Efficacy of antithrombotic therapy in chronic heart failure: the HELAS study.

abstract：:Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in card...

journal_title：European journal of heart failure

authors： Ahmad T,Miller PE,McCullough M,Desai NR,Riello R,Psotka M,Böhm M,Allen LA,Teerlink JR,Rosano GMC,Lindenfeld J

更新日期：2019-09-01 00:00:00

abstract：AIMS:Chronic heart failure (CHF) is associated with a higher risk for diabetes mellitus. Retinol binding protein 4 (RBP 4) is an adipose tissue-derived protein with pro-diabetogenic effects. A complete understanding of the association of CHF and insulin resistance remains elusive. The purpose of this study was to exami...

journal_title：European journal of heart failure

authors： Bobbert P,Weithäuser A,Andres J,Bobbert T,Kühl U,Schultheiss HP,Rauch U,Skurk C

更新日期：2009-12-01 00:00:00

abstract：AIMS:The identification of valuable markers of sudden cardiac death (SCD) in patients with established HF remains a challenge. We sought to assess the value of clinical, echocardiographic and biochemical variables to predict SCD in a consecutive cohort of patients with heart failure (HF) due to systolic dysfunction. M...

journal_title：European journal of heart failure

authors： Bayes-Genis A,Vazquez R,Puig T,Fernandez-Palomeque C,Fabregat J,Bardají A,Pascual-Figal D,Ordoñez-Llanos J,Valdes M,Gabarrús A,Pavon R,Pastor L,Gonzalez Juanatey JR,Almendral J,Fiol M,Nieto V,Macaya C,Cinca J,Bayes de

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Carvedilol improves left ventricular (LV) function when heart failure is due to LV systolic dysfunction, but the magnitude of the response is heterogeneous among patients with coronary disease, possibly reflecting the presence or volume of hibernating myocardium. AIMS:The primary objective of the study is t...

journal_title：European journal of heart failure

authors： Cleland JG,Pennel D,Ray S,Murray G,MacFarlane P,Cowley A,Coats A,Lahiri A

更新日期：1999-06-01 00:00:00

abstract：:The TRUE-AHF is a randomized, double-blind, parallel-group, placebo-controlled trial which is evaluating the effects of a 48-h infusion of ularitide (15 ng/kg/min) on the short- and long-term clinical course of patients with acute heart failure. Noteworthy features of the study include the early enrolment of patients ...

journal_title：European journal of heart failure

authors： Packer M,Holcomb R,Abraham WT,Anker S,Dickstein K,Filippatos G,Krum H,Maggioni AP,McMurray JJV,Mebazaa A,O'Connor C,Peacock F,Ponikowski P,Ruschitzka F,van Veldhuisen DJ,Holzmeister J,TRUE-AHF Investigators and Committees

更新日期：2017-05-01 00:00:00

abstract：AIMS:Beta-blockers (BBs) improve outcomes in heart failure. Results from the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) trial previously demonstrated the feasibility of heart rate, not maximum dose, as a treatment goal. In this pre-specified analysis, we investigated the prognostic value of achieved ...

journal_title：European journal of heart failure

authors： Düngen HD,Musial-Bright L,Inkrot S,Apostolović S,Edelmann F,Lainščak M,Sekularac N,Störk S,Tahirovic E,Tscholl V,Krackhardt F,Loncar G,Trippel TD,Gelbrich G

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The development of heart failure after acute myocardial infarction (AMI) has been shown to be associated with inflammation, which is positively and negatively regulated by T helper (Th) 1 and Th2 lymphocytes, respectively. Several studies have indicated that statins can improve heart function after AMI. AIM...

journal_title：European journal of heart failure

authors： Cheng X,Liao YH,Zhang J,Li B,Ge H,Yuan J,Wang M,Lu B,Liu Y,Cheng Y

更新日期：2005-12-01 00:00:00

abstract：AIMS:To characterize the relationship between known and newly diagnosed atrial fibrillation (AF) and the risk of death and major cardiovascular (CV) events in patients with acute myocardial infarction (MI) complicated by heart failure (HF) and/or left ventricular systolic dysfunction (LVSD). METHODS:The VALIANT trial ...

journal_title：European journal of heart failure

authors： Køber L,Swedberg K,McMurray JJ,Pfeffer MA,Velazquez EJ,Diaz R,Maggioni AP,Mareev V,Opolski G,Van de Werf F,Zannad F,Ertl G,Solomon SD,Zelenkofske S,Rouleau JL,Leimberger JD,Califf RM

更新日期：2006-10-01 00:00:00

abstract：AIMS:Impaired tissue perfusion is often observed in patients with acute heart failure. We tested whether low-dose nitroglycerin (NTG) improves microcirculatory perfusion in patients admitted for acute heart failure. METHODS AND RESULTS:In 20 acute heart failure patients, NTG was given as intravenous infusion at a fixe...

