Clinical trials update from the European Society of Cardiology Meeting 2010: SHIFT, PEARL-HF, STAR-heart, and HEBE-III.

abstract：BACKGROUND:It is not clear if long-term antithrombotic treatment has a beneficial effect on the incidence of thromboembolism in chronic heart failure (CHF). The HELAS study (Heart failure Long-term Antithrombotic Study) is a multicentre, randomised, double-blind, placebo-controlled trial to evaluate antithrombotic trea...

journal_title：European journal of heart failure

authors： Cokkinos DV,Haralabopoulos GC,Kostis JB,Toutouzas PK,HELAS investigators.

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) is frequent among patients hospitalized with acute heart failure syndromes (AHFS). AIMS:To describe the influence of coronary revascularization status on survival in patients with AHFS. METHODS AND RESULTS:OPTIMIZE-HF enrolled 48,612 patients with AHFS from 259 U.S. hospitals....

journal_title：European journal of heart failure

authors： Rossi JS,Flaherty JD,Fonarow GC,Nunez E,Gattis Stough W,Abraham WT,Albert NM,Greenberg BH,O'Connor CM,Yancy CW,Young JB,Davidson CJ,Gheorghiade M

更新日期：2008-12-01 00:00:00

abstract：AIMS:To identify novel risk markers for incident heart failure using proteomic profiling of 80 proteins previously associated with cardiovascular pathology. METHODS AND RESULTS:Proteomic profiling (proximity extension assay) was performed in two community-based prospective cohorts of elderly individuals without heart ...

journal_title：European journal of heart failure

authors： Stenemo M,Nowak C,Byberg L,Sundström J,Giedraitis V,Lind L,Ingelsson E,Fall T,Ärnlöv J

更新日期：2018-01-01 00:00:00

abstract：AIMS:Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF. METHODS AND RESULTS:The study included 279 participants from the PARAMOUNT study (57% women) with analysable b...

journal_title：European journal of heart failure

authors： Gori M,Lam CS,Gupta DK,Santos AB,Cheng S,Shah AM,Claggett B,Zile MR,Kraigher-Krainer E,Pieske B,Voors AA,Packer M,Bransford T,Lefkowitz M,McMurray JJ,Solomon SD,PARAMOUNT Investigators.

更新日期：2014-05-01 00:00:00

abstract：AIMS:Urine proteome analysis (UPA) has already provided accurate discriminatory patterns of urinary peptides for renal disease, coronary artery disease, and asymptomatic LV diastolic dysfunction. UPA has now been used to characterize a discriminatory peptide biomarker pattern and establish a diagnostic classifier for h...

journal_title：European journal of heart failure

authors： Farmakis D,Koeck T,Mullen W,Parissis J,Gogas BD,Nikolaou M,Lekakis J,Mischak H,Filippatos G

更新日期：2016-07-01 00:00:00

abstract：AIMS:Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and...

journal_title：European journal of heart failure

authors： Kapelios CJ,Laroche C,Crespo-Leiro MG,Anker SD,Coats AJS,Díaz-Molina B,Filippatos G,Lainscak M,Maggioni AP,McDonagh T,Mebazaa A,Metra M,Moura B,Mullens W,Piepoli MF,Rosano GMC,Ruschitzka F,Seferovic PM,Lund LH,Heart

更新日期：2020-08-01 00:00:00

abstract：AIMS:Chronic heart failure (CHF) is associated with a higher risk for diabetes mellitus. Retinol binding protein 4 (RBP 4) is an adipose tissue-derived protein with pro-diabetogenic effects. A complete understanding of the association of CHF and insulin resistance remains elusive. The purpose of this study was to exami...

journal_title：European journal of heart failure

authors： Bobbert P,Weithäuser A,Andres J,Bobbert T,Kühl U,Schultheiss HP,Rauch U,Skurk C

更新日期：2009-12-01 00:00:00

abstract：AIMS:Non-invasive measures of cardiac mechanical function may have the potential to serve as markers of risk for heart failure; however, limited data exist regarding clinical correlates and heritability of these measures in the community. METHODS AND RESULTS:We used speckle-tracking echocardiography to assess LV strai...

journal_title：European journal of heart failure

authors： Cheng S,McCabe EL,Larson MG,Chen MH,Osypiuk E,Lehman BT,Stantchev P,Aragam J,Solomon SD,Benjamin EJ,Vasan RS

更新日期：2015-01-01 00:00:00

abstract：AIMS:Aldosterone activation is central to the sodium–fluid retention that marks the progression of heart failure (HF). The actions of dietary sodium restriction, a mainstay in HF management, on cardiorenal and neuroendocrine adaptations during the progression of HF are poorly understood. The study aim was to assess the...

journal_title：European journal of heart failure

authors： Miller WL,Borgeson DD,Grantham JA,Luchner A,Redfield MM,Burnett JC Jr

更新日期：2015-02-01 00:00:00

abstract：AIMS:The 'Hospital at home' (HaH) model avoids hospital admission by transferring healthcare and treatment to the patient's home. We aimed to compare the effectiveness and direct healthcare costs of treating elderly patients with decompensated heart failure (HF) using HaH care vs. inpatient hospital care (IHC) in a car...

