Self-rating of quality of life provides additional prognostic information in heart failure. Insights into the EPICAL study.


BACKGROUND:The relationship between quality of life (QoL) and survival have been poorly investigated. The aim of this study was to determine the value of QoL score as a prognostic factor in a prospective cohort of patients with advanced chronic heart failure (CHF). METHODS:QoL assessment was performed with a generic questionnaire: the Duke Health Profile (DHP) and a disease-specific instrument: the Minnesota Living With Heart Failure Questionnaire (LIhFE), in a sample of 108 patients registered in the EPICAL program (hospitalised patients with severe CHF defined by a NYHA grade III/IV, oedema or hypotension, and LVEF < 30%). Prognostic value of general, physical, mental and social dimensions on survival and hospital-free survival were tested in a Cox model. RESULTS:One-year survival rate was 76%, 1-year hospital-free survival 38%. QoL was significantly associated with outcomes: for both questionnaires, a 10-point decrement in baseline score was associated with a 23-36% increase in the risk of death or hospitalisation for heart failure. For hospital-free survival, this relationship remained significant after adjustment for others prognostic factors. CONCLUSION:QoL score is a predictive factor of survival and an independent predictive factor of hospital-free survival in patients with advanced CHF. This assessment may provide additional information for clinical management and therapeutic decisions.


Eur J Heart Fail


Alla F,Briançon S,Guillemin F,Juillière Y,Mertès PM,Villemot JP,Zannad F,EPICAL Investigators.





Has Abstract


2002-06-01 00:00:00














  • Myocarditis as a precipitating factor for heart failure: evaluation and 1-year follow-up using cardiovascular magnetic resonance and endomyocardial biopsy.

    abstract:AIMS:The aim of this study was to evaluate myocarditis as a precipitating factor for heart failure using cardiovascular magnetic resonance (CMR) and endomyocardial biopsy. METHODS AND RESULTS:Eighty-five patients with suspected myocarditis and 20 controls were evaluated. Seventy-one patients with positive CMR were ref...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Mavrogeni S,Spargias C,Bratis C,Kolovou G,Markussis V,Papadopoulou E,Constadoulakis P,Papadimitropoulos M,Douskou M,Pavlides G,Cokkinos D

    更新日期:2011-08-01 00:00:00

  • Insights into the importance of the electrocardiogram in patients with acute heart failure.

    abstract:BACKGROUND:Patients presenting to the emergency department (ED) with acute heart failure (AHF) are at an increased risk of morbidity and mortality. The electrocardiogram (ECG) is a routine investigation in patients with AHF used to identify potential causes and/or complications. It is unclear whether 12-lead ECG charac...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Gouda P,Brown P,Rowe BH,McAlister FA,Ezekowitz JA

    更新日期:2016-08-01 00:00:00

  • Hereditary hemochromatosis gene (HFE) mutations C282Y, H63D and S65C in patients with idiopathic dilated cardiomyopathy.

    abstract:BACKGROUND:Hereditary hemochromatosis (HH), a common autosomal recessive disease, leads to excessive iron accumulation in some organs, including the heart. It is therefore not surprising that cardiomyopathy is one of the most severe complications of HH. The HFE gene defects have been thought to contribute to idiopathic...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Hannuksela J,Leppilampi M,Peuhkurinen K,Kärkkäinen S,Saastamoinen E,Heliö T,Kaartinen M,Nieminen MS,Nieminen P,Parkkila S

    更新日期:2005-01-01 00:00:00

  • Autoantibodies against cardiac troponin I in patients with congestive heart failure.

    abstract:AIMS:In this randomized, double-blind clinical study, we investigated the relationship between autoantibodies against cardiac troponin I (cTnI) and disease severity in elderly congestive heart failure (CHF) patients before and after titration of beta-blocker therapy. METHODS AND RESULTS:Anti-cTnI, cTnI, and N-terminal...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: Düngen HD,Platzeck M,Vollert J,Searle J,Müller C,Reiche J,Mehrhof F,Müller R,Möckel M

