Effect of dofetilide on QT dispersion and the prognostic implications of changes in QT dispersion for patients with congestive heart failure.

Abstract:

AIMS:Drug-induced changes in QT dispersion may be a way of detecting harmful repolarisation abnormalities for patients receiving antiarrhythmic drugs affecting ventricular repolarisation. METHODS AND RESULTS:In 463 congestive heart failure (CHF) patients enrolled in the Danish Investigations Of Arrhythmia and Mortality On Dofetilide-CHF (DIAMOND-CHF) study, both pre-treatment and on-treatment day 2-6 QT dispersion was available from standard 12-lead ECGs. Patients were randomised in a double-blind manner to receive either placebo or dofetilide, a new class III antiarrhythmic drug. During a median follow-up of 19 months (minimum 1 year), 179 patients (39%) died (135 patients from cardiac causes). Changes in QT dispersion did not predict all-cause or cardiac mortality for patients treated with dofetilide in multivariate survival analysis (Risk ratio: 1.02, 95% confidence interval: 0.97-1.08, P>0.4). This finding was independent of pre-treatment QT dispersion. Dofetilide caused a small QT dispersion increment of 8 ms, not different from the changes seen in the placebo group (3 ms). CONCLUSION:For patients with CHF and reduced left ventricular systolic function, changes in QT dispersion following treatment with dofetilide do not predict all-cause or cardiac mortality. The dofetilide-induced QT dispersion changes are small and comparable to those seen in placebo treated patients.

journal_name

Eur J Heart Fail

authors

Brendorp B,Elming H,Jun L,Køber L,Torp-Pedersen C,DIAMOND Study Group. Danish Investigations Of Arrhythmia and Mortality On Dofetilide.

doi

10.1016/s1388-9842(01)00235-5

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

201-6

issue

2

eissn

1388-9842

issn

1879-0844

pii

S1388984201002355

journal_volume

4

pub_type

临床试验,杂志文章,随机对照试验
  • Negative inotropic effects of recombinant interleukin 2 in patients without left ventricular dysfunction.

    abstract:UNLABELLED:Experimental data have shown that rIL2 has negative inotropic properties. This has not been investigated in humans with normal left ventricular function. Seventeen consecutive renal cell carcinoma patients who received rIL2 therapy because of dissemination were analyzed before and after treatment with a low ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00073-8

    authors: Tio RA,Nieken J,de Vries EG,Pfeiffer C,de Jongste MJ,Pieper E,Moshage H,Limburg PC,Mulder NH

    更新日期:2000-06-01 00:00:00

  • Left atrial enlargement and NT-proBNP as predictors of sudden cardiac death in patients with heart failure.

    abstract:AIMS:The identification of valuable markers of sudden cardiac death (SCD) in patients with established HF remains a challenge. We sought to assess the value of clinical, echocardiographic and biochemical variables to predict SCD in a consecutive cohort of patients with heart failure (HF) due to systolic dysfunction. M...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ejheart.2007.05.001

    authors: Bayes-Genis A,Vazquez R,Puig T,Fernandez-Palomeque C,Fabregat J,Bardají A,Pascual-Figal D,Ordoñez-Llanos J,Valdes M,Gabarrús A,Pavon R,Pastor L,Gonzalez Juanatey JR,Almendral J,Fiol M,Nieto V,Macaya C,Cinca J,Bayes de

    更新日期:2007-08-01 00:00:00

  • Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials.

    abstract::Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in card...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1557

    authors: Ahmad T,Miller PE,McCullough M,Desai NR,Riello R,Psotka M,Böhm M,Allen LA,Teerlink JR,Rosano GMC,Lindenfeld J

    更新日期:2019-09-01 00:00:00

  • Myocarditis as a precipitating factor for heart failure: evaluation and 1-year follow-up using cardiovascular magnetic resonance and endomyocardial biopsy.