journal_title：European journal of heart failure

authors： Mendoza H,Martín MJ,García A,Arós F,Aizpuru F,Regalado De Los Cobos J,Belló MC,Lopetegui P,Cia JM

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Approximately one third of patients with chronic heart failure have left bundle branch block (LBBB) on their 12-lead ECG. METHODS AND RESULTS:1418 consecutive patients (average (SD) age 70.5 (10.4) years; 74% male) first seen in a community heart failure clinic between December 2001 and June 2006 had a 12 l...

journal_title：European journal of heart failure

authors： Clark AL,Goode K,Cleland JG

更新日期：2008-07-01 00:00:00

abstract：AIMS:Left atrial (LA) mechanical function may play a significant role in the development and progression of heart failure with preserved ejection fraction (HFpEF). We performed a systematic review and meta-analysis to evaluate association of impaired LA function with outcomes in HFpEF. METHODS AND RESULTS:Multiple dat...

journal_title：European journal of heart failure

authors： Khan MS,Memon MM,Murad MH,Vaduganathan M,Greene SJ,Hall M,Triposkiadis F,Lam CSP,Shah AM,Butler J,Shah SJ

更新日期：2020-03-01 00:00:00

abstract：AIMS:The aim of the study was to evaluate the efficacy and clinical outcome of peritoneal dialysis (PD) treatment in patients with severe refractory heart failure (HF) and chronic kidney disease (CKD). METHODS AND RESULTS:The PD treatment was performed in 118 patients [49.2% New York Heart Association (NYHA) III and 5...

journal_title：European journal of heart failure

authors： Koch M,Haastert B,Kohnle M,Rump LC,Kelm M,Trapp R,Aker S

更新日期：2012-05-01 00:00:00

abstract：AIMS:To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms. METHODS AND RESULTS:A total of 300 consecutive hospitalized CHF patients were screened for ...

journal_title：European journal of heart failure

authors： Parissis JT,Farmakis D,Nikolaou M,Birmpa D,Bistola V,Paraskevaidis I,Ikonomidis I,Gaitani S,Venetsanou K,Filippatos G,Kremastinos DT

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The association between serum digoxin concentration (SDC) and outcomes in women with heart failure (HF) has not been well studied. AIMS:To test the hypothesis that the effect of digoxin on outcomes in women with HF is bi-directional and dependent on SDC, as in men, and is modified by ejection fraction (EF)....

journal_title：European journal of heart failure

authors： Ahmed A,Aban IB,Weaver MT,Aronow WS,Fleg JL

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Acute dyspnoea as a presenting symptom is a frequent diagnostic challenge for physicians. The main differential diagnosis is between dyspnoea of cardiac and non-cardiac origin. Natriuretic peptides have been shown to be useful in this setting. Ultrasound lung comets (ULCs) are a simple, echographic method wh...

journal_title：European journal of heart failure

authors： Gargani L,Frassi F,Soldati G,Tesorio P,Gheorghiade M,Picano E

更新日期：2008-01-01 00:00:00

abstract：AIMS:It is unclear whether myocardial velocity or deformation indices of dyssynchrony are better at predicting response to cardiac resynchronization therapy (CRT). Therefore, two indices of left ventricular (LV) dyssynchrony based on myocardial velocity and deformation were compared to predict success of CRT. METHODS ...

journal_title：European journal of heart failure

authors： Mele D,Toselli T,Capasso F,Stabile G,Piacenti M,Piepoli M,Giatti S,Klersy C,Sallusti L,Ferrari R

更新日期：2009-04-01 00:00:00

abstract：:Many patients with Congestive Heart Failure (CHF) are anaemic. This anaemia is associated with more severe CHF and a higher incidence of mortality, hospitalisation and morbidity. The only way to prove that the anaemia is causing this worsening of CHF is to correct it. We review here some of the published papers about ...

journal_title：European journal of heart failure

authors： Silverberg DS,Wexler D,Iaina A,Schwartz D

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Recent advances in pharmacological and pacemaker-based treatments for heart failure (HF) have brought about significant improvements in left ventricular function. AIMS:To identify the proportion of treated systolic HF patients in whom left ventricular systolic function improves and/or returns to normal. ME...

journal_title：European journal of heart failure

authors： Murphy NF,O'Loughlin C,Ledwidge M,McCaffrey D,McDonald K

更新日期：2007-12-01 00:00:00

abstract：AIMS:Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS:We studied 1527 p...

journal_title：European journal of heart failure

authors： Cogswell RJ,Norby FL,Gottesman RF,Chen LY,Solomon S,Shah A,Alonso A

更新日期：2017-10-01 00:00:00

abstract：AIMS:The Exercise Joins Education: Combined Therapy to Improve Outcomes in Newly-discharged Heart Failure (EJECTION-HF) study will evaluate the impact of a supervised exercise training programme (ETP) on clinical outcomes in recently hospitalized heart failure patients attending a disease management programme (DMP). Me...

