当前位置： SCI文献检索 > EUROPEAN JOURNAL OF HEART FAILURE期刊下所有文献 > Arrhythmogenic autoantibodies against calcium channel lead to sudden death in idiopathic dilated cardiomyopathy.

Arrhythmogenic autoantibodies against calcium channel lead to sudden death in idiopathic dilated cardiomyopathy.

Abstract：

AIMS:Calcium channel plays an important role in the autoimmune pathogenesis of idiopathic dilated cardiomyopathy (DCM). Autoantibodies have emerged as a new upstream target of sudden death in DCM. We sought to validate the hypothesis that autoantibodies against l-type calcium channel (CC-AAbs) are arrhythmogenic and lead to sudden death in patients with DCM. METHODS AND RESULTS:We investigated sudden death and ventricular arrhythmias in 80 patients with DCM in a prospective, case follow-up survey. During a follow-up of 32 (SD 8) months, CC-AAbs-positive patients not only had a higher incidence of ventricular tachycardia (VT) but also a higher incidence of sudden death than CC-AAbs-negative patients (for VT: 59.0 vs. 24.4%, P = 0.002 and for sudden death: 20.5 vs. 4.9%, P = 0.045). Further univariate and multivariate analyses showed that the occurrence of CC-AAbs was the strongest independent predictor for sudden death (odds ratio: 10.20, 95% confidence interval: 2.43-36.78, P = 0.0027). Experimental studies in ex vivo systems using affinity-purified CC-AAbs from patients demonstrated that CC-AAbs were able to induce VT by prolongation of action potential duration (APD) and triggered activity by early afterdepolarization (EAD). CONCLUSION:Our results demonstrate for the first time to our knowledge that there is a high incidence of sudden death and VT in CC-AAbs-positive patients with DCM. Furthermore, experimental data from ex vivo systems suggest that CC-AAbs might induce VT by prolongation of APD and triggered activity by EAD.

journal_name

Eur J Heart Fail

journal_title

European journal of heart failure

authors

Xiao H,Wang M,Du Y,Yuan J,Cheng X,Chen Z,Zou A,Wei F,Zhao G,Liao YH

doi

10.1093/eurjhf/hfq198

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

264-70

issue

3

eissn

1388-9842

issn

1879-0844

pii

hfq198

journal_volume

13

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF HEART FAILURE文献大全
  • Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials.

    abstract：:Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in card...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,评审

    doi：10.1002/ejhf.1557

    authors： Ahmad T,Miller PE,McCullough M,Desai NR,Riello R,Psotka M,Böhm M,Allen LA,Teerlink JR,Rosano GMC,Lindenfeld J

    更新日期：2019-09-01 00:00:00

  • MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure.

    abstract：AIMS:Differentiation of heart failure with reduced (HFrEF) or preserved (HFpEF) ejection fraction independent of echocardiography is challenging in the community. Diagnostic strategies based on monitoring circulating microRNA (miRNA) levels may prove to be of clinical value in the near future. The aim of this study was...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.244

    authors： Watson CJ,Gupta SK,O'Connell E,Thum S,Glezeva N,Fendrich J,Gallagher J,Ledwidge M,Grote-Levi L,McDonald K,Thum T

    更新日期：2015-04-01 00:00:00

  • Circulating proteins as predictors of incident heart failure in the elderly.

    abstract：AIMS:To identify novel risk markers for incident heart failure using proteomic profiling of 80 proteins previously associated with cardiovascular pathology. METHODS AND RESULTS:Proteomic profiling (proximity extension assay) was performed in two community-based prospective cohorts of elderly individuals without heart ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ejhf.980

    authors： Stenemo M,Nowak C,Byberg L,Sundström J,Giedraitis V,Lind L,Ingelsson E,Fall T,Ärnlöv J

    更新日期：2018-01-01 00:00:00

  • Elevated urinary neutrophil gelatinase-associated lipocalcin after acute heart failure treatment is associated with worsening renal function and adverse events.

