Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathy.

abstract：AIMS:To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ≤35%). METHODS AND RESULTS:A 5-day open-label run-in (sacubitril/valsartan 50 mg twice daily) preceded an 11-week, dou...

journal_title：European journal of heart failure

authors： Senni M,McMurray JJ,Wachter R,McIntyre HF,Reyes A,Majercak I,Andreka P,Shehova-Yankova N,Anand I,Yilmaz MB,Gogia H,Martinez-Selles M,Fischer S,Zilahi Z,Cosmi F,Gelev V,Galve E,Gómez-Doblas JJ,Nociar J,Radomska M,S

更新日期：2016-09-01 00:00:00

abstract：AIMS:Supervised exercise can benefit selected patients with heart failure, however the effectiveness of home-based exercise remains uncertain. We aimed to assess the effectiveness of a home-based exercise programme in addition to specialist heart failure nurse care. METHODS AND RESULTS:This was a randomized controlled...

journal_title：European journal of heart failure

authors： Jolly K,Taylor RS,Lip GY,Davies M,Davis R,Mant J,Singh S,Greenfield S,Ingram J,Stubley J,Bryan S,Stevens A

更新日期：2009-02-01 00:00:00

abstract：AIMS:With improvement in survival of chronic heart failure (HF), the clinical importance of co-morbidity is increasing. The aim of this study was to assess the incidence and risk of cancer and all-cause mortality in a large Danish HF cohort. METHODS AND RESULTS:A total of 9307 outpatients with verified HF without a pr...

journal_title：European journal of heart failure

authors： Banke A,Schou M,Videbaek L,Møller JE,Torp-Pedersen C,Gustafsson F,Dahl JS,Køber L,Hildebrandt PR,Gislason GH

更新日期：2016-03-01 00:00:00

abstract：:BNP is a marker of systolic left ventricular dysfunction (LVSD) and heart failure. To assess BNP for the detection of diastolic dysfunction in the general population, we examined 1678 subjects within an age- and sex-stratified survey (MONICA Augsburg). BNP was measured using a commercially available RIA (Shionogi). BN...

journal_title：European journal of heart failure

authors： Lukowicz TV,Fischer M,Hense HW,Döring A,Stritzke J,Riegger G,Schunkert H,Luchner A,MONICA Investigators.

更新日期：2005-06-01 00:00:00

abstract：AIMS:The objective of this study was to establish the acute effects of hypoxia on clinical, spirometric, haemodynamic, and echocardiographic variables. Reducing inspired oxygen to 15%, as experienced during commercial air travel, decreases arterial oxygen saturation, increases respiratory rate and pulmonary artery pres...

journal_title：European journal of heart failure

authors： Hobkirk JP,Damy T,Walters M,Bennett A,Smith SJ,Ingle L,Clark AL,Cleland JG

更新日期：2013-05-01 00:00:00

abstract：AIMS:Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF). Considering different treatment mechanisms underlying renin-angiotensin system (RAS) suppression and parasym...

journal_title：European journal of heart failure

authors： Li M,Zheng C,Kawada T,Inagaki M,Uemura K,Sugimachi M

更新日期：2014-10-01 00:00:00

abstract：AIMS:The aim of this study was to evaluate myocarditis as a precipitating factor for heart failure using cardiovascular magnetic resonance (CMR) and endomyocardial biopsy. METHODS AND RESULTS:Eighty-five patients with suspected myocarditis and 20 controls were evaluated. Seventy-one patients with positive CMR were ref...

journal_title：European journal of heart failure

authors： Mavrogeni S,Spargias C,Bratis C,Kolovou G,Markussis V,Papadopoulou E,Constadoulakis P,Papadimitropoulos M,Douskou M,Pavlides G,Cokkinos D

