Trends in prevalence of comorbidities in heart failure clinical trials.

abstract：AIMS:Calcium channel plays an important role in the autoimmune pathogenesis of idiopathic dilated cardiomyopathy (DCM). Autoantibodies have emerged as a new upstream target of sudden death in DCM. We sought to validate the hypothesis that autoantibodies against l-type calcium channel (CC-AAbs) are arrhythmogenic and le...

journal_title：European journal of heart failure

authors： Xiao H,Wang M,Du Y,Yuan J,Cheng X,Chen Z,Zou A,Wei F,Zhao G,Liao YH

更新日期：2011-03-01 00:00:00

abstract：:This article provides information and a commentary on trials presented at the American Heart Association meeting held in November 2005, relevant to the pathophysiology, prevention and treatment of heart failure. All reports should be considered as preliminary data, as analyses may change in the final publication. In R...

journal_title：European journal of heart failure

authors： Cleland JG,Freemantle N,Coletta AP,Clark AL

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Patients presenting to the emergency department (ED) with acute heart failure (AHF) are at an increased risk of morbidity and mortality. The electrocardiogram (ECG) is a routine investigation in patients with AHF used to identify potential causes and/or complications. It is unclear whether 12-lead ECG charac...

journal_title：European journal of heart failure

authors： Gouda P,Brown P,Rowe BH,McAlister FA,Ezekowitz JA

更新日期：2016-08-01 00:00:00

abstract：AIMS:A restrictive transmitral filling (RF) pattern predicts increased mortality in heart failure (HF) with reduced left ventricular (LV) systolic function. We performed a combined evaluation of LV function and RF for prognosis in patients with HF with and without systolic dysfunction. METHODS AND RESULTS:Doppler echo...

journal_title：European journal of heart failure

authors： Akkan D,Kjaergaard J,Møller JE,Hassager C,Torp-Pedersen C,Køber L,EchoCardiography and Heart Outcome Study (ECHOS) investigators.

更新日期：2008-07-01 00:00:00

abstract：AIMS:Incident heart failure (HF) continues to pose a common and serious problem. We sought to examine the value of echocardiographic predictors of new HF in a community-based elderly population at risk for HF, independent of and incremental to clinical evaluation. METHODS AND RESULTS:Asymptomatic patients ≥65 years ol...

journal_title：European journal of heart failure

authors： Yang H,Negishi K,Wang Y,Nolan M,Saito M,Marwick TH

更新日期：2016-11-01 00:00:00

abstract：AIMS:Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF. METHODS AND RESULTS:The study included 279 participants from the PARAMOUNT study (57% women) with analysable b...

journal_title：European journal of heart failure

authors： Gori M,Lam CS,Gupta DK,Santos AB,Cheng S,Shah AM,Claggett B,Zile MR,Kraigher-Krainer E,Pieske B,Voors AA,Packer M,Bransford T,Lefkowitz M,McMurray JJ,Solomon SD,PARAMOUNT Investigators.

更新日期：2014-05-01 00:00:00

abstract：AIMS:Several studies have shown that older patients with heart failure with reduced ejection fraction (HFrEF) are undertreated. The aim of this study was to evaluate the association of up-titration of angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB) and beta-blockers on outcome acros...

journal_title：European journal of heart failure

authors： Mordi IR,Ouwerkerk W,Anker SD,Cleland JG,Dickstein K,Metra M,Ng LL,Samani NJ,van Veldhuisen DJ,Zannad F,Voors AA,Lang CC

更新日期：2020-03-25 00:00:00

abstract：AIMS:Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS:We studied 1527 p...

journal_title：European journal of heart failure

authors： Cogswell RJ,Norby FL,Gottesman RF,Chen LY,Solomon S,Shah A,Alonso A

更新日期：2017-10-01 00:00:00

abstract：AIMS:A recent study suggested that no single echocardiographic index of cardiac dyssynchrony can reliably identify candidates for cardiac resynchronization therapy (CRT). We examined the value of three simple echocardiographic indices for predicting the 6-month clinical and echocardiographic responses to CRT. METHODS ...

journal_title：European journal of heart failure

authors： Bordachar P,Lafitte S,Réant P,Reuter S,Clementy J,Mletzko RU,Siegel RM,Goscinska-Bis K,Bowes R,Morgan J,Bénard S,Leclercq C

更新日期：2010-06-01 00:00:00

abstract：:Patients with mild-moderate chronic heart failure (CHF) often have raised levels of serum uric acid (UA). This is due, amongst other factors, to reduced UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels wors...

journal_title：European journal of heart failure

authors： Reyes AJ

更新日期：2005-06-01 00:00:00

abstract：AIMS:Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong biochemical marker of heart failure and left ventricular dysfunction (LVD). Due to renal arterio-venous clearance of NT-proBNP and the correlation of plasma concentrations with renal function, we hypothesized that NT-proBNP may have potential ...