journal_title：European journal of heart failure

authors： den Uil CA,Lagrand WK,Spronk PE,van der Ent M,Jewbali LS,Brugts JJ,Ince C,Simoons ML

更新日期：2009-04-01 00:00:00

abstract：AIM:Heart failure (HF) is a common condition with which high mortality, morbidity, and poor quality of life are associated. It has previously been shown that use of HF management programmes (HFMPs) in HF clinics can be beneficial. The purpose of this study was to evaluate if the use of HFMPs also has beneficial effects...

journal_title：European journal of heart failure

authors： Agvall B,Alehagen U,Dahlström U

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:High-sensitivity C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) and, in recent studies, incident heart failure (HF). Whether the association of inflammation with incident HF is explained by worse baseline left ventricular dysfunction or by underlying CHD is unkn...

journal_title：European journal of heart failure

authors： Williams ES,Shah SJ,Ali S,Na BY,Schiller NB,Whooley MA

更新日期：2008-01-01 00:00:00

abstract：AIMS:Insulin-dependent positive inotropic effects (PIE) are partially Ca(2+) independent. This mechanism is potentially glucose dependent. In contrast to most animal species, human myocardium expresses high levels of sodium-glucose-transporter-1 (SGLT-1) mRNA besides the common glucose-transporters-1 and -4 (GLUT1, GLU...

journal_title：European journal of heart failure

authors： von Lewinski D,Gasser R,Rainer PP,Huber MS,Wilhelm B,Roessl U,Haas T,Wasler A,Grimm M,Bisping E,Pieske B

更新日期：2010-02-01 00:00:00

abstract：:Patients with obesity, a reduced exercise capacity, increased cardiac filling pressures and a measured left ventricular ejection fraction in the normal range do not have a homogeneous disorder, but instead, exhibit one of three phenotypes. First, many obese people exhibit sodium retention, plasma volume expansion and ...

journal_title：European journal of heart failure

authors： Packer M

更新日期：2019-02-01 00:00:00

abstract：AIMS:In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. METHOD...

journal_title：European journal of heart failure

authors： Wettersten N,Horiuchi Y,van Veldhuisen DJ,Mueller C,Filippatos G,Nowak R,Hogan C,Kontos MC,Cannon CM,Müeller GA,Birkhahn R,Taub P,Vilke GM,Barnett O,McDonald K,Mahon N,Nuñez J,Briguori C,Passino C,Murray PT,Maisel

更新日期：2019-12-01 00:00:00

abstract：AIMS:To determine the association between obesity and outcomes in post-acute myocardial infarction (AMI) patients with systolic heart failure (HF). METHODS AND RESULTS:Of the 6632 Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) participants, 6611 had data on baseline bod...

journal_title：European journal of heart failure

authors： Wu AH,Pitt B,Anker SD,Vincent J,Mujib M,Ahmed A

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:A low peak oxygen uptake (pVO(2)) and steep VE/VCO(2) slope are independently associated with a worse prognosis in patients with chronic heart failure (CHF). We wished to confirm whether combining these variables as a ratio would lead to a more accurate predictor of prognosis than using either alone. METHOD...

journal_title：European journal of heart failure

authors： Ingle L,Witte KK,Cleland JG,Clark AL

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that discharge planning and post-discharge support for CHF patients can contribute greatly to the medical management of heart failure (CHF) in the community and that the quality of the CHF patient's close personal relationships can influence outcome in CHF. However, there has bee...

journal_title：European journal of heart failure

authors： Molloy GJ,Johnston DW,Witham MD

更新日期：2005-06-01 00:00:00

abstract：AIMS:Liver X receptors (LXRs) transcriptionally regulate inflammation, metabolism, and immunity. Synthetic LXR agonists have been evaluated for their efficacy in the cardiovascular system; however, they elicit prolipogenic side effects which substantially limit their therapeutic use. AZ876 is a novel high-affinity LXR ...

journal_title：European journal of heart failure

authors： Cannon MV,Yu H,Candido WM,Dokter MM,Lindstedt EL,Silljé HH,van Gilst WH,de Boer RA

更新日期：2015-03-01 00:00:00

abstract：AIMS:To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms. METHODS AND RESULTS:A total of 300 consecutive hospitalized CHF patients were screened for ...

journal_title：European journal of heart failure

authors： Parissis JT,Farmakis D,Nikolaou M,Birmpa D,Bistola V,Paraskevaidis I,Ikonomidis I,Gaitani S,Venetsanou K,Filippatos G,Kremastinos DT

更新日期：2009-10-01 00:00:00

abstract：:Anti-beta-1-adrenergic receptor antibodies (anti-β1AR Abs) have long been implicated in the pathogenesis of dilated cardiomyopathy (DCM). It is believed that these autoantibodies bind to and constitutively stimulate the β1AR to promote pathological cardiac remodelling and β1AR desensitization and downregulation. The p...

