abstract：AIMS:Oral sucrosomial iron (SI) combines enhanced bioavailability and tolerance compared to conventional oral iron along with similar efficacy compared to intravenous iron in several conditions associated with iron deficiency (ID). METHODS AND RESULTS:In this non-randomized, open-label study, we sought to evaluate pro...

journal_title：European journal of heart failure

authors： Karavidas A,Troganis E,Lazaros G,Balta D,Karavidas IN,Polyzogopoulou E,Parissis J,Farmakis D

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:EMPEROR-Preserved is an ongoing trial evaluating the effect of empagliflozin in patients with heart failure with preserved ejection fraction (HFpEF). This report describes the baseline characteristics of the EMPEROR-Preserved cohort and compares it with patients enrolled in prior HFpEF trials. METHODS:EMPER...

journal_title：European journal of heart failure

authors： Anker SD,Butler J,Filippatos G,Khan MS,Ferreira JP,Bocchi E,Böhm M,Rocca HPB,Choi DJ,Chopra V,Chuquiure E,Giannetti N,Gomez-Mesa JE,Janssens S,Januzzi JL,Gonzalez-Juanatey JR,Merkely B,Nicholls SJ,Perrone SV,Piña IL

更新日期：2020-11-29 00:00:00

abstract：AIMS:To examine the current status of care and needs of adult congenital heart disease (ACHD) services in the Central and South Eastern European (CESEE) region. METHODS AND RESULTS:We obtained data regarding the national ACHD status for 19 CESEE countries from their ACHD representative based on an extensive survey for...

journal_title：European journal of heart failure

authors： Brida M,Šimkova I,Jovović L,Prokšelj K,Antonová P,Balint HO,Gumbiene L,Lebid IH,Komar M,Kratunkov P,Kovačević Preradović T,Ermel R,Strenge A,Coman IM,Vukomanović V,Gatzoulis MA,Roos-Hesselink JW,Diller GP

更新日期：2020-11-02 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) is one of the most effective therapies for heart failure with reduced ejection fraction and leads to improved quality of life, reductions in heart failure hospitalization rates and reduces all-cause mortality. Nevertheless, up to two-thirds of eligible patients are not referred ...

journal_title：European journal of heart failure

authors： Mullens W,Auricchio A,Martens P,Witte K,Cowie MR,Delgado V,Dickstein K,Linde C,Vernooy K,Leyva F,Bauersachs J,Israel CW,Lund L,Donal E,Boriani G,Jaarsma T,Berruezo A,Traykov V,Yousef Z,Kalarus Z,Nielsen JC,Steff

更新日期：2020-11-02 00:00:00

abstract：AIMS:This study aimed to determine the prognostic value of serum uric acid (SUA) on outcomes in heart failure (HF) with preserved ejection fraction (HFpEF), and whether sacubitril-valsartan reduces SUA and use of SUA-related therapies. METHODS AND RESULTS:We analysed 4795 participants from the Prospective Comparison o...

journal_title：European journal of heart failure

authors： Selvaraj S,Claggett BL,Pfeffer MA,Desai AS,Mc Causland FR,McGrath MM,Anand IS,van Veldhuisen DJ,Kober L,Janssens S,Cleland JGF,Pieske B,Rouleau JL,Zile MR,Shi VC,Lefkowitz MP,McMurray JJV,Solomon SD

更新日期：2020-11-01 00:00:00

abstract：AIMS:In amyloid patients, cardiac involvement dramatically worsens functional capacity and prognosis. We sought to study how the cardiopulmonary exercise test (CPET) could help in functional assessment and risk stratification of patients with cardiac amyloidosis (CA). METHODS AND RESULTS:We carried out a multicentre s...

journal_title：European journal of heart failure

authors： Nicol M,Deney A,Lairez O,Vergaro G,Emdin M,Carecci A,Inamo J,Montfort A,Neviere R,Damy T,Harel S,Royer B,Baudet M,Cohen-Solal A,Arnulf B,Logeart D

