当前位置： SCI文献检索 > EUROPEAN JOURNAL OF HEART FAILURE期刊下所有文献 > BNP as a marker of diastolic dysfunction in the general population: Importance of left ventricular hypertrophy.

BNP as a marker of diastolic dysfunction in the general population: Importance of left ventricular hypertrophy.

Abstract：

:BNP is a marker of systolic left ventricular dysfunction (LVSD) and heart failure. To assess BNP for the detection of diastolic dysfunction in the general population, we examined 1678 subjects within an age- and sex-stratified survey (MONICA Augsburg). BNP was measured using a commercially available RIA (Shionogi). BNP increased in subjects with diastolic dysfunction (mean 20.3+/-4.7 pg/ml vs. control 9.6+/-0.5 pg/ml, p<0.001), but to a lesser extent than in subjects with LV hypertrophy (LVH, mean 37.3+/-49.1 pg/ml, p<0.001 vs. control) or LVSD (mean 76.2+/-23.2 pg/ml, p<0.001 vs. control). Individuals with sole diastolic abnormality displayed BNP concentrations at the control level (mean 9.7+/-1.7 pg/ml). In univariate analysis, age, BMI, systolic blood pressure, left atrial size, LV mass index, diastolic dysfunction and EF displayed a significant correlation with BNP (p<0.001). However, LV mass index displaced diastolic dysfunction as a significant predictor of BNP in multivariate analysis. Upon ROC analysis, sensitivity and specificity for the detection of diastolic dysfunction by BNP were only 61% and 55%, respectively. Nevertheless, a normal BNP test virtually excluded the presence of diastolic dysfunction and concomitant LVH (NPV 99.9%). Increased BNP concentrations in subjects with diastolic dysfunction are strongly related to LVH. Population-wide screening for diastolic dysfunction with BNP cannot be recommended although a normal BNP test usually excludes diastolic dysfunction and LV hypertrophy.

journal_name

Eur J Heart Fail

journal_title

European journal of heart failure

authors

Lukowicz TV,Fischer M,Hense HW,Döring A,Stritzke J,Riegger G,Schunkert H,Luchner A,MONICA Investigators.

doi

10.1016/j.ejheart.2004.12.010

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

525-31

issue

4

eissn

1388-9842

issn

1879-0844

pii

S1388-9842(04)00379-4

journal_volume

7

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF HEART FAILURE文献大全
  • Prognosis of patients with chronic coronary artery disease and severe left ventricular dysfunction. The importance of myocardial viability.

    abstract：BACKGROUND AND AIM:The choice of optimal treatment strategy in patients with coronary artery disease (CAD) and severe left ventricular (LV) dysfunction is often difficult. The aim of this study was to compare long-term results of patients with chronic CAD, severe heart failure and a defined scope of myocardial viabilit...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/s1388-9842(02)00089-2

    authors： Meluzín J,Cerný J,Spinarová L,Toman J,Groch L,Stetka F,Frélich M,Hude P,Krejcí J,Rambousková L,Panovský R

    更新日期：2003-01-01 00:00:00

  • High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts.

    abstract：:We investigated the hypothesis that increased intracellular [Na+]i in heart failure contributes to preservation of SR Ca2+ load which may become particularly evident at slow heart rates. [Na+]i in SBFI-loaded myocytes from rabbits with pacing-induced heart failure (PHF) was significantly higher at each frequency as co...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2006.01.013

    authors： Schillinger W,Teucher N,Christians C,Kohlhaas M,Sossalla S,Van Nguyen P,Schmidt AG,Schunck O,Nebendahl K,Maier LS,Zeitz O,Hasenfuss G

    更新日期：2006-11-01 00:00:00

  • Adaptive servoventilation improves cardiac function in patients with chronic heart failure and Cheyne-Stokes respiration.

    abstract：BACKGROUND AND AIMS:Sleep disordered breathing (SDB), especially Cheyne-Stokes respiration (CSR) is common in patients with chronic heart failure (CHF). Adaptive servoventilation (ASV) was recently introduced to treat CSR in CHF. The aim of this study was to investigate the effects of ASV on CSR and CHF parameters. ME...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2008.04.007

    authors： Oldenburg O,Schmidt A,Lamp B,Bitter T,Muntean BG,Langer C,Horstkotte D

    更新日期：2008-06-01 00:00:00

  • Myostatin activation in patients with advanced heart failure and after mechanical unloading.