更新日期：2011-08-01 00:00:00

abstract：AIMS:Oral sucrosomial iron (SI) combines enhanced bioavailability and tolerance compared to conventional oral iron along with similar efficacy compared to intravenous iron in several conditions associated with iron deficiency (ID). METHODS AND RESULTS:In this non-randomized, open-label study, we sought to evaluate pro...

journal_title：European journal of heart failure

authors： Karavidas A,Troganis E,Lazaros G,Balta D,Karavidas IN,Polyzogopoulou E,Parissis J,Farmakis D

更新日期：2021-01-09 00:00:00

abstract：AIMS:Heart failure (HF) patients with a mid-range ejection fraction (HFmrEF) are not well characterized. Accordingly, we examined the epidemiology, pathophysiology and clinical outcomes of HF patients with a left ventricular ejection fraction (LVEF) of 40-50%. METHODS AND RESULTS:We identified 168 patients with an LVE...

journal_title：European journal of heart failure

authors： Rastogi A,Novak E,Platts AE,Mann DL

更新日期：2017-12-01 00:00:00

abstract：:Heart failure and sleep apnoea are major health problems with an increasingly recognized association; evidence suggests that sleep apnoea may play a role in the progression of heart failure. However, confounding factors such as obesity, hypertension and coronary heart disease make this relationship uncertain and an in...

journal_title：European journal of heart failure

authors： Ferreira S,Winck J,Bettencourt P,Rocha-Goncalves F

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Knowledge on clinical characteristics and prognosis of patients with heart failure originates from studies of selected populations in clinical trials or from epidemiological observations. Reports on the large numbers of patients with heart failure treated in community hospitals are sparse. OBJECTIVE:Are the...

journal_title：European journal of heart failure

authors： Taubert G,Bergmeier C,Andresen H,Senges J,Potratz J

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Hospital management of CHF and predictors of hospital mortality remain unclear. METHODS:To address these issues, we analyzed the hospital admissions for CHF during 1996 in a large university hospital. Patients discharged with the principal diagnosis of CHF were considered eligible for the study. RESULTS:Am...

journal_title：European journal of heart failure

authors： Grigioni F,Carinci V,Favero L,Bacchi Reggiani L,Magnani G,Potena L,Barbieri A,Magelli C,Branzi A,Magnani B

更新日期：2002-01-01 00:00:00

abstract：AIMS:The true incidence of life-threatening ventricular tachyarrhythmic events and the risk of sudden cardiac death in the early stage of peripartum cardiomyopathy (PPCM) are still unknown. We aimed to assess the usefulness of the wearable cardioverter/defibrillator (WCD) to bridge a potential risk for life-threatening...

journal_title：European journal of heart failure

authors： Duncker D,Haghikia A,König T,Hohmann S,Gutleben KJ,Westenfeld R,Oswald H,Klein H,Bauersachs J,Hilfiker-Kleiner D,Veltmann C

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies. Patients with restrictive cardiomyopathy (RCM) plus atrioventricular block (AVB) due to DES defects are frequently unrecognized unless d...

journal_title：European journal of heart failure

authors： Arbustini E,Pasotti M,Pilotto A,Pellegrini C,Grasso M,Previtali S,Repetto A,Bellini O,Azan G,Scaffino M,Campana C,Piccolo G,Viganò M,Tavazzi L

更新日期：2006-08-01 00:00:00

abstract：AIMS:To examine the impact of diabetes mellitus on long-term clinical outcomes in patients with myocardial infarction (MI) complicated by clinical signs of heart failure (HF) or left ventricular dysfunction (LVD). METHODS AND RESULTS:The High-Risk MI Database consists of individual data from 28 771 patients and was cr...

journal_title：European journal of heart failure

authors： Tajik AA,Dobre D,Aguilar D,Kjekshus J,Zannad F,Dickstein K,High-Risk MI Database Scientific Committee.