更新日期：2020-10-02 00:00:00

abstract：AIMS:To characterize the prevalence and clinical relevance of malnutrition in patients undergoing transcatheter tricuspid valve edge-to-edge repair (TTVR). METHODS AND RESULTS:Overall, 86 consecutive patients (mean age 78 ± 7 years) with moderate-to-severe tricuspid regurgitation (TR) at prohibitive surgical risk were...

journal_title：European journal of heart failure

authors： Besler C,Unterhuber M,Rommel KP,Unger E,Hartung P,von Roeder M,Noack T,Zachäus M,Halm U,Borger M,Desch S,Thiele H,Lurz P

更新日期：2020-10-01 00:00:00

abstract：AIMS:We sought to describe the frequency, type and timing of clinical events, and delineate patterns in their transitions, after a first episode of heart failure (HF). METHODS AND RESULTS:In 1036 Framingham participants with new-onset HF (mean age 79 years; 53% women), we used mixture models to estimate probabilities ...

journal_title：European journal of heart failure

authors： Velagaleti RS,Larson MG,Enserro D,Song RJ,Vasan RS

更新日期：2020-10-01 00:00:00

abstract：:Self-care is essential in the long-term management of chronic heart failure. Heart failure guidelines stress the importance of patient education on treatment adherence, lifestyle changes, symptom monitoring and adequate response to possible deterioration. Self-care is related to medical and person-centred outcomes in ...

journal_title：European journal of heart failure

authors： Jaarsma T,Hill L,Bayes-Genis A,La Rocca HB,Castiello T,Čelutkienė J,Marques-Sule E,Plymen CM,Piper SE,Riegel B,Rutten FH,Ben Gal T,Bauersachs J,Coats AJS,Chioncel O,Lopatin Y,Lund LH,Lainscak M,Moura B,Mullens W,P

更新日期：2020-09-18 00:00:00

abstract：AIMS:Over the last 30 years, many medicine development programmes in acute and chronic heart failure (HF) with preserved ejection fraction (HFpEF) have failed, in contrast to those in HF with reduced ejection fraction (HFrEF). We explore how the neutral results in larger HF trials may be attributable to chance and/or t...

journal_title：European journal of heart failure

authors： Davison BA,Takagi K,Senger S,Koch G,Metra M,Kimmoun A,Mebazaa A,Voors AA,Nielsen OW,Chioncel O,Pang PS,Greenberg BH,Maggioni AP,Cohen-Solal A,Ertl G,Sato N,Teerlink JR,Filippatos G,Ponikowski P,Gayat E,Edwards C,

更新日期：2020-09-01 00:00:00

abstract：AIMS:Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and...

journal_title：European journal of heart failure

authors： Kapelios CJ,Laroche C,Crespo-Leiro MG,Anker SD,Coats AJS,Díaz-Molina B,Filippatos G,Lainscak M,Maggioni AP,McDonagh T,Mebazaa A,Metra M,Moura B,Mullens W,Piepoli MF,Rosano GMC,Ruschitzka F,Seferovic PM,Lund LH,Heart

更新日期：2020-08-01 00:00:00

abstract：:The heart failure syndrome has first been described as an emerging epidemic about 25 years ago. Today, because of a growing and ageing population, the total number of heart failure patients still continues to rise. However, the case mix of heart failure seems to be evolving. Incidence has stabilized and may even be de...

journal_title：European journal of heart failure

authors： Groenewegen A,Rutten FH,Mosterd A,Hoes AW

更新日期：2020-08-01 00:00:00

abstract：AIMS:Advances in diagnostic imaging have increased the recognition of coexisting transthyretin cardiac amyloidosis (ATTR-CA) and severe aortic stenosis (AS), with a reported prevalence between 8-16%. In this prospective study, we aimed to evaluate the implications of ATTR-CA on outcomes after transcatheter aortic valve...