    更新日期:2010-07-01 00:00:00

  • Effects of applying a standardised management algorithm for moderate to severe renal dysfunction in patients with chronic stable heart failure.

    abstract:BACKGROUND:No specific guidelines exist on how to manage renal dysfunction (RD) in patients with chronic heart failure (CHF). AIMS:To identify the proportion of patients with moderate to severe RD and CHF who showed an improvement in their renal function in response to a systematic management algorithm. METHODS:Stabl...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: de Silva R,Nikitin NP,Witte KK,Rigby AS,Loh H,Nicholson A,Bhandari S,Clark AL,Cleland JG

    更新日期:2007-04-01 00:00:00

  • Prognostic importance of a short deceleration time in symptomatic congestive heart failure.

    abstract:AIMS:A restrictive transmitral filling (RF) pattern predicts increased mortality in heart failure (HF) with reduced left ventricular (LV) systolic function. We performed a combined evaluation of LV function and RF for prognosis in patients with HF with and without systolic dysfunction. METHODS AND RESULTS:Doppler echo...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Akkan D,Kjaergaard J,Møller JE,Hassager C,Torp-Pedersen C,Køber L,EchoCardiography and Heart Outcome Study (ECHOS) investigators.

    更新日期:2008-07-01 00:00:00

  • Role of beta-blockers in patients admitted for worsening heart failure in a real world setting: data from the Italian Survey on Acute Heart Failure.

    abstract:AIMS:Randomized trials have shown that beta-blockers (BBs) reduce mortality in chronic heart failure (HF). Less data are available on the role of BBs in patients with acute HF, specifically if BBs should be continued or temporarily withdrawn. The aim of this study was to evaluate the role of BBs on in-hospital outcomes...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Orso F,Baldasseroni S,Fabbri G,Gonzini L,Lucci D,D'Ambrosi C,Gobbi M,Lecchi G,Randazzo S,Masotti G,Tavazzi L,Maggioni AP,Italian Survey on Acute Heart Failure Investigators.

    更新日期:2009-01-01 00:00:00

  • A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors.

    abstract:BACKGROUND:Mortality in patients with mild to moderate chronic heart failure remains high. At present there is no easy way of identifying patients within this population at increased risk of death in the medium to long term. AIMS:To develop a prognostic index to identify outpatients with mild to moderate chronic heart...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Kearney MT,Nolan J,Lee AJ,Brooksby PW,Prescott R,Shah AM,Zaman AG,Eckberg DL,Lindsay HS,Batin PD,Andrews R,Fox KA

    更新日期:2003-08-01 00:00:00

  • Utility of lung ultrasound in predicting pulmonary and cardiac pressures.

    abstract:AIMS:Quantification of linear lung ultrasound (LUS) artefacts (B-lines) represents a novel, non-invasive approach to assess pulmonary congestion. We investigated the relationship between the number of B-lines (vertical artefacts arising from the pleural line) and intracardiac pressures. METHODS AND RESULTS:Prior to sc...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Platz E,Lattanzi A,Agbo C,Takeuchi M,Resnic FS,Solomon SD,Desai AS

    更新日期:2012-11-01 00:00:00

  • BNP as a marker of diastolic dysfunction in the general population: Importance of left ventricular hypertrophy.

    abstract::BNP is a marker of systolic left ventricular dysfunction (LVSD) and heart failure. To assess BNP for the detection of diastolic dysfunction in the general population, we examined 1678 subjects within an age- and sex-stratified survey (MONICA Augsburg). BNP was measured using a commercially available RIA (Shionogi). BN...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Lukowicz TV,Fischer M,Hense HW,Döring A,Stritzke J,Riegger G,Schunkert H,Luchner A,MONICA Investigators.

