro, and on postnatal muscle fiber development in the soleus muscle of rats during the first 40 days of postnatal life was analyzed. The proliferative activity of satellite cells was determined by means of bromod...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Jacobs SC,Bär PR,Bootsma AL

    更新日期:1996-10-01 00:00:00

  • Intracellular localization of actin with fluorescently labelled heavy meromyosin.

    abstract::An improved technique for fluorescent labelling of heavy meromyosin has made it possible to detect on a light microscopic level the cellular sites of actin localization. Rabbit heavy meromyosin (HMM) was labelled with fluorescein isothiocyanate so that the actin binding site was protected during the reaction. The spec...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Sanger JW

    更新日期:1975-08-27 00:00:00

  • Degeneration of osteoblasts involved in intramembranous ossification of fetal rat calvaria.

    abstract::Ossification of calvariae from day-21 rat fetuses was reinvestigated by electron microscopy using different fixation techniques (glutaraldehyde/OsO4, tannic acid, ruthenium red, K-pyroantimonate). An osteoid layer with scattered mineral deposits was found at the mineralization front. Directly beyond this layer, a shee...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Zimmermann B

    更新日期:1992-01-01 00:00:00

  • Tissue- and cell-specific distribution of creatine kinase B: a new and highly specific monoclonal antibody for use in immunohistochemistry.

    abstract::A synthetic 17-mer peptide corresponding to an unique sequence in the amino-terminal region of human creatine kinase B was used to raise a new and highly B-subunit-specific monoclonal antibody, CK-BYK/21E10. We show here that the monoclonal antibody is suitable for immunohistochemistry of unfixed frozen sections as we...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Sistermans EA,de Kok YJ,Peters W,Ginsel LA,Jap PH,Wieringa B

    更新日期:1995-05-01 00:00:00

  • Treatment of cancer stem cells from human colon adenocarcinoma cell line HT-29 with resveratrol and sulindac induced mesenchymal-endothelial transition rate.

    abstract::In the current experiment, the combined regime of resveratrol and a Wnt-3a inhibitor, sulindac, were examined on the angiogenic potential of cancer stem cells from human colon adenocarcinoma cell line HT-29 during 7 days. Cancer stem cells were enriched via a magnetic-activated cell sorter technique and cultured in en...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Pouyafar A,Rezabakhsh A,Rahbarghazi R,Heydarabad MZ,Shokrollahi E,Sokullu E,Khaksar M,Nourazarian A,Avci ÇB

    更新日期:2019-06-01 00:00:00

  • Irradiation influences the expression of substance P and enkephalin in the rat larynx.

    abstract::The effects of radiotherapy on neuropeptide expression in the rat larynx were studied. Irradiation was given for five days, 6 or 8 Gray daily. Ten days after the end of irradiation, the larynx, the laryngeal nerves and different ganglia related to the larynx were dissected out from irradiated and control animals and p...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Lidegran M,Domeij S,Dahlqvist A,Henriksson R,Franzén L,Gustafsson H,Forsgren S

    更新日期:1995-01-01 00:00:00

  • Ultrastructural localization of dipeptidyl peptidase IV in rat salivary glands by immunocytochemistry.

    abstract::The ultrastructural localization of dipeptidyl peptidase IV (DPP IV) (EC in rat submandibular and parotid glands was studied immunocytochemically by the peroxidase-antiperoxidase (PAP) method, using a monospecific antiserum against rat kidney DPP IV. There were no differences in the immunocytochemical locali...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Sahara N,Suzuki K

    更新日期:1984-01-01 00:00:00

  • Calcitonin gene-related peptide immunoreactivity in airway epithelial cells of the human fetus and infant.

    abstract::Calcitonin gene-related peptide-immunoreactive cells were identified within the epithelium of distal conducting airways in the human fetus and infant. Several peptides and amines, including calcitonin, have been identified previously within a specific population of airway epithelial cells. These cells, referred to as ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Johnson DE,Wobken JD

    更新日期:1987-12-01 00:00:00

  • Quantitative analysis of rod-cored vesicles and dense granules of large granular lymphocytes in the liver, spleen, and peripheral blood of rats.

    abstract::Large granular lymphocytes (LGL) comprise a natural defense system in the liver and exert an inhibitory effect on tumor cell metastasis. In order to demonstrate the maturation of LGL in the liver from the morphological aspect, we evaluated electron-microscopically the frequency of 0.2 micron vesicles (rod-cored and "e...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Kaneda K,Pilaro AM,Sayers TJ,Nagashima K,Gonda MA,Ortaldo JR,Wiltrout RH

    更新日期:1994-04-01 00:00:00

  • Insights into the evolution of digestive systems from studies of Trichoplax adhaerens.

    abstract::Trichoplax, a member of the phylum Placozoa, is a tiny ciliated marine animal that glides on surfaces feeding on algae and cyanobacteria. It stands out from other animals in that it lacks an internal digestive system and, instead, digests food trapped under its lower surface. Here we review recent work on the phenotyp...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Smith CL,Mayorova TD

    更新日期:2019-09-01 00:00:00

  • In-advance trans-medullary stimulation of bone marrow enhances spontaneous repair of full-thickness articular cartilage defects in rabbits.

    abstract::Mesenchymal stromal cells (MSCs), especially those lying close to cartilage defects, are an important cell source for cartilage regeneration. We hypothesize that a larger number of MSCs might become available, if the bone marrow in the immediate vicinity of the subchondral bone is stimulated for MSCs in advance of the...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Nishizawa K,Imai S,Mimura T,Kubo M,Araki S,Shioji S,Takemura Y,Matsusue Y

    更新日期:2010-09-01 00:00:00