    abstract：AIMS:Myostatin inhibits myoblast differentiation/proliferation and may play a role in heart failure (HF) and reverse remodelling after left ventricular assist device (LVAD) support. This study sought to characterize myostatin expression and activation in advanced HF before and after LVAD support. METHODS AND RESULTS:L...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfq039

    authors： George I,Bish LT,Kamalakkannan G,Petrilli CM,Oz MC,Naka Y,Sweeney HL,Maybaum S

    更新日期：2010-05-01 00:00:00

  • Correlation of flow mediated dilation with inflammatory markers in patients with impaired cardiac function. Beneficial effects of inhibition of ACE.

    abstract：:Impaired cardiac function is frequently accompanied by peripheral vascular dysfunction and a pro-inflammatory condition, which may be associated with elevated levels of angiotensin II. We hypothesized that the magnitude of flow mediated dilatation (FMD) of the brachial artery of post myocardial infarction patients wil...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ejheart.2005.10.011

    authors： Kovacs I,Toth J,Tarjan J,Koller A

    更新日期：2006-08-01 00:00:00

  • Echocardiographic screening for non-ischaemic stage B heart failure in the community.

    abstract：AIMS:Incident heart failure (HF) continues to pose a common and serious problem. We sought to examine the value of echocardiographic predictors of new HF in a community-based elderly population at risk for HF, independent of and incremental to clinical evaluation. METHODS AND RESULTS:Asymptomatic patients ≥65 years ol...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.643

    authors： Yang H,Negishi K,Wang Y,Nolan M,Saito M,Marwick TH

    更新日期：2016-11-01 00:00:00

  • The conundrum of patients with obesity, exercise intolerance, elevated ventricular filling pressures and a measured ejection fraction in the normal range.

    abstract：:Patients with obesity, a reduced exercise capacity, increased cardiac filling pressures and a measured left ventricular ejection fraction in the normal range do not have a homogeneous disorder, but instead, exhibit one of three phenotypes. First, many obese people exhibit sodium retention, plasma volume expansion and ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,评审

    doi：10.1002/ejhf.1377

    authors： Packer M

    更新日期：2019-02-01 00:00:00

  • Heart failure with preserved ejection fraction: the impact of stricter definitions.

    abstract：AIMS:To determine the impact of internationally recognized criteria for the diagnosis of heart failure with preserved ejection fraction (HF-PEF) on the feasibility of recruitment into a HF-PEF trial. METHODS AND RESULTS:We reviewed the medical records of 5883 consecutive patients admitted with heart failure across eig...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.106

    authors： Patel HC,Hayward C,di Mario C,Cowie MR,Lyon AR,Rosen SD

    更新日期：2014-07-01 00:00:00

  • Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM.

    abstract：BACKGROUND:Limited comparative studies assessing the health-related quality of life (HRQL) in heart failure (HF) patients with preserved vs. low ejection fraction (LVEF) have been disparate. AIMS:The aims of this study were a) to characterize HRQL in a large population of HF patients with preserved and low LVEF and b)...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ejheart.2006.10.012

    authors： Lewis EF,Lamas GA,O'Meara E,Granger CB,Dunlap ME,McKelvie RS,Probstfield JL,Young JB,Michelson EL,Halling K,Carlsson J,Olofsson B,McMurray JJ,Yusuf S,Swedberg K,Pfeffer MA,CHARM Investigators.

    更新日期：2007-01-01 00:00:00

  • Left atrial structure and function and the risk of death or heart failure in atrial fibrillation.

    abstract：AIMS:The present study aimed to assess the association between left atrial (LA) structure and function and the risk for cardiovascular (CV) death or heart failure (HF) hospitalization in a population with atrial fibrillation (AF). METHODS AND RESULTS:In a prospective echocardiographic substudy of the Effective Anticoa...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1002/ejhf.1606

    authors： Inciardi RM,Giugliano RP,Claggett B,Gupta DK,Chandra A,Ruff CT,Antman EM,Mercuri MF,Grosso MA,Braunwald E,Solomon SD,ENGAGE AF-TIMI 48 Investigators.

