Abstract:
AIMS:Congestive heart failure (CHF) is associated with impaired renal function. Previously, we have demonstrated that rats with decompensated CHF exhibited exaggerated sensitivity to the adverse renal effects of increased increased intra-abdominal pressure (IAP) as compared with normal controls. This study tested whether phosphodiesterase 5 (PDE5) inhibition protects against the adverse renal effects of increased IAP in rats with CHF. METHODS AND RESULTS:Following baseline periods, rats with compensated and decompensated CHF induced by the placement of an aorto-caval fistula (ACF), rats with myocardial infarction (MI) induced by left anterior descending (LAD) artery ligation, and sham controls were subjected to consecutive IAPs: 7, 10, or 14 mmHg. Urine flow (V), Na(+) excretion (U(Na)V), glomerular filtration rate (GFR), and renal plasma flow (RPF) were determined. The effects of pre-treatment with tadalafil on the adverse renal effects of IAP were examined in rats with decompensated CHF and MI. Elevation of IAP to 10 and 14 mmHg produced linear reductions in these parameters. Basal renal function and haemodynamics were lower in CHF rats. Decompensated CHF rats and MI rats that were subjected to 10 and 14 mmHg exhibited exaggerated declines in V, U(Na)V, GFR, and RPF. In contrast, no adverse renal effects were observed in rats with compensated CHF subjected to IAP. Pre-treatment of decompensated CHF rats and MI rats with tadalafil ameliorated the adverse renal effects of high IAP. CONCLUSION:Decompensated CHF and MI rats are vulnerable to the adverse renal effects of IAP. Tadalafil abolishes IAP-induced renal dysfunction, supporting a therapeutic role for PDE5 inhibition in CHF associated with ascites.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Bishara B,Abu-Saleh N,Awad H,Ghrayeb N,Goltsman I,Aronson D,Khamaysi I,Assady S,Armaly Z,Haddad S,Haddad E,Abassi Zdoi
10.1093/eurjhf/hfs102subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1104-11issue
10eissn
1388-9842issn
1879-0844pii
hfs102journal_volume
14pub_type
杂志文章abstract::BNP is a marker of systolic left ventricular dysfunction (LVSD) and heart failure. To assess BNP for the detection of diastolic dysfunction in the general population, we examined 1678 subjects within an age- and sex-stratified survey (MONICA Augsburg). BNP was measured using a commercially available RIA (Shionogi). BN...
journal_title:European journal of heart failure
pub_type: 杂志文章
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abstract:AIMS:We aimed to determine the relation between baseline systolic blood pressure (SBP), change in SBP, and worsening renal function (WRF) in acute heart failure (AHF) patients enrolled in the Pre-RELAX-AHF trial. METHODS AND RESULTS:The Pre-RELAX-AHF study enrolled 234 patients within 16 h of admission (median 7 h) fo...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurjhf/hfr060
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journal_title:European journal of heart failure
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doi:10.1016/j.ejheart.2007.11.003
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
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doi:10.1093/eurjhf/hfq024
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abstract:AIMS:Severe heart failure (HF) is often associated with cachexia that reverses post-heart transplantation (HTx) with frequent development of obesity. Ghrelin is a novel appetite-stimulating hormone. The aim was to determine the role of ghrelin in regulating appetite, food intake, and body composition in HF and post-HTx...
journal_title:European journal of heart failure
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doi:10.1093/eurjhf/hfp088
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-04-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2012-08-01 00:00:00
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.201
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfs068
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abstract:AIMS:Acute heart failure (AHF) has a poor prognosis. We evaluated 3- and 12-month mortality in different clinical classes of AHF patients from 30 European countries who were included in the EuroHeart Failure Survey (EHFS) II. METHODS AND RESULTS:Follow-up data were available for 2981 AHF patients, of these 62% had a h...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2005.01.008
更新日期:2005-03-16 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ejheart.2006.08.004
更新日期:2007-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2005.01.020
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2007.02.006
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.09.003
更新日期:2004-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2007.01.008
更新日期:2007-06-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfp191
更新日期:2010-02-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2006.01.008
更新日期:2006-11-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2005.04.015
更新日期:2006-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.10.012
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1093/eurjhf/hfp097
更新日期:2009-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
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更新日期:2017-05-01 00:00:00