    abstract：AIMS:Reliable detectors of worsening renal function (WRF) in Emergency Department (ED) patients with acute heart failure (AHF) are limited. We hypothesized that initial urinary neutrophil gelatinase-associated lipocalcin (NGAL) levels, and changes in urinary NGAL levels after initial ED AHF therapy, would be associated...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfs087

    authors： Collins SP,Hart KW,Lindsell CJ,Fermann GJ,Weintraub NL,Miller KF,Roll SN,Sperling MI,Sawyer DB,Storrow AB

    更新日期：2012-09-01 00:00:00

  • European Society of Cardiology Working Group on Adult Congenital Heart Disease and Study Group for Adult Congenital Heart Care in Central and South Eastern European Countries consensus paper: current status, provision gaps and investment required.

    abstract：AIMS:To examine the current status of care and needs of adult congenital heart disease (ACHD) services in the Central and South Eastern European (CESEE) region. METHODS AND RESULTS:We obtained data regarding the national ACHD status for 19 CESEE countries from their ACHD representative based on an extensive survey for...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.2040

    authors： Brida M,Šimkova I,Jovović L,Prokšelj K,Antonová P,Balint HO,Gumbiene L,Lebid IH,Komar M,Kratunkov P,Kovačević Preradović T,Ermel R,Strenge A,Coman IM,Vukomanović V,Gatzoulis MA,Roos-Hesselink JW,Diller GP

    更新日期：2020-11-02 00:00:00

  • Right ventricular dysfunction is an independent predictor for mortality in ST-elevation myocardial infarction patients presenting with cardiogenic shock on admission.

    abstract：AIMS:Despite improvement in prognosis for ST-elevation myocardial infarction (STEMI) patients, mortality remains high in STEMI patients presenting with cardiogenic shock (CS). Right ventricular (RV) dysfunction is an established independent predictor for adverse prognosis in STEMI patients without CS. The purpose of ou...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfp204

    authors： Engström AE,Vis MM,Bouma BJ,van den Brink RB,Baan J Jr,Claessen BE,Kikkert WJ,Sjauw KD,Meuwissen M,Koch KT,de Winter RJ,Tijssen JG,Piek JJ,Henriques JP

    更新日期：2010-03-01 00:00:00

  • Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties.

    abstract：:Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbid...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,评审

    doi：10.1093/eurjhf/hft129

    authors： Dobre D,Borer JS,Fox K,Swedberg K,Adams KF,Cleland JG,Cohen-Solal A,Gheorghiade M,Gueyffier F,O'Connor CM,Fiuzat M,Patak A,Piña IL,Rosano G,Sabbah HN,Tavazzi L,Zannad F

    更新日期：2014-01-01 00:00:00

  • Adaptive servoventilation improves cardiac function in patients with chronic heart failure and Cheyne-Stokes respiration.

    abstract：BACKGROUND AND AIMS:Sleep disordered breathing (SDB), especially Cheyne-Stokes respiration (CSR) is common in patients with chronic heart failure (CHF). Adaptive servoventilation (ASV) was recently introduced to treat CSR in CHF. The aim of this study was to investigate the effects of ASV on CSR and CHF parameters. ME...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2008.04.007

    authors： Oldenburg O,Schmidt A,Lamp B,Bitter T,Muntean BG,Langer C,Horstkotte D

    更新日期：2008-06-01 00:00:00

  • Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel.

    abstract：AIMS:The objective of this study was to establish the acute effects of hypoxia on clinical, spirometric, haemodynamic, and echocardiographic variables. Reducing inspired oxygen to 15%, as experienced during commercial air travel, decreases arterial oxygen saturation, increases respiratory rate and pulmonary artery pres...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hft003

    authors： Hobkirk JP,Damy T,Walters M,Bennett A,Smith SJ,Ingle L,Clark AL,Cleland JG

    更新日期：2013-05-01 00:00:00

  • Telemedical Interventional Monitoring in Heart Failure (TIM-HF), a randomized, controlled intervention trial investigating the impact of telemedicine on mortality in ambulatory patients with heart failure: study design.

    abstract：AIMS:Remote patient management (telemonitoring) may help to detect early signs of cardiac decompensation, allowing optimization of and adherence to treatments in chronic heart failure (CHF). Two meta-analyses have suggested that telemedicine in CHF can reduce mortality by 30-35%. The aim of the TIM-HF study was to inve...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1093/eurjhf/hfq199

    authors： Koehler F,Winkler S,Schieber M,Sechtem U,Stangl K,Böhm M,Boll H,Kim SS,Koehler K,Lücke S,Honold M,Heinze P,Schweizer T,Braecklein M,Kirwan BA,Gelbrich G,Anker SD,TIM-HF Investigators.