    abstract:AIMS:The aim of this study was to evaluate myocarditis as a precipitating factor for heart failure using cardiovascular magnetic resonance (CMR) and endomyocardial biopsy. METHODS AND RESULTS:Eighty-five patients with suspected myocarditis and 20 controls were evaluated. Seventy-one patients with positive CMR were ref...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfr052

    authors: Mavrogeni S,Spargias C,Bratis C,Kolovou G,Markussis V,Papadopoulou E,Constadoulakis P,Papadimitropoulos M,Douskou M,Pavlides G,Cokkinos D

    更新日期:2011-08-01 00:00:00

  • Attenuation of postoperative noradrenaline need by nitric oxide inhibition using L-NMMA.

    abstract::In the present report we describe that NG-monomethyl-L-arginine acetate, a non-specific nitric oxide synthesis inhibitor, administered at 1 mg kg(-1) h(-1) to a patient with critical hypotension following mitral valve surgery combined with passive containment surgery, increased the urinary output and arterial blood pr...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.02.001

    authors: Franco-Cereceda A,Holm P,Bredin F,Adding C

    更新日期:2005-12-01 00:00:00

  • Myocardial gene expression alterations in peripheral blood mononuclear cells of patients with idiopathic dilated cardiomyopathy.

    abstract:AIMS:To assess cardiac gene expression in peripheral blood cells of patients with idiopathic dilated cardiomyopathy (IDCM) and its relationship to echocardiographic left ventricular (LV) function. METHODS AND RESULTS:A complete echocardiographic study and blood sampling were performed in 65 consecutive stable IDCM pat...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfq057

    authors: Kontaraki JE,Parthenakis FI,Nyktari EG,Patrianakos AP,Vardas PE

    更新日期:2010-06-01 00:00:00

  • Wall motion index, estimated glomerular filtration rate and mortality risk in patients with heart failure or myocardial infarction: a pooled analysis of 18,010 patients.

    abstract:AIMS:This study was designed to assess whether the prognostic significance of estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF) interact in populations with heart failure (HF) and myocardial infarction (MI). METHODS:Patients were recruited from four screening registers (N=18,010...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2008.04.006

    authors: Schou M,Torp-Pedersen C,Gustafsson F,Abdulla J,Kober L

    更新日期:2008-07-01 00:00:00

  • Correlation between serial measurements of N-terminal pro brain natriuretic peptide and ambulatory cardiac filling pressures in outpatients with chronic heart failure.

    abstract:BACKGROUND:Serial measurements of N-terminal pro brain natriuretic peptide (NT-proBNP) have been suggested for the management of outpatients with chronic heart failure (CHF). The relationship between NT-proBNP plasma levels and central haemodynamic parameters in this setting is not known. METHODS:In 19 outpatients wit...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.03.002

    authors: Braunschweig F,Fahrleitner-Pammer A,Mangiavacchi M,Ghio S,Fotuhi P,Hoppe UC,Linde C

    更新日期:2006-12-01 00:00:00

  • The use of diuretics in heart failure with congestion - a position statement from the Heart Failure Association of the European Society of Cardiology.

    abstract::The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly through the use of diuretic therapy. The appropriate use of diuretic...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1369

    authors: Mullens W,Damman K,Harjola VP,Mebazaa A,Brunner-La Rocca HP,Martens P,Testani JM,Tang WHW,Orso F,Rossignol P,Metra M,Filippatos G,Seferovic PM,Ruschitzka F,Coats AJ

    更新日期:2019-02-01 00:00:00

  • Pharmacotherapeutic approaches for decompensated heart failure: a role for the calcium sensitiser, levosimendan?

    abstract::Although no universal definition exists, decompensated heart failure may be regarded as either a worsening of chronic heart failure or new-onset heart failure precipitated by an acute incident. Haemodynamic management of patients hospitalised with decompensated heart failure may include the administration of diuretics...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/s1388-9842(02)00118-6

    authors: Greenberg B,Borghi C,Perrone S

    更新日期:2003-01-01 00:00:00

  • Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel.

    abstract:AIMS:The objective of this study was to establish the acute effects of hypoxia on clinical, spirometric, haemodynamic, and echocardiographic variables. Reducing inspired oxygen to 15%, as experienced during commercial air travel, decreases arterial oxygen saturation, increases respiratory rate and pulmonary artery pres...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft003

    authors: Hobkirk JP,Damy T,Walters M,Bennett A,Smith SJ,Ingle L,Clark AL,Cleland JG