journal_title：European journal of heart failure

authors： Rosenblum H,Masri A,Narotsky DL,Goldsmith J,Hamid N,Hahn RT,Kodali S,Vahl T,Nazif T,Khalique OK,Bokhari S,Soman P,Cavalcante JL,Maurer MS,Castaño A

更新日期：2020-07-30 00:00:00

abstract：AIMS:To determine whether a strategy of intensive blood pressure control reduces the risk of heart failure (HF) events consistently across the spectrum of kidney function and albuminuria. METHODS AND RESULTS:SPRINT was a randomized clinical trial in which 9361 individuals ≥50 years, at high risk for or with cardiovasc...

journal_title：European journal of heart failure

authors： Vaduganathan M,Pareek M,Kristensen AMD,Biering-Sørensen T,Byrne C,Almarzooq Z,Olesen TB,Olsen MH,Bhatt DL

更新日期：2020-07-21 00:00:00

abstract：AIMS:The primary objective of this systematic review was to estimate the prevalence and temporal changes in chronic comorbid conditions reported in heart failure (HF) clinical trials. METHODS AND RESULTS:We searched MEDLINE for HF trials enrolling more than 400 patients published between 2001 and 2016.Trials were divi...

journal_title：European journal of heart failure

authors： Khan MS,Samman Tahhan A,Vaduganathan M,Greene SJ,Alrohaibani A,Anker SD,Vardeny O,Fonarow GC,Butler J

更新日期：2020-06-01 00:00:00

abstract：AIMS:Women with heart failure (HF) are under-represented in individual randomized clinical trials (RCTs). Little is known about sex-specific treatment effects in HF medications. We evaluated sex differences in the response to mineralocorticoid receptor antagonists (MRAs) in major HF MRA trials, including a broad spectr...

journal_title：European journal of heart failure

authors： Rossello X,Ferreira JP,Pocock SJ,McMurray JJV,Solomon SD,Lam CSP,Girerd N,Pitt B,Rossignol P,Zannad F

更新日期：2020-05-01 00:00:00

abstract：:Alternations in gut microbial composition (i.e. loss of microbial diversity or 'gut dysbiosis') have been associated with heart failure with reduced ejection fraction (HFrEF). It has also been suggested that increased chronic low-level inflammation and immune system dysregulation seen in patients with HFrEF could be r...

journal_title：European journal of heart failure

authors： Madan S,Mehra MR

更新日期：2020-04-01 00:00:00

abstract：:Appropriate interpretation of changes in markers of kidney function is essential during the treatment of acute and chronic heart failure. Historically, kidney function was primarily assessed by serum creatinine and the calculation of estimated glomerular filtration rate. An increase in serum creatinine, also termed wo...

journal_title：European journal of heart failure

authors： Mullens W,Damman K,Testani JM,Martens P,Mueller C,Lassus J,Tang WHW,Skouri H,Verbrugge FH,Orso F,Hill L,Ural D,Lainscak M,Rossignol P,Metra M,Mebazaa A,Seferovic P,Ruschitzka F,Coats A

更新日期：2020-04-01 00:00:00

abstract：AIMS:Several studies have shown that older patients with heart failure with reduced ejection fraction (HFrEF) are undertreated. The aim of this study was to evaluate the association of up-titration of angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB) and beta-blockers on outcome acros...

journal_title：European journal of heart failure

authors： Mordi IR,Ouwerkerk W,Anker SD,Cleland JG,Dickstein K,Metra M,Ng LL,Samani NJ,van Veldhuisen DJ,Zannad F,Voors AA,Lang CC

更新日期：2020-03-25 00:00:00

abstract：AIMS:Left atrial (LA) mechanical function may play a significant role in the development and progression of heart failure with preserved ejection fraction (HFpEF). We performed a systematic review and meta-analysis to evaluate association of impaired LA function with outcomes in HFpEF. METHODS AND RESULTS:Multiple dat...

