Searching for new mechanisms of myocardial fibrosis with diagnostic and/or therapeutic potential.

abstract：:Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is associated with increased mortality. Impaired renal function is also a risk factor for developing HFpEF. A new paradigm for HFpEF, proposing a sequence of events leading to myocardial remodelling and dysfunction in HFpEF, was ...

journal_title：European journal of heart failure

authors： Ter Maaten JM,Damman K,Verhaar MC,Paulus WJ,Duncker DJ,Cheng C,van Heerebeek L,Hillege HL,Lam CS,Navis G,Voors AA

更新日期：2016-06-01 00:00:00

abstract：AIM:We used Near Infrared Spectrophotometry (NIRS) during arterial occlusion to measure resting skeletal muscle oxygen consumption in chronic heart failure (CHF) patients and in age-matched healthy volunteers (HVs). METHODS:Fifteen CHF patients (ten males) and eleven HVs (six males) had echocardiographic evaluation fo...

journal_title：European journal of heart failure

authors： Abozguia K,Phan TT,Shivu GN,Maher AR,Ahmed I,Wagenmakers A,Frenneaux MP

更新日期：2008-07-01 00:00:00

abstract：AIMS:The 'Hospital at home' (HaH) model avoids hospital admission by transferring healthcare and treatment to the patient's home. We aimed to compare the effectiveness and direct healthcare costs of treating elderly patients with decompensated heart failure (HF) using HaH care vs. inpatient hospital care (IHC) in a car...

journal_title：European journal of heart failure

authors： Mendoza H,Martín MJ,García A,Arós F,Aizpuru F,Regalado De Los Cobos J,Belló MC,Lopetegui P,Cia JM

更新日期：2009-12-01 00:00:00

abstract：:The use of erythropoietin (EPO) has revolutionized the treatment of anaemia associated with many conditions including chronic kidney disease (CKD). However, little is known of the cellular impact of EPO on the uraemic heart. The discovery that the EPO receptor (EPOR) is also expressed on non-haematopoietic cells inclu...

journal_title：European journal of heart failure

authors： Smith K,Semple D,Bhandari S,Seymour AM

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:High-sensitivity C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) and, in recent studies, incident heart failure (HF). Whether the association of inflammation with incident HF is explained by worse baseline left ventricular dysfunction or by underlying CHD is unkn...

journal_title：European journal of heart failure

authors： Williams ES,Shah SJ,Ali S,Na BY,Schiller NB,Whooley MA

更新日期：2008-01-01 00:00:00

abstract：AIMS:In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. METHOD...

journal_title：European journal of heart failure

authors： Wettersten N,Horiuchi Y,van Veldhuisen DJ,Mueller C,Filippatos G,Nowak R,Hogan C,Kontos MC,Cannon CM,Müeller GA,Birkhahn R,Taub P,Vilke GM,Barnett O,McDonald K,Mahon N,Nuñez J,Briguori C,Passino C,Murray PT,Maisel

更新日期：2019-12-01 00:00:00

abstract：UNLABELLED:Experimental data have shown that rIL2 has negative inotropic properties. This has not been investigated in humans with normal left ventricular function. Seventeen consecutive renal cell carcinoma patients who received rIL2 therapy because of dissemination were analyzed before and after treatment with a low ...

journal_title：European journal of heart failure

authors： Tio RA,Nieken J,de Vries EG,Pfeiffer C,de Jongste MJ,Pieper E,Moshage H,Limburg PC,Mulder NH

更新日期：2000-06-01 00:00:00

abstract：:Cardiac contractility modulating (CCM) signals delivered by the OPTIMIZER System are being investigated as a treatment for medically refractory heart failure. Previous chronic studies of CCM have excluded patients with prolonged QRS and a cardiac resynchronization therapy (CRT) device. However, symptoms persist in mor...

journal_title：European journal of heart failure

authors： Butter C,Meyhöfer J,Seifert M,Neuss M,Minden HH

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) improves symptoms, left ventricular ejection fraction (LVEF) and survival in patients with heart failure and wide QRS, however, long term clinical outcome is unknown. AIMS:To identify predictors of mortality and evaluate the effects of CRT after long term follow-up. ...

journal_title：European journal of heart failure

authors： Kronborg MB,Mortensen PT,Kirkfeldt RE,Nielsen JC

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Mechanical stress plays a crucial role in tissue morphogenesis and remodeling. These processes depend in part on force transmission mediated through integrins and the cytoskeleton. METHODS:Ventricular myocytes isolated from neonatal Sprague-Dawley rats (NRVMs) were exposed to persistent centrifugal force st...

journal_title：European journal of heart failure

authors： Yutao X,Geru W,Xiaojun B,Tao G,Aiqun M

更新日期：2006-01-01 00:00:00

abstract：AIMS:To determine the effects of a nurse-led intervention designed to improve self-management of patients with heart failure in a primary health care setting regarding health-related quality of life and depression. METHODS:Patients at eight primary health care centres were screened by the Diagnosis Related Groups regi...

