A rationale for early extracorporeal membrane oxygenation in patients with postinfarction ventricular septal rupture complicated by cardiogenic shock.


AIMS:Ventricular septal rupture (VSR) became a rare mechanical complication of myocardial infarction in the era of percutaneous coronary interventions but is associated with extreme mortality in patients who present with cardiogenic shock (CS). Promising outcomes have been reported with the use of circulatory support allowing haemodynamic stabilization, followed by delayed repair. Therefore, we analysed our experience with an early use of Veno-Arterial Extracorporeal Membrane Oxygenation (V-A ECMO) for postinfarction VSR. METHODS AND RESULTS:We conducted a retrospective search of institutional database for patients presenting with postinfarction VSR from January 2007 to June 2016. Data from 31 consecutive patients (mean age 69.5 ± 9.1 years) who were admitted to hospital were analysed. Seven out of 31 patients with VSR who were in refractory CS received V-A ECMO support preoperatively. ECMO improved end-organ perfusion with decreased lactate levels 24 hours after implantation (7.9 mmol/L vs. 1.6 mmol/L, p = 0.01), normalized arterial pH (7.25 vs. 7.40, p < 0.04), improved mean arterial pressure (64 mmHg vs. 83 mmHg, p < 0.01) and lowered heart rate (115/min vs. 68/min, p < 0.01). Mean duration of ECMO support was 12 days, 5 out of 7 patients underwent surgical repair, 4 were weaned from ECMO, 3 survived 30 days and 2 survived more than 1 year. The most frequent complication (5 patients) and the cause of death (3 patients) was bleeding. CONCLUSIONS:Our experience suggests that early V-A ECMO in patients with VSR and refractory CS might prevent irreversible multiorgan failure by improved end-organ perfusion. Bleeding complications remain an important limitation of this approach.


Eur J Heart Fail


Rob D,Špunda R,Lindner J,Rohn V,Kunstýř J,Balík M,Rulíšek J,Kopecký P,Lipš M,Šmíd O,Kovárník T,Mlejnský F,Linhart A,Bělohlávek J




Has Abstract


2017-05-01 00:00:00








19 Suppl 2


  • Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens.

    abstract:AIMS:To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ≤35%). METHODS AND RESULTS:A 5-day open-label run-in (sacubitril/valsartan 50 mg twice daily) preceded an 11-week, dou...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: Senni M,McMurray JJ,Wachter R,McIntyre HF,Reyes A,Majercak I,Andreka P,Shehova-Yankova N,Anand I,Yilmaz MB,Gogia H,Martinez-Selles M,Fischer S,Zilahi Z,Cosmi F,Gelev V,Galve E,Gómez-Doblas JJ,Nociar J,Radomska M,S

    更新日期:2016-09-01 00:00:00

  • Concomitant implantation of Impella® on top of veno-arterial extracorporeal membrane oxygenation may improve survival of patients with cardiogenic shock.

    abstract:AIMS:Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support stabilizes patients with cardiogenic shock. Despite improved oxygenation and peripheral circulation, LV unloading may be impeded due to the increased afterload, resulting in a failing static left ventricle and in high mortality. METHODS AND RESUL...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Pappalardo F,Schulte C,Pieri M,Schrage B,Contri R,Soeffker G,Greco T,Lembo R,Müllerleile K,Colombo A,Sydow K,De Bonis M,Wagner F,Reichenspurner H,Blankenberg S,Zangrillo A,Westermann D

    更新日期:2017-03-01 00:00:00

  • Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs.

    abstract:OBJECTIVE:To study changes in connexin, metalloproteinase and tissue inhibitor of metalloproteinase levels during tachycardia-induced cardiomyopathy (TIC). METHODS:Canine models of TIC were established by rapid right atrial pacing at 350-400 beats per min for 8 weeks in 11 dogs, six dogs acted as a sham operation grou...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Zhong JQ,Zhang W,Gao H,Li Y,Zhong M,Li D,Zhang C,Zhang Y

    更新日期:2007-01-01 00:00:00

  • Aetiology, comorbidity and drug therapy of chronic heart failure in the real world: the EPICA substudy.

    abstract:BACKGROUND:Chronic heart failure (CHF) is common and is frequently managed by primary care physicians (PCPs). Despite the European Society of Cardiology (ESC) Guidelines, standard treatments for CHF are frequently underutilised, particularly in primary care. AIM:To evaluate current drug therapy for CHF in adults with ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Ceia F,Fonseca C,Mota T,Morais H,Matias F,Costa C,Oliveira AG

    更新日期:2004-10-01 00:00:00

  • Gut dysbiosis and heart failure: navigating the universe within.

