Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.

abstract：AIMS:Myostatin inhibits myoblast differentiation/proliferation and may play a role in heart failure (HF) and reverse remodelling after left ventricular assist device (LVAD) support. This study sought to characterize myostatin expression and activation in advanced HF before and after LVAD support. METHODS AND RESULTS:L...

journal_title：European journal of heart failure

authors： George I,Bish LT,Kamalakkannan G,Petrilli CM,Oz MC,Naka Y,Sweeney HL,Maybaum S

更新日期：2010-05-01 00:00:00

abstract：AIMS:Severe heart failure (HF) is often associated with cachexia that reverses post-heart transplantation (HTx) with frequent development of obesity. Ghrelin is a novel appetite-stimulating hormone. The aim was to determine the role of ghrelin in regulating appetite, food intake, and body composition in HF and post-HTx...

journal_title：European journal of heart failure

authors： Lund LH,Williams JJ,Freda P,LaManca JJ,LeJemtel TH,Mancini DM

更新日期：2009-08-01 00:00:00

abstract：AIM:Evaluation of N-terminal pro-brain natriuretic peptide (NT-proBNP) to confirm or disprove heart failure in community patients complaining of dyspnoea. METHODS AND RESULTS:General practitioners referred 345 consecutive patients complaining of dyspnoea to our hospital-based clinic, where a diagnosis was established ...

journal_title：European journal of heart failure

authors： Nielsen LS,Svanegaard J,Klitgaard NA,Egeblad H

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Long-term prognosis of coronary artery disease (CAD) patients is worsened when stress ischemia persists on treatment, but the relationship with adverse cardiac remodelling had never been investigated. AIM:To analyze changes in blood markers of fibrosis in patients with chronic CAD exhibiting exercise ischae...

journal_title：European journal of heart failure

authors： Radauceanu A,Moulin F,Djaballah W,Marie PY,Alla F,Dousset B,Virion JM,Capiaumont J,Karcher G,Aliot E,Zannad F

更新日期：2007-04-01 00:00:00

abstract：AIMS:The present study aimed to assess the association between left atrial (LA) structure and function and the risk for cardiovascular (CV) death or heart failure (HF) hospitalization in a population with atrial fibrillation (AF). METHODS AND RESULTS:In a prospective echocardiographic substudy of the Effective Anticoa...

journal_title：European journal of heart failure

authors： Inciardi RM,Giugliano RP,Claggett B,Gupta DK,Chandra A,Ruff CT,Antman EM,Mercuri MF,Grosso MA,Braunwald E,Solomon SD,ENGAGE AF-TIMI 48 Investigators.

更新日期：2019-12-01 00:00:00

abstract：UNLABELLED:We compare the effectiveness of direct adenoviral angiopoietin-1 (Ad-Ang-1) injection with transplantation of skeletal myoblasts (SkMs) over-expressing angiopoietin-1 (Ang-1) for angiogenic response and improvement of heart function in an experimental porcine model of myocardial infarction (MI). METHODS:Ad-...

journal_title：European journal of heart failure

authors： Ye L,Haider HKh,Jiang S,Tan RS,Toh WC,Ge R,Sim EK

更新日期：2007-05-01 00:00:00

abstract：AIMS:Left ventricular contractile reserve is a prognostic indicator for adverse outcome in patients with severe chronic heart failure with reduced ejection fraction (HFrEF). We investigated the dobutamine-induced changes of LV multidimensional deformation and their predictive value for cardiac mortality of patients wit...

journal_title：European journal of heart failure

authors： Paraskevaidis IA,Ikonomidis I,Simitsis P,Parissis J,Stasinos V,Makavos G,Lekakis J

更新日期：2017-07-01 00:00:00

abstract：AIMS:Women with heart failure (HF) are under-represented in individual randomized clinical trials (RCTs). Little is known about sex-specific treatment effects in HF medications. We evaluated sex differences in the response to mineralocorticoid receptor antagonists (MRAs) in major HF MRA trials, including a broad spectr...

journal_title：European journal of heart failure

authors： Rossello X,Ferreira JP,Pocock SJ,McMurray JJV,Solomon SD,Lam CSP,Girerd N,Pitt B,Rossignol P,Zannad F

更新日期：2020-05-01 00:00:00

abstract：AIMS:Reliable detectors of worsening renal function (WRF) in Emergency Department (ED) patients with acute heart failure (AHF) are limited. We hypothesized that initial urinary neutrophil gelatinase-associated lipocalcin (NGAL) levels, and changes in urinary NGAL levels after initial ED AHF therapy, would be associated...

journal_title：European journal of heart failure

authors： Collins SP,Hart KW,Lindsell CJ,Fermann GJ,Weintraub NL,Miller KF,Roll SN,Sperling MI,Sawyer DB,Storrow AB

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Most patients suspected of having heart failure (HF) will get a 12-lead electrocardiogram (ECG) but its utility for excluding HF or assisting in its management has rarely been investigated. METHODS:The EuroHeart Failure survey identified 11,327 patients hospitalised with a suspected diagnosis of HF from 115...

journal_title：European journal of heart failure

authors： Khan NK,Goode KM,Cleland JG,Rigby AS,Freemantle N,Eastaugh J,Clark AL,de Silva R,Calvert MJ,Swedberg K,Komajda M,Mareev V,Follath F,EuroHeart Failure Survey Investigators.

