Abstract：
BACKGROUND:Hereditary hemochromatosis (HH), a common autosomal recessive disease, leads to excessive iron accumulation in some organs, including the heart. It is therefore not surprising that cardiomyopathy is one of the most severe complications of HH. The HFE gene defects have been thought to contribute to idiopathic dilated cardiomyopathy (IDCM) in some patients, even though the results of genotype analyses have so far been contradictory. Hence we set out here to evaluate the prevalence and potential role of HFE mutations in patients with IDCM. METHODS:A total of 91 IDCM patients and 102 controls were subjected to HFE mutation analyses, in which C282Y, H63D and S65C mutations were determined for each patient. We also analyzed the impact of the C282Y and H63D mutations on the left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and New York Heart Association (NYHA) functional classes. RESULTS:The prevalences of heterozygosity for the C282Y, H63D and S65C mutations in the IDCM patients were 13.2%, 22.0% and 2.2%, respectively. LVEDD was significantly higher (P=0.037) in those with the C282Y mutation at the end of the follow-up period than in those with no mutation. CONCLUSIONS:Our data showed no significant deviations in C282Y, H63D and S65C mutation frequencies between the IDCM patients and controls, suggesting that these mutations do not increase the risk of IDCM. Heterozygosity for the C282Y mutation may nevertheless be a modifying factor contributing to LV dilatation and remodeling.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Hannuksela J,Leppilampi M,Peuhkurinen K,Kärkkäinen S,Saastamoinen E,Heliö T,Kaartinen M,Nieminen MS,Nieminen P,Parkkila Sdoi
10.1016/j.ejheart.2004.03.007keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
103-8issue
1eissn
1388-9842issn
1879-0844pii
S1388984204001072journal_volume
7pub_type
杂志文章abstract：AIMS:To evaluate in patients with heart failure (HF) due to systolic dysfunction the occurrence of polypharmacy, alternative medicine, immunization against influenza, and patients' knowledge about their medication. METHODS AND RESULTS:Sixty-five patients, 49 men, mean age 60.5+/-12.0 years answered a confidential ques...
journal_title：European journal of heart failure
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更新日期：2004-03-01 00:00:00
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abstract：:Cardiac resynchronization therapy (CRT) is one of the most effective therapies for heart failure with reduced ejection fraction and leads to improved quality of life, reductions in heart failure hospitalization rates and reduces all-cause mortality. Nevertheless, up to two-thirds of eligible patients are not referred ...
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journal_title：European journal of heart failure
pub_type： 临床试验,杂志文章
doi：10.1016/j.ejheart.2007.06.001
更新日期：2007-09-01 00:00:00
abstract：AIMS:Most studies on acute heart failure (HF) exploring the relationship between admissions to hospital for HF and subsequent outcomes have focused only on HF coded as the primary diagnosis, but many other patients have admissions complicated by HF requiring attention. Failure to quantify the total hospital burden of H...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.505
更新日期：2016-05-01 00:00:00
abstract：AIMS:With improvement in survival of chronic heart failure (HF), the clinical importance of co-morbidity is increasing. The aim of this study was to assess the incidence and risk of cancer and all-cause mortality in a large Danish HF cohort. METHODS AND RESULTS:A total of 9307 outpatients with verified HF without a pr...
journal_title：European journal of heart failure
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doi：10.1002/ejhf.472
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abstract：AIMS:Pronounced trabeculation is presented in both left ventricular non-compaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the differentiation difficult. We hypothesized that echocardiographic deformation analysis would help to differentiate these two cardiomyopathies. METHODS AND RESULTS:We inv...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfr164
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abstract：OBJECTIVE:To investigate in vivo effects of long-term selective beta1-blockade on cardiac energy metabolism, remodelling, function and plasma cytokines in a rat model of post-infarct congestive heart failure (CHF). METHODS:Myocardial infarction (MI) was induced in male rats by ligation of the left coronary artery. Thr...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(03)00153-3
更新日期：2003-12-01 00:00:00
abstract：AIMS:Severe heart failure (HF) is often associated with cachexia that reverses post-heart transplantation (HTx) with frequent development of obesity. Ghrelin is a novel appetite-stimulating hormone. The aim was to determine the role of ghrelin in regulating appetite, food intake, and body composition in HF and post-HTx...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfp088
更新日期：2009-08-01 00:00:00
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journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究
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abstract：BACKGROUND:Plasma levels of N-terminal pro-brain natriuretic peptide (NT-pro BNP) are increased in patients with chronic heart failure (CHF). Beta-blockers (BB) may influence these levels but it is unclear whether changes in NT-pro BNP reflect concomitant changes in prognosis. OBJECTIVES:To assess the prognostic impor...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ejheart.2007.07.010
更新日期：2007-08-01 00:00:00
abstract：AIMS:To investigate temporal trends in the risk of heart failure (HF) complicating acute myocardial infarction (AMI) and to determine whether these trends differ by gender or age. METHODS AND RESULTS:The national Swedish hospital discharge and death registries from 1993 to 2004 were used to calculate age- and gender-s...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfq205
更新日期：2011-02-01 00:00:00
abstract：:Galectins are a family of soluble beta-galactoside-binding lectins that play many important regulatory roles in inflammation, immunity, and cancer. Recently, a role for galectin-3 in the pathophysiology of heart failure (HF) has been suggested. Numerous studies have demonstrated the up-regulation of galectin-3 in hype...