journal_title：European journal of heart failure

authors： Mårtensson J,Strömberg A,Dahlström U,Karlsson JE,Fridlund B

更新日期：2005-03-16 00:00:00

abstract：BACKGROUND:Hereditary hemochromatosis (HH), a common autosomal recessive disease, leads to excessive iron accumulation in some organs, including the heart. It is therefore not surprising that cardiomyopathy is one of the most severe complications of HH. The HFE gene defects have been thought to contribute to idiopathic...

journal_title：European journal of heart failure

authors： Hannuksela J,Leppilampi M,Peuhkurinen K,Kärkkäinen S,Saastamoinen E,Heliö T,Kaartinen M,Nieminen MS,Nieminen P,Parkkila S

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The role of the right ventricle has been relatively neglected proportionate to its importance. We sought to evaluate the impact of right ventricular (RV) and NT-proBNP on the outcome of patients with heart failure (HF) and functional mitral regurgitation (MR). METHODS AND PATIENTS:Outpatients with left vent...

journal_title：European journal of heart failure

authors： Dini FL,Fontanive P,Panicucci E,Andreini D,Chella P,De Tommasi SM

更新日期：2008-06-01 00:00:00

abstract：AIMS:To characterize the relationship between known and newly diagnosed atrial fibrillation (AF) and the risk of death and major cardiovascular (CV) events in patients with acute myocardial infarction (MI) complicated by heart failure (HF) and/or left ventricular systolic dysfunction (LVSD). METHODS:The VALIANT trial ...

journal_title：European journal of heart failure

authors： Køber L,Swedberg K,McMurray JJ,Pfeffer MA,Velazquez EJ,Diaz R,Maggioni AP,Mareev V,Opolski G,Van de Werf F,Zannad F,Ertl G,Solomon SD,Zelenkofske S,Rouleau JL,Leimberger JD,Califf RM

更新日期：2006-10-01 00:00:00

abstract：AIMS:Red cell distribution width (RDW) has been associated with cardiovascular disease, but the relation to heart failure (HF) is unclear. We investigated the association between RDW and incidence of first hospitalization due to HF in a population-based cohort. METHODS AND RESULTS:Red cell distribution width was measu...

journal_title：European journal of heart failure

authors： Borné Y,Smith JG,Melander O,Hedblad B,Engström G

更新日期：2011-12-01 00:00:00

abstract：AIMS:Recent studies have shown that microRNAs (miRNAs), besides being potent regulators of gene expression, can additionally serve as circulating biomarkers of disease. The aim of this study is to determine if plasma miRNAs can be used as indicators of disease progression or therapeutic efficacy in hypertension-induced...

journal_title：European journal of heart failure

authors： Dickinson BA,Semus HM,Montgomery RL,Stack C,Latimer PA,Lewton SM,Lynch JM,Hullinger TG,Seto AG,van Rooij E

更新日期：2013-06-01 00:00:00

abstract：AIMS:Brain natriuretic peptide (BNP), NT-proBNP and troponins are useful for the assessment of patients with heart failure. Few data exist about their serial changes and their prognostic value in patients with acute heart failure (AHF). METHODS AND RESULTS:NT-proBNP and troponin-T plasma levels were measured at baseli...

journal_title：European journal of heart failure

authors： Metra M,Nodari S,Parrinello G,Specchia C,Brentana L,Rocca P,Fracassi F,Bordonali T,Milani P,Danesi R,Verzura G,Chiari E,Dei Cas L

更新日期：2007-08-01 00:00:00

abstract：AIMS:Oral sucrosomial iron (SI) combines enhanced bioavailability and tolerance compared to conventional oral iron along with similar efficacy compared to intravenous iron in several conditions associated with iron deficiency (ID). METHODS AND RESULTS:In this non-randomized, open-label study, we sought to evaluate pro...

journal_title：European journal of heart failure

authors： Karavidas A,Troganis E,Lazaros G,Balta D,Karavidas IN,Polyzogopoulou E,Parissis J,Farmakis D

更新日期：2021-01-09 00:00:00

abstract：:Although no universal definition exists, decompensated heart failure may be regarded as either a worsening of chronic heart failure or new-onset heart failure precipitated by an acute incident. Haemodynamic management of patients hospitalised with decompensated heart failure may include the administration of diuretics...

journal_title：European journal of heart failure

authors： Greenberg B,Borghi C,Perrone S

更新日期：2003-01-01 00:00:00

abstract：AIMS:Insulin-dependent positive inotropic effects (PIE) are partially Ca(2+) independent. This mechanism is potentially glucose dependent. In contrast to most animal species, human myocardium expresses high levels of sodium-glucose-transporter-1 (SGLT-1) mRNA besides the common glucose-transporters-1 and -4 (GLUT1, GLU...

journal_title：European journal of heart failure

authors： von Lewinski D,Gasser R,Rainer PP,Huber MS,Wilhelm B,Roessl U,Haas T,Wasler A,Grimm M,Bisping E,Pieske B

