Abstract:
BACKGROUND:Several studies have shown that cardiac-resynchronization therapy (CRT) improves haemodynamic function, cardiac symptoms, and heart rate variability (HRV) and reduces the risk of mortality and sudden death in subjects with chronic heart failure (CHF). In subjects with CHF, power spectral values for the low-frequency (LF) component of RR variability < or =13 ms2, are associated with an increased risk of sudden death. AIMS AND METHODS:To assess whether spectral indexes obtained by power spectral analysis of HRV and systolic blood pressure (SBP) variability could predict malignant ventricular arrhythmias in patients with severe CHF treated with an implantable cardioverter-defibrillator (ICD) alone or with ICD+CRT. In addition, changes in non-invasive spectral indices using short-term power spectral analysis of HRV and SBP variability during controlled breathing in 15 patients with CHF treated with an ICD alone and 16 patients receiving ICD+CRT, were assessed pre-treatment and at 1 year. RESULTS:Arrhythmias necessitating an appropriate ICD shock were more frequent in subjects who had low LF power. CRT improved all spectral components, including LF power. CONCLUSIONS:Low LF power values predict an increased risk of malignant ventricular arrhythmias; after 1 year of CRT most non-spectral and spectral data, including LF power, improved. Whether these improvements lead to better long-term survival in patients with CHF remains unclear.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Piccirillo G,Magrì D,di Carlo S,De Laurentis T,Torrini A,Matera S,Magnanti M,Bernardi L,Barillà F,Quaglione R,Ettorre E,Marigliano Vdoi
10.1016/j.ejheart.2006.01.008keywords:
subject
Has Abstractpub_date
2006-11-01 00:00:00pages
716-22issue
7eissn
1388-9842issn
1879-0844pii
S1388-9842(06)00009-2journal_volume
8pub_type
杂志文章,随机对照试验abstract:AIMS:To compare the effects of lipophilic simvastatin and hydrophilic rosuvastatin on plasma adiponectin and glycated haemoglobin A1c (HbA1c) levels in patients with non-ischaemic chronic heart failure (NICHF). METHODS AND RESULTS:Seventy-one stable outpatients with NICHF, who were already receiving standard therapy f...
journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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更新日期:2006-06-01 00:00:00
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