journal_title：European journal of heart failure

authors： Jungbauer CG,Buchner S,Birner C,Resch M,Heinicke N,Debl K,Buesing M,Biermeier D,Schmitz G,Riegger G,Luchner A

更新日期：2010-04-01 00:00:00

abstract：AIMS:In amyloid patients, cardiac involvement dramatically worsens functional capacity and prognosis. We sought to study how the cardiopulmonary exercise test (CPET) could help in functional assessment and risk stratification of patients with cardiac amyloidosis (CA). METHODS AND RESULTS:We carried out a multicentre s...

journal_title：European journal of heart failure

authors： Nicol M,Deney A,Lairez O,Vergaro G,Emdin M,Carecci A,Inamo J,Montfort A,Neviere R,Damy T,Harel S,Royer B,Baudet M,Cohen-Solal A,Arnulf B,Logeart D

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Clinical trials, the gold standard for the evaluation of new therapeutic strategies, may prove a drug to be beneficial, harmful or neutral according to its effect on the end-point(s) under study. AIMS:To study the reaction and perspective of the patients participating in a clinical heart failure trial, part...

journal_title：European journal of heart failure

authors： Yuval R,Uziel K,Gordon N,Merdler A,Khader N,Karkabi B,Flugelman MY,Halon DA,Lewis BS

更新日期：2001-03-01 00:00:00

abstract：AIMS:The objective of this study was to establish the acute effects of hypoxia on clinical, spirometric, haemodynamic, and echocardiographic variables. Reducing inspired oxygen to 15%, as experienced during commercial air travel, decreases arterial oxygen saturation, increases respiratory rate and pulmonary artery pres...

journal_title：European journal of heart failure

authors： Hobkirk JP,Damy T,Walters M,Bennett A,Smith SJ,Ingle L,Clark AL,Cleland JG

更新日期：2013-05-01 00:00:00

abstract：AIMS:To evaluate right-ventricular (RV) function during stress echocardiography (SE) and to assess its relationship with exercise capacity in heart failure (HF) patients. METHODS AND RESULTS:We included 88 patients aged 60.9 +/- 11.2 years with a mean LVEF of 27.2 +/- 9.5%. The following RV parameters were measured at...

journal_title：European journal of heart failure

authors： Rubis P,Podolec P,Kopec G,Olszowska M,Tracz W

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Biventricular (BiV) pacing has been found to improve systolic function and exercise tolerance in patients with severe congestive heart failure and bundle branch block. The mechanisms behind this beneficial effect is still not sufficiently clarified. AIM:To evaluate the regional myocardial perfusion (MP) dur...

journal_title：European journal of heart failure

authors： Nielsen JC,Bøttcher M,Jensen HK,Nielsen TT,Pedersen AK,Mortensen PT

更新日期：2003-03-01 00:00:00

abstract：INTRODUCTION:Patients with chronic heart failure (CHF) experience breathlessness and fatigue on exercise. One of the abnormalities seen on maximal exercise testing is an increased ventilatory response to exercise (VE/VCO(2) slope). The cause of this is unknown, but is likely to be due to a combination of interacting pe...

journal_title：European journal of heart failure

authors： Witte KK,Clark AL

更新日期：2004-10-01 00:00:00

abstract：AIMS:In the Digitalis Investigation Group (DIG) trial, digoxin reduced mortality or hospitalization due to heart failure (HF) in several pre-specified high-risk subgroups of HF patients, but data on protocol-specified 2-year outcomes were not presented. In the current study, we examined the effect of digoxin on HF deat...

journal_title：European journal of heart failure

authors： Gheorghiade M,Patel K,Filippatos G,Anker SD,van Veldhuisen DJ,Cleland JG,Metra M,Aban IB,Greene SJ,Adams KF,McMurray JJ,Ahmed A

更新日期：2013-05-01 00:00:00

abstract：AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...

journal_title：European journal of heart failure

authors： Bowen TS,Rolim NP,Fischer T,Baekkerud FH,Medeiros A,Werner S,Brønstad E,Rognmo O,Mangner N,Linke A,Schuler G,Silva GJ,Wisløff U,Adams V,Optimex Study Group.

