Regional myocardial perfusion during chronic biventricular pacing and after acute change of the pacing mode in patients with congestive heart failure and bundle branch block treated with an atrioventricular sequential biventricular pacemaker.

Abstract:

BACKGROUND:Biventricular (BiV) pacing has been found to improve systolic function and exercise tolerance in patients with severe congestive heart failure and bundle branch block. The mechanisms behind this beneficial effect is still not sufficiently clarified. AIM:To evaluate the regional myocardial perfusion (MP) during BiV pacing and after acute change of the pacing mode to conventional dual chamber (DDD) pacing, and single chamber atrial (AAI) pacing in patients with severe congestive heart failure and prolonged QRS width treated with chronic BiV pacing. METHODS AND RESULTS:Fourteen patients (age 63+/-7 years, 13 male) were evaluated 13+/-7 months after implantation of a triple-chamber biventricular pacemaker. MP was quantified with 13N-labeled ammonia positron emission tomography during BiV pacing, DDD pacing, and AAI pacing. MP was assessed in the anterior, lateral, inferior, and septal regions, and the global mean MP was calculated. Clinical assessment was performed before pacemaker implantation and after at least 3 months of BiV pacing including a 6-min walk test (WT), New York Heart Association (NYHA) class functional score and echocardiography. Global mean MP (BiV: 0.65+/-0.20 vs. DDD: 0.65+/-0.21 vs. AAI: 0.65+/-0.18 mlg(-1)min(-1)) and MP in each of the four regions did not differ between the three pacing modes. The patients improved clinically during BiV pacing; 6 min WT increased (338+/-59 vs. 415+/-73 m, P<0.001), NYHA class score improved (class I/II/III/IV: 0/0/11/3 vs. 1/9/2/0, P<0.001), and left ventricular ejection fraction increased (21+/-5 vs. 29+/-8%, P=0.004). CONCLUSION:No differences in regional MP are detectable after chronic BiV pacing when the pacing mode is changed acutely in patients with severe congestive heart failure and bundle branch block. This finding indicates, that the clinical improvement caused by BiV pacing is not associated with any increase in the MP and thereby oxygen demand.

journal_name

Eur J Heart Fail

authors

Nielsen JC,Bøttcher M,Jensen HK,Nielsen TT,Pedersen AK,Mortensen PT

doi

10.1016/s1388-9842(02)00245-3

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

179-86

issue

2

eissn

1388-9842

issn

1879-0844

pii

S1388984202002453

journal_volume

5

pub_type

杂志文章,多中心研究
  • Chronic heart failure is associated with vascular remodeling of the brachial artery.

    abstract:AIMS:Endothelial dysfunction has been shown to correlate with severity of congestive heart failure (CHF) and recent data suggest morphological changes of peripheral vasculature to be associated with the syndrome. We therefore investigated the hypothesis that vascular remodeling is associated with functional changes in ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.04.008

    authors: Poelzl G,Frick M,Huegel H,Lackner B,Alber HF,Mair J,Herold M,Schwarzacher S,Pachinger O,Weidinger F

    更新日期:2005-01-01 00:00:00

  • Usefulness of bifocal pacing in patients with heart failure and intraventricular conduction delay.

    abstract:BACKGROUND:Bifocal pacing (BFP) has been proposed as a feasible alternative to cardiac resynchronization therapy. AIM:To evaluate BFP in patients with severe heart failure and significant intraventricular conduction delay and to compare it with biventricular pacing (BVP). METHODS:Echocardiographic examination includi...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.09.003

    authors: Bulava A,Lukl J

    更新日期:2007-03-01 00:00:00

  • Telomere biology in heart failure.

    abstract::The incidence and prevalence of cardiovascular disease increases progressively with advancing age. Cardiovascular disease is a major cause of morbidity and mortality in Western Countries. In the near future, as the population ages, it is expected that the population prevalence of cardiovascular disease will increase d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2008.08.007

    authors: Wong LS,de Boer RA,Samani NJ,van Veldhuisen DJ,van der Harst P

    更新日期:2008-11-01 00:00:00

  • The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial.