    更新日期：2010-12-01 00:00:00

  • Efficacy of antithrombotic therapy in chronic heart failure: the HELAS study.

    abstract：BACKGROUND:It is not clear if long-term antithrombotic treatment has a beneficial effect on the incidence of thromboembolism in chronic heart failure (CHF). The HELAS study (Heart failure Long-term Antithrombotic Study) is a multicentre, randomised, double-blind, placebo-controlled trial to evaluate antithrombotic trea...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ejheart.2006.02.012

    authors： Cokkinos DV,Haralabopoulos GC,Kostis JB,Toutouzas PK,HELAS investigators.

    更新日期：2006-06-01 00:00:00

  • Incidence of cancer in patients with chronic heart failure: a long-term follow-up study.

    abstract：AIMS:With improvement in survival of chronic heart failure (HF), the clinical importance of co-morbidity is increasing. The aim of this study was to assess the incidence and risk of cancer and all-cause mortality in a large Danish HF cohort. METHODS AND RESULTS:A total of 9307 outpatients with verified HF without a pr...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.472

    authors： Banke A,Schou M,Videbaek L,Møller JE,Torp-Pedersen C,Gustafsson F,Dahl JS,Køber L,Hildebrandt PR,Gislason GH

    更新日期：2016-03-01 00:00:00

  • Left atrial enlargement and NT-proBNP as predictors of sudden cardiac death in patients with heart failure.

    abstract：AIMS:The identification of valuable markers of sudden cardiac death (SCD) in patients with established HF remains a challenge. We sought to assess the value of clinical, echocardiographic and biochemical variables to predict SCD in a consecutive cohort of patients with heart failure (HF) due to systolic dysfunction. M...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ejheart.2007.05.001

    authors： Bayes-Genis A,Vazquez R,Puig T,Fernandez-Palomeque C,Fabregat J,Bardají A,Pascual-Figal D,Ordoñez-Llanos J,Valdes M,Gabarrús A,Pavon R,Pastor L,Gonzalez Juanatey JR,Almendral J,Fiol M,Nieto V,Macaya C,Cinca J,Bayes de

    更新日期：2007-08-01 00:00:00

  • High prevalence of subclinical cerebral infarction in patients with heart failure with preserved ejection fraction.

    abstract：AIMS:Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS:We studied 1527 p...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.812

    authors： Cogswell RJ,Norby FL,Gottesman RF,Chen LY,Solomon S,Shah A,Alonso A

    更新日期：2017-10-01 00:00:00

  • Heart failure treatment up-titration and outcome and age: an analysis of BIOSTAT-CHF.

    abstract：AIMS:Several studies have shown that older patients with heart failure with reduced ejection fraction (HFrEF) are undertreated. The aim of this study was to evaluate the association of up-titration of angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB) and beta-blockers on outcome acros...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.1799

    authors： Mordi IR,Ouwerkerk W,Anker SD,Cleland JG,Dickstein K,Metra M,Ng LL,Samani NJ,van Veldhuisen DJ,Zannad F,Voors AA,Lang CC

    更新日期：2020-03-25 00:00:00

  • Low value of simple echocardiographic indices of ventricular dyssynchrony in predicting the response to cardiac resynchronization therapy.

    abstract：AIMS:A recent study suggested that no single echocardiographic index of cardiac dyssynchrony can reliably identify candidates for cardiac resynchronization therapy (CRT). We examined the value of three simple echocardiographic indices for predicting the 6-month clinical and echocardiographic responses to CRT. METHODS ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1093/eurjhf/hfq058

    authors： Bordachar P,Lafitte S,Réant P,Reuter S,Clementy J,Mletzko RU,Siegel RM,Goscinska-Bis K,Bowes R,Morgan J,Bénard S,Leclercq C

