Abstract：
:Heart failure (HF) in elderly patients is associated with more diffuse symptoms and signs due to the presence of other noncardiac comorbidities. This can cause difficulties in assessing the correct diagnosis and initiating appropriate therapy. The four most frequently occurring noncardiac comorbidities and therapies used to treat them are discussed in the present paper. Hypertension is an important precursor of HF, and is still the most common risk factor for HF in the general population. About 50% of patients with untreated hypertension will develop HF. Pressure overload leads to the development of left ventricular hypertrophy (LVH) and diastolic dysfunction. Diabetes, which occurs in about 20-30% of patients with HF, is an important comorbidity resulting in morphological and metabolic disturbances affecting myocardial blood flow and hormonal regulation leading to a poor outcome and necessitating aggressive conventional treatment. Chronic obstructive pulmonary disease (COPD), occurs in approximately 20-30% of heart failure patients, and may complicate HF treatment, it is therefore important to recognize and treat it effectively. Finally, the early detection of anemia, which occurs in 20-30% of HF patients, is important since it is associated with functional impairment and increased mortality and morbidity. Combined treatment with erythropoietin and intravenous iron has shown beneficial effects on clinical symptoms and morbidity. In conclusion early detection of concomitant diseases in patients with HF is important and should be considered carefully when initiating therapy.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Dahlström Udoi
10.1016/j.ejheart.2005.01.008keywords:
subject
Has Abstractpub_date
2005-03-16 00:00:00pages
309-16issue
3eissn
1388-9842issn
1879-0844pii
S1388-9842(05)00012-7journal_volume
7pub_type
杂志文章,评审abstract：BACKGROUND:Patients with chronic heart failure (CHF) have frequent episodes of exacerbation leading to recurrent hospitalization. AIMS:To explore factors related to patients seeking care for worsening CHF. METHODS:Eighty-eight patients diagnosed with a deteriorating CHF condition were interviewed. Data were analysed ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2006.11.002
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Nuclear factor kappa B (NF-kappaB) is activated by several factors, which increase the inflammatory response, and this activation, in turn, leads to the expression of several genes such as cytokines, and may play an important role in cardiovascular diseases. AIMS:The aim of the study is to examine the effec...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2003.10.007
更新日期：2004-03-01 00:00:00
abstract：AIMS:Inflammatory heart disease represents an important cause of chronic dilated cardiomyopathy (DCM). Predicting the clinical course of patients with inflammatory cardiomyopathy (iCMP) is difficult, and the prognostic value of current biological markers remains controversial. We tested whether expression of selected m...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.579
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVES:To compare the efficacy of the homeopathic Crataegus preparation Cralonin for non-inferiority to standard treatment for mild cardiac insufficiency. METHODS:Multicentre non-randomised cohort study in patients aged 50-75 years in New York Heart Association class II. Patients received Cralonin (n=110) or ACE i...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究
doi：10.1016/s1388-9842(02)00237-4
更新日期：2003-06-01 00:00:00
abstract：AIMS:To determine whether a strategy of intensive blood pressure control reduces the risk of heart failure (HF) events consistently across the spectrum of kidney function and albuminuria. METHODS AND RESULTS:SPRINT was a randomized clinical trial in which 9361 individuals ≥50 years, at high risk for or with cardiovasc...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.1971
更新日期：2020-07-21 00:00:00
abstract：BACKGROUND:New-onset atrial fibrillation (AF) after acute myocardial infarction (AMI) frequently occurs in association with postinfarction complications, particularly with heart failure (HF). AIMS:To evaluate whether postinfarction HF is associated with the subsequent development of AF and whether AF independently pre...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2004.07.018
更新日期：2005-06-01 00:00:00
abstract：AIMS:To investigate the annual hospitalization rate and seasonal variation in confirmed heart failure (HF) admissions. METHODS AND RESULTS:Records from all admissions to one hospital during 1 year with a HF diagnostic code were reviewed. From 1953 admissions, 595 were excluded because they did not fulfill the diagnost...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(02)00116-2
更新日期：2002-12-01 00:00:00
abstract：:The incidence and prevalence of cardiovascular disease increases progressively with advancing age. Cardiovascular disease is a major cause of morbidity and mortality in Western Countries. In the near future, as the population ages, it is expected that the population prevalence of cardiovascular disease will increase d...