    abstract:BACKGROUND:Crataegus preparations have been used for centuries especially in Europe. To date, no proper data on their efficacy and safety as an add-on-treatment are available. Therefore a large morbidity/mortality trial was performed. AIM:To investigate the efficacy and safety of an add-on treatment with Crataegus ext...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ejheart.2008.10.004

    authors: Holubarsch CJ,Colucci WS,Meinertz T,Gaus W,Tendera M,Survival and Prognosis: Investigation of Crataegus Extract WS 1442 in CHF (SPICE) trial study group.

    更新日期:2008-12-01 00:00:00

  • Pilot assessment of the response of several pulmonary hemodynamic variables to sublingual sildenafil in candidates for heart transplantation.

    abstract:OBJECTIVE:To determine the acute vasodilator effect of sublingual sildenafil in heart transplant candidates with severe pulmonary hypertension due to severe left ventricular dysfunction (LVD). BACKGROUND:Pulmonary hypertension confers an increased risk of early graft failure. PATIENTS AND METHODS:Seven patients, (mea...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2003.11.015

    authors: Angel Gómez-Sánchez M,Saenz De La Calzada C,Escribano Subías P,Francisco Delgado Jiménez J,Lázaro Salvador M,Albarrán González A,Cea Calvo L

    更新日期:2004-08-01 00:00:00

  • Selective beta1-blockade attenuates post-infarct remodelling without improvement in myocardial energy metabolism and function in rats with heart failure.

    abstract:OBJECTIVE:To investigate in vivo effects of long-term selective beta1-blockade on cardiac energy metabolism, remodelling, function and plasma cytokines in a rat model of post-infarct congestive heart failure (CHF). METHODS:Myocardial infarction (MI) was induced in male rats by ligation of the left coronary artery. Thr...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(03)00153-3

    authors: Omerovic E,Bollano E,Soussi B,Waagstein F

    更新日期:2003-12-01 00:00:00

  • N-terminal pro-brain natriuretic peptide for discriminating between cardiac and non-cardiac dyspnoea.

    abstract:AIM:Evaluation of N-terminal pro-brain natriuretic peptide (NT-proBNP) to confirm or disprove heart failure in community patients complaining of dyspnoea. METHODS AND RESULTS:General practitioners referred 345 consecutive patients complaining of dyspnoea to our hospital-based clinic, where a diagnosis was established ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2003.10.003

    authors: Nielsen LS,Svanegaard J,Klitgaard NA,Egeblad H

    更新日期:2004-01-01 00:00:00

  • Elevated circulating levels of thioredoxin and stress in chronic heart failure.

    abstract:BACKGROUND:Chronic heart failure (CHF) is a complex syndrome, in which reactive oxygen species and inflammatory cytokines are important stressors that contribute to the pathogenesis. AIM:We have studied physiological stress response parameters in CHF, in particular the redox-active regulator thioredoxin. SUBJECTS:A c...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.03.003

    authors: Jekell A,Hossain A,Alehagen U,Dahlström U,Rosén A

    更新日期:2004-12-01 00:00:00

  • Disruption of the relationship between renin and atrial natriuretic peptide early in the course of ventricular dysfunction.

    abstract:BACKGROUND:Plasma renin activity is normal in left ventricular dysfunction in the absence of diuretic therapy. In health there is a reciprocal relationship between renin and atrial natriuretic peptide (ANP) but a positive correlation in advanced heart failure. The relationship between renin and ANP in mild left ventric...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(99)00058-6

    authors: Dutka DP,Puri S,Strong R,Cleland JG

    更新日期:1999-12-01 00:00:00

  • The impact of heart failure on prognosis of diabetic and non-diabetic patients with myocardial infarction: a 15-year follow-up study.

