当前位置： SCI文献检索 > EUROPEAN JOURNAL OF HEART FAILURE期刊下所有文献 > Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure.

Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure.

Abstract：

BACKGROUND:Suppression of the renin-angiotensin-aldosterone system (RAAS) is therapeutically valuable in chronic heart failure (CHF). RAAS inhibition can be achieved in a number of ways though an orally active renin inhibitor (RI) has never been studied before. We describe the neurohumoral effects of an RI. METHODS AND RESULTS:27 patients with NYHA class II or III CHF and an ejection fraction

journal_name

Eur J Heart Fail

journal_title

European journal of heart failure

authors

Seed A,Gardner R,McMurray J,Hillier C,Murdoch D,MacFadyen R,Bobillier A,Mann J,McDonagh T

doi

10.1016/j.ejheart.2007.09.002

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

1120-7

issue

11

eissn

1388-9842

issn

1879-0844

pii

S1388-9842(07)00362-5

journal_volume

9

pub_type

杂志文章,随机对照试验

相关文献

EUROPEAN JOURNAL OF HEART FAILURE文献大全
  • First use of cardiac contractility modulation (CCM) in a patient failing CRT therapy: clinical and technical aspects of combined therapies.

    abstract：:Cardiac contractility modulating (CCM) signals delivered by the OPTIMIZER System are being investigated as a treatment for medically refractory heart failure. Previous chronic studies of CCM have excluded patients with prolonged QRS and a cardiac resynchronization therapy (CRT) device. However, symptoms persist in mor...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2007.05.012

    authors： Butter C,Meyhöfer J,Seifert M,Neuss M,Minden HH

    更新日期：2007-09-01 00:00:00

  • Wall motion index, estimated glomerular filtration rate and mortality risk in patients with heart failure or myocardial infarction: a pooled analysis of 18,010 patients.

    abstract：AIMS:This study was designed to assess whether the prognostic significance of estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF) interact in populations with heart failure (HF) and myocardial infarction (MI). METHODS:Patients were recruited from four screening registers (N=18,010...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2008.04.006

    authors： Schou M,Torp-Pedersen C,Gustafsson F,Abdulla J,Kober L

    更新日期：2008-07-01 00:00:00

  • Experience of commencing Carvedilol in elderly patients with heart failure in a routine outpatient clinic.

    abstract：:Carvedilol has been shown to be beneficial for patients with heart failure, but it is not clear how it should be initiated in routine clinical practice, particularly in the elderly. This study is a retrospective review of 19 patients of age 80+/-4 years with heart failure, who had Carvedilol treatment initiated in a r...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/s1388-9842(00)00092-1

    authors： Owen A

    更新日期：2000-09-01 00:00:00

  • Angiopoietin-1 for myocardial angiogenesis: a comparison between delivery strategies.

    abstract：UNLABELLED:We compare the effectiveness of direct adenoviral angiopoietin-1 (Ad-Ang-1) injection with transplantation of skeletal myoblasts (SkMs) over-expressing angiopoietin-1 (Ang-1) for angiogenic response and improvement of heart function in an experimental porcine model of myocardial infarction (MI). METHODS:Ad-...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2006.10.022

    authors： Ye L,Haider HKh,Jiang S,Tan RS,Toh WC,Ge R,Sim EK

    更新日期：2007-05-01 00:00:00

  • Viewpoint: the prothrombotic state in heart failure: a maladaptive inflammatory response?

    abstract：:Patients with heart failure (HF) are at an increased risk of stroke, sudden death and venous thromboembolism, which are all linked to thrombus formation (thrombogenesis). The present 'viewpoint' article will discuss how the prothrombotic state in HF may be perpetuated by a chronic inflammatory state that is maladaptiv...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejheart.2006.05.009

    authors： Chong AY,Lip GY

    更新日期：2007-02-01 00:00:00

  • Myocarditis as a precipitating factor for heart failure: evaluation and 1-year follow-up using cardiovascular magnetic resonance and endomyocardial biopsy.

    abstract：AIMS:The aim of this study was to evaluate myocarditis as a precipitating factor for heart failure using cardiovascular magnetic resonance (CMR) and endomyocardial biopsy. METHODS AND RESULTS:Eighty-five patients with suspected myocarditis and 20 controls were evaluated. Seventy-one patients with positive CMR were ref...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfr052

    authors： Mavrogeni S,Spargias C,Bratis C,Kolovou G,Markussis V,Papadopoulou E,Constadoulakis P,Papadimitropoulos M,Douskou M,Pavlides G,Cokkinos D

    更新日期：2011-08-01 00:00:00

  • Serum digoxin concentration and outcomes in women with heart failure: A bi-directional effect and a possible effect modification by ejection fraction.