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Myocardial contractility can be altered using voltage clamp techniques by modulating amplitude and duration of the action potential resulting in enhanced calcium entry in the cell of isolated muscle strips (Non-Excitatory Currents; NEC). Extracellular electrical stimuli delivered during the absolute refracto...

journal_title：European journal of heart failure

authors： Brunckhorst CB,Shemer I,Mika Y,Ben-Haim SA,Burkhoff D

更新日期：2006-01-01 00:00:00

abstract：:Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in card...

journal_title：European journal of heart failure

authors： Ahmad T,Miller PE,McCullough M,Desai NR,Riello R,Psotka M,Böhm M,Allen LA,Teerlink JR,Rosano GMC,Lindenfeld J

更新日期：2019-09-01 00:00:00

abstract：AIMS:To investigate temporal trends in the risk of heart failure (HF) complicating acute myocardial infarction (AMI) and to determine whether these trends differ by gender or age. METHODS AND RESULTS:The national Swedish hospital discharge and death registries from 1993 to 2004 were used to calculate age- and gender-s...

journal_title：European journal of heart failure

authors： Shafazand M,Rosengren A,Lappas G,Swedberg K,Schaufelberger M

更新日期：2011-02-01 00:00:00

abstract：AIMS:To investigate the prevalence of iron deficiency (ID) in heart failure (HF) patients with normal vs. abnormal red cell indices (RCI), the associations between iron parameters and RCI, and prognostic consequences of ID independently of RCI. METHODS AND RESULTS:We analysed clinical data of 1821 patients with HF [me...

journal_title：European journal of heart failure

authors： Tkaczyszyn M,Comín-Colet J,Voors AA,van Veldhuisen DJ,Enjuanes C,Moliner-Borja P,Rozentryt P,Poloński L,Banasiak W,Ponikowski P,van der Meer P,Jankowska EA

更新日期：2018-01-01 00:00:00

abstract：AIMS:Previous evaluations of natriuretic peptide (NP) levels in patients with acute dyspnoea presenting to the emergency department (ED) have selected only a minority of patients for echocardiography. We aimed to evaluate the association between NPs and more subtle echocardiographic findings and to assess the potential...

journal_title：European journal of heart failure

authors： Shah KB,Kop WJ,Christenson RH,Diercks DB,Kuo D,Henderson S,Hanson K,Li SY,deFilippi CR

更新日期：2009-07-01 00:00:00

abstract：AIMS:To investigate the annual hospitalization rate and seasonal variation in confirmed heart failure (HF) admissions. METHODS AND RESULTS:Records from all admissions to one hospital during 1 year with a HF diagnostic code were reviewed. From 1953 admissions, 595 were excluded because they did not fulfill the diagnost...

journal_title：European journal of heart failure

authors： Martínez-Sellés M,García Robles JA,Prieto L,Serrano JA,Muñoz R,Frades E,Almendral J

更新日期：2002-12-01 00:00:00

abstract：AIMS:This study was designed to assess whether the prognostic significance of estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF) interact in populations with heart failure (HF) and myocardial infarction (MI). METHODS:Patients were recruited from four screening registers (N=18,010...

journal_title：European journal of heart failure

authors： Schou M,Torp-Pedersen C,Gustafsson F,Abdulla J,Kober L

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:A low peak oxygen uptake (pVO(2)) and steep VE/VCO(2) slope are independently associated with a worse prognosis in patients with chronic heart failure (CHF). We wished to confirm whether combining these variables as a ratio would lead to a more accurate predictor of prognosis than using either alone. METHOD...

journal_title：European journal of heart failure

authors： Ingle L,Witte KK,Cleland JG,Clark AL

更新日期：2008-01-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the clinical picture and outcome of cardiogenic shock and to develop a risk prediction score for short-term mortality. METHODS AND RESULTS:The CardShock study was a multicentre, prospective, observational study conducted between 2010 and 2012. Patients with either acute co...

journal_title：European journal of heart failure

authors： Harjola VP,Lassus J,Sionis A,Køber L,Tarvasmäki T,Spinar J,Parissis J,Banaszewski M,Silva-Cardoso J,Carubelli V,Di Somma S,Tolppanen H,Zeymer U,Thiele H,Nieminen MS,Mebazaa A,CardShock Study Investigators.,GREAT network

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) is frequent among patients hospitalized with acute heart failure syndromes (AHFS). AIMS:To describe the influence of coronary revascularization status on survival in patients with AHFS. METHODS AND RESULTS:OPTIMIZE-HF enrolled 48,612 patients with AHFS from 259 U.S. hospitals....

journal_title：European journal of heart failure

authors： Rossi JS,Flaherty JD,Fonarow GC,Nunez E,Gattis Stough W,Abraham WT,Albert NM,Greenberg BH,O'Connor CM,Yancy CW,Young JB,Davidson CJ,Gheorghiade M

更新日期：2008-12-01 00:00:00

abstract：AIMS:Patients with acute heart failure (HF) in Africa are rarely being treated with a hydralazine/nitrates combination. Therefore the effect of this treatment was studied here. METHODS AND RESULTS:The study was planned to enrol 500 patients during an acute HF admission, from nine sub-Saharan African countries. Patient...

journal_title：European journal of heart failure

authors： Sliwa K,Damasceno A,Davison BA,Mayosi BM,Sani MU,Ogah O,Mondo C,Ojji D,Dzudie A,Kouam CK,Yonga G,Ba SA,Ogola E,Edwards C,Milo O,Cotter G

更新日期：2016-10-01 00:00:00