    abstract:BACKGROUND:Information about the occurrence of heart failure in the acute phase of myocardial infarction (MI) in diabetic patients and its impact on prognosis are sparse. AIM:The purpose of the present study was to describe how MI patients with diabetes mellitus (DM) differed from MI patients without DM with respect t...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00117-3

    authors: Melchior T,Rask-Madsen C,Torp-Pedersen C,Hildebrandt P,Køber L,Jensen G

    更新日期:2001-01-01 00:00:00

  • Patients supported for over 4 years with left ventricular assist devices.

    abstract::Ventricular assist device implantation has become an established therapy in adults and children for bridging to heart transplantation or to aid myocardial recovery. Recently, implantation of left ventricular assist devices as definitive therapy has been recognized as a better option than pharmacological treatment in p...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.02.003

    authors: Potapov EV,Jurmann MJ,Drews T,Pasic M,Loebe M,Weng Y,Hetzer R

    更新日期:2006-11-01 00:00:00

  • A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry.

    abstract:AIMS:Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage. METHODS AND RESULTS:Patients with TTS were recruited from the Inter...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ejhf.683

    authors: Ghadri JR,Cammann VL,Jurisic S,Seifert B,Napp LC,Diekmann J,Bataiosu DR,D'Ascenzo F,Ding KJ,Sarcon A,Kazemian E,Birri T,Ruschitzka F,Lüscher TF,Templin C,InterTAK co-investigators.

    更新日期:2017-08-01 00:00:00

  • Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction.

    abstract:BACKGROUND:Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion. AIMS:To investigate the relationship between venous congestion and glomerular filtration rate (GFR) in patients with cardiac dysfunction. METHODS AND RESULTS:Right a...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ejheart.2007.05.010

    authors: Damman K,Navis G,Smilde TD,Voors AA,van der Bij W,van Veldhuisen DJ,Hillege HL

    更新日期:2007-09-01 00:00:00

  • Lung function with carvedilol and bisoprolol in chronic heart failure: is beta selectivity relevant?

    abstract:BACKGROUND:Carvedilol is a beta-blocker with similar affinity for beta1- and beta2 receptors, while bisoprolol has higher beta1 affinity. The respiratory system is characterized by beta2-receptor prevalence. Airway beta receptors regulate bronchial tone and alveolar beta receptors regulate alveolar fluid re-absorption ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ejheart.2007.04.006

    authors: Agostoni P,Contini M,Cattadori G,Apostolo A,Sciomer S,Bussotti M,Palermo P,Fiorentini C

    更新日期:2007-08-01 00:00:00

  • Prognostic significance of new atrial fibrillation and its relation to heart failure following acute myocardial infarction.

    abstract:BACKGROUND:New-onset atrial fibrillation (AF) after acute myocardial infarction (AMI) frequently occurs in association with postinfarction complications, particularly with heart failure (HF). AIMS:To evaluate whether postinfarction HF is associated with the subsequent development of AF and whether AF independently pre...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.07.018

    authors: Asanin M,Perunicic J,Mrdovic I,Matic M,Vujisic-Tesic B,Arandjelovic A,Vasiljevic Z,Ostojic M

    更新日期:2005-06-01 00:00:00

  • Aetiology, comorbidity and drug therapy of chronic heart failure in the real world: the EPICA substudy.

    abstract:BACKGROUND:Chronic heart failure (CHF) is common and is frequently managed by primary care physicians (PCPs). Despite the European Society of Cardiology (ESC) Guidelines, standard treatments for CHF are frequently underutilised, particularly in primary care. AIM:To evaluate current drug therapy for CHF in adults with ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.09.003

    authors: Ceia F,Fonseca C,Mota T,Morais H,Matias F,Costa C,Oliveira AG

    更新日期:2004-10-01 00:00:00

  • Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials.

    abstract::Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in card...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1557

    authors: Ahmad T,Miller PE,McCullough M,Desai NR,Riello R,Psotka M,Böhm M,Allen LA,Teerlink JR,Rosano GMC,Lindenfeld J

