Abstract:
AIMS:Current guidelines for the diagnosis of heart failure with normal or preserved ejection fraction (HFpEF) are based on measurements at rest. However, in HFpEF ventricular dysfunction is more apparent on exercise. We hypothesized that Mitral annular plane systolic excursion (MAPSE) which is easy to acquire on exercise could be used to detect occult left ventricular (LV) impairment. METHODS AND RESULTS:Cardiopulmonary exercise testing and 2D-Doppler echocardiography were performed at rest and on exercise. MAPSE was assessed by using M-mode (apical four-chamber view). Sixty-two patients with HFpEF [LV ejection fraction (LVEF)=60 ± 7%] with reduced VO(2) max (18.6 ± 5.2 mL/min/kg) and 36 control subjects (LVEF=62 ± 7%, VO(2) max 29.4 ± 4.8 mL/min/kg) were studied. MAPSE at rest was significantly lower in patients (10.9 ± 2.1 vs. 12.1 ± 2.2 mm in controls, P= 0.008) which was even more pronounced on exercise (12.0 ± 2.2 mm and 16.2 ± 2.7 mm, respectively, P< 0.001). At rest MAPSE correlated with longitudinal strain (r = 0.432, P= 0.001), peak systolic myocardial velocity (r = 0.545, P< 0.001), and early diastolic myocardial velocity (r = 0.322, P= 0.02) and on exercise with LV apical rotation (r = 0.582, P< 0.001), longitudinal strain (r = 0.589, P< 0.001), and myocardial tissue velocities (P< 0.001). The area under the receiver operating characteristic curve for MAPSE was 0.655 (confidence interval 0.540-0.770) at rest and 0.901 (confidence interval 0.835-0.967) on exercise, to differentiate between patients and controls. CONCLUSION:Mitral annular plane systolic excursion at rest and on exercise correlates well with more sophisticated measurements of ventricular function in HFpEF patients. It is potentially a useful and easily acquired measurement, especially on exercise, for the diagnosis of HFpEF.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Wenzelburger FW,Tan YT,Choudhary FJ,Lee ES,Leyva F,Sanderson JEdoi
10.1093/eurjhf/hfr081subject
Has Abstractpub_date
2011-09-01 00:00:00pages
953-60issue
9eissn
1388-9842issn
1879-0844pii
hfr081journal_volume
13pub_type
杂志文章abstract::Cardiac resynchronization therapy (CRT) is one of the most effective therapies for heart failure with reduced ejection fraction and leads to improved quality of life, reductions in heart failure hospitalization rates and reduces all-cause mortality. Nevertheless, up to two-thirds of eligible patients are not referred ...
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更新日期:2003-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 已发布勘误
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journal_title:European journal of heart failure
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-11-01 00:00:00
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journal_title:European journal of heart failure
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更新日期:2018-07-01 00:00:00
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更新日期:1999-03-01 00:00:00
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journal_title:European journal of heart failure
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更新日期:2006-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章
doi:10.1002/ejhf.79
更新日期:2014-06-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2006-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:European journal of heart failure
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更新日期:2010-09-01 00:00:00
abstract:AIMS:Loop diuretics are essential for the treatment of chronic heart failure (CHF) but short-acting diuretics are reported to induce sympathetic nervous system (SNS) activation. This study was performed to compare therapeutic effects of two loop diuretics, long-acting azosemide and short-acting furosemide, using (123)I...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2011-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hft100
更新日期:2013-11-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.07.018
更新日期:2005-06-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
doi:10.1093/eurjhf/hfp032
更新日期:2009-04-01 00:00:00
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更新日期:2019-09-01 00:00:00