    更新日期：2010-06-01 00:00:00

  • Evolving concepts in dilated cardiomyopathy.

    abstract：:Dilated cardiomyopathy (DCM) represents a particular aetiology of systolic heart failure that frequently has a genetic background and usually affects young patients with few co-morbidities. The prognosis of DCM has improved substantially during the last decades due to more accurate aetiological characterization, the r...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,评审

    doi：10.1002/ejhf.1103

    authors： Merlo M,Cannatà A,Gobbo M,Stolfo D,Elliott PM,Sinagra G

    更新日期：2018-02-01 00:00:00

  • Quality of life in patients with chronic heart failure and their carers: a 3-year follow-up study assessing hospitalization and mortality.

    abstract：AIMS:Chronic heart failure (CHF) due to left ventricular systolic dysfunction is associated with poor quality of life (QoL). This study aimed to assess factors affecting health-related QoL in CHF patients and their carers and the impact of QoL on clinical outcomes. METHODS AND RESULTS:Demographic, social, and clinical...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfq114

    authors： Iqbal J,Francis L,Reid J,Murray S,Denvir M

    更新日期：2010-09-01 00:00:00

  • Vagal heart rate responses to chronic beta-blockade in human heart failure relate to cardiac norepinephrine spillover.

    abstract：:We have documented a pre-junctional beta-2 adrenoceptor mediated reduction in cardiac norepinephrine spillover (CNES) in heart failure patients receiving chronic beta-blockade. Our present objective was to ascertain the consequence of this decrease for vagal heart rate (HR) regulation by determining CNES, arterial bar...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2004.10.012

    authors： Kubo T,Parker JD,Azevedo ER,Atchison DJ,Newton GE,Picton P,Floras JS

    更新日期：2005-08-01 00:00:00

  • Idiopathic dilated cardiomyopathy exhibits defective vascularization and vessel formation.

    abstract：BACKGROUND:Ultrastructural findings of idiopathic dilated cardiomyopathy (IDCM) include myocyte atrophy and myofilament loss, yet little is known about the vascular abnormalities present in IDCM. METHODS AND RESULTS:Patients with IDCM and controls underwent multi-slice CT to examine length and diameter of epicardial v...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2007.07.008

    authors： Roura S,Planas F,Prat-Vidal C,Leta R,Soler-Botija C,Carreras F,Llach A,Hove-Madsen L,Pons Lladó G,Farré J,Cinca J,Bayes-Genis A

    更新日期：2007-10-01 00:00:00

  • Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.

    abstract：AIMS:Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF). Considering different treatment mechanisms underlying renin-angiotensin system (RAS) suppression and parasym...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.164

    authors： Li M,Zheng C,Kawada T,Inagaki M,Uemura K,Sugimachi M

    更新日期：2014-10-01 00:00:00

  • Outcome in patients with an ICD incorporating cardiac resynchronisation therapy: differences between primary and secondary prophylaxis.

    abstract：BACKGROUND:The incidence of ventricular tachyarrhythmias in ICD patients with cardiac resynchronisation therapy (CRT-D) is not well studied. AIM:To analyse event free survival in CRT-D patients with a primary or a secondary prophylactic ICD indication. METHODS:Prospective, single centre. Eighty-six patients, 44% with...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2005.05.006

    authors： Theuns DA,Thornton AS,Klootwijk AP,Scholten MF,Vantrimpont PJ,Balk AH,Jordaens LJ

    更新日期：2005-10-01 00:00:00

  • Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction.

    abstract：AIM:To evaluate the long-term outcome of patients with Takotsubo syndrome (TTS) and severely reduced left ventricular ejection fraction (LVEF ≤ 35%) at presentation. METHODS AND RESULTS:The study population included 326 patients (mean age 69.5 ± 10.7 years, 28 male) with TTS enrolled in the Takotsubo Italian Network, ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.1373

    authors： Citro R,Radano I,Parodi G,Di Vece D,Zito C,Novo G,Provenza G,Bellino M,Prota C,Silverio A,Antonini-Canterin F,Rigo F,Vriz O,Galasso G,Bossone E,Salerno-Uriarte J,Piscione F