    更新日期:2019-09-01 00:00:00

  • Gut dysbiosis and heart failure: navigating the universe within.

    abstract::Alternations in gut microbial composition (i.e. loss of microbial diversity or 'gut dysbiosis') have been associated with heart failure with reduced ejection fraction (HFrEF). It has also been suggested that increased chronic low-level inflammation and immune system dysregulation seen in patients with HFrEF could be r...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1792

    authors: Madan S,Mehra MR

    更新日期:2020-04-01 00:00:00

  • Effects of diuretic treatment on cardiac and circulating RAS in chronic heart failure post-myocardial infarction in rats.

    abstract:BACKGROUND:Cardiac angiotensin converting enzyme (ACE) is activated by an increase in wall stress and is involved in remodeling processes. Heart failure is often treated with ACE inhibitors and diuretics although diuretic treatment could activate the renin-angiotensin system (RAS). AIMS:To examine the effects of diure...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(02)00242-8

    authors: Seeland U,Kouchi I,Zolk O,Jockenhövel F,Itter G,Linz W,Böhm M

    更新日期:2003-06-01 00:00:00

  • Trends in prevalence of comorbidities in heart failure clinical trials.

    abstract:AIMS:The primary objective of this systematic review was to estimate the prevalence and temporal changes in chronic comorbid conditions reported in heart failure (HF) clinical trials. METHODS AND RESULTS:We searched MEDLINE for HF trials enrolling more than 400 patients published between 2001 and 2016.Trials were divi...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1818

    authors: Khan MS,Samman Tahhan A,Vaduganathan M,Greene SJ,Alrohaibani A,Anker SD,Vardeny O,Fonarow GC,Butler J

    更新日期:2020-06-01 00:00:00

  • Association between enrolment in a heart failure quality registry and subsequent mortality-a nationwide cohort study.

    abstract:AIMS:Heart failure (HF) quality registries report quality of care but it is unknown whether they improve outcomes. The aims were to assess predictors of enrolment in a HF registry, test the hypothesis that enrolment in a HF registry is associated with reduced mortality, and assess potential explanatory factors for this...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.762

    authors: Lund LH,Carrero JJ,Farahmand B,Henriksson KM,Jonsson Å,Jernberg T,Dahlström U

    更新日期:2017-09-01 00:00:00

  • Effects of Atorvastatin on Th polarization in patients with acute myocardial infarction.

    abstract:BACKGROUND:The development of heart failure after acute myocardial infarction (AMI) has been shown to be associated with inflammation, which is positively and negatively regulated by T helper (Th) 1 and Th2 lymphocytes, respectively. Several studies have indicated that statins can improve heart function after AMI. AIM...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.01.020

    authors: Cheng X,Liao YH,Zhang J,Li B,Ge H,Yuan J,Wang M,Lu B,Liu Y,Cheng Y

    更新日期:2005-12-01 00:00:00

  • Baseline Characteristics of Patients with Heart Failure with Preserved Ejection Fraction in the EMPEROR-Preserved Trial.

    abstract:BACKGROUND:EMPEROR-Preserved is an ongoing trial evaluating the effect of empagliflozin in patients with heart failure with preserved ejection fraction (HFpEF). This report describes the baseline characteristics of the EMPEROR-Preserved cohort and compares it with patients enrolled in prior HFpEF trials. METHODS:EMPER...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.2064

    authors: Anker SD,Butler J,Filippatos G,Khan MS,Ferreira JP,Bocchi E,Böhm M,Rocca HPB,Choi DJ,Chopra V,Chuquiure E,Giannetti N,Gomez-Mesa JE,Janssens S,Januzzi JL,Gonzalez-Juanatey JR,Merkely B,Nicholls SJ,Perrone SV,Piña IL

    更新日期:2020-11-29 00:00:00

  • Multi-ethnic comparisons of diabetes in heart failure with reduced ejection fraction: insights from the HF-ACTION trial and the ASIAN-HF registry.

