Abstract:
AIMS:In amyloid patients, cardiac involvement dramatically worsens functional capacity and prognosis. We sought to study how the cardiopulmonary exercise test (CPET) could help in functional assessment and risk stratification of patients with cardiac amyloidosis (CA). METHODS AND RESULTS:We carried out a multicentre study including patients with light chain (AL) or transthyretin (TTR) CA. All patients underwent exhaustive examination including CPET and follow-up. The primary prognostic endpoint was the occurrence of death or heart failure hospitalization. Overall, 150 patients were included (91 AL and 59 TTR CA). Median age, systolic blood pressure, N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin T were 70 (64-78) years, 121 [interquartile range (IQR) 109-139] mmHg, 2806 (IQR 1218-4638) ng/L and 64 (IQR 33-120) ng/L, respectively. New York Heart Association classes were I-II in 64%. Median peak oxygen consumption (VO2 ) and circulatory power were low at 13.0 (10.0-16.9) mL/kg/min and 1730 (1318-2614) mmHg/mL/min, respectively. The minute ventilation/carbon dioxide production slope was increased to 37 (IQR 33-45). A total of 77 patients (51%) had chronotropic insufficiency. After a median follow-up of 20 months, there were 37 deaths and 44 heart failure hospitalizations. At multivariate Cox analysis, peak VO2 ≤13 mL/kg/min [hazard ratio (HR) 2.7, 95% confidence interval (CI) 1.6-4.8], circulatory power ≤1730 mmHg/mL/min (HR 2.4, 95% CI 1.2-4.6) and NT-proBNP ≥1800 ng/L (HR 2.2, 95% CI 1.1-4.3) were found to be associated with the primary outcome. No events occurred in patients with both peak VO2 >13 mL/kg/min and NT-proBNP <1800 ng/L, while the association of VO2 ≤13 mL/kg/min with NT-proBNP ≥1800 ng/L identified a very high-risk subgroup. CONCLUSION:In CA, CPET is helpful in assessing functional capacity, circulatory and chronotropic responses as well as the prognosis of patients along with cardiac biomarkers.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Nicol M,Deney A,Lairez O,Vergaro G,Emdin M,Carecci A,Inamo J,Montfort A,Neviere R,Damy T,Harel S,Royer B,Baudet M,Cohen-Solal A,Arnulf B,Logeart Ddoi
10.1002/ejhf.2016subject
Has Abstractpub_date
2020-10-02 00:00:00eissn
1388-9842issn
1879-0844pub_type
杂志文章abstract:AIMS:To determine the impact of internationally recognized criteria for the diagnosis of heart failure with preserved ejection fraction (HF-PEF) on the feasibility of recruitment into a HF-PEF trial. METHODS AND RESULTS:We reviewed the medical records of 5883 consecutive patients admitted with heart failure across eig...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.106
更新日期:2014-07-01 00:00:00
abstract:AIM:To describe differences in patient characteristics and outcomes by ethnicity in patients with diabetes mellitus (DM) and heart failure (HF) with reduced ejection fraction (HFrEF, ejection fraction ≤35%) in a multi-ethnic cohort. METHODS AND RESULTS:Patient level data from two cohorts (HF-ACTION and ASIAN-HF) were ...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ejhf.1223
更新日期:2018-09-01 00:00:00
abstract:AIMS:Liver X receptors (LXRs) transcriptionally regulate inflammation, metabolism, and immunity. Synthetic LXR agonists have been evaluated for their efficacy in the cardiovascular system; however, they elicit prolipogenic side effects which substantially limit their therapeutic use. AZ876 is a novel high-affinity LXR ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.243
更新日期:2015-03-01 00:00:00
abstract:AIMS:Heart failure (HF) quality registries report quality of care but it is unknown whether they improve outcomes. The aims were to assess predictors of enrolment in a HF registry, test the hypothesis that enrolment in a HF registry is associated with reduced mortality, and assess potential explanatory factors for this...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.762
更新日期:2017-09-01 00:00:00
abstract:AIMS:To determine the effects of a nurse-led intervention designed to improve self-management of patients with heart failure in a primary health care setting regarding health-related quality of life and depression. METHODS:Patients at eight primary health care centres were screened by the Diagnosis Related Groups regi...
journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ejheart.2004.01.016
更新日期:2005-03-16 00:00:00
abstract:AIMS:Chronic heart failure (CHF) due to left ventricular systolic dysfunction is associated with poor quality of life (QoL). This study aimed to assess factors affecting health-related QoL in CHF patients and their carers and the impact of QoL on clinical outcomes. METHODS AND RESULTS:Demographic, social, and clinical...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfq114
更新日期:2010-09-01 00:00:00
abstract:AIMS:The purpose of this study was to determine that the administration of an angiotensin converting enzyme (ACE) inhibitor enalapril would confer protection against doxorubicin-induced experimental heart failure, and attenuate the development of left ventricular dysfunction. METHODS:Seventeen dogs were chronically in...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00091-0
更新日期:2002-10-01 00:00:00
abstract:AIMS:Left ventricular contractile reserve is a prognostic indicator for adverse outcome in patients with severe chronic heart failure with reduced ejection fraction (HFrEF). We investigated the dobutamine-induced changes of LV multidimensional deformation and their predictive value for cardiac mortality of patients wit...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.787
更新日期:2017-07-01 00:00:00
abstract:AIMS:To investigate the relationship between decongestion, central venous pressure, and risk of worsening renal function (WRF) in patients with acute decompensated heart failure (ADHF). METHODS AND RESULTS:We studied 475 patients with ADHF, of whom 238 underwent right heart catheterization. Right atrial pressure (RAP)...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurjhf/hft036
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:The incidence of ventricular tachyarrhythmias in ICD patients with cardiac resynchronisation therapy (CRT-D) is not well studied. AIM:To analyse event free survival in CRT-D patients with a primary or a secondary prophylactic ICD indication. METHODS:Prospective, single centre. Eighty-six patients, 44% with...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2005.05.006
更新日期:2005-10-01 00:00:00
abstract::This article provides information and a commentary on trials presented at the American Heart Association meeting held in November 2005, relevant to the pathophysiology, prevention and treatment of heart failure. All reports should be considered as preliminary data, as analyses may change in the final publication. In R...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2005.12.003
更新日期:2006-01-01 00:00:00
abstract:AIMS:Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.706
更新日期:2017-03-01 00:00:00
abstract:AIMS:To assess adherence to medical treatment in patients with heart failure (HF) using a specific questionnaire and measurement of the serum concentration of digoxin. METHODS AND RESULTS:Forty patients with symptomatic HF and a clinical indication for digoxin were included in this pilot study. The assessment of adher...
journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1093/eurjhf/hfq015
更新日期:2010-04-01 00:00:00
abstract:AIMS:Urine proteome analysis (UPA) has already provided accurate discriminatory patterns of urinary peptides for renal disease, coronary artery disease, and asymptomatic LV diastolic dysfunction. UPA has now been used to characterize a discriminatory peptide biomarker pattern and establish a diagnostic classifier for h...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.544
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the utility of NT-proBNP in the emergency diagnosis and in-hospital monitoring of patients with acute dyspnoea and ventricular dysfunction. BACKGROUND:Misdiagnosis of heart failure (HF) is common in the urgent care setting using clinical diagnostic tests. Reports show that BNP is useful to diagno...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2003.12.013
更新日期:2004-03-15 00:00:00
abstract::The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly through the use of diuretic therapy. The appropriate use of diuretic...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1002/ejhf.1369
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Bifocal pacing (BFP) has been proposed as a feasible alternative to cardiac resynchronization therapy. AIM:To evaluate BFP in patients with severe heart failure and significant intraventricular conduction delay and to compare it with biventricular pacing (BVP). METHODS:Echocardiographic examination includi...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2006.09.003
更新日期:2007-03-01 00:00:00
abstract::Heart failure (HF) in elderly patients is associated with more diffuse symptoms and signs due to the presence of other noncardiac comorbidities. This can cause difficulties in assessing the correct diagnosis and initiating appropriate therapy. The four most frequently occurring noncardiac comorbidities and therapies u...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2005.01.008
