Abstract：
AIMS:Galectin-3 is a prognostic heart failure (HF) biomarker that may mediate cardiac fibrosis. We examined the value of serial galectin-3 measurement for prognosis and response to therapy in chronic HF. METHODS AND RESULTS:A total of 151 subjects with LV systolic dysfunction (LVSD) were followed through 908 visits over 10 ± 3 months. The amount of time spent with a galectin-3 level ≤ 20.0 ng/mL and changes between baseline and subsequent values were considered across visits, and used to assess risk for adverse cardiovascular (CV) events and associations with LV remodelling. Medication effects on galectin-3 were examined. Median galectin-3 values at baseline, 3 months, and 6 months were higher in patients with CV events (21.7 vs. 18.4 ng/mL, P = 0.03; 21.7 vs. 16.5 ng/mL, P = 0.03; 23.2 vs. 16.0 ng/mL, P = 0.007). Galectin-3 concentration changed in 35.2% of subjects during study procedures; time spent at ≤ 20.0 ng/mL was significantly associated with a lower rate of CV events, independently predicted fewer CV events even adjusted for relevant variables including study allocation, NT-proBNP, and renal function [odds ratio (OR) = 0.90; P = 0.05], and predicted increase in LV ejection fraction (OR = 1.20; P = 0.04). Serial galectin-3 measurement at 6 months added prognostic value beyond the baseline level (P = 0.02). There were no significant effects of medications on galectin-3 levels. CONCLUSION:In chronic HF due to LVSD, serial galectin-3 measurement adds incremental prognostic information and predicts LV remodelling. In this study, HF therapies had no clear effects on galectin-3 levels.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Motiwala SR,Szymonifka J,Belcher A,Weiner RB,Baggish AL,Sluss P,Gaggin HK,Bhardwaj A,Januzzi JLdoi
10.1093/eurjhf/hft075subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1157-63issue
10eissn
1388-9842issn
1879-0844pii
hft075journal_volume
15pub_type
杂志文章abstract：:Carvedilol has been shown to be beneficial for patients with heart failure, but it is not clear how it should be initiated in routine clinical practice, particularly in the elderly. This study is a retrospective review of 19 patients of age 80+/-4 years with heart failure, who had Carvedilol treatment initiated in a r...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(00)00092-1
更新日期：2000-09-01 00:00:00
abstract：AIMS:Aldosterone activation is central to the sodium–fluid retention that marks the progression of heart failure (HF). The actions of dietary sodium restriction, a mainstay in HF management, on cardiorenal and neuroendocrine adaptations during the progression of HF are poorly understood. The study aim was to assess the...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.212
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Several studies have shown that cardiac-resynchronization therapy (CRT) improves haemodynamic function, cardiac symptoms, and heart rate variability (HRV) and reduces the risk of mortality and sudden death in subjects with chronic heart failure (CHF). In subjects with CHF, power spectral values for the low-f...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ejheart.2006.01.008
更新日期：2006-11-01 00:00:00
abstract：AIMS:Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.1796
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Oxygen (O2) uptake at peak exercise (VO2 peak) is an objective measurement of functional capacity in patients with chronic heart failure (CHF). The significance of recovery O2 kinetics parameters in predicting exercise capacity, and the parameters of submaximal exercise testing have not been thoroughly exami...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(01)00187-8
更新日期：2001-12-01 00:00:00
abstract：AIMS:Ventricular septal rupture (VSR) became a rare mechanical complication of myocardial infarction in the era of percutaneous coronary interventions but is associated with extreme mortality in patients who present with cardiogenic shock (CS). Promising outcomes have been reported with the use of circulatory support a...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.852
更新日期：2017-05-01 00:00:00
abstract：UNLABELLED:Experimental data have shown that rIL2 has negative inotropic properties. This has not been investigated in humans with normal left ventricular function. Seventeen consecutive renal cell carcinoma patients who received rIL2 therapy because of dissemination were analyzed before and after treatment with a low ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(00)00073-8
更新日期：2000-06-01 00:00:00
abstract：:The use of erythropoietin (EPO) has revolutionized the treatment of anaemia associated with many conditions including chronic kidney disease (CKD). However, little is known of the cellular impact of EPO on the uraemic heart. The discovery that the EPO receptor (EPOR) is also expressed on non-haematopoietic cells inclu...