    abstract：BACKGROUND:The association between serum digoxin concentration (SDC) and outcomes in women with heart failure (HF) has not been well studied. AIMS:To test the hypothesis that the effect of digoxin on outcomes in women with HF is bi-directional and dependent on SDC, as in men, and is modified by ejection fraction (EF)....

    journal_title：European journal of heart failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ejheart.2005.10.002

    authors： Ahmed A,Aban IB,Weaver MT,Aronow WS,Fleg JL

    更新日期：2006-06-01 00:00:00

  • Primary proteasome inhibition results in cardiac dysfunction.

    abstract：AIMS:The proteasome prevents the intracellular accumulation of proteins and its impairment can lead to structural and functional alterations, as noted for the coronary vasculature in a previous study. Utilizing the same model, this study was designed to test the hypothesis that chronic proteasome inhibition (PSI) also ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hft034

    authors： Herrmann J,Wohlert C,Saguner AM,Flores A,Nesbitt LL,Chade A,Lerman LO,Lerman A

    更新日期：2013-06-01 00:00:00

  • The St Vincent's potentially inappropriate medicines study: development of a disease-specific consensus list and its evaluation in ambulatory heart failure care.

    abstract：AIMS:Heart failure (HF) patients may be at risk of prescription of potentially inappropriate medicines (PIMs) yet no disease-specific list is available to assess PIM use in this population. A Consensus Potentially Inappropriate Medicines in Heart Failure (PIMHF) list was developed, assessed, and compared with an establ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.132

    authors： Bermingham M,Ryder M,Travers B,Edwards N,Lalor L,Kelly D,Gallagher J,O'Hanlon R,McDonald K,Ledwidge M

    更新日期：2014-08-01 00:00:00

  • Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.

    abstract：AIMS:Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF). Considering different treatment mechanisms underlying renin-angiotensin system (RAS) suppression and parasym...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.164

    authors： Li M,Zheng C,Kawada T,Inagaki M,Uemura K,Sugimachi M

    更新日期：2014-10-01 00:00:00

  • Oral glucose tolerance testing in an outpatient heart failure clinic reveals a high proportion of undiagnosed diabetic patients with an adverse prognosis.

    abstract：AIMS:We evaluated the applicability and prognostic importance of oral glucose tolerance testing (OGTT) among outpatients with systolic heart failure (SHF). METHODS AND RESULTS:Consecutive patients with SHF and left ventricular ejection fraction (LVEF) ≤ 45% referred to a heart failure clinic (n= 413) were included in ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfq216

    authors： Egstrup M,Schou M,Gustafsson I,Kistorp CN,Hildebrandt PR,Tuxen CD

    更新日期：2011-03-01 00:00:00

  • Echocardiographic screening for non-ischaemic stage B heart failure in the community.

    abstract：AIMS:Incident heart failure (HF) continues to pose a common and serious problem. We sought to examine the value of echocardiographic predictors of new HF in a community-based elderly population at risk for HF, independent of and incremental to clinical evaluation. METHODS AND RESULTS:Asymptomatic patients ≥65 years ol...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.643

    authors： Yang H,Negishi K,Wang Y,Nolan M,Saito M,Marwick TH

    更新日期：2016-11-01 00:00:00

  • Clinical profile and management of heart failure: rural community hospital vs. metropolitan heart center.

    abstract：BACKGROUND:Knowledge on clinical characteristics and prognosis of patients with heart failure originates from studies of selected populations in clinical trials or from epidemiological observations. Reports on the large numbers of patients with heart failure treated in community hospitals are sparse. OBJECTIVE:Are the...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/s1388-9842(01)00142-8

    authors： Taubert G,Bergmeier C,Andresen H,Senges J,Potratz J

    更新日期：2001-10-01 00:00:00

  • Haemodynamic effects of an acute vasodilator challenge in heart failure patients with reduced ejection fraction and different forms of post-capillary pulmonary hypertension.

    abstract：AIMS:The most recent European guidelines have proposed new definitions of pulmonary hypertension (PH) in left heart disease, to better approach the characteristics required to reflect the presence of pulmonary vascular disease. The purpose of this study was to assess whether different haemodynamic definitions of post-c...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.1067

    authors： Ghio S,Crimi G,Temporelli PL,Traversi E,La Rovere MT,Cannito A,Vizza D,Scelsi L,Raineri C,Guazzi M,Oltrona Visconti L

    更新日期：2018-04-01 00:00:00

  • Echocardiographic quantification of regional deformation helps to distinguish isolated left ventricular non-compaction from dilated cardiomyopathy.

    abstract：AIMS:Pronounced trabeculation is presented in both left ventricular non-compaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the differentiation difficult. We hypothesized that echocardiographic deformation analysis would help to differentiate these two cardiomyopathies. METHODS AND RESULTS:We inv...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfr164

    authors： Niemann M,Liu D,Hu K,Cikes M,Beer M,Herrmann S,Gaudron PD,Hillenbrand H,Voelker W,Ertl G,Weidemann F

