Abstract:
BACKGROUND:Serial measurements of N-terminal pro brain natriuretic peptide (NT-proBNP) have been suggested for the management of outpatients with chronic heart failure (CHF). The relationship between NT-proBNP plasma levels and central haemodynamic parameters in this setting is not known. METHODS:In 19 outpatients with CHF, NT-proBNP was related to central haemodynamic information, continuously measured with an implanted haemodynamic monitor (IHM) during 24 h of daily living activities ("24 h") and during supine rest ("rest"). In 13 patients, three to seven serial measurements were obtained with a mean time interval of 39 days (range 19-113). RESULTS:At the first visit (n=19), NT-proBNP plasma levels were dispersed over a wide range of filling pressures and not correlated with the 24 h median of the right ventricular systolic pressure (RVSP) and the estimated pulmonary artery pressure (ePAD). However, in the individual patient, serial measurements yielded significant positive correlations between NT-proBNP and RVSP (p=0.006) and ePAD (p=0.001). During "24 h" compared with "rest", the median RVSP and ePAD were elevated by 20+/-16% and 32+/-18%, respectively, and corresponded better with NT-proBNP (p<0.05). CONCLUSION:In outpatients with CHF, single measurements of NT-proBNP are not correlated with cardiac filling pressures. However, serial measurements of NT-proBNP in each individual patient show a significant positive correlation with central haemodynamic parameters and reflect changes in the haemodynamic state over time.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Braunschweig F,Fahrleitner-Pammer A,Mangiavacchi M,Ghio S,Fotuhi P,Hoppe UC,Linde Cdoi
10.1016/j.ejheart.2006.03.002subject
Has Abstractpub_date
2006-12-01 00:00:00pages
797-803issue
8eissn
1388-9842issn
1879-0844pii
S1388-9842(06)00068-7journal_volume
8pub_type
杂志文章abstract:AIMS:Differentiation of heart failure with reduced (HFrEF) or preserved (HFpEF) ejection fraction independent of echocardiography is challenging in the community. Diagnostic strategies based on monitoring circulating microRNA (miRNA) levels may prove to be of clinical value in the near future. The aim of this study was...
journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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更新日期:2014-10-01 00:00:00
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journal_title:European journal of heart failure
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doi:10.1093/eurjhf/hfq216
更新日期:2011-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/s1388-9842(02)00118-6
更新日期:2003-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-02-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2004.03.020
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.2008
更新日期:2020-09-18 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-12-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejheart.2007.05.010
更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2007-11-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2008.04.003
更新日期:2008-06-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1971
更新日期:2020-07-21 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ejhf.1223
更新日期:2018-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2010-06-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ejheart.2007.05.001
更新日期:2007-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2003.11.015
更新日期:2004-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
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更新日期:2003-06-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfq205
更新日期:2011-02-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfn008
更新日期:2009-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.559
更新日期:2016-11-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.03.007
更新日期:2005-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2005.11.013
更新日期:2006-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2006.01.013
更新日期:2006-11-01 00:00:00