    abstract::Alternations in gut microbial composition (i.e. loss of microbial diversity or 'gut dysbiosis') have been associated with heart failure with reduced ejection fraction (HFrEF). It has also been suggested that increased chronic low-level inflammation and immune system dysregulation seen in patients with HFrEF could be r...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: Madan S,Mehra MR

    更新日期:2020-04-01 00:00:00

  • Galectin-3: a novel mediator of heart failure development and progression.

    abstract::Galectins are a family of soluble beta-galactoside-binding lectins that play many important regulatory roles in inflammation, immunity, and cancer. Recently, a role for galectin-3 in the pathophysiology of heart failure (HF) has been suggested. Numerous studies have demonstrated the up-regulation of galectin-3 in hype...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: de Boer RA,Voors AA,Muntendam P,van Gilst WH,van Veldhuisen DJ

    更新日期:2009-09-01 00:00:00

  • The dynamic assessment of right-ventricular function and its relation to exercise capacity in heart failure.

    abstract:AIMS:To evaluate right-ventricular (RV) function during stress echocardiography (SE) and to assess its relationship with exercise capacity in heart failure (HF) patients. METHODS AND RESULTS:We included 88 patients aged 60.9 +/- 11.2 years with a mean LVEF of 27.2 +/- 9.5%. The following RV parameters were measured at...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Rubis P,Podolec P,Kopec G,Olszowska M,Tracz W

    更新日期:2010-03-01 00:00:00

  • Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure.

    abstract:BACKGROUND:It has been suggested that oxidative stress may play a role in the pathogenesis of heart failure, this may have potential implications for therapeutic strategies. However, measures of oxidative stress are subject to confounding inaccuracies. IgG antibodies to oxidized LDL reflect exposure to the lipoprotein ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: George J,Wexler D,Roth A,Barak T,Sheps D,Keren G

    更新日期:2006-01-01 00:00:00

  • Heart failure with normal ejection fraction is uncommon in acute myocardial infarction settings but associated with poor outcomes: a study of 91,360 patients admitted with index myocardial infarction between 1998 and 2010.

    abstract:AIM:Data are scant on the incidence and prognosis of heart failure (HF) with normal ejection fraction (HFNEF, EF >49%) in an acute myocardial infarction (AMI) setting. The aim of this study was to examine incidence and predictors of HFNEF during an index acute myocardial infarction (AMI) and its subsequent associations...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Desta L,Jernberg T,Spaak J,Hofman-Bang C,Persson H

    更新日期:2016-01-01 00:00:00

  • Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial.

    abstract:BACKGROUND:We describe the baseline characteristics of subjects randomised in the largest placebo-controlled, morbidity-mortality trial to date in patients with heart failure and preserved ejection fraction - the irbesartan in heart failure with preserved systolic function trial (I-PRESERVE). METHODS AND RESULTS:4133 ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: McMurray JJ,Carson PE,Komajda M,McKelvie R,Zile MR,Ptaszynska A,Staiger C,Donovan JM,Massie BM

    更新日期:2008-02-01 00:00:00

  • The incomplete bucindolol evaluation in acute myocardial infarction Trial (BEAT).

    abstract:UNLABELLED:The aim of this study was to evaluate the efficacy of adding the beta-blocker bucindolol to standard therapy shortly after a myocardial infarction in a high-risk population with reduced left ventricular function. METHODS:The study was planned to include 2000 patients with an enzyme confirmed myocardial infa...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Torp-Pedersen C,Køber L,Ball S,Hall A,Brendorp B,Ottesen M,Berning J,Jensen G,Hampton J,Zilles P,Eberle S,Carlsen J

    更新日期:2002-08-01 00:00:00

  • The impact of heart failure on prognosis of diabetic and non-diabetic patients with myocardial infarction: a 15-year follow-up study.

    abstract:BACKGROUND:Information about the occurrence of heart failure in the acute phase of myocardial infarction (MI) in diabetic patients and its impact on prognosis are sparse. AIM:The purpose of the present study was to describe how MI patients with diabetes mellitus (DM) differed from MI patients without DM with respect t...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Melchior T,Rask-Madsen C,Torp-Pedersen C,Hildebrandt P,Køber L,Jensen G

    更新日期:2001-01-01 00:00:00

  • N-terminal pro-brain natriuretic peptide for discriminating between cardiac and non-cardiac dyspnoea.

    abstract:AIM:Evaluation of N-terminal pro-brain natriuretic peptide (NT-proBNP) to confirm or disprove heart failure in community patients complaining of dyspnoea. METHODS AND RESULTS:General practitioners referred 345 consecutive patients complaining of dyspnoea to our hospital-based clinic, where a diagnosis was established ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Nielsen LS,Svanegaard J,Klitgaard NA,Egeblad H

