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Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications.

Abstract：

AIMS:To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction. METHODS:3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myocardial Infarction Trial with definite acute myocardial infarction and echocardiographic assessment of left ventricular systolic function were included between 1998 and 1999 in this prospective observational study. Main outcome measures were occurrences of in-hospital complications and all cause mortality. RESULTS:Congestive heart failure was seen during hospitalisation in 1464 patients (46%), 717 patients had preserved left ventricular systolic function (wall motion index > or =1.3 corresponding to ejection fraction > or =0.40), and 732 patients had systolic dysfunction (wall motion index <1.3). One year mortality in patients with no heart failure, heart failure with preserved systolic function, and heart failure with systolic dysfunction were 6, 22 and 35%, P<0.0001. Unadjusted risk of death from all causes associated with heart failure and preserved systolic function was 3.3 (95% CI 2.8-4.0), and after adjustment for baseline characteristics and left ventricular systolic function in multivariate Cox proportional hazards analysis the risk was 2.1 (95% CI 1.7-2.6), P<0.0001. CONCLUSIONS:Congestive heart failure is frequently present in patients with preserved left ventricular systolic function, and is associated with increased risk of in-hospital complications and death following acute myocardial infarction.

journal_name

Eur J Heart Fail

journal_title

European journal of heart failure

authors

Møller JE,Brendorp B,Ottesen M,Køber L,Egstrup K,Poulsen SH,Torp-Pedersen C,Bucindolol Evaluation in Acute Myocardial Infarction Trail Group.

doi

10.1016/s1388-9842(03)00159-4

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

811-9

issue

6

eissn

1388-9842

issn

1879-0844

pii

S1388984203001594

journal_volume

5

pub_type

杂志文章

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