    abstract:AIM:To describe differences in patient characteristics and outcomes by ethnicity in patients with diabetes mellitus (DM) and heart failure (HF) with reduced ejection fraction (HFrEF, ejection fraction ≤35%) in a multi-ethnic cohort. METHODS AND RESULTS:Patient level data from two cohorts (HF-ACTION and ASIAN-HF) were ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/ejhf.1223

    authors: Cooper LB,Yap J,Tay WT,Teng TK,MacDonald M,Anand IS,Sharma A,O'Connor CM,Kraus WE,Mentz RJ,Lam CS,HF-ACTION and ASIAN-HF Investigators.

    更新日期:2018-09-01 00:00:00

  • Heart failure update.

    abstract::The RUSSLAN study, which randomised 504 patients with post-infarction heart failure in whom intravenous inotropic support might be deemed appropriate, was presented for the first time in a hotline session at the annual meeting of the Working Group on Heart Failure of the European Society of Cardiology. The study sugge...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1388-9842(99)00040-9

    authors: Gomes UC,Cleland JG

    更新日期:1999-08-01 00:00:00

  • Predicting hospitalization due to worsening heart failure using daily weight measurement: analysis of the Trans-European Network-Home-Care Management System (TEN-HMS) study.

    abstract:AIMS:We sought to test the utility of weight gain algorithms to predict episodes of worsening heart failure (WHF) using home-telemonitoring data collected as part of the TEN-HMS study. METHODS AND RESULTS:Simple rule-of-thumb (RoT) algorithms (i.e. 3 lbs in 1 day and 5 lbs in 3 days) and a moving average convergence d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hfp033

    authors: Zhang J,Goode KM,Cuddihy PE,Cleland JG,TEN-HMS Investigators.

    更新日期:2009-04-01 00:00:00

  • Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects.

    abstract:BACKGROUND:Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies. Patients with restrictive cardiomyopathy (RCM) plus atrioventricular block (AVB) due to DES defects are frequently unrecognized unless d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.11.003

    authors: Arbustini E,Pasotti M,Pilotto A,Pellegrini C,Grasso M,Previtali S,Repetto A,Bellini O,Azan G,Scaffino M,Campana C,Piccolo G,Viganò M,Tavazzi L

    更新日期:2006-08-01 00:00:00

  • Long-term prognostic impact of therapeutic strategies in patients with idiopathic dilated cardiomyopathy: changing mortality over the last 30 years.

    abstract:AIMS:ACE-inhibitors, β-blockers, implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy (CRT) improved prognosis of heart failure. We sought to analyse the long-term prognostic impact of evidence-based integrated therapeutic strategies in patients with idiopathic dilated cardiomyopathy (IDCM...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.16

    authors: Merlo M,Pivetta A,Pinamonti B,Stolfo D,Zecchin M,Barbati G,Di Lenarda A,Sinagra G

    更新日期:2014-03-01 00:00:00

  • Prognostic importance of exercise brain natriuretic peptide in asymptomatic degenerative mitral regurgitation.

    abstract:AIM:The exercise Doppler echocardiographic stress test can be of interest in the management of asymptomatic patients with primary mitral regurgitation (MR). The resting brain natriuretic peptide (BNP) level is a good surrogate marker of the consequences of MR and is a powerful predictor of outcome. The incremental prog...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfs114

    authors: Magne J,Mahjoub H,Pibarot P,Pirlet C,Pierard LA,Lancellotti P

    更新日期:2012-11-01 00:00:00

  • Heart failure and sleep apnoea: to sleep perchance to dream.

    abstract::Heart failure and sleep apnoea are major health problems with an increasingly recognized association; evidence suggests that sleep apnoea may play a role in the progression of heart failure. However, confounding factors such as obesity, hypertension and coronary heart disease make this relationship uncertain and an in...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2005.07.013

    authors: Ferreira S,Winck J,Bettencourt P,Rocha-Goncalves F

    更新日期:2006-05-01 00:00:00