    更新日期：2019-06-01 00:00:00

  • Clinical course after a first episode of heart failure: insights from the Framingham Heart Study.

    abstract：AIMS:We sought to describe the frequency, type and timing of clinical events, and delineate patterns in their transitions, after a first episode of heart failure (HF). METHODS AND RESULTS:In 1036 Framingham participants with new-onset HF (mean age 79 years; 53% women), we used mixture models to estimate probabilities ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.1918

    authors： Velagaleti RS,Larson MG,Enserro D,Song RJ,Vasan RS

    更新日期：2020-10-01 00:00:00

  • Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure.

    abstract：AIMS:Recent studies have shown that microRNAs (miRNAs), besides being potent regulators of gene expression, can additionally serve as circulating biomarkers of disease. The aim of this study is to determine if plasma miRNAs can be used as indicators of disease progression or therapeutic efficacy in hypertension-induced...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hft018

    authors： Dickinson BA,Semus HM,Montgomery RL,Stack C,Latimer PA,Lewton SM,Lynch JM,Hullinger TG,Seto AG,van Rooij E

    更新日期：2013-06-01 00:00:00

  • Low-dose nitroglycerin improves microcirculation in hospitalized patients with acute heart failure.

    abstract：AIMS:Impaired tissue perfusion is often observed in patients with acute heart failure. We tested whether low-dose nitroglycerin (NTG) improves microcirculatory perfusion in patients admitted for acute heart failure. METHODS AND RESULTS:In 20 acute heart failure patients, NTG was given as intravenous infusion at a fixe...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfp021

    authors： den Uil CA,Lagrand WK,Spronk PE,van der Ent M,Jewbali LS,Brugts JJ,Ince C,Simoons ML

    更新日期：2009-04-01 00:00:00

  • Serum digoxin concentration and outcomes in women with heart failure: A bi-directional effect and a possible effect modification by ejection fraction.

    abstract：BACKGROUND:The association between serum digoxin concentration (SDC) and outcomes in women with heart failure (HF) has not been well studied. AIMS:To test the hypothesis that the effect of digoxin on outcomes in women with HF is bi-directional and dependent on SDC, as in men, and is modified by ejection fraction (EF)....

    journal_title：European journal of heart failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ejheart.2005.10.002

    authors： Ahmed A,Aban IB,Weaver MT,Aronow WS,Fleg JL

    更新日期：2006-06-01 00:00:00

  • Left ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats.

    abstract：BACKGROUND:In most animal models of chronic hemodynamic overload of the left ventricle (LV) as well as in human end stage heart failure, the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) mRNA levels are decreased in parallel with increased atrial natriuretic peptide (ANP) mRNA levels. The situation in the remote my...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2004.10.007

    authors： Prunier F,Chen Y,Gellen B,Heimburger M,Choqueux C,Escoubet B,Michel JB,Mercadier JJ

    更新日期：2005-08-01 00:00:00

  • Effect of warfarin on survival in patients with concomitant left ventricular systolic dysfunction and pulmonary hypertension: a population cohort study.

    abstract：BACKGROUND:The use of oral anticoagulation in patients with heart failure in sinus rhythm remains controversial as previous large randomized controlled trials (RCTs) have not shown a survival benefit. However, heterogeneity exists among heart failure patients and it is possible that high-risk subgroups may benefit from...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.199

    authors： Goudie A,Elder D,Deshmukh H,Szwejkowski BR,Lang CC,George J

    更新日期：2015-01-01 00:00:00

  • A Rapid Access Heart Failure Clinic provides a prompt diagnosis and appropriate management of new heart failure presenting in the community.

    abstract：BACKGROUND AND AIMS:The diagnosis of heart failure is an important clinical problem and yet reported diagnostic accuracy in primary care is less than 50%. We established a Rapid Access Heart Failure Clinic (RAHFC) in a district general hospital serving a population of 292,000 in SE London, UK, to diagnose and manage ne...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/s1388-9842(00)00108-2

    authors： Fox KF,Cowie MR,Wood DA,Coats AJ,Poole-Wilson PA,Sutton GC

    更新日期：2000-12-01 00:00:00