journal_title：European journal of heart failure
pub_type： 杂志文章,评审
doi：10.1093/eurjhf/hfp093
更新日期：2009-08-01 00:00:00
abstract：AIMS:To assess adherence to medical treatment in patients with heart failure (HF) using a specific questionnaire and measurement of the serum concentration of digoxin. METHODS AND RESULTS:Forty patients with symptomatic HF and a clinical indication for digoxin were included in this pilot study. The assessment of adher...
journal_title：European journal of heart failure
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1093/eurjhf/hfq015
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Hereditary hemochromatosis (HH), a common autosomal recessive disease, leads to excessive iron accumulation in some organs, including the heart. It is therefore not surprising that cardiomyopathy is one of the most severe complications of HH. The HFE gene defects have been thought to contribute to idiopathic...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2004.03.007
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Plasma renin activity is normal in left ventricular dysfunction in the absence of diuretic therapy. In health there is a reciprocal relationship between renin and atrial natriuretic peptide (ANP) but a positive correlation in advanced heart failure. The relationship between renin and ANP in mild left ventric...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(99)00058-6
更新日期：1999-12-01 00:00:00
abstract：AIMS:Liver X receptors (LXRs) transcriptionally regulate inflammation, metabolism, and immunity. Synthetic LXR agonists have been evaluated for their efficacy in the cardiovascular system; however, they elicit prolipogenic side effects which substantially limit their therapeutic use. AZ876 is a novel high-affinity LXR ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.243
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Myocardial contractility can be altered using voltage clamp techniques by modulating amplitude and duration of the action potential resulting in enhanced calcium entry in the cell of isolated muscle strips (Non-Excitatory Currents; NEC). Extracellular electrical stimuli delivered during the absolute refracto...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2005.05.011
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Beneficial effects of left ventricular (LV)-based pacing on acute hemodynamic parameters were reported in several series, but only a few studies examined the long-term effects of this new pacing procedure. AIMS:To assess long-term effects of permanent LV-based pacing on LV function and mitral regurgitation ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(01)00145-3
更新日期：2001-08-01 00:00:00
abstract：AIMS:Quantification of linear lung ultrasound (LUS) artefacts (B-lines) represents a novel, non-invasive approach to assess pulmonary congestion. We investigated the relationship between the number of B-lines (vertical artefacts arising from the pleural line) and intracardiac pressures. METHODS AND RESULTS:Prior to sc...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfs144
更新日期：2012-11-01 00:00:00
abstract：AIMS:Impaired tissue perfusion is often observed in patients with acute heart failure. We tested whether low-dose nitroglycerin (NTG) improves microcirculatory perfusion in patients admitted for acute heart failure. METHODS AND RESULTS:In 20 acute heart failure patients, NTG was given as intravenous infusion at a fixe...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfp021
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:Cognitive impairment is common among chronic heart failure (CHF) patients. AIMS:To determine the prognostic significance of cognitive impairment in patients participating in a randomized study of a CHF management program (CHF-MP). METHODS:CHF patients were randomized to a CHF-MP (n=100) or usual care (n=10...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2005.11.013
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Suppression of the renin-angiotensin-aldosterone system (RAAS) is therapeutically valuable in chronic heart failure (CHF). RAAS inhibition can be achieved in a number of ways though an orally active renin inhibitor (RI) has never been studied before. We describe the neurohumoral effects of an RI. METHODS AN...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ejheart.2007.09.002
更新日期：2007-11-01 00:00:00
abstract：AIMS:The 'Hospital at home' (HaH) model avoids hospital admission by transferring healthcare and treatment to the patient's home. We aimed to compare the effectiveness and direct healthcare costs of treating elderly patients with decompensated heart failure (HF) using HaH care vs. inpatient hospital care (IHC) in a car...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1093/eurjhf/hfp143
更新日期：2009-12-01 00:00:00
abstract：:The ELITE-II, BEST and CHAMP Trials were reported for the first time at the American Heart Association in November 1999. These trials provide valuable new information to guide clinical practice in the management of heart failure and of myocardial infarction, although none mandate a major change from current clinical p...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(00)00053-2
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Information about the occurrence of heart failure in the acute phase of myocardial infarction (MI) in diabetic patients and its impact on prognosis are sparse. