First use of cardiac contractility modulation (CCM) in a patient failing CRT therapy: clinical and technical aspects of combined therapies.

Abstract:

:Cardiac contractility modulating (CCM) signals delivered by the OPTIMIZER System are being investigated as a treatment for medically refractory heart failure. Previous chronic studies of CCM have excluded patients with prolonged QRS and a cardiac resynchronization therapy (CRT) device. However, symptoms persist in more than 25% of these CRT patients. CCM may offer a therapeutic option for these non-responders. Here we report the first use of CCM signals in a patient who did not respond to treatment with a CRT-D device. We show that the implantation is technically feasible, that the OPTIMIZER and CRT-D devices can coexist without interference and that acute haemodynamic and clinical improvements can be observed. The results suggest that systematic investigation of CCM treatment in CRT non-responders is warranted.

journal_name

Eur J Heart Fail

authors

Butter C,Meyhöfer J,Seifert M,Neuss M,Minden HH

doi

10.1016/j.ejheart.2007.05.012

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

955-8

issue

9

eissn

1388-9842

issn

1879-0844

pii

S1388-9842(07)00246-2

journal_volume

9

pub_type

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