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To achieve angiogenic interaction between VEGF(165) and angiopoietin-1 (Ang-1) using a novel adenoviral bicistronic vector (Ad-Bic) encoding the two factors and delivered ex vivo using sex-mismatched human skeletal myoblasts. METHODS AND RESULTS:A myocardial infarction model was developed in 29 female pigs; ...

journal_title：European journal of heart failure

authors： Ye L,Haider HKh,Jiang S,Tan RS,Ge R,Law PK,Sim EK

更新日期：2007-01-01 00:00:00

abstract：AIMS:To evaluate right-ventricular (RV) function during stress echocardiography (SE) and to assess its relationship with exercise capacity in heart failure (HF) patients. METHODS AND RESULTS:We included 88 patients aged 60.9 +/- 11.2 years with a mean LVEF of 27.2 +/- 9.5%. The following RV parameters were measured at...

journal_title：European journal of heart failure

authors： Rubis P,Podolec P,Kopec G,Olszowska M,Tracz W

更新日期：2010-03-01 00:00:00

abstract：AIMS:The aim of the study was to evaluate the efficacy and clinical outcome of peritoneal dialysis (PD) treatment in patients with severe refractory heart failure (HF) and chronic kidney disease (CKD). METHODS AND RESULTS:The PD treatment was performed in 118 patients [49.2% New York Heart Association (NYHA) III and 5...

journal_title：European journal of heart failure

authors： Koch M,Haastert B,Kohnle M,Rump LC,Kelm M,Trapp R,Aker S

更新日期：2012-05-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the clinical picture and outcome of cardiogenic shock and to develop a risk prediction score for short-term mortality. METHODS AND RESULTS:The CardShock study was a multicentre, prospective, observational study conducted between 2010 and 2012. Patients with either acute co...

journal_title：European journal of heart failure

authors： Harjola VP,Lassus J,Sionis A,Køber L,Tarvasmäki T,Spinar J,Parissis J,Banaszewski M,Silva-Cardoso J,Carubelli V,Di Somma S,Tolppanen H,Zeymer U,Thiele H,Nieminen MS,Mebazaa A,CardShock Study Investigators.,GREAT network

更新日期：2015-05-01 00:00:00

abstract：AIM:Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with reduced ejection fraction (HFrEF), but are underutilized. Hyperkalaemia may be one reason, but the underlying reasons for underuse are unknown. The aim of this study was to investigate the independent predictors of MRA underuse in ...

journal_title：European journal of heart failure

authors： Savarese G,Carrero JJ,Pitt B,Anker SD,Rosano GMC,Dahlström U,Lund LH

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Information about the occurrence of heart failure in the acute phase of myocardial infarction (MI) in diabetic patients and its impact on prognosis are sparse. AIM:The purpose of the present study was to describe how MI patients with diabetes mellitus (DM) differed from MI patients without DM with respect t...

journal_title：European journal of heart failure

authors： Melchior T,Rask-Madsen C,Torp-Pedersen C,Hildebrandt P,Køber L,Jensen G

更新日期：2001-01-01 00:00:00

abstract：AIMS:Drug-induced changes in QT dispersion may be a way of detecting harmful repolarisation abnormalities for patients receiving antiarrhythmic drugs affecting ventricular repolarisation. METHODS AND RESULTS:In 463 congestive heart failure (CHF) patients enrolled in the Danish Investigations Of Arrhythmia and Mortalit...

journal_title：European journal of heart failure

authors： Brendorp B,Elming H,Jun L,Køber L,Torp-Pedersen C,DIAMOND Study Group. Danish Investigations Of Arrhythmia and Mortality On Dofetilide.

更新日期：2002-03-01 00:00:00

abstract：:Alternations in gut microbial composition (i.e. loss of microbial diversity or 'gut dysbiosis') have been associated with heart failure with reduced ejection fraction (HFrEF). It has also been suggested that increased chronic low-level inflammation and immune system dysregulation seen in patients with HFrEF could be r...

journal_title：European journal of heart failure

authors： Madan S,Mehra MR

更新日期：2020-04-01 00:00:00

abstract：AIMS:Monitoring early signs of clinical deterioration could allow physicians to adjust medical treatment for patients at risk of acute heart failure decompensation. To date, several strategies using different surrogate measures of clinical status emerged, but none has yet been proven to predict clinical events. We hypo...

journal_title：European journal of heart failure

authors： Auricchio A,Gold MR,Brugada J,Nölker G,Arunasalam S,Leclercq C,Defaye P,Calò L,Baumann O,Leyva F

更新日期：2014-06-01 00:00:00

abstract：:Ambulatory blood pressure monitoring has established its use in the definition of white coat hypertension and monitoring of treatment of essential hypertension. Any role for ambulatory blood pressure monitoring in heart failure is not well defined. However, from the limited studies available, ambulatory blood pressure...

journal_title：European journal of heart failure

authors： Goyal D,Macfadyen RJ,Watson RD,Lip GY

更新日期：2005-03-02 00:00:00