    更新日期：2019-12-01 00:00:00

  • Elevated urinary neutrophil gelatinase-associated lipocalcin after acute heart failure treatment is associated with worsening renal function and adverse events.

    abstract：AIMS:Reliable detectors of worsening renal function (WRF) in Emergency Department (ED) patients with acute heart failure (AHF) are limited. We hypothesized that initial urinary neutrophil gelatinase-associated lipocalcin (NGAL) levels, and changes in urinary NGAL levels after initial ED AHF therapy, would be associated...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfs087

    authors： Collins SP,Hart KW,Lindsell CJ,Fermann GJ,Weintraub NL,Miller KF,Roll SN,Sperling MI,Sawyer DB,Storrow AB

    更新日期：2012-09-01 00:00:00

  • Clinical picture and risk prediction of short-term mortality in cardiogenic shock.

    abstract：AIMS:The aim of this study was to investigate the clinical picture and outcome of cardiogenic shock and to develop a risk prediction score for short-term mortality. METHODS AND RESULTS:The CardShock study was a multicentre, prospective, observational study conducted between 2010 and 2012. Patients with either acute co...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ejhf.260

    authors： Harjola VP,Lassus J,Sionis A,Køber L,Tarvasmäki T,Spinar J,Parissis J,Banaszewski M,Silva-Cardoso J,Carubelli V,Di Somma S,Tolppanen H,Zeymer U,Thiele H,Nieminen MS,Mebazaa A,CardShock Study Investigators.,GREAT network

    更新日期：2015-05-01 00:00:00

  • Heart failure update.

    abstract：:The RUSSLAN study, which randomised 504 patients with post-infarction heart failure in whom intravenous inotropic support might be deemed appropriate, was presented for the first time in a hotline session at the annual meeting of the Working Group on Heart Failure of the European Society of Cardiology. The study sugge...

    journal_title：European journal of heart failure

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1388-9842(99)00040-9

    authors： Gomes UC,Cleland JG

    更新日期：1999-08-01 00:00:00

  • Trends in prevalence of comorbidities in heart failure clinical trials.

    abstract：AIMS:The primary objective of this systematic review was to estimate the prevalence and temporal changes in chronic comorbid conditions reported in heart failure (HF) clinical trials. METHODS AND RESULTS:We searched MEDLINE for HF trials enrolling more than 400 patients published between 2001 and 2016.Trials were divi...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.1818

    authors： Khan MS,Samman Tahhan A,Vaduganathan M,Greene SJ,Alrohaibani A,Anker SD,Vardeny O,Fonarow GC,Butler J

    更新日期：2020-06-01 00:00:00

  • Prevalence and prognostic significance of atrial fibrillation in outpatients with heart failure due to left ventricular systolic dysfunction.

    abstract：INTRODUCTION:Atrial fibrillation (AF) is common in patients with heart failure (HF) due to left ventricular systolic dysfunction (LVSD), with conflicting prognostic data. The aim of our study was to assess the prevalence and incidence of AF in patients with HF and to determine the prognostic impact of baseline AF and t...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ejheart.2006.08.004

    authors： Corell P,Gustafsson F,Schou M,Markenvard J,Nielsen T,Hildebrandt P

    更新日期：2007-03-01 00:00:00

  • Left atrial enlargement and NT-proBNP as predictors of sudden cardiac death in patients with heart failure.

    abstract：AIMS:The identification of valuable markers of sudden cardiac death (SCD) in patients with established HF remains a challenge. We sought to assess the value of clinical, echocardiographic and biochemical variables to predict SCD in a consecutive cohort of patients with heart failure (HF) due to systolic dysfunction. M...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ejheart.2007.05.001

    authors： Bayes-Genis A,Vazquez R,Puig T,Fernandez-Palomeque C,Fabregat J,Bardají A,Pascual-Figal D,Ordoñez-Llanos J,Valdes M,Gabarrús A,Pavon R,Pastor L,Gonzalez Juanatey JR,Almendral J,Fiol M,Nieto V,Macaya C,Cinca J,Bayes de

