Ghrelin resistance occurs in severe heart failure and resolves after heart transplantation.

Abstract:

AIMS:Severe heart failure (HF) is often associated with cachexia that reverses post-heart transplantation (HTx) with frequent development of obesity. Ghrelin is a novel appetite-stimulating hormone. The aim was to determine the role of ghrelin in regulating appetite, food intake, and body composition in HF and post-HTx. METHODS AND RESULTS:We measured serial ghrelin, hunger sensation, caloric intake, and body composition in 12 HF patients awaiting HTx, 12 patients 12.7 +/- 8.6 months post-HTx, and 7 controls. Seven of 12 HF patients were followed for longitudinal analysis post-HTx. Body mass index was 23.1 +/- 3.1 in HF and 31.5 +/- 5.5 post-HTx (P < 0.001). Heart transplantation patients had gained 18.0 +/- 7.7 kg since HTx. Ghrelin area under the curve between controlled meals (control: 186 +/- 39; HF: 264 +/- 71; HTx: 194 +/- 47 ng min/mL, P < 0.007) was higher in HF, but test meal caloric intake (control: 1185 +/- 650; HF: 391 +/- 103; HTx: 831 +/- 309 kcal, P < 0.008) was lower in HF. The longitudinal analysis confirmed these findings. CONCLUSION:Heart failure may be associated with resistance to the appetite-stimulating effects of ghrelin, which may contribute to cachexia. Heart transplantation may be associated with resolution of ghrelin resistance, which may contribute to weight gain. These findings are preliminary and should be confirmed in larger trials.

journal_name

Eur J Heart Fail

authors

Lund LH,Williams JJ,Freda P,LaManca JJ,LeJemtel TH,Mancini DM

doi

10.1093/eurjhf/hfp088

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

789-94

issue

8

eissn

1388-9842

issn

1879-0844

pii

hfp088

journal_volume

11

pub_type

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    doi:10.1016/s1388-9842(00)00074-x

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    pub_type: 杂志文章

    doi:10.1002/ejhf.1752

    authors: Besler C,Unterhuber M,Rommel KP,Unger E,Hartung P,von Roeder M,Noack T,Zachäus M,Halm U,Borger M,Desch S,Thiele H,Lurz P

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  • The prevalence and incidence of left bundle branch block in ambulant patients with chronic heart failure.

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2008.05.001

    authors: Clark AL,Goode K,Cleland JG

    更新日期:2008-07-01 00:00:00