    更新日期:2013-05-01 00:00:00

  • The impact of heart failure on prognosis of diabetic and non-diabetic patients with myocardial infarction: a 15-year follow-up study.

    abstract:BACKGROUND:Information about the occurrence of heart failure in the acute phase of myocardial infarction (MI) in diabetic patients and its impact on prognosis are sparse. AIM:The purpose of the present study was to describe how MI patients with diabetes mellitus (DM) differed from MI patients without DM with respect t...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00117-3

    authors: Melchior T,Rask-Madsen C,Torp-Pedersen C,Hildebrandt P,Køber L,Jensen G

    更新日期:2001-01-01 00:00:00

  • Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years.

    abstract:AIMS:Exercise-derived parameters, specifically peak exercise oxygen uptake (peak VO2 ) and minute ventilation/carbon dioxide relationship slope (VE/VCO2 slope), have a pivotal prognostic value in heart failure (HF). It is unknown how the prognostic threshold of peak VO2 and VE/VCO2 slope has changed over the last 20 ye...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ejhf.1364

    authors: Paolillo S,Veglia F,Salvioni E,Corrà U,Piepoli M,Lagioia R,Limongelli G,Sinagra G,Cattadori G,Scardovi AB,Metra M,Senni M,Bonomi A,Scrutinio D,Raimondo R,Emdin M,Magrì D,Parati G,Re F,Cicoira M,Minà C,Correale M

    更新日期:2019-02-01 00:00:00

  • European Society of Cardiology Working Group on Adult Congenital Heart Disease and Study Group for Adult Congenital Heart Care in Central and South Eastern European Countries consensus paper: current status, provision gaps and investment required.

    abstract:AIMS:To examine the current status of care and needs of adult congenital heart disease (ACHD) services in the Central and South Eastern European (CESEE) region. METHODS AND RESULTS:We obtained data regarding the national ACHD status for 19 CESEE countries from their ACHD representative based on an extensive survey for...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.2040

    authors: Brida M,Šimkova I,Jovović L,Prokšelj K,Antonová P,Balint HO,Gumbiene L,Lebid IH,Komar M,Kratunkov P,Kovačević Preradović T,Ermel R,Strenge A,Coman IM,Vukomanović V,Gatzoulis MA,Roos-Hesselink JW,Diller GP

    更新日期:2020-11-02 00:00:00

  • Exercise training in recently hospitalized heart failure patients enrolled in a disease management programme: design of the EJECTION-HF randomized controlled trial.

    abstract:AIMS:The Exercise Joins Education: Combined Therapy to Improve Outcomes in Newly-discharged Heart Failure (EJECTION-HF) study will evaluate the impact of a supervised exercise training programme (ETP) on clinical outcomes in recently hospitalized heart failure patients attending a disease management programme (DMP). Me...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hfr139

    authors: Mudge AM,Denaro CP,Scott AC,Atherton JJ,Meyers DE,Marwick TH,Adsett JA,Mullins RW,Suna JM,Scuffham PA,O'Rourke PK

    更新日期:2011-12-01 00:00:00

  • Preferences of heart failure patients in daily clinical practice: quality of life or longevity?

    abstract:AIMS:Knowledge of patient preferences is vital for delivering optimal healthcare. This study uses utility measurement to assess the preferences of heart failure (HF) patients regarding quality of life or longevity. The utility approach represents the perspective of a patient; facilitates the combination of mortality, m...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft071

    authors: Kraai IH,Vermeulen KM,Luttik ML,Hoekstra T,Jaarsma T,Hillege HL

    更新日期:2013-10-01 00:00:00

  • Heart failure in a multiethnic population in Kuala Lumpur, Malaysia.

    abstract:BACKGROUND:There are established differences in cardiovascular disease in different racial groups. Worldwide, the literature regarding the clinical epidemiology of congestive heart failure (CHF) in non-white populations is scarce. OBJECTIVES:To document the prevalence of CHF in the multiracial population of Malaysia, ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(03)00013-8

    authors: Chong AY,Rajaratnam R,Hussein NR,Lip GY

    更新日期:2003-08-01 00:00:00

  • Prevention of heart failure events with intensive versus standard blood pressure lowering across the spectrum of kidney function and albuminuria: a SPRINT substudy.