    更新日期：2012-02-01 00:00:00

  • Ghrelin resistance occurs in severe heart failure and resolves after heart transplantation.

    abstract：AIMS:Severe heart failure (HF) is often associated with cachexia that reverses post-heart transplantation (HTx) with frequent development of obesity. Ghrelin is a novel appetite-stimulating hormone. The aim was to determine the role of ghrelin in regulating appetite, food intake, and body composition in HF and post-HTx...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfp088

    authors： Lund LH,Williams JJ,Freda P,LaManca JJ,LeJemtel TH,Mancini DM

    更新日期：2009-08-01 00:00:00

  • Simultaneous angiotensin converting enzyme inhibition moderates ventricular dysfunction caused by doxorubicin.

    abstract：AIMS:The purpose of this study was to determine that the administration of an angiotensin converting enzyme (ACE) inhibitor enalapril would confer protection against doxorubicin-induced experimental heart failure, and attenuate the development of left ventricular dysfunction. METHODS:Seventeen dogs were chronically in...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/s1388-9842(02)00091-0

    authors： Vaynblat M,Shah HR,Bhaskaran D,Ramdev G,Davis WJ 3rd,Cunningham JN Jr,Chiavarelli M

    更新日期：2002-10-01 00:00:00

  • High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts.

    abstract：:We investigated the hypothesis that increased intracellular [Na+]i in heart failure contributes to preservation of SR Ca2+ load which may become particularly evident at slow heart rates. [Na+]i in SBFI-loaded myocytes from rabbits with pacing-induced heart failure (PHF) was significantly higher at each frequency as co...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2006.01.013

    authors： Schillinger W,Teucher N,Christians C,Kohlhaas M,Sossalla S,Van Nguyen P,Schmidt AG,Schunck O,Nebendahl K,Maier LS,Zeitz O,Hasenfuss G

    更新日期：2006-11-01 00:00:00

  • Angiotensin II subtype 1 (AT1) receptors contribute to ischemic contracture and regulate chemomechanical energy transduction in isolated transgenic rat (alphaMHC-hAT1)594-17 hearts.

    abstract：BACKGROUND:The role of AT1 receptors in myocardial ischemia/reperfusion injury is unclear. We, therefore, investigated the effects of the AT1 receptor antagonist irbesartan (Irb) in isolated hearts of selective myocardial AT1 overexpressing transgenic [transgenic(alphaMHC-hAT1)594-17] and Sprague-Dawley rats (SD) subje...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/s1388-9842(02)00005-3

    authors： Han H,Hoffmann S,Hu K,Ertl G

    更新日期：2002-03-01 00:00:00

  • Central venous pressure at emergency room presentation predicts cardiac rehospitalization in patients with decompensated heart failure.

    abstract：AIMS:To investigate the relationship between central venous pressure (CVP) at presentation to the emergency room (ER) and the risk of cardiac rehospitalization and mortality in patients with decompensated heart failure (DHF). METHODS AND RESULTS:Central venous pressure was determined non-invasively using high-resoluti...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfq024

    authors： Uthoff H,Thalhammer C,Potocki M,Reichlin T,Noveanu M,Aschwanden M,Staub D,Arenja N,Socrates T,Twerenbold R,Mutschmann-Sanchez S,Heinisch C,Jaeger KA,Mebazaa A,Mueller C

    更新日期：2010-05-01 00:00:00

  • Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle.

    abstract：AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.239

    authors： Bowen TS,Rolim NP,Fischer T,Baekkerud FH,Medeiros A,Werner S,Brønstad E,Rognmo O,Mangner N,Linke A,Schuler G,Silva GJ,Wisløff U,Adams V,Optimex Study Group.

    更新日期：2015-03-01 00:00:00

  • Optimized Implementation of cardiac resynchronization therapy - a call for action for referral and optimization of care.

    abstract：:Cardiac resynchronization therapy (CRT) is one of the most effective therapies for heart failure with reduced ejection fraction and leads to improved quality of life, reductions in heart failure hospitalization rates and reduces all-cause mortality. Nevertheless, up to two-thirds of eligible patients are not referred ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1002/ejhf.2046

    authors： Mullens W,Auricchio A,Martens P,Witte K,Cowie MR,Delgado V,Dickstein K,Linde C,Vernooy K,Leyva F,Bauersachs J,Israel CW,Lund L,Donal E,Boriani G,Jaarsma T,Berruezo A,Traykov V,Yousef Z,Kalarus Z,Nielsen JC,Steff

    更新日期：2020-11-02 00:00:00

  • Bi treatment with hydralazine/nitrates vs. placebo in Africans admitted with acute HEart Failure (BA-HEF).