journal_title：European journal of heart failure

authors： Mudge AM,Denaro CP,Scott AC,Atherton JJ,Meyers DE,Marwick TH,Adsett JA,Mullins RW,Suna JM,Scuffham PA,O'Rourke PK

更新日期：2011-12-01 00:00:00

abstract：AIMS:Latent heart failure at rest can be observed in a number of patients upon exercise. Considering left atrial (LA) remodelling as the reflection of the cumulative effects of the LV filling pressure (FP) over time, our aim was to investigate whether the LA volume would predict abnormal exercise LVFP. METHODS AND RES...

journal_title：European journal of heart failure

authors： Hammoudi N,Achkar M,Laveau F,Boubrit L,Djebbar M,Allali Y,Komajda M,Isnard R

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Hospital management of CHF and predictors of hospital mortality remain unclear. METHODS:To address these issues, we analyzed the hospital admissions for CHF during 1996 in a large university hospital. Patients discharged with the principal diagnosis of CHF were considered eligible for the study. RESULTS:Am...

journal_title：European journal of heart failure

authors： Grigioni F,Carinci V,Favero L,Bacchi Reggiani L,Magnani G,Potena L,Barbieri A,Magelli C,Branzi A,Magnani B

更新日期：2002-01-01 00:00:00

abstract：:Patients with mild-moderate chronic heart failure (CHF) often have raised levels of serum uric acid (UA). This is due, amongst other factors, to reduced UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels wors...

journal_title：European journal of heart failure

authors： Reyes AJ

更新日期：2005-06-01 00:00:00

abstract：AIMS:Growth differentiation factor-15 (GDF-15) is associated with adverse prognosis in cardiovascular (CV) and non-CV diseases. We evaluated the association of GDF-15 with CV and non-CV outcomes in the PARADIGM-HF trial. METHODS AND RESULTS:In 1935 patients with heart failure and reduced ejection fraction (HFrEF) in P...

journal_title：European journal of heart failure

authors： Bouabdallaoui N,Claggett B,Zile MR,McMurray JJV,O'Meara E,Packer M,Prescott MF,Swedberg K,Solomon SD,Rouleau JL,PARADIGM-HF Investigators and Committees.

更新日期：2018-12-01 00:00:00

abstract：AIMS:Rho kinases (ROCKs) are the best characterized effectors of the small G-protein RhoA, and play a role in enhanced vasoconstriction in animal models of congestive heart failure (CHF). This study examined if ROCK activity is increased in CHF and how it is associated with the outcome in CHF. METHODS AND RESULTS:Pati...

journal_title：European journal of heart failure

authors： Dong M,Liao JK,Fang F,Lee AP,Yan BP,Liu M,Yu CM

更新日期：2012-09-01 00:00:00

abstract：AIMS:To examine the current status of care and needs of adult congenital heart disease (ACHD) services in the Central and South Eastern European (CESEE) region. METHODS AND RESULTS:We obtained data regarding the national ACHD status for 19 CESEE countries from their ACHD representative based on an extensive survey for...

journal_title：European journal of heart failure

authors： Brida M,Šimkova I,Jovović L,Prokšelj K,Antonová P,Balint HO,Gumbiene L,Lebid IH,Komar M,Kratunkov P,Kovačević Preradović T,Ermel R,Strenge A,Coman IM,Vukomanović V,Gatzoulis MA,Roos-Hesselink JW,Diller GP

更新日期：2020-11-02 00:00:00

abstract：:The Elecsys NT-proBNP assay is based on two polyclonal antibodies directed at residues 1-21 and 39-50 of the NT-proBNP molecule. Analytical performance was assessed using NCCLS protocol EP-5A using three serum pools in a preliminary study then as part of a multicentre evaluation (16 instruments in 8 hospitals). Using ...

journal_title：European journal of heart failure

authors： Collinson PO,Barnes SC,Gaze DC,Galasko G,Lahiri A,Senior R

更新日期：2004-03-15 00:00:00

abstract：:The ELITE-II, BEST and CHAMP Trials were reported for the first time at the American Heart Association in November 1999. These trials provide valuable new information to guide clinical practice in the management of heart failure and of myocardial infarction, although none mandate a major change from current clinical p...

journal_title：European journal of heart failure

authors： Witte K,Thackray S,Banerjee T,Clark AL,Cleland JG

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies. Patients with restrictive cardiomyopathy (RCM) plus atrioventricular block (AVB) due to DES defects are frequently unrecognized unless d...

journal_title：European journal of heart failure

authors： Arbustini E,Pasotti M,Pilotto A,Pellegrini C,Grasso M,Previtali S,Repetto A,Bellini O,Azan G,Scaffino M,Campana C,Piccolo G,Viganò M,Tavazzi L

更新日期：2006-08-01 00:00:00