更新日期：2007-05-01 00:00:00

abstract：AIMS:Risk stratification in patients admitted with worsening heart failure (HF) is essential for tailoring therapy and counselling. Risk models are available but rarely used, in part because many require laboratory and imaging results that are not routinely available. Body temperature is associated with prognosis in ot...

journal_title：European journal of heart failure

authors： Payvar S,Spertus JA,Miller AB,Casscells SW,Pang PS,Zannad F,Swedberg K,Maggioni AP,Reid KJ,Gheorghiade M,Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) Investigators.

更新日期：2013-12-01 00:00:00

abstract：AIMS:To test the hypothesis that an earlier post-acute myocardial infarction (AMI) eplerenone initiation in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) is associated with better long-term outcomes. METHODS AND RESULTS:The 6632 patients of the EPHESUS study were randomized from day...

journal_title：European journal of heart failure

authors： Adamopoulos C,Ahmed A,Fay R,Angioi M,Filippatos G,Vincent J,Pitt B,Zannad F,EPHESUS Investigators.

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Chronic heart failure (CHF) is a complex syndrome, in which reactive oxygen species and inflammatory cytokines are important stressors that contribute to the pathogenesis. AIM:We have studied physiological stress response parameters in CHF, in particular the redox-active regulator thioredoxin. SUBJECTS:A c...

journal_title：European journal of heart failure

authors： Jekell A,Hossain A,Alehagen U,Dahlström U,Rosén A

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Hospital management of CHF and predictors of hospital mortality remain unclear. METHODS:To address these issues, we analyzed the hospital admissions for CHF during 1996 in a large university hospital. Patients discharged with the principal diagnosis of CHF were considered eligible for the study. RESULTS:Am...

journal_title：European journal of heart failure

authors： Grigioni F,Carinci V,Favero L,Bacchi Reggiani L,Magnani G,Potena L,Barbieri A,Magelli C,Branzi A,Magnani B

更新日期：2002-01-01 00:00:00

abstract：AIMS:Recent studies have shown that microRNAs (miRNAs), besides being potent regulators of gene expression, can additionally serve as circulating biomarkers of disease. The aim of this study is to determine if plasma miRNAs can be used as indicators of disease progression or therapeutic efficacy in hypertension-induced...

journal_title：European journal of heart failure

authors： Dickinson BA,Semus HM,Montgomery RL,Stack C,Latimer PA,Lewton SM,Lynch JM,Hullinger TG,Seto AG,van Rooij E

更新日期：2013-06-01 00:00:00

abstract：AIMS:The true incidence of life-threatening ventricular tachyarrhythmic events and the risk of sudden cardiac death in the early stage of peripartum cardiomyopathy (PPCM) are still unknown. We aimed to assess the usefulness of the wearable cardioverter/defibrillator (WCD) to bridge a potential risk for life-threatening...

journal_title：European journal of heart failure

authors： Duncker D,Haghikia A,König T,Hohmann S,Gutleben KJ,Westenfeld R,Oswald H,Klein H,Bauersachs J,Hilfiker-Kleiner D,Veltmann C

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Clinical trials, the gold standard for the evaluation of new therapeutic strategies, may prove a drug to be beneficial, harmful or neutral according to its effect on the end-point(s) under study. AIMS:To study the reaction and perspective of the patients participating in a clinical heart failure trial, part...

journal_title：European journal of heart failure

authors： Yuval R,Uziel K,Gordon N,Merdler A,Khader N,Karkabi B,Flugelman MY,Halon DA,Lewis BS

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:The rate constant for global fatty acid influx (k(1)) was studied in 12 male patients with dilated cardiomyopathy (DCM). METHOD:10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions. RESULTS...

journal_title：European journal of heart failure

authors： Miche E,Radzewitz A,Notohamiprodjo G,Baller D,Kloppe A,Eckert S,Gleichmann U

更新日期：2002-08-01 00:00:00

abstract：AIMS:Calcium channel plays an important role in the autoimmune pathogenesis of idiopathic dilated cardiomyopathy (DCM). Autoantibodies have emerged as a new upstream target of sudden death in DCM. We sought to validate the hypothesis that autoantibodies against l-type calcium channel (CC-AAbs) are arrhythmogenic and le...

journal_title：European journal of heart failure

authors： Xiao H,Wang M,Du Y,Yuan J,Cheng X,Chen Z,Zou A,Wei F,Zhao G,Liao YH

更新日期：2011-03-01 00:00:00

abstract：AIMS:Supervised exercise can benefit selected patients with heart failure, however the effectiveness of home-based exercise remains uncertain. We aimed to assess the effectiveness of a home-based exercise programme in addition to specialist heart failure nurse care. METHODS AND RESULTS:This was a randomized controlled...

