Abstract:
OBJECTIVE:To investigate in vivo effects of long-term selective beta1-blockade on cardiac energy metabolism, remodelling, function and plasma cytokines in a rat model of post-infarct congestive heart failure (CHF). METHODS:Myocardial infarction (MI) was induced in male rats by ligation of the left coronary artery. Three different groups of rats were studied, MI rats treated with metoprolol (n=17), MI rats treated with saline (n=14) and sham-operated rats (n=12). The treatment with metoprolol 1 mg/kg/h was initiated in the third week post-infarct for a period of 6 weeks. All rats were investigated non-invasively with volume-selective 31P magnetic resonance spectroscopy and echocardiography for evaluation of left ventricular (LV) energy metabolism, morphology and function. Plasma concentration of IL-1beta and IL-6 and density of beta-adrenergic receptors were analyzed. RESULTS:Metoprolol attenuated the increase in LV dimensions and volumes. Treatment with metoprolol had no effect on PCr/ATP and LV function. Plasma level of IL-1beta was higher and IL-6 was lower in the metoprolol group. Density of beta-adrenergic receptors was similar in all three groups. CONCLUSION:Selective beta1-blockade in rats with chronic CHF attenuates post-infarct structural remodelling, without concomitant improvement in myocardial energy metabolism and function. Improvements in myocardial energy metabolism and function do not precede and are not a prerequisite for an anti-remodelling effect of beta1-blockade in the setting of chronic CHF.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Omerovic E,Bollano E,Soussi B,Waagstein Fdoi
10.1016/s1388-9842(03)00153-3keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
725-32issue
6eissn
1388-9842issn
1879-0844pii
S1388984203001533journal_volume
5pub_type
杂志文章abstract:BACKGROUND:Platelet-endothelial interactions modulated by adhesion molecules, may play an important role in the pathogenesis of congestive heart failure (CHF). Soluble levels of these molecules and platelet-derived substances are reportedly elevated in patients with CHF. However, no data are available on the plasma lev...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(99)00029-x
更新日期:1999-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2007-11-01 00:00:00
abstract:AIMS:To determine the effects of a nurse-led intervention designed to improve self-management of patients with heart failure in a primary health care setting regarding health-related quality of life and depression. METHODS:Patients at eight primary health care centres were screened by the Diagnosis Related Groups regi...
journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ejheart.2004.01.016
更新日期:2005-03-16 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2003.12.013
更新日期:2004-03-15 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2003.09.009
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Approximately one third of patients with chronic heart failure have left bundle branch block (LBBB) on their 12-lead ECG. METHODS AND RESULTS:1418 consecutive patients (average (SD) age 70.5 (10.4) years; 74% male) first seen in a community heart failure clinic between December 2001 and June 2006 had a 12 l...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2008.05.001
更新日期:2008-07-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2016-06-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2011-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfq198
更新日期:2011-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1547
更新日期:2019-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurjhf/hfq043
更新日期:2010-06-01 00:00:00
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2007.10.010
更新日期:2008-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1002/ejhf.121
更新日期:2014-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
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更新日期:2007-04-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-07-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2006-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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更新日期:2021-01-09 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2007.07.017
更新日期:2007-10-01 00:00:00