journal_title：European journal of heart failure
pub_type： 杂志文章,评审
doi：10.1016/j.ejheart.2008.08.007
更新日期：2008-11-01 00:00:00
abstract：UNLABELLED:Experimental data have shown that rIL2 has negative inotropic properties. This has not been investigated in humans with normal left ventricular function. Seventeen consecutive renal cell carcinoma patients who received rIL2 therapy because of dissemination were analyzed before and after treatment with a low ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(00)00073-8
更新日期：2000-06-01 00:00:00
abstract：AIMS:Structural abnormalities causing cardiac deterioration in hypertensive heart disease (HHD) are poorly understood. The aim of the study was to evaluate left ventricular (LV) myocardial changes in patients with HHD and cardiac failure. METHODS AND RESULTS:Among 1229 patients undergoing an LV or biventricular endomy...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfs169
更新日期：2013-03-01 00:00:00
abstract：AIMS:Calcium channel plays an important role in the autoimmune pathogenesis of idiopathic dilated cardiomyopathy (DCM). Autoantibodies have emerged as a new upstream target of sudden death in DCM. We sought to validate the hypothesis that autoantibodies against l-type calcium channel (CC-AAbs) are arrhythmogenic and le...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfq198
更新日期：2011-03-01 00:00:00
abstract：AIMS:Congestive heart failure (CHF) is associated with impaired renal function. Previously, we have demonstrated that rats with decompensated CHF exhibited exaggerated sensitivity to the adverse renal effects of increased increased intra-abdominal pressure (IAP) as compared with normal controls. This study tested wheth...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfs102
更新日期：2012-10-01 00:00:00
abstract：:Most treatments for chronic heart failure are effective both in preventing its onset and reducing its progression. However, statins prevent the development of heart failure, but they do not decrease morbidity and mortality in those with established heart failure. This apparent discordance cannot be explained by an eff...
journal_title：European journal of heart failure
pub_type： 杂志文章,评审
doi：10.1002/ejhf.1183
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS:7060 subjects with two or more visits in the Reykjavík Study were followed--during 30 years from 1967. All underwent oral glucose toler...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2007.07.017
更新日期：2007-10-01 00:00:00
abstract：AIMS:The proteasome prevents the intracellular accumulation of proteins and its impairment can lead to structural and functional alterations, as noted for the coronary vasculature in a previous study. Utilizing the same model, this study was designed to test the hypothesis that chronic proteasome inhibition (PSI) also ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hft034
更新日期：2013-06-01 00:00:00
abstract：AIMS:The left ventricular phenotype of idiopathic dilated cardiomyopathy (DCM) can appear similar in paediatric and adult patients. However, the aetiology of paediatric DCM is usually idiopathic, and often leads an aggressive clinical course. A structural underpinning of DCM is extracellular matrix changes, which are d...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfq184
更新日期：2011-03-01 00:00:00
abstract：AIMS:Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF). Considering different treatment mechanisms underlying renin-angiotensin system (RAS) suppression and parasym...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.164
更新日期：2014-10-01 00:00:00
abstract：AIMS:Urine proteome analysis (UPA) has already provided accurate discriminatory patterns of urinary peptides for renal disease, coronary artery disease, and asymptomatic LV diastolic dysfunction. UPA has now been used to characterize a discriminatory peptide biomarker pattern and establish a diagnostic classifier for h...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.544
更新日期：2016-07-01 00:00:00
abstract：AIMS:Randomized trials have shown that beta-blockers (BBs) reduce mortality in chronic heart failure (HF). Less data are available on the role of BBs in patients with acute HF, specifically if BBs should be continued or temporarily withdrawn. The aim of this study was to evaluate the role of BBs on in-hospital outcomes...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfn008
更新日期：2009-01-01 00:00:00
abstract：:Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are global epidemics incurring significant morbidity and mortality. The combination presents many diagnostic challenges. Clinical symptoms and signs frequently overlap. Evaluation of cardiac and pulmonary function is often problematic and occasionally...