journal_title：European journal of heart failure

authors： Khan MS,Memon MM,Murad MH,Vaduganathan M,Greene SJ,Hall M,Triposkiadis F,Lam CSP,Shah AM,Butler J,Shah SJ

更新日期：2020-03-01 00:00:00

abstract：AIMS:Acute heart failure is a high mortality disease and its pathophysiology is not completely understood. Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in angiotensin II and enkephalins cleavage. The aim of this study was to investigate the association of circulating DPP3 (cDPP3) levels and mortality in...

journal_title：European journal of heart failure

authors： Deniau B,Rehfeld L,Santos K,Dienelt A,Azibani F,Sadoune M,Kounde PR,Samuel JL,Tolpannen H,Lassus J,Harjola VP,Vodovar N,Bergmann A,Hartmann O,Mebazaa A,Blet A

更新日期：2020-02-01 00:00:00

abstract：:Transthyretin amyloidosis (ATTR) is a rare, yet underdiagnosed disease characterized by progressive impairment of neurologic and cardiac function due to deposition of misfolded transthyretin. Despite great efforts, such as the introduction of orthotopic liver transplant, the devastating prognosis for both variant and ...

journal_title：European journal of heart failure

authors： Müller ML,Butler J,Heidecker B

更新日期：2020-01-01 00:00:00

abstract：AIMS:The MITRA-FR trial showed that among symptomatic patients with severe secondary mitral regurgitation, percutaneous repair did not reduce the risk of death or hospitalization for heart failure at 12 months compared with guideline-directed medical treatment alone. We report the 24-month outcome from this trial. MET...

journal_title：European journal of heart failure

authors： Iung B,Armoiry X,Vahanian A,Boutitie F,Mewton N,Trochu JN,Lefèvre T,Messika-Zeitoun D,Guerin P,Cormier B,Brochet E,Thibault H,Himbert D,Thivolet S,Leurent G,Bonnet G,Donal E,Piriou N,Piot C,Habib G,Rouleau F,Car

更新日期：2019-12-01 00:00:00

abstract：AIMS:The present study aimed to assess the association between left atrial (LA) structure and function and the risk for cardiovascular (CV) death or heart failure (HF) hospitalization in a population with atrial fibrillation (AF). METHODS AND RESULTS:In a prospective echocardiographic substudy of the Effective Anticoa...

journal_title：European journal of heart failure

authors： Inciardi RM,Giugliano RP,Claggett B,Gupta DK,Chandra A,Ruff CT,Antman EM,Mercuri MF,Grosso MA,Braunwald E,Solomon SD,ENGAGE AF-TIMI 48 Investigators.

更新日期：2019-12-01 00:00:00

abstract：AIMS:In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. METHOD...

journal_title：European journal of heart failure

authors： Wettersten N,Horiuchi Y,van Veldhuisen DJ,Mueller C,Filippatos G,Nowak R,Hogan C,Kontos MC,Cannon CM,Müeller GA,Birkhahn R,Taub P,Vilke GM,Barnett O,McDonald K,Mahon N,Nuñez J,Briguori C,Passino C,Murray PT,Maisel

更新日期：2019-12-01 00:00:00

abstract：AIMS:Transcatheter tricuspid valve repair (TTVR) is an emerging technique to treat tricuspid regurgitation (TR). Predictors of adverse outcomes are scarce, and stratification by TR aetiologies is lacking. METHODS AND RESULTS:We report the bi-centre procedural outcomes of 164 patients undergoing TTVR for TR stratified ...

journal_title：European journal of heart failure

authors： Schlotter F,Orban M,Rommel KP,Besler C,von Roeder M,Braun D,Unterhuber M,Borger M,Hagl C,Orban M,Nabauer M,Massberg S,Thiele H,Hausleiter J,Lurz P

更新日期：2019-09-01 00:00:00

abstract：:Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in card...

journal_title：European journal of heart failure

authors： Ahmad T,Miller PE,McCullough M,Desai NR,Riello R,Psotka M,Böhm M,Allen LA,Teerlink JR,Rosano GMC,Lindenfeld J