更新日期：2017-05-01 00:00:00

abstract：AIMS:Loop diuretics are essential for the treatment of chronic heart failure (CHF) but short-acting diuretics are reported to induce sympathetic nervous system (SNS) activation. This study was performed to compare therapeutic effects of two loop diuretics, long-acting azosemide and short-acting furosemide, using (123)I...

journal_title：European journal of heart failure

authors： Hisatake S,Nanjo S,Fujimoto S,Yamashina S,Yuzawa H,Namiki A,Nakano H,Yamazaki J

更新日期：2011-08-01 00:00:00

abstract：AIMS:Growth differentiation factor-15 (GDF-15) is associated with adverse prognosis in cardiovascular (CV) and non-CV diseases. We evaluated the association of GDF-15 with CV and non-CV outcomes in the PARADIGM-HF trial. METHODS AND RESULTS:In 1935 patients with heart failure and reduced ejection fraction (HFrEF) in P...

journal_title：European journal of heart failure

authors： Bouabdallaoui N,Claggett B,Zile MR,McMurray JJV,O'Meara E,Packer M,Prescott MF,Swedberg K,Solomon SD,Rouleau JL,PARADIGM-HF Investigators and Committees.

更新日期：2018-12-01 00:00:00

abstract：AIMS:In the Digitalis Investigation Group (DIG) trial, digoxin reduced mortality or hospitalization due to heart failure (HF) in several pre-specified high-risk subgroups of HF patients, but data on protocol-specified 2-year outcomes were not presented. In the current study, we examined the effect of digoxin on HF deat...

journal_title：European journal of heart failure

authors： Gheorghiade M,Patel K,Filippatos G,Anker SD,van Veldhuisen DJ,Cleland JG,Metra M,Aban IB,Greene SJ,Adams KF,McMurray JJ,Ahmed A

更新日期：2013-05-01 00:00:00

abstract：AIMS:The proteasome prevents the intracellular accumulation of proteins and its impairment can lead to structural and functional alterations, as noted for the coronary vasculature in a previous study. Utilizing the same model, this study was designed to test the hypothesis that chronic proteasome inhibition (PSI) also ...

journal_title：European journal of heart failure

authors： Herrmann J,Wohlert C,Saguner AM,Flores A,Nesbitt LL,Chade A,Lerman LO,Lerman A

更新日期：2013-06-01 00:00:00

abstract：AIMS:In amyloid patients, cardiac involvement dramatically worsens functional capacity and prognosis. We sought to study how the cardiopulmonary exercise test (CPET) could help in functional assessment and risk stratification of patients with cardiac amyloidosis (CA). METHODS AND RESULTS:We carried out a multicentre s...

journal_title：European journal of heart failure

authors： Nicol M,Deney A,Lairez O,Vergaro G,Emdin M,Carecci A,Inamo J,Montfort A,Neviere R,Damy T,Harel S,Royer B,Baudet M,Cohen-Solal A,Arnulf B,Logeart D

更新日期：2020-10-02 00:00:00

abstract：AIMS:Patients with acute heart failure (HF) in Africa are rarely being treated with a hydralazine/nitrates combination. Therefore the effect of this treatment was studied here. METHODS AND RESULTS:The study was planned to enrol 500 patients during an acute HF admission, from nine sub-Saharan African countries. Patient...

journal_title：European journal of heart failure

authors： Sliwa K,Damasceno A,Davison BA,Mayosi BM,Sani MU,Ogah O,Mondo C,Ojji D,Dzudie A,Kouam CK,Yonga G,Ba SA,Ogola E,Edwards C,Milo O,Cotter G

更新日期：2016-10-01 00:00:00

abstract：AIMS:Endothelial dysfunction has been shown to correlate with severity of congestive heart failure (CHF) and recent data suggest morphological changes of peripheral vasculature to be associated with the syndrome. We therefore investigated the hypothesis that vascular remodeling is associated with functional changes in ...

journal_title：European journal of heart failure

authors： Poelzl G,Frick M,Huegel H,Lackner B,Alber HF,Mair J,Herold M,Schwarzacher S,Pachinger O,Weidinger F