journal_title：European journal of heart failure
pub_type： 杂志文章,评审
doi：10.1093/eurjhf/hfn013
更新日期：2009-02-01 00:00:00
abstract：AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.239
更新日期：2015-03-01 00:00:00
abstract：AIMS:To evaluate in patients with heart failure (HF) due to systolic dysfunction the occurrence of polypharmacy, alternative medicine, immunization against influenza, and patients' knowledge about their medication. METHODS AND RESULTS:Sixty-five patients, 49 men, mean age 60.5+/-12.0 years answered a confidential ques...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2003.09.009
更新日期：2004-03-01 00:00:00
abstract：AIMS:We sought to describe the frequency, type and timing of clinical events, and delineate patterns in their transitions, after a first episode of heart failure (HF). METHODS AND RESULTS:In 1036 Framingham participants with new-onset HF (mean age 79 years; 53% women), we used mixture models to estimate probabilities ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.1918
更新日期：2020-10-01 00:00:00
abstract：AIMS:The aim of this study was to investigate the prognostic impact of right ventricular (RV) size in patients with chronic heart failure. METHODS AND RESULTS:Normal volunteers (n = 80) and patients (n = 380) with left ventricular (LV) ejection fraction <45% on echocardiography and on optimal treatment for heart failu...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfq161
更新日期：2011-01-01 00:00:00
abstract：AIMS:Beta-blockers (BBs) improve outcomes in heart failure. Results from the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) trial previously demonstrated the feasibility of heart rate, not maximum dose, as a treatment goal. In this pre-specified analysis, we investigated the prognostic value of achieved ...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1002/ejhf.121
更新日期：2014-08-01 00:00:00
abstract：AIMS:Angiotensin receptor-neprilysin inhibitors (ARNis) acts an ARB and neprilysin inhibitor. Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure (HF). Therefore, we evaluated the effects and mechanisms of ARNi in HF with reduced ejection fraction (HFrEF) in streptozotocin-ind...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.474
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:The incidence of ventricular tachyarrhythmias in ICD patients with cardiac resynchronisation therapy (CRT-D) is not well studied. AIM:To analyse event free survival in CRT-D patients with a primary or a secondary prophylactic ICD indication. METHODS:Prospective, single centre. Eighty-six patients, 44% with...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2005.05.006
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Crataegus preparations have been used for centuries especially in Europe. To date, no proper data on their efficacy and safety as an add-on-treatment are available. Therefore a large morbidity/mortality trial was performed. AIM:To investigate the efficacy and safety of an add-on treatment with Crataegus ext...
journal_title：European journal of heart failure
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ejheart.2008.10.004
更新日期：2008-12-01 00:00:00
abstract：AIMS:The primary objective of this systematic review was to estimate the prevalence and temporal changes in chronic comorbid conditions reported in heart failure (HF) clinical trials. METHODS AND RESULTS:We searched MEDLINE for HF trials enrolling more than 400 patients published between 2001 and 2016.Trials were divi...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.1818
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Plasma renin activity is normal in left ventricular dysfunction in the absence of diuretic therapy. In health there is a reciprocal relationship between renin and atrial natriuretic peptide (ANP) but a positive correlation in advanced heart failure. The relationship between renin and ANP in mild left ventric...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(99)00058-6
更新日期：1999-12-01 00:00:00
