Abstract:
:We have recently reported that Sox2-expressing pituitary stem/progenitor cells contact each other via a tight-junction protein CAR to form stem/progenitor cell niches in the marginal cell layer facing the lumen and in the clusters scattered in the parenchyma of the anterior lobe. However, the microenvironment of the niche for the maintenance of stem cell function in the pituitary remains obscure. In this study of pituitary stem/progenitor cell niches, we have attempted to identify the expression of juxtacrine factor ephrin and its receptor. We have found that ephrin-B2 is expressed in the pituitary throughout development but changes its localization pattern. Notably, in the adult pituitary, ephrin-B2 immuno-signals occur in SOX2-, E-cadherin-, and CAR-triple-positive stem/progenitor cells in the niches. Our data suggest that ephrin-B2 signaling has an important role in the formation of pituitary stem/progenitor cell niches and in pituitary organogenesis.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Yoshida S,Kato T,Higuchi M,Chen M,Ueharu H,Nishimura N,Kato Ydoi
10.1007/s00441-014-2054-ysubject
Has Abstractpub_date
2015-03-01 00:00:00pages
755-66issue
3eissn
0302-766Xissn
1432-0878journal_volume
359pub_type
杂志文章abstract::The published online version contains mistake in Title and in Acknowledgement section. Please find below for the needed corrections. ...
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