更新日期：2019-09-01 00:00:00

abstract：AIM:To evaluate the long-term outcome of patients with Takotsubo syndrome (TTS) and severely reduced left ventricular ejection fraction (LVEF ≤ 35%) at presentation. METHODS AND RESULTS:The study population included 326 patients (mean age 69.5 ± 10.7 years, 28 male) with TTS enrolled in the Takotsubo Italian Network, ...

journal_title：European journal of heart failure

authors： Citro R,Radano I,Parodi G,Di Vece D,Zito C,Novo G,Provenza G,Bellino M,Prota C,Silverio A,Antonini-Canterin F,Rigo F,Vriz O,Galasso G,Bossone E,Salerno-Uriarte J,Piscione F

更新日期：2019-06-01 00:00:00

abstract：AIMS:Exercise-derived parameters, specifically peak exercise oxygen uptake (peak VO2 ) and minute ventilation/carbon dioxide relationship slope (VE/VCO2 slope), have a pivotal prognostic value in heart failure (HF). It is unknown how the prognostic threshold of peak VO2 and VE/VCO2 slope has changed over the last 20 ye...

journal_title：European journal of heart failure

authors： Paolillo S,Veglia F,Salvioni E,Corrà U,Piepoli M,Lagioia R,Limongelli G,Sinagra G,Cattadori G,Scardovi AB,Metra M,Senni M,Bonomi A,Scrutinio D,Raimondo R,Emdin M,Magrì D,Parati G,Re F,Cicoira M,Minà C,Correale M

更新日期：2019-02-01 00:00:00

abstract：:The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly through the use of diuretic therapy. The appropriate use of diuretic...

journal_title：European journal of heart failure

authors： Mullens W,Damman K,Harjola VP,Mebazaa A,Brunner-La Rocca HP,Martens P,Testani JM,Tang WHW,Orso F,Rossignol P,Metra M,Filippatos G,Seferovic PM,Ruschitzka F,Coats AJ

更新日期：2019-02-01 00:00:00

abstract：:Patients with obesity, a reduced exercise capacity, increased cardiac filling pressures and a measured left ventricular ejection fraction in the normal range do not have a homogeneous disorder, but instead, exhibit one of three phenotypes. First, many obese people exhibit sodium retention, plasma volume expansion and ...

journal_title：European journal of heart failure

authors： Packer M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) is a global public health problem. Unfortunately, little is known about HFpEF across Asia. METHODS AND RESULTS:We prospectively studied clinical characteristics, echocardiographic parameters and outcomes in 1204 patients with HFpEF (left ventricular eje...

journal_title：European journal of heart failure

authors： Tromp J,Teng TH,Tay WT,Hung CL,Narasimhan C,Shimizu W,Park SW,Liew HB,Ngarmukos T,Reyes EB,Siswanto BB,Yu CM,Zhang S,Yap J,MacDonald M,Ling LH,Leineweber K,Richards AM,Zile MR,Anand IS,Lam CSP,ASIAN-HF Investiga

更新日期：2019-01-01 00:00:00

abstract：AIMS:Growth differentiation factor-15 (GDF-15) is associated with adverse prognosis in cardiovascular (CV) and non-CV diseases. We evaluated the association of GDF-15 with CV and non-CV outcomes in the PARADIGM-HF trial. METHODS AND RESULTS:In 1935 patients with heart failure and reduced ejection fraction (HFrEF) in P...

journal_title：European journal of heart failure

authors： Bouabdallaoui N,Claggett B,Zile MR,McMurray JJV,O'Meara E,Packer M,Prescott MF,Swedberg K,Solomon SD,Rouleau JL,PARADIGM-HF Investigators and Committees.