更新日期:2005-03-16 00:00:00
abstract:BACKGROUND:Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS:7060 subjects with two or more visits in the Reykjavík Study were followed--during 30 years from 1967. All underwent oral glucose toler...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2007.07.017
更新日期:2007-10-01 00:00:00
abstract:AIMS:Endothelial dysfunction has been shown to correlate with severity of congestive heart failure (CHF) and recent data suggest morphological changes of peripheral vasculature to be associated with the syndrome. We therefore investigated the hypothesis that vascular remodeling is associated with functional changes in ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.04.008
更新日期:2005-01-01 00:00:00
abstract:AIMS:The Exercise Joins Education: Combined Therapy to Improve Outcomes in Newly-discharged Heart Failure (EJECTION-HF) study will evaluate the impact of a supervised exercise training programme (ETP) on clinical outcomes in recently hospitalized heart failure patients attending a disease management programme (DMP). Me...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurjhf/hfr139
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Chronic heart failure (CHF) is common and is frequently managed by primary care physicians (PCPs). Despite the European Society of Cardiology (ESC) Guidelines, standard treatments for CHF are frequently underutilised, particularly in primary care. AIM:To evaluate current drug therapy for CHF in adults with ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.09.003
更新日期:2004-10-01 00:00:00
abstract::Anti-beta-1-adrenergic receptor antibodies (anti-β1AR Abs) have long been implicated in the pathogenesis of dilated cardiomyopathy (DCM). It is believed that these autoantibodies bind to and constitutively stimulate the β1AR to promote pathological cardiac remodelling and β1AR desensitization and downregulation. The p...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1093/eurjhf/hft065
更新日期:2013-07-01 00:00:00
abstract::The incidence and prevalence of cardiovascular disease increases progressively with advancing age. Cardiovascular disease is a major cause of morbidity and mortality in Western Countries. In the near future, as the population ages, it is expected that the population prevalence of cardiovascular disease will increase d...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2008.08.007
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND AND AIM:The choice of optimal treatment strategy in patients with coronary artery disease (CAD) and severe left ventricular (LV) dysfunction is often difficult. The aim of this study was to compare long-term results of patients with chronic CAD, severe heart failure and a defined scope of myocardial viabilit...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00089-2
更新日期:2003-01-01 00:00:00
abstract::COMBAT is a prospective, multicenter, randomized, blinded clinical study, with crossover design. The main objective is the comparative evaluation of atrio-biventricular versus conventional atrioventricular stimulation (atrio and right ventricle) in patients with heart failure and bradycardia as the primary indication ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.06.008
更新日期:2005-03-02 00:00:00
abstract::Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is associated with increased mortality. Impaired renal function is also a risk factor for developing HFpEF. A new paradigm for HFpEF, proposing a sequence of events leading to myocardial remodelling and dysfunction in HFpEF, was ...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1002/ejhf.497
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Serial measurements of N-terminal pro brain natriuretic peptide (NT-proBNP) have been suggested for the management of outpatients with chronic heart failure (CHF). The relationship between NT-proBNP plasma levels and central haemodynamic parameters in this setting is not known. METHODS:In 19 outpatients wit...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2006.03.002
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVES:To compare the efficacy of the homeopathic Crataegus preparation Cralonin for non-inferiority to standard treatment for mild cardiac insufficiency. METHODS:Multicentre non-randomised cohort study in patients aged 50-75 years in New York Heart Association class II. Patients received Cralonin (n=110) or ACE i...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
doi:10.1016/s1388-9842(02)00237-4
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:The rate constant for global fatty acid influx (k(1)) was studied in 12 male patients with dilated cardiomyopathy (DCM). METHOD:10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions. RESULTS...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00024-7
更新日期:2002-08-01 00:00:00