    abstract:AIMS:To determine whether a strategy of intensive blood pressure control reduces the risk of heart failure (HF) events consistently across the spectrum of kidney function and albuminuria. METHODS AND RESULTS:SPRINT was a randomized clinical trial in which 9361 individuals ≥50 years, at high risk for or with cardiovasc...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1971

    authors: Vaduganathan M,Pareek M,Kristensen AMD,Biering-Sørensen T,Byrne C,Almarzooq Z,Olesen TB,Olsen MH,Bhatt DL

    更新日期:2020-07-21 00:00:00

  • Alveolar-capillary membrane conductance is the best pulmonary function correlate of exercise ventilation efficiency in heart failure patients.

    abstract:BACKGROUND:In heart failure (HF), changes in lung mechanics and gas diffusion are limiting factors to exercise. Their contribution to an increased exercise ventilation to CO2 production (VE/VCO2) slope is undefined. METHODS:A total of 67 stable HF patients underwent cardiopulmonary exercise and pulmonary function test...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.10.009

    authors: Guazzi M,Reina G,Tumminello G,Guazzi MD

    更新日期:2005-10-01 00:00:00

  • Clinical trials update from the European Society of Cardiology: CHARM, BASEL, EUROPA and ESTEEM.

    abstract::This article contains a series of reports on recent research developments in the field of heart failure. Reports of key presentations made at the European Society of Cardiology meeting, held in Vienna, Austria, between 30 August and 3 September 2003 are reported. In the CHARM study, candesartan reduced cardiovascular ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(03)00161-2

    authors: Coletta AP,Cleland JG,Freemantle N,Loh H,Memon A,Clark AL

    更新日期:2003-10-01 00:00:00

  • Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure.

    abstract:BACKGROUND:Suppression of the renin-angiotensin-aldosterone system (RAAS) is therapeutically valuable in chronic heart failure (CHF). RAAS inhibition can be achieved in a number of ways though an orally active renin inhibitor (RI) has never been studied before. We describe the neurohumoral effects of an RI. METHODS AN...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ejheart.2007.09.002

    authors: Seed A,Gardner R,McMurray J,Hillier C,Murdoch D,MacFadyen R,Bobillier A,Mann J,McDonagh T

    更新日期:2007-11-01 00:00:00

  • Increasing glucose levels and BMI predict future heart failure experience from the Reykjavík Study.

    abstract:BACKGROUND:Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS:7060 subjects with two or more visits in the Reykjavík Study were followed--during 30 years from 1967. All underwent oral glucose toler...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.07.017

    authors: Thrainsdottir IS,Aspelund T,Gudnason V,Malmberg K,Sigurdsson G,Thorgeirsson G,Hardarson T,Rydén L

    更新日期:2007-10-01 00:00:00

  • Perceived benefit after participating in positive or negative/neutral heart failure trials: the patients' perspective.

    abstract:BACKGROUND:Clinical trials, the gold standard for the evaluation of new therapeutic strategies, may prove a drug to be beneficial, harmful or neutral according to its effect on the end-point(s) under study. AIMS:To study the reaction and perspective of the patients participating in a clinical heart failure trial, part...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00151-3

    authors: Yuval R,Uziel K,Gordon N,Merdler A,Khader N,Karkabi B,Flugelman MY,Halon DA,Lewis BS

    更新日期:2001-03-01 00:00:00

  • Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure: a long-term cardiopulmonary exercise testing placebo-controlled study.

    abstract:AIMS:Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in ∼20% of heart failure (HF) patients and carries a very unfavourable prognosis. Pulmonary vasoconstriction has been suggested to be involved in this disorder. We hypothesized that modulation of pulmonary vascular hypertone by oversigna...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfr147

    authors: Guazzi M,Vicenzi M,Arena R

    更新日期:2012-01-01 00:00:00

  • Myostatin activation in patients with advanced heart failure and after mechanical unloading.