    更新日期:2005-06-01 00:00:00

  • Incidence of cancer in patients with chronic heart failure: a long-term follow-up study.

    abstract:AIMS:With improvement in survival of chronic heart failure (HF), the clinical importance of co-morbidity is increasing. The aim of this study was to assess the incidence and risk of cancer and all-cause mortality in a large Danish HF cohort. METHODS AND RESULTS:A total of 9307 outpatients with verified HF without a pr...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Banke A,Schou M,Videbaek L,Møller JE,Torp-Pedersen C,Gustafsson F,Dahl JS,Køber L,Hildebrandt PR,Gislason GH

    更新日期:2016-03-01 00:00:00

  • Arrhythmogenic autoantibodies against calcium channel lead to sudden death in idiopathic dilated cardiomyopathy.

    abstract:AIMS:Calcium channel plays an important role in the autoimmune pathogenesis of idiopathic dilated cardiomyopathy (DCM). Autoantibodies have emerged as a new upstream target of sudden death in DCM. We sought to validate the hypothesis that autoantibodies against l-type calcium channel (CC-AAbs) are arrhythmogenic and le...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Xiao H,Wang M,Du Y,Yuan J,Cheng X,Chen Z,Zou A,Wei F,Zhao G,Liao YH

    更新日期:2011-03-01 00:00:00

  • Predictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction.

    abstract:UNLABELLED:IMS: Recurrent myocardial infarction (MI) is common after a first MI and is associated with increased morbidity and mortality. Predictors and prognosis of a recurrent MI with contemporary management are not well known. METHODS AND RESULTS:We assessed the predictors and prognostic impact of a first recurrent...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: Thune JJ,Signorovitch JE,Kober L,McMurray JJ,Swedberg K,Rouleau J,Maggioni A,Velazquez E,Califf R,Pfeffer MA,Solomon SD

    更新日期:2011-02-01 00:00:00

  • Outcomes in patients hospitalized for heart failure and chronic obstructive pulmonary disease: differences in clinical profile and treatment between 2002 and 2009.

    abstract:AIMS:Heart failure (HF) and chronic obstructive pulmonary disease (COPD) frequently co-exist, and each is a major public health issue. In a large cohort of hospitalized HF patients, we evaluated: (i) the impact of COPD on clinical outcomes; (ii) whether outcomes and treatments changed from 2002 to 2009; and (iii) the r...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Staszewsky L,Cortesi L,Tettamanti M,Dal Bo GA,Fortino I,Bortolotti A,Merlino L,Latini R,Roncaglioni MC,Baviera M

    更新日期:2016-07-01 00:00:00

  • Diagnosis and management of aortic valve stenosis in patients with heart failure.

    abstract::Aortic stenosis (AS) is the most frequent degenerative valvular heart disease in Western countries and its prevalence increases in parallel with the ageing process of the population. Heart failure (HF), defined by the presence of reduced left ventricular ejection fraction, may be present in up to a quarter of patients...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: Kamperidis V,Delgado V,van Mieghem NM,Kappetein AP,Leon MB,Bax JJ

    更新日期:2016-05-01 00:00:00

  • Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure: a long-term cardiopulmonary exercise testing placebo-controlled study.

    abstract:AIMS:Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in ∼20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pulmonary vasoconstriction has been suggested to be involved in this disorder. We hypothesized that modulation of pulmonary vascular hypertone by oversigna...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: Guazzi M,Vicenzi M,Arena R

    更新日期:2012-01-01 00:00:00

  • Trends in prevalence of comorbidities in heart failure clinical trials.

    abstract:AIMS:The primary objective of this systematic review was to estimate the prevalence and temporal changes in chronic comorbid conditions reported in heart failure (HF) clinical trials. METHODS AND RESULTS:We searched MEDLINE for HF trials enrolling more than 400 patients published between 2001 and 2016.Trials were divi...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Khan MS,Samman Tahhan A,Vaduganathan M,Greene SJ,Alrohaibani A,Anker SD,Vardeny O,Fonarow GC,Butler J