更新日期：2005-01-01 00:00:00

abstract：:Galectins are a family of soluble beta-galactoside-binding lectins that play many important regulatory roles in inflammation, immunity, and cancer. Recently, a role for galectin-3 in the pathophysiology of heart failure (HF) has been suggested. Numerous studies have demonstrated the up-regulation of galectin-3 in hype...

journal_title：European journal of heart failure

authors： de Boer RA,Voors AA,Muntendam P,van Gilst WH,van Veldhuisen DJ

更新日期：2009-09-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the prognostic impact of right ventricular (RV) size in patients with chronic heart failure. METHODS AND RESULTS:Normal volunteers (n = 80) and patients (n = 380) with left ventricular (LV) ejection fraction <45% on echocardiography and on optimal treatment for heart failu...

journal_title：European journal of heart failure

authors： Bourantas CV,Loh HP,Bragadeesh T,Rigby AS,Lukaschuk EI,Garg S,Tweddel AC,Alamgir FM,Nikitin NP,Clark AL,Cleland JG

更新日期：2011-01-01 00:00:00

abstract：AIMS:Rho kinases (ROCKs) are the best characterized effectors of the small G-protein RhoA, and play a role in enhanced vasoconstriction in animal models of congestive heart failure (CHF). This study examined if ROCK activity is increased in CHF and how it is associated with the outcome in CHF. METHODS AND RESULTS:Pati...

journal_title：European journal of heart failure

authors： Dong M,Liao JK,Fang F,Lee AP,Yan BP,Liu M,Yu CM

更新日期：2012-09-01 00:00:00

abstract：:Although no universal definition exists, decompensated heart failure may be regarded as either a worsening of chronic heart failure or new-onset heart failure precipitated by an acute incident. Haemodynamic management of patients hospitalised with decompensated heart failure may include the administration of diuretics...

journal_title：European journal of heart failure

authors： Greenberg B,Borghi C,Perrone S

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Although discontinuation of chronic ACE inhibitor (ACEi) therapy after myocardial infarction (MI) is common in clinical practice, some clinical studies reported an increased incidence of ischemia-related events after withdrawal. To further address this issue, we assessed hemodynamic, neurohormonal and vascul...

journal_title：European journal of heart failure

authors： Westendorp B,Schoemaker RG,Buikema H,Boomsma F,van Veldhuisen DJ,van Gilst WH

更新日期：2006-03-01 00:00:00

abstract：AIMS:This study aimed to determine the prognostic value of serum uric acid (SUA) on outcomes in heart failure (HF) with preserved ejection fraction (HFpEF), and whether sacubitril-valsartan reduces SUA and use of SUA-related therapies. METHODS AND RESULTS:We analysed 4795 participants from the Prospective Comparison o...

journal_title：European journal of heart failure

authors： Selvaraj S,Claggett BL,Pfeffer MA,Desai AS,Mc Causland FR,McGrath MM,Anand IS,van Veldhuisen DJ,Kober L,Janssens S,Cleland JGF,Pieske B,Rouleau JL,Zile MR,Shi VC,Lefkowitz MP,McMurray JJV,Solomon SD

更新日期：2020-11-01 00:00:00

abstract：AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...

journal_title：European journal of heart failure

authors： Bowen TS,Rolim NP,Fischer T,Baekkerud FH,Medeiros A,Werner S,Brønstad E,Rognmo O,Mangner N,Linke A,Schuler G,Silva GJ,Wisløff U,Adams V,Optimex Study Group.

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that discharge planning and post-discharge support for CHF patients can contribute greatly to the medical management of heart failure (CHF) in the community and that the quality of the CHF patient's close personal relationships can influence outcome in CHF. However, there has bee...

journal_title：European journal of heart failure

authors： Molloy GJ,Johnston DW,Witham MD

更新日期：2005-06-01 00:00:00