journal_title：European journal of heart failure

authors： Jolly K,Taylor RS,Lip GY,Davies M,Davis R,Mant J,Singh S,Greenfield S,Ingram J,Stubley J,Bryan S,Stevens A

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The epidemiology of heart failure in Arabia, with a population different from the West in cultural and ethnic origin, has not been studied before. AIMS:To determine the prevalence and aetiologies of symptomatic heart failure in an indigenous Arab population over a 3-year period. METHODS:All patients with h...

journal_title：European journal of heart failure

authors： Agarwal AK,Venugopalan P,de Bono D

更新日期：2001-06-01 00:00:00

abstract：AIMS:Beta-blockers (BBs) improve outcomes in heart failure. Results from the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) trial previously demonstrated the feasibility of heart rate, not maximum dose, as a treatment goal. In this pre-specified analysis, we investigated the prognostic value of achieved ...

journal_title：European journal of heart failure

authors： Düngen HD,Musial-Bright L,Inkrot S,Apostolović S,Edelmann F,Lainščak M,Sekularac N,Störk S,Tahirovic E,Tscholl V,Krackhardt F,Loncar G,Trippel TD,Gelbrich G

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:Regional presynaptic sympathetic innervation varies considerably in the cardiomyopathic human heart, as shown in previous studies in vivo and in vitro. The goal of the present study was to correlate markers of presynaptic sympathetic innervation with local measurement of the postsynaptic beta-adrenergic syst...

journal_title：European journal of heart failure

authors： Ungerer M,Weig HJ,Kübert S,Overbeck M,Bengel F,Schömig A,Schwaiger M

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Information about the occurrence of heart failure in the acute phase of myocardial infarction (MI) in diabetic patients and its impact on prognosis are sparse. AIM:The purpose of the present study was to describe how MI patients with diabetes mellitus (DM) differed from MI patients without DM with respect t...

journal_title：European journal of heart failure

authors： Melchior T,Rask-Madsen C,Torp-Pedersen C,Hildebrandt P,Køber L,Jensen G

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:In heart failure (HF), changes in lung mechanics and gas diffusion are limiting factors to exercise. Their contribution to an increased exercise ventilation to CO2 production (VE/VCO2) slope is undefined. METHODS:A total of 67 stable HF patients underwent cardiopulmonary exercise and pulmonary function test...

journal_title：European journal of heart failure

authors： Guazzi M,Reina G,Tumminello G,Guazzi MD

更新日期：2005-10-01 00:00:00

abstract：AIMS:The left ventricular phenotype of idiopathic dilated cardiomyopathy (DCM) can appear similar in paediatric and adult patients. However, the aetiology of paediatric DCM is usually idiopathic, and often leads an aggressive clinical course. A structural underpinning of DCM is extracellular matrix changes, which are d...

journal_title：European journal of heart failure

authors： Hsia TY,Ringewald JM,Stroud RE,Forbus GA,Bradley SM,Chung WK,Spinale FG

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS:7060 subjects with two or more visits in the Reykjavík Study were followed--during 30 years from 1967. All underwent oral glucose toler...

journal_title：European journal of heart failure

authors： Thrainsdottir IS,Aspelund T,Gudnason V,Malmberg K,Sigurdsson G,Thorgeirsson G,Hardarson T,Rydén L

更新日期：2007-10-01 00:00:00

abstract：AIMS:Remote patient management (telemonitoring) may help to detect early signs of cardiac decompensation, allowing optimization of and adherence to treatments in chronic heart failure (CHF). Two meta-analyses have suggested that telemedicine in CHF can reduce mortality by 30-35%. The aim of the TIM-HF study was to inve...

journal_title：European journal of heart failure

authors： Koehler F,Winkler S,Schieber M,Sechtem U,Stangl K,Böhm M,Boll H,Kim SS,Koehler K,Lücke S,Honold M,Heinze P,Schweizer T,Braecklein M,Kirwan BA,Gelbrich G,Anker SD,TIM-HF Investigators.

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:New-onset atrial fibrillation (AF) after acute myocardial infarction (AMI) frequently occurs in association with postinfarction complications, particularly with heart failure (HF). AIMS:To evaluate whether postinfarction HF is associated with the subsequent development of AF and whether AF independently pre...

journal_title：European journal of heart failure

authors： Asanin M,Perunicic J,Mrdovic I,Matic M,Vujisic-Tesic B,Arandjelovic A,Vasiljevic Z,Ostojic M

更新日期：2005-06-01 00:00:00

abstract：:Myocardial fibrosis is the result of excessive fibrillar collagen synthesis and deposition without reciprocally balanced degradation. It causes cardiac dysfunction, arrhythmias, and ischaemia, and thereby determines the clinical course and outcome of cardiac patients even when adequately treated. Therefore, further re...

journal_title：European journal of heart failure

authors： Heymans S,González A,Pizard A,Papageorgiou AP,López-Andrés N,Jaisser F,Thum T,Zannad F,Díez J

更新日期：2015-08-01 00:00:00