更新日期：2018-12-01 00:00:00

abstract：:This article updates the Heart Failure Association of the European Society of Cardiology (ESC) 2007 classification of advanced heart failure and describes new diagnostic and treatment options for these patients. Recognizing the patient with advanced heart failure is critical to facilitate timely referral to advanced h...

journal_title：European journal of heart failure

authors： Crespo-Leiro MG,Metra M,Lund LH,Milicic D,Costanzo MR,Filippatos G,Gustafsson F,Tsui S,Barge-Caballero E,De Jonge N,Frigerio M,Hamdan R,Hasin T,Hülsmann M,Nalbantgil S,Potena L,Bauersachs J,Gkouziouta A,Ruhparwar A,

更新日期：2018-11-01 00:00:00

abstract：AIMS:We investigated which patients with heart failure (HF) should receive specialist palliative care (SPC) by first creating a definition of need for SPC in patients hospitalised with HF using patient-reported outcome measures (PROMs) and then testing this definition using the outcome of days alive and out of hospital...

journal_title：European journal of heart failure

authors： Campbell RT,Petrie MC,Jackson CE,Jhund PS,Wright A,Gardner RS,Sonecki P,Pozzi A,McSkimming P,McConnachie A,Finlay F,Davidson P,Denvir MA,Johnson MJ,Hogg KJ,McMurray JJV

更新日期：2018-09-01 00:00:00

abstract：AIM:Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with reduced ejection fraction (HFrEF), but are underutilized. Hyperkalaemia may be one reason, but the underlying reasons for underuse are unknown. The aim of this study was to investigate the independent predictors of MRA underuse in ...

journal_title：European journal of heart failure

authors： Savarese G,Carrero JJ,Pitt B,Anker SD,Rosano GMC,Dahlström U,Lund LH

更新日期：2018-09-01 00:00:00

abstract：AIM:To describe differences in patient characteristics and outcomes by ethnicity in patients with diabetes mellitus (DM) and heart failure (HF) with reduced ejection fraction (HFrEF, ejection fraction ≤35%) in a multi-ethnic cohort. METHODS AND RESULTS:Patient level data from two cohorts (HF-ACTION and ASIAN-HF) were ...

journal_title：European journal of heart failure

authors： Cooper LB,Yap J,Tay WT,Teng TK,MacDonald M,Anand IS,Sharma A,O'Connor CM,Kraus WE,Mentz RJ,Lam CS,HF-ACTION and ASIAN-HF Investigators.

更新日期：2018-09-01 00:00:00

abstract：:Most treatments for chronic heart failure are effective both in preventing its onset and reducing its progression. However, statins prevent the development of heart failure, but they do not decrease morbidity and mortality in those with established heart failure. This apparent discordance cannot be explained by an eff...

journal_title：European journal of heart failure

authors： Packer M

更新日期：2018-07-01 00:00:00

abstract：AIMS:The most recent European guidelines have proposed new definitions of pulmonary hypertension (PH) in left heart disease, to better approach the characteristics required to reflect the presence of pulmonary vascular disease. The purpose of this study was to assess whether different haemodynamic definitions of post-c...

journal_title：European journal of heart failure

authors： Ghio S,Crimi G,Temporelli PL,Traversi E,La Rovere MT,Cannito A,Vizza D,Scelsi L,Raineri C,Guazzi M,Oltrona Visconti L

更新日期：2018-04-01 00:00:00

abstract：AIMS:We investigated the association between quantified metabolite, lipid and lipoprotein measures and incident heart failure hospitalisation (HFH) in the elderly, and examined whether circulating metabolic measures improve HFH prediction. METHODS AND RESULTS:Overall, 80 metabolic measures from the PROspective Study o...

journal_title：European journal of heart failure

authors： Delles C,Rankin NJ,Boachie C,McConnachie A,Ford I,Kangas A,Soininen P,Trompet S,Mooijaart SP,Jukema JW,Zannad F,Ala-Korpela M,Salomaa V,Havulinna AS,Welsh P,Würtz P,Sattar N

更新日期：2018-04-01 00:00:00