    更新日期:2004-01-01 00:00:00

  • Hospitalization for congestive heart failure: is it still a cardiology business?

    abstract:BACKGROUND:Hospital management of CHF and predictors of hospital mortality remain unclear. METHODS:To address these issues, we analyzed the hospital admissions for CHF during 1996 in a large university hospital. Patients discharged with the principal diagnosis of CHF were considered eligible for the study. RESULTS:Am...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Grigioni F,Carinci V,Favero L,Bacchi Reggiani L,Magnani G,Potena L,Barbieri A,Magelli C,Branzi A,Magnani B

    更新日期:2002-01-01 00:00:00

  • A Rapid Access Heart Failure Clinic provides a prompt diagnosis and appropriate management of new heart failure presenting in the community.

    abstract:BACKGROUND AND AIMS:The diagnosis of heart failure is an important clinical problem and yet reported diagnostic accuracy in primary care is less than 50%. We established a Rapid Access Heart Failure Clinic (RAHFC) in a district general hospital serving a population of 292,000 in SE London, UK, to diagnose and manage ne...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Fox KF,Cowie MR,Wood DA,Coats AJ,Poole-Wilson PA,Sutton GC

    更新日期:2000-12-01 00:00:00

  • Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications.

    abstract:AIMS:To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction. METHODS:3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myoc...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Møller JE,Brendorp B,Ottesen M,Køber L,Egstrup K,Poulsen SH,Torp-Pedersen C,Bucindolol Evaluation in Acute Myocardial Infarction Trail Group.

    更新日期:2003-12-01 00:00:00

  • Exercise training in recently hospitalized heart failure patients enrolled in a disease management programme: design of the EJECTION-HF randomized controlled trial.

    abstract:AIMS:The Exercise Joins Education: Combined Therapy to Improve Outcomes in Newly-discharged Heart Failure (EJECTION-HF) study will evaluate the impact of a supervised exercise training programme (ETP) on clinical outcomes in recently hospitalized heart failure patients attending a disease management programme (DMP). Me...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mudge AM,Denaro CP,Scott AC,Atherton JJ,Meyers DE,Marwick TH,Adsett JA,Mullins RW,Suna JM,Scuffham PA,O'Rourke PK

    更新日期:2011-12-01 00:00:00

  • Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry.

    abstract:AIMS:Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Kapelios CJ,Laroche C,Crespo-Leiro MG,Anker SD,Coats AJS,Díaz-Molina B,Filippatos G,Lainscak M,Maggioni AP,McDonagh T,Mebazaa A,Metra M,Moura B,Mullens W,Piepoli MF,Rosano GMC,Ruschitzka F,Seferovic PM,Lund LH,Heart

    更新日期:2020-08-01 00:00:00

  • Renal denervation in heart failure with preserved ejection fraction (RDT-PEF): a randomized controlled trial.

    abstract:AIM:Heart failure with preserved ejection fraction (HFpEF) is associated with increased sympathetic nervous system (SNS) tone. Attenuating the SNS with renal denervation (RDT) might be helpful and there are no data currently in humans with HFpEF. METHODS AND RESULTS:In this single-centre, randomized, open-controlled s...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: Patel HC,Rosen SD,Hayward C,Vassiliou V,Smith GC,Wage RR,Bailey J,Rajani R,Lindsay AC,Pennell DJ,Underwood SR,Prasad SK,Mohiaddin R,Gibbs JS,Lyon AR,Di Mario C

    更新日期:2016-06-01 00:00:00

  • Usefulness of bifocal pacing in patients with heart failure and intraventricular conduction delay.

    abstract:BACKGROUND:Bifocal pacing (BFP) has been proposed as a feasible alternative to cardiac resynchronization therapy. AIM:To evaluate BFP in patients with severe heart failure and significant intraventricular conduction delay and to compare it with biventricular pacing (BVP). METHODS:Echocardiographic examination includi...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Bulava A,Lukl J

    更新日期:2007-03-01 00:00:00

  • B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure.

    abstract:AIMS:In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. METHOD...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Wettersten N,Horiuchi Y,van Veldhuisen DJ,Mueller C,Filippatos G,Nowak R,Hogan C,Kontos MC,Cannon CM,Müeller GA,Birkhahn R,Taub P,Vilke GM,Barnett O,McDonald K,Mahon N,Nuñez J,Briguori C,Passino C,Murray PT,Maisel

    更新日期:2019-12-01 00:00:00

  • Relationship between right ventricular volumes measured by cardiac magnetic resonance imaging and prognosis in patients with chronic heart failure.