    更新日期:2020-06-01 00:00:00

  • Ejection fraction and blood pressure are important and interactive predictors of 4-week mortality in severe acute heart failure.

    abstract:BACKGROUND:In acute heart failure syndromes (AHFS), the prognostic value of left ventricular ejection fraction (LVEF), although widely accepted, has been recently challenged. In contrast, blood pressure is increasingly gaining ground over LVEF as predictor of mortality. Therefore, it is not clear whether both LVEF and ...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章


    authors: Adamopoulos C,Zannad F,Fay R,Mebazaa A,Cohen-Solal A,Guize L,Juillière Y,Alla F

    更新日期:2007-09-01 00:00:00

  • Increasing glucose levels and BMI predict future heart failure experience from the Reykjavík Study.

    abstract:BACKGROUND:Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS:7060 subjects with two or more visits in the Reykjavík Study were followed--during 30 years from 1967. All underwent oral glucose toler...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Thrainsdottir IS,Aspelund T,Gudnason V,Malmberg K,Sigurdsson G,Thorgeirsson G,Hardarson T,Rydén L

    更新日期:2007-10-01 00:00:00

  • Echocardiographic screening for non-ischaemic stage B heart failure in the community.

    abstract:AIMS:Incident heart failure (HF) continues to pose a common and serious problem. We sought to examine the value of echocardiographic predictors of new HF in a community-based elderly population at risk for HF, independent of and incremental to clinical evaluation. METHODS AND RESULTS:Asymptomatic patients ≥65 years ol...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Yang H,Negishi K,Wang Y,Nolan M,Saito M,Marwick TH

    更新日期:2016-11-01 00:00:00

  • Telemedical Interventional Monitoring in Heart Failure (TIM-HF), a randomized, controlled intervention trial investigating the impact of telemedicine on mortality in ambulatory patients with heart failure: study design.

    abstract:AIMS:Remote patient management (telemonitoring) may help to detect early signs of cardiac decompensation, allowing optimization of and adherence to treatments in chronic heart failure (CHF). Two meta-analyses have suggested that telemedicine in CHF can reduce mortality by 30-35%. The aim of the TIM-HF study was to inve...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: Koehler F,Winkler S,Schieber M,Sechtem U,Stangl K,Böhm M,Boll H,Kim SS,Koehler K,Lücke S,Honold M,Heinze P,Schweizer T,Braecklein M,Kirwan BA,Gelbrich G,Anker SD,TIM-HF Investigators.

    更新日期:2010-12-01 00:00:00

  • N-terminal pro-brain natriuretic peptide from fresh urine for the biochemical detection of heart failure and left ventricular dysfunction.

    abstract:AIMS:Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong biochemical marker of heart failure and left ventricular dysfunction (LVD). Due to renal arterio-venous clearance of NT-proBNP and the correlation of plasma concentrations with renal function, we hypothesized that NT-proBNP may have potential ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Jungbauer CG,Buchner S,Birner C,Resch M,Heinicke N,Debl K,Buesing M,Biermeier D,Schmitz G,Riegger G,Luchner A

    更新日期:2010-04-01 00:00:00

  • High prevalence of subclinical cerebral infarction in patients with heart failure with preserved ejection fraction.

    abstract:AIMS:Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS:We studied 1527 p...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Cogswell RJ,Norby FL,Gottesman RF,Chen LY,Solomon S,Shah A,Alonso A

    更新日期:2017-10-01 00:00:00

  • A rationale for early extracorporeal membrane oxygenation in patients with postinfarction ventricular septal rupture complicated by cardiogenic shock.

    abstract:AIMS:Ventricular septal rupture (VSR) became a rare mechanical complication of myocardial infarction in the era of percutaneous coronary interventions but is associated with extreme mortality in patients who present with cardiogenic shock (CS). Promising outcomes have been reported with the use of circulatory support a...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Rob D,Špunda R,Lindner J,Rohn V,Kunstýř J,Balík M,Rulíšek J,Kopecký P,Lipš M,Šmíd O,Kovárník T,Mlejnský F,Linhart A,Bělohlávek J