journal_title：European journal of heart failure
pub_type： 杂志文章,评审
doi：10.1093/eurjhf/hfp097
更新日期：2009-09-01 00:00:00
abstract：AIMS:Calcium channel plays an important role in the autoimmune pathogenesis of idiopathic dilated cardiomyopathy (DCM). Autoantibodies have emerged as a new upstream target of sudden death in DCM. We sought to validate the hypothesis that autoantibodies against l-type calcium channel (CC-AAbs) are arrhythmogenic and le...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfq198
更新日期：2011-03-01 00:00:00
abstract：AIM:We used Near Infrared Spectrophotometry (NIRS) during arterial occlusion to measure resting skeletal muscle oxygen consumption in chronic heart failure (CHF) patients and in age-matched healthy volunteers (HVs). METHODS:Fifteen CHF patients (ten males) and eleven HVs (six males) had echocardiographic evaluation fo...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2008.05.009
更新日期：2008-07-01 00:00:00
abstract：AIMS:Quantification of linear lung ultrasound (LUS) artefacts (B-lines) represents a novel, non-invasive approach to assess pulmonary congestion. We investigated the relationship between the number of B-lines (vertical artefacts arising from the pleural line) and intracardiac pressures. METHODS AND RESULTS:Prior to sc...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfs144
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Knowledge on clinical characteristics and prognosis of patients with heart failure originates from studies of selected populations in clinical trials or from epidemiological observations. Reports on the large numbers of patients with heart failure treated in community hospitals are sparse. OBJECTIVE:Are the...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(01)00142-8
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:There is increasing evidence that discharge planning and post-discharge support for CHF patients can contribute greatly to the medical management of heart failure (CHF) in the community and that the quality of the CHF patient's close personal relationships can influence outcome in CHF. However, there has bee...
journal_title：European journal of heart failure
pub_type： 杂志文章,评审
doi：10.1016/j.ejheart.2004.07.008
更新日期：2005-06-01 00:00:00
abstract：AIMS:To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction. METHODS:3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myoc...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(03)00159-4
更新日期：2003-12-01 00:00:00
abstract：AIM:Heart failure with preserved ejection fraction (HFpEF) is associated with increased sympathetic nervous system (SNS) tone. Attenuating the SNS with renal denervation (RDT) might be helpful and there are no data currently in humans with HFpEF. METHODS AND RESULTS:In this single-centre, randomized, open-controlled s...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
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abstract：AIMS:Cardiogenic shock is the leading cause of in-hospital mortality after acute myocardial infarction (MI). This study investigates the importance of age and preexisting diabetes mellitus on the incidence and prognosis of cardiogenic shock in a large group of consecutive patients with MI. METHODS AND RESULTS:Baseline...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2004.09.007
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:The rate constant for global fatty acid influx (k(1)) was studied in 12 male patients with dilated cardiomyopathy (DCM). METHOD:10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions. RESULTS...
journal_title：European journal of heart failure
pub_type： 杂志文章
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更新日期：2002-08-01 00:00:00
abstract：AIMS:We aimed to determine the relation between baseline systolic blood pressure (SBP), change in SBP, and worsening renal function (WRF) in acute heart failure (AHF) patients enrolled in the Pre-RELAX-AHF trial. METHODS AND RESULTS:The Pre-RELAX-AHF study enrolled 234 patients within 16 h of admission (median 7 h) fo...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2011-09-01 00:00:00
abstract：UNLABELLED:Experimental data have shown that rIL2 has negative inotropic properties. This has not been investigated in humans with normal left ventricular function. Seventeen consecutive renal cell carcinoma patients who received rIL2 therapy because of dissemination were analyzed before and after treatment with a low ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(00)00073-8
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:Carvedilol is a beta-blocker with similar affinity for beta1- and beta2 receptors, while bisoprolol has higher beta1 affinity. The respiratory system is characterized by beta2-receptor prevalence. Airway beta receptors regulate bronchial tone and alveolar beta receptors regulate alveolar fluid re-absorption ...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ejheart.2007.04.006
更新日期：2007-08-01 00:00:00
abstract：AIMS:Mutations in the lamin A/C gene (LMNA) cause a variety of clinical phenotypes, including dilated cardiomyopathy. LMNA is one of the most prevalent mutated genes in dilated cardiomyopathy, and is associated with a high risk of arrhythmias, sudden cardiac death, and heart failure. There are few data on the impact of...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究
doi：10.1093/eurjhf/hfs191
更新日期：2013-04-01 00:00:00
abstract：AIMS:To investigate the relationship between decongestion, central venous pressure, and risk of worsening renal function (WRF) in patients with acute decompensated heart failure (ADHF). METHODS AND RESULTS:We studied 475 patients with ADHF, of whom 238 underwent right heart catheterization. Right atrial pressure (RAP)...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1093/eurjhf/hft036
更新日期：2013-06-01 00:00:00
abstract：AIMS:Previous evaluations of natriuretic peptide (NP) levels in patients with acute dyspnoea presenting to the emergency department (ED) have selected only a minority of patients for echocardiography. We aimed to evaluate the association between NPs and more subtle echocardiographic findings and to assess the potential...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究
doi：10.1093/eurjhf/hfp075
更新日期：2009-07-01 00:00:00
abstract：AIMS:Endothelial dysfunction has been shown to correlate with severity of congestive heart failure (CHF) and recent data suggest morphological changes of peripheral vasculature to be associated with the syndrome. We therefore investigated the hypothesis that vascular remodeling is associated with functional changes in ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2004.04.008
更新日期：2005-01-01 00:00:00
abstract：AIMS:Ventricular septal rupture (VSR) became a rare mechanical complication of myocardial infarction in the era of percutaneous coronary interventions but is associated with extreme mortality in patients who present with cardiogenic shock (CS). Promising outcomes have been reported with the use of circulatory support a...
journal_title：European journal of heart failure
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
