Cellular basis of uraemic cardiomyopathy: a role for erythropoietin?

Abstract:

:The use of erythropoietin (EPO) has revolutionized the treatment of anaemia associated with many conditions including chronic kidney disease (CKD). However, little is known of the cellular impact of EPO on the uraemic heart. The discovery that the EPO receptor (EPOR) is also expressed on non-haematopoietic cells including cardiomyocytes highlights a role of EPO beyond haematopoiesis. Animal models of heart failure have shown EPO can potentially reverse cardiac remodelling and improve myocardial function. Damage to the kidney, during uraemia, results in a decreased EPO production, which may render the uraemic heart more susceptible to damage and heart failure. Here we review current data on the cellular actions of EPO in models of left ventricular hypertrophy and heart failure and highlight parallels with the uraemic heart.

journal_name

Eur J Heart Fail

authors

Smith K,Semple D,Bhandari S,Seymour AM

doi

10.1093/eurjhf/hfp093

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

732-8

issue

8

eissn

1388-9842

issn

1879-0844

pii

hfp093

journal_volume

11

pub_type

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