    abstract:AIMS:The aim of this study was to investigate the prognostic impact of right ventricular (RV) size in patients with chronic heart failure. METHODS AND RESULTS:Normal volunteers (n = 80) and patients (n = 380) with left ventricular (LV) ejection fraction <45% on echocardiography and on optimal treatment for heart failu...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Bourantas CV,Loh HP,Bragadeesh T,Rigby AS,Lukaschuk EI,Garg S,Tweddel AC,Alamgir FM,Nikitin NP,Clark AL,Cleland JG

    更新日期:2011-01-01 00:00:00

  • Heart failure update.

    abstract::The RUSSLAN study, which randomised 504 patients with post-infarction heart failure in whom intravenous inotropic support might be deemed appropriate, was presented for the first time in a hotline session at the annual meeting of the Working Group on Heart Failure of the European Society of Cardiology. The study sugge...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gomes UC,Cleland JG

    更新日期:1999-08-01 00:00:00

  • Family caregiving and congestive heart failure. Review and analysis.

    abstract:BACKGROUND:There is increasing evidence that discharge planning and post-discharge support for CHF patients can contribute greatly to the medical management of heart failure (CHF) in the community and that the quality of the CHF patient's close personal relationships can influence outcome in CHF. However, there has bee...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: Molloy GJ,Johnston DW,Witham MD

    更新日期:2005-06-01 00:00:00

  • Heart failure with preserved ejection fraction in Asia.

    abstract:BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) is a global public health problem. Unfortunately, little is known about HFpEF across Asia. METHODS AND RESULTS:We prospectively studied clinical characteristics, echocardiographic parameters and outcomes in 1204 patients with HFpEF (left ventricular eje...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究


    authors: Tromp J,Teng TH,Tay WT,Hung CL,Narasimhan C,Shimizu W,Park SW,Liew HB,Ngarmukos T,Reyes EB,Siswanto BB,Yu CM,Zhang S,Yap J,MacDonald M,Ling LH,Leineweber K,Richards AM,Zile MR,Anand IS,Lam CSP,ASIAN-HF Investiga

    更新日期:2019-01-01 00:00:00

  • Ultrasound lung comets for the differential diagnosis of acute cardiogenic dyspnoea: a comparison with natriuretic peptides.

    abstract:BACKGROUND:Acute dyspnoea as a presenting symptom is a frequent diagnostic challenge for physicians. The main differential diagnosis is between dyspnoea of cardiac and non-cardiac origin. Natriuretic peptides have been shown to be useful in this setting. Ultrasound lung comets (ULCs) are a simple, echographic method wh...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Gargani L,Frassi F,Soldati G,Tesorio P,Gheorghiade M,Picano E

    更新日期:2008-01-01 00:00:00

  • The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure.

    abstract::Patients with mild-moderate chronic heart failure (CHF) often have raised levels of serum uric acid (UA). This is due, amongst other factors, to reduced UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels wors...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: Reyes AJ

    更新日期:2005-06-01 00:00:00

  • Oral glucose tolerance testing in an outpatient heart failure clinic reveals a high proportion of undiagnosed diabetic patients with an adverse prognosis.

    abstract:AIMS:We evaluated the applicability and prognostic importance of oral glucose tolerance testing (OGTT) among outpatients with systolic heart failure (SHF). METHODS AND RESULTS:Consecutive patients with SHF and left ventricular ejection fraction (LVEF) ≤ 45% referred to a heart failure clinic (n= 413) were included in ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Egstrup M,Schou M,Gustafsson I,Kistorp CN,Hildebrandt PR,Tuxen CD

    更新日期:2011-03-01 00:00:00

  • Influence of cardiac-resynchronization therapy on heart rate and blood pressure variability: 1-year follow-up.

    abstract:BACKGROUND:Several studies have shown that cardiac-resynchronization therapy (CRT) improves haemodynamic function, cardiac symptoms, and heart rate variability (HRV) and reduces the risk of mortality and sudden death in subjects with chronic heart failure (CHF). In subjects with CHF, power spectral values for the low-f...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: Piccirillo G,Magrì D,di Carlo S,De Laurentis T,Torrini A,Matera S,Magnanti M,Bernardi L,Barillà F,Quaglione R,Ettorre E,Marigliano V

    更新日期:2006-11-01 00:00:00

  • Heart failure in a multiethnic population in Kuala Lumpur, Malaysia.

    abstract:BACKGROUND:There are established differences in cardiovascular disease in different racial groups. Worldwide, the literature regarding the clinical epidemiology of congestive heart failure (CHF) in non-white populations is scarce. OBJECTIVES:To document the prevalence of CHF in the multiracial population of Malaysia, ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Chong AY,Rajaratnam R,Hussein NR,Lip GY

    更新日期:2003-08-01 00:00:00