    abstract：AIMS:Patients with acute heart failure (HF) in Africa are rarely being treated with a hydralazine/nitrates combination. Therefore the effect of this treatment was studied here. METHODS AND RESULTS:The study was planned to enrol 500 patients during an acute HF admission, from nine sub-Saharan African countries. Patient...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1002/ejhf.581

    authors： Sliwa K,Damasceno A,Davison BA,Mayosi BM,Sani MU,Ogah O,Mondo C,Ojji D,Dzudie A,Kouam CK,Yonga G,Ba SA,Ogola E,Edwards C,Milo O,Cotter G

    更新日期：2016-10-01 00:00:00

  • Does the physical examination still have a role in patients with suspected heart failure?

    abstract：AIMS:The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in patients in a community heart failure clinic. METHODS AND RESULTS:Analysis...

    journal_title：European journal of heart failure

    pub_type： 杂志文章,多中心研究

    doi：10.1093/eurjhf/hfr128

    authors： Damy T,Kallvikbacka-Bennett A,Zhang J,Goode K,Buga L,Hobkirk J,Yassin A,Dubois-Randé JL,Hittinger L,Cleland JG,Clark AL

    更新日期：2011-12-01 00:00:00

  • Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study.

    abstract：AIMS:To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms. METHODS AND RESULTS:A total of 300 consecutive hospitalized CHF patients were screened for ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfp125

    authors： Parissis JT,Farmakis D,Nikolaou M,Birmpa D,Bistola V,Paraskevaidis I,Ikonomidis I,Gaitani S,Venetsanou K,Filippatos G,Kremastinos DT

    更新日期：2009-10-01 00:00:00

  • Chronic heart failure is associated with vascular remodeling of the brachial artery.

    abstract：AIMS:Endothelial dysfunction has been shown to correlate with severity of congestive heart failure (CHF) and recent data suggest morphological changes of peripheral vasculature to be associated with the syndrome. We therefore investigated the hypothesis that vascular remodeling is associated with functional changes in ...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2004.04.008

    authors： Poelzl G,Frick M,Huegel H,Lackner B,Alber HF,Mair J,Herold M,Schwarzacher S,Pachinger O,Weidinger F

    更新日期：2005-01-01 00:00:00

  • Clinical evaluation of geriatric outpatients with suspected heart failure: value of symptoms, signs, and additional tests.

    abstract：AIMS:Heart failure (HF) is common in geriatric patients. Clinicians face diagnostic challenges primarily due to comorbidity and limited access to echocardiography. The purpose of this study was to identify independent determinants of the presence of HF in geriatric outpatients and to determine the optimal diagnostic st...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfr021

    authors： Oudejans I,Mosterd A,Bloemen JA,Valk MJ,van Velzen E,Wielders JP,Zuithoff NP,Rutten FH,Hoes AW

    更新日期：2011-05-01 00:00:00

  • Alveolar-capillary membrane conductance is the best pulmonary function correlate of exercise ventilation efficiency in heart failure patients.

    abstract：BACKGROUND:In heart failure (HF), changes in lung mechanics and gas diffusion are limiting factors to exercise. Their contribution to an increased exercise ventilation to CO2 production (VE/VCO2) slope is undefined. METHODS:A total of 67 stable HF patients underwent cardiopulmonary exercise and pulmonary function test...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1016/j.ejheart.2004.10.009

    authors： Guazzi M,Reina G,Tumminello G,Guazzi MD

    更新日期：2005-10-01 00:00:00

  • Patients with heart failure in primary health care: effects of a nurse-led intervention on health-related quality of life and depression.

    abstract：AIMS:To determine the effects of a nurse-led intervention designed to improve self-management of patients with heart failure in a primary health care setting regarding health-related quality of life and depression. METHODS:Patients at eight primary health care centres were screened by the Diagnosis Related Groups regi...

    journal_title：European journal of heart failure

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ejheart.2004.01.016

    authors： Mårtensson J,Strömberg A,Dahlström U,Karlsson JE,Fridlund B

    更新日期：2005-03-16 00:00:00

  • Low-dose nitroglycerin improves microcirculation in hospitalized patients with acute heart failure.

    abstract：AIMS:Impaired tissue perfusion is often observed in patients with acute heart failure. We tested whether low-dose nitroglycerin (NTG) improves microcirculatory perfusion in patients admitted for acute heart failure. METHODS AND RESULTS:In 20 acute heart failure patients, NTG was given as intravenous infusion at a fixe...

    journal_title：European journal of heart failure

    pub_type： 杂志文章

    doi：10.1093/eurjhf/hfp021

    authors： den Uil CA,Lagrand WK,Spronk PE,van der Ent M,Jewbali LS,Brugts JJ,Ince C,Simoons ML

    更新日期：2009-04-01 00:00:00