    更新日期：2007-08-01 00:00:00

  • Chronic heart failure is associated with vascular remodeling of the brachial artery.

    abstract：AIMS:Endothelial dysfunction has been shown to correlate with severity of congestive heart failure (CHF) and recent data suggest morphological changes of peripheral vasculature to be associated with the syndrome. We therefore investigated the hypothesis that vascular remodeling is associated with functional changes in ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2004.04.008

    authors： Poelzl G,Frick M,Huegel H,Lackner B,Alber HF,Mair J,Herold M,Schwarzacher S,Pachinger O,Weidinger F

    更新日期：2005-01-01 00:00:00

  • Connecting heart failure with preserved ejection fraction and renal dysfunction: the role of endothelial dysfunction and inflammation.

    abstract：:Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is associated with increased mortality. Impaired renal function is also a risk factor for developing HFpEF. A new paradigm for HFpEF, proposing a sequence of events leading to myocardial remodelling and dysfunction in HFpEF, was ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,评审

    doi：10.1002/ejhf.497

    authors： Ter Maaten JM,Damman K,Verhaar MC,Paulus WJ,Duncker DJ,Cheng C,van Heerebeek L,Hillege HL,Lam CS,Navis G,Voors AA

    更新日期：2016-06-01 00:00:00

  • Mitral annular plane systolic excursion on exercise: a simple diagnostic tool for heart failure with preserved ejection fraction.

    abstract：AIMS:Current guidelines for the diagnosis of heart failure with normal or preserved ejection fraction (HFpEF) are based on measurements at rest. However, in HFpEF ventricular dysfunction is more apparent on exercise. We hypothesized that Mitral annular plane systolic excursion (MAPSE) which is easy to acquire on exerci...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfr081

    authors： Wenzelburger FW,Tan YT,Choudhary FJ,Lee ES,Leyva F,Sanderson JE

    更新日期：2011-09-01 00:00:00

  • C-reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study.

    abstract：BACKGROUND:High-sensitivity C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) and, in recent studies, incident heart failure (HF). Whether the association of inflammation with incident HF is explained by worse baseline left ventricular dysfunction or by underlying CHD is unkn...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2007.11.003

    authors： Williams ES,Shah SJ,Ali S,Na BY,Schiller NB,Whooley MA

    更新日期：2008-01-01 00:00:00

  • A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors.

    abstract：BACKGROUND:Mortality in patients with mild to moderate chronic heart failure remains high. At present there is no easy way of identifying patients within this population at increased risk of death in the medium to long term. AIMS:To develop a prognostic index to identify outpatients with mild to moderate chronic heart...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/s1388-9842(03)00053-9

    authors： Kearney MT,Nolan J,Lee AJ,Brooksby PW,Prescott R,Shah AM,Zaman AG,Eckberg DL,Lindsay HS,Batin PD,Andrews R,Fox KA

    更新日期：2003-08-01 00:00:00

  • Outcome in patients with an ICD incorporating cardiac resynchronisation therapy: differences between primary and secondary prophylaxis.

    abstract：BACKGROUND:The incidence of ventricular tachyarrhythmias in ICD patients with cardiac resynchronisation therapy (CRT-D) is not well studied. AIM:To analyse event free survival in CRT-D patients with a primary or a secondary prophylactic ICD indication. METHODS:Prospective, single centre. Eighty-six patients, 44% with...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2005.05.006

    authors： Theuns DA,Thornton AS,Klootwijk AP,Scholten MF,Vantrimpont PJ,Balk AH,Jordaens LJ

    更新日期：2005-10-01 00:00:00

  • Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial.

    abstract：AIMS:To test the hypothesis that an earlier post-acute myocardial infarction (AMI) eplerenone initiation in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) is associated with better long-term outcomes. METHODS AND RESULTS:The 6632 patients of the EPHESUS study were randomized from day...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1093/eurjhf/hfp136

    authors： Adamopoulos C,Ahmed A,Fay R,Angioi M,Filippatos G,Vincent J,Pitt B,Zannad F,EPHESUS Investigators.

