Serum levels of large tenascin-C variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy.

Abstract:

AIMS:Chronic hypertension may cause left ventricular hypertrophy (LVH). The role of matrix metalloproteinases (MMPs), tissue inhibitors of matrix metalloproteinases (TIMPs), and tenascin-C (Tn-C) splice variants in concentric vs. eccentric left ventricular remodelling has not been investigated. METHODS AND RESULTS:Serum levels of B or C domain containing Tn-C, MMP-9, TIMP-1, -2, and -4 were determined in concentric (left ventricular posterior wall thickness >13 mm and intraventricular septum >13 mm, n = 61) and eccentric (end-diastolic left ventricular diameter >55 mm or end-systolic left ventricular diameter >40 mm, n = 34) LVH by enzyme-linked immunoassays. Levels of B domain containing Tn-C were higher in patients with LVH than in normal volunteers (P = 0.020) and higher in eccentric LVH (EH) compared with concentric LVH (CH) (P = 0.003). A cut-off value of 900 ng/mL might discriminate between these different forms of LVH. Matrix metalloproteinase-9 was higher in patients with LVH than in normal volunteers (P = 0.042), and levels were decreased in EH compared with CH (P = 0.028). Patients with LVH had higher levels of TIMP-1 (P = 0.059), TIMP-2 (P = 0.043), and TIMP-4 (P = 0.163) than normal volunteers, but there were no differences between the LVH groups. CONCLUSION:Our data suggest that myocardial remodelling in LVH is associated with changes in serum levels of MMP-9, TIMP-1, -2, -4, and Tn-C splice variants. In addition, B domain containing Tn-C discriminated EH from CH and might be suggested as a potential diagnostic marker.

journal_name

Eur J Heart Fail

authors

Franz M,Berndt A,Altendorf-Hofmann A,Fiedler N,Richter P,Schumm J,Fritzenwanger M,Figulla HR,Brehm BR

doi

10.1093/eurjhf/hfp128

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

1057-62

issue

11

eissn

1388-9842

issn

1879-0844

pii

hfp128

journal_volume

11

pub_type

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    doi:10.1002/ejhf.1373

    authors: Citro R,Radano I,Parodi G,Di Vece D,Zito C,Novo G,Provenza G,Bellino M,Prota C,Silverio A,Antonini-Canterin F,Rigo F,Vriz O,Galasso G,Bossone E,Salerno-Uriarte J,Piscione F

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    doi:10.1016/j.ejheart.2005.02.001

    authors: Franco-Cereceda A,Holm P,Bredin F,Adding C

    更新日期:2005-12-01 00:00:00

  • Echocardiographic quantification of regional deformation helps to distinguish isolated left ventricular non-compaction from dilated cardiomyopathy.

    abstract:AIMS:Pronounced trabeculation is presented in both left ventricular non-compaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the differentiation difficult. We hypothesized that echocardiographic deformation analysis would help to differentiate these two cardiomyopathies. METHODS AND RESULTS:We inv...

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    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfr164

    authors: Niemann M,Liu D,Hu K,Cikes M,Beer M,Herrmann S,Gaudron PD,Hillenbrand H,Voelker W,Ertl G,Weidemann F

    更新日期:2012-02-01 00:00:00

  • Serum aldosterone is associated with mortality and re-hospitalization in patients with reduced ejection fraction hospitalized for acute heart failure: analysis from the EVEREST trial.

    abstract:AIMS:Post-discharge morbidity and mortality for acute heart failure (AHF) patients remains high. Although the adverse effects of neurohormonal activation are well known in chronic HF, the prognostic significance of serum aldosterone in patients hospitalized for AHF has not been well studied. METHODS AND RESULTS:A seco...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft100

    authors: Girerd N,Pang PS,Swedberg K,Fought A,Kwasny MJ,Subacius H,Konstam MA,Maggioni A,Gheorghiade M,Zannad F,EVEREST investigators.

    更新日期:2013-11-01 00:00:00