    abstract:AIMS:Myostatin inhibits myoblast differentiation/proliferation and may play a role in heart failure (HF) and reverse remodelling after left ventricular assist device (LVAD) support. This study sought to characterize myostatin expression and activation in advanced HF before and after LVAD support. METHODS AND RESULTS:L...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfq039

    authors: George I,Bish LT,Kamalakkannan G,Petrilli CM,Oz MC,Naka Y,Sweeney HL,Maybaum S

    更新日期:2010-05-01 00:00:00

  • Baseline characteristics and outcomes of patients with heart failure receiving bronchodilators in the CHARM programme.

    abstract:AIMS:Heart failure (HF) and chronic obstructive pulmonary disease are common partners. Bronchodilators are associated with adverse cardiovascular outcomes in patients with pulmonary disease. The outcome of patients with HF prescribed bronchodilators is poorly defined. METHODS AND RESULTS:The Candesartan in Heart failu...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfq040

    authors: Hawkins NM,Wang D,Petrie MC,Pfeffer MA,Swedberg K,Granger CB,Yusuf S,Solomon SD,Ostergren J,Michelson EL,Pocock SJ,Maggioni AP,McMurray JJ,CHARM Investigators and Committees.

    更新日期:2010-06-01 00:00:00

  • Rationale for and design of the TRUE-AHF trial: the effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure.

    abstract::The TRUE-AHF is a randomized, double-blind, parallel-group, placebo-controlled trial which is evaluating the effects of a 48-h infusion of ularitide (15 ng/kg/min) on the short- and long-term clinical course of patients with acute heart failure. Noteworthy features of the study include the early enrolment of patients ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ejhf.698

    authors: Packer M,Holcomb R,Abraham WT,Anker S,Dickstein K,Filippatos G,Krum H,Maggioni AP,McMurray JJV,Mebazaa A,O'Connor C,Peacock F,Ponikowski P,Ruschitzka F,van Veldhuisen DJ,Holzmeister J,TRUE-AHF Investigators and Committees

    更新日期:2017-05-01 00:00:00

  • Mechanical stretch-induced hypertrophy of neonatal rat ventricular myocytes is mediated by beta(1)-integrin-microtubule signaling pathways.

    abstract:BACKGROUND:Mechanical stress plays a crucial role in tissue morphogenesis and remodeling. These processes depend in part on force transmission mediated through integrins and the cytoskeleton. METHODS:Ventricular myocytes isolated from neonatal Sprague-Dawley rats (NRVMs) were exposed to persistent centrifugal force st...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.05.014

    authors: Yutao X,Geru W,Xiaojun B,Tao G,Aiqun M

    更新日期:2006-01-01 00:00:00

  • Improved angiogenic response in pig heart following ischaemic injury using human skeletal myoblast simultaneously expressing VEGF165 and angiopoietin-1.

    abstract:OBJECTIVE:To achieve angiogenic interaction between VEGF(165) and angiopoietin-1 (Ang-1) using a novel adenoviral bicistronic vector (Ad-Bic) encoding the two factors and delivered ex vivo using sex-mismatched human skeletal myoblasts. METHODS AND RESULTS:A myocardial infarction model was developed in 29 female pigs; ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.04.008

    authors: Ye L,Haider HKh,Jiang S,Tan RS,Ge R,Law PK,Sim EK

    更新日期:2007-01-01 00:00:00

  • Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction.

    abstract:AIM:To evaluate the long-term outcome of patients with Takotsubo syndrome (TTS) and severely reduced left ventricular ejection fraction (LVEF ≤ 35%) at presentation. METHODS AND RESULTS:The study population included 326 patients (mean age 69.5 ± 10.7 years, 28 male) with TTS enrolled in the Takotsubo Italian Network, ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1373

    authors: Citro R,Radano I,Parodi G,Di Vece D,Zito C,Novo G,Provenza G,Bellino M,Prota C,Silverio A,Antonini-Canterin F,Rigo F,Vriz O,Galasso G,Bossone E,Salerno-Uriarte J,Piscione F

    更新日期:2019-06-01 00:00:00