    更新日期：2009-11-01 00:00:00

  • B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure.

    abstract：AIMS:In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. METHOD...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.1627

    authors： Wettersten N,Horiuchi Y,van Veldhuisen DJ,Mueller C,Filippatos G,Nowak R,Hogan C,Kontos MC,Cannon CM,Müeller GA,Birkhahn R,Taub P,Vilke GM,Barnett O,McDonald K,Mahon N,Nuñez J,Briguori C,Passino C,Murray PT,Maisel

    更新日期：2019-12-01 00:00:00

  • Dietary sodium modulation of aldosterone activation and renal function during the progression of experimental heart failure.

    abstract：AIMS:Aldosterone activation is central to the sodium–fluid retention that marks the progression of heart failure (HF). The actions of dietary sodium restriction, a mainstay in HF management, on cardiorenal and neuroendocrine adaptations during the progression of HF are poorly understood. The study aim was to assess the...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.212

    authors： Miller WL,Borgeson DD,Grantham JA,Luchner A,Redfield MM,Burnett JC Jr

    更新日期：2015-02-01 00:00:00

  • Clinical course after a first episode of heart failure: insights from the Framingham Heart Study.

    abstract：AIMS:We sought to describe the frequency, type and timing of clinical events, and delineate patterns in their transitions, after a first episode of heart failure (HF). METHODS AND RESULTS:In 1036 Framingham participants with new-onset HF (mean age 79 years; 53% women), we used mixture models to estimate probabilities ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.1918

    authors： Velagaleti RS,Larson MG,Enserro D,Song RJ,Vasan RS

    更新日期：2020-10-01 00:00:00

  • A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry.

    abstract：AIMS:Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage. METHODS AND RESULTS:Patients with TTS were recruited from the Inter...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1002/ejhf.683

    authors： Ghadri JR,Cammann VL,Jurisic S,Seifert B,Napp LC,Diekmann J,Bataiosu DR,D'Ascenzo F,Ding KJ,Sarcon A,Kazemian E,Birri T,Ruschitzka F,Lüscher TF,Templin C,InterTAK co-investigators.

    更新日期：2017-08-01 00:00:00

  • [123I]-phenylpentadecanoic acid uptake in patients with dilated cardiomyopathy.

    abstract：BACKGROUND:The rate constant for global fatty acid influx (k(1)) was studied in 12 male patients with dilated cardiomyopathy (DCM). METHOD:10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions. RESULTS...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/s1388-9842(02)00024-7

    authors： Miche E,Radzewitz A,Notohamiprodjo G,Baller D,Kloppe A,Eckert S,Gleichmann U

    更新日期：2002-08-01 00:00:00

  • Improved angiogenic response in pig heart following ischaemic injury using human skeletal myoblast simultaneously expressing VEGF165 and angiopoietin-1.

    abstract：OBJECTIVE:To achieve angiogenic interaction between VEGF(165) and angiopoietin-1 (Ang-1) using a novel adenoviral bicistronic vector (Ad-Bic) encoding the two factors and delivered ex vivo using sex-mismatched human skeletal myoblasts. METHODS AND RESULTS:A myocardial infarction model was developed in 29 female pigs; ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2006.04.008

    authors： Ye L,Haider HKh,Jiang S,Tan RS,Ge R,Law PK,Sim EK

    更新日期：2007-01-01 00:00:00

  • Effects of Atorvastatin on Th polarization in patients with acute myocardial infarction.

    abstract：BACKGROUND:The development of heart failure after acute myocardial infarction (AMI) has been shown to be associated with inflammation, which is positively and negatively regulated by T helper (Th) 1 and Th2 lymphocytes, respectively. Several studies have indicated that statins can improve heart function after AMI. AIM...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2005.01.020

    authors： Cheng X,Liao YH,Zhang J,Li B,Ge H,Yuan J,Wang M,Lu B,Liu Y,Cheng Y

    更新日期：2005-12-01 00:00:00