    更新日期:2017-05-01 00:00:00

  • Angiotensin II subtype 1 (AT1) receptors contribute to ischemic contracture and regulate chemomechanical energy transduction in isolated transgenic rat (alphaMHC-hAT1)594-17 hearts.

    abstract:BACKGROUND:The role of AT1 receptors in myocardial ischemia/reperfusion injury is unclear. We, therefore, investigated the effects of the AT1 receptor antagonist irbesartan (Irb) in isolated hearts of selective myocardial AT1 overexpressing transgenic [transgenic(alphaMHC-hAT1)594-17] and Sprague-Dawley rats (SD) subje...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Han H,Hoffmann S,Hu K,Ertl G

    更新日期:2002-03-01 00:00:00

  • Genetic aspects of heart failure.

    abstract::Heart failure is a major health problem and is associated with a high mortality and morbidity. Recently, the role of the genetic background in the onset and the development of the disease has been evidenced in both heart failure with and without systolic dysfunction and in familial and non-familial forms of this condi...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: Komajda M,Charron P,Tesson F

    更新日期:1999-06-01 00:00:00

  • Rationale and design of the AdaptResponse trial: a prospective randomized study of cardiac resynchronization therapy with preferential adaptive left ventricular-only pacing.

    abstract::The AdaptResponse trial is designed to test the hypothesis that preferential adaptive left ventricular-only pacing with the AdaptivCRT® algorithm reduces the incidence of the combined endpoint of all-cause mortality and intervention for heart failure (HF) decompensation, compared with conventional cardiac resynchroniz...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,meta分析,评审


    authors: Filippatos G,Birnie D,Gold MR,Gerritse B,Hersi A,Jacobs S,Kusano K,Leclercq C,Mullens W,Wilkoff BL,AdaptResponse Investigators.

    更新日期:2017-07-01 00:00:00

  • Oral glucose tolerance testing in an outpatient heart failure clinic reveals a high proportion of undiagnosed diabetic patients with an adverse prognosis.

    abstract:AIMS:We evaluated the applicability and prognostic importance of oral glucose tolerance testing (OGTT) among outpatients with systolic heart failure (SHF). METHODS AND RESULTS:Consecutive patients with SHF and left ventricular ejection fraction (LVEF) ≤ 45% referred to a heart failure clinic (n= 413) were included in ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Egstrup M,Schou M,Gustafsson I,Kistorp CN,Hildebrandt PR,Tuxen CD

    更新日期:2011-03-01 00:00:00

  • Regional myocardial perfusion during chronic biventricular pacing and after acute change of the pacing mode in patients with congestive heart failure and bundle branch block treated with an atrioventricular sequential biventricular pacemaker.

    abstract:BACKGROUND:Biventricular (BiV) pacing has been found to improve systolic function and exercise tolerance in patients with severe congestive heart failure and bundle branch block. The mechanisms behind this beneficial effect is still not sufficiently clarified. AIM:To evaluate the regional myocardial perfusion (MP) dur...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究


    authors: Nielsen JC,Bøttcher M,Jensen HK,Nielsen TT,Pedersen AK,Mortensen PT

    更新日期:2003-03-01 00:00:00

  • Multidimensional contractile reserve predicts adverse outcome in patients with severe systolic heart failure: a 4-year follow-up study.

    abstract:AIMS:Left ventricular contractile reserve is a prognostic indicator for adverse outcome in patients with severe chronic heart failure with reduced ejection fraction (HFrEF). We investigated the dobutamine-induced changes of LV multidimensional deformation and their predictive value for cardiac mortality of patients wit...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Paraskevaidis IA,Ikonomidis I,Simitsis P,Parissis J,Stasinos V,Makavos G,Lekakis J

    更新日期:2017-07-01 00:00:00