journal_title：European journal of heart failure

authors： Patel PA,Hernandez AF

更新日期：2013-07-01 00:00:00

abstract：AIMS:As periprocedural risk is low, MitraClip implantation is often performed in critically ill, not fully recompensated patients, who are in NYHA functional class IV at the time of the procedure, to accelerate convalescence. We herein sought to evaluate the procedural and 30-day outcome of this patient group. METHODS...

journal_title：European journal of heart failure

authors： Rudolph V,Huntgeburth M,von Bardeleben RS,Boekstegers P,Lubos E,Schillinger W,Ouarrak T,Eggebrecht H,Butter C,Plicht B,May A,Franzen O,Schofer J,Senges J,Baldus S

更新日期：2014-11-01 00:00:00

abstract：AIMS:The aim of this review is to assess the effects of exercise training on the symptoms of depression in heart failure (HF) patients. METHODS AND RESULTS:Randomized controlled trials of exercise training in patients with HF and symptoms of depression were identified. The depression data were pooled using meta-analys...

journal_title：European journal of heart failure

authors： Tu RH,Zeng ZY,Zhong GQ,Wu WF,Lu YJ,Bo ZD,He Y,Huang WQ,Yao LM

更新日期：2014-07-01 00:00:00

abstract：AIM:Data are scant on the incidence and prognosis of heart failure (HF) with normal ejection fraction (HFNEF, EF >49%) in an acute myocardial infarction (AMI) setting. The aim of this study was to examine incidence and predictors of HFNEF during an index acute myocardial infarction (AMI) and its subsequent associations...

journal_title：European journal of heart failure

authors： Desta L,Jernberg T,Spaak J,Hofman-Bang C,Persson H

更新日期：2016-01-01 00:00:00

abstract：AIMS:To investigate the relationship between central venous pressure (CVP) at presentation to the emergency room (ER) and the risk of cardiac rehospitalization and mortality in patients with decompensated heart failure (DHF). METHODS AND RESULTS:Central venous pressure was determined non-invasively using high-resoluti...

journal_title：European journal of heart failure

authors： Uthoff H,Thalhammer C,Potocki M,Reichlin T,Noveanu M,Aschwanden M,Staub D,Arenja N,Socrates T,Twerenbold R,Mutschmann-Sanchez S,Heinisch C,Jaeger KA,Mebazaa A,Mueller C

更新日期：2010-05-01 00:00:00

abstract：AIMS:Although pulse pressure (PP) is a recognized risk factor for various cardiovascular diseases, its association with cardiovascular outcomes in patients with heart failure with preserved ejection fraction (HFpEF) is uncertain. METHODS AND RESULTS:We enrolled 512 of 951 consecutive HFpEF patients admitted to the Kum...

journal_title：European journal of heart failure

authors： Tokitsu T,Yamamoto E,Hirata Y,Kusaka H,Fujisue K,Sueta D,Sugamura K,Sakamoto K,Tsujita K,Kaikita K,Hokimoto S,Sugiyama S,Ogawa H

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:For patients undergoing heart transplantation, an elevated pulmonary vascular resistance (PVR) increases mortality in the early post-heart transplant period. This study aimed to assess the effects of chronic sildenafil administration on the PVR, transpulmonary gradient (TPG), and cardiac output (CO) in pat...

journal_title：European journal of heart failure

authors： Jabbour A,Keogh A,Hayward C,Macdonald P

更新日期：2007-06-01 00:00:00

abstract：:Alternations in gut microbial composition (i.e. loss of microbial diversity or 'gut dysbiosis') have been associated with heart failure with reduced ejection fraction (HFrEF). It has also been suggested that increased chronic low-level inflammation and immune system dysregulation seen in patients with HFrEF could be r...

journal_title：European journal of heart failure

authors： Madan S,Mehra MR

更新日期：2020-04-01 00:00:00

abstract：AIMS:Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in ∼20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pulmonary vasoconstriction has been suggested to be involved in this disorder. We hypothesized that modulation of pulmonary vascular hypertone by oversigna...

journal_title：European journal of heart failure

authors： Guazzi M,Vicenzi M,Arena R

更新日期：2012-01-01 00:00:00

abstract：AIMS:Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms...

journal_title：European journal of heart failure

authors： Angermann CE,Kaspar M,Marx A,Kittel-Schneider S,Menhofer D,Störk S,Ertl G,Domschke K,Deckert J,Reif A

更新日期：2017-03-01 00:00:00

abstract：:We investigated the hypothesis that increased intracellular [Na+]i in heart failure contributes to preservation of SR Ca2+ load which may become particularly evident at slow heart rates. [Na+]i in SBFI-loaded myocytes from rabbits with pacing-induced heart failure (PHF) was significantly higher at each frequency as co...

journal_title：European journal of heart failure

authors： Schillinger W,Teucher N,Christians C,Kohlhaas M,Sossalla S,Van Nguyen P,Schmidt AG,Schunck O,Nebendahl K,Maier LS,Zeitz O,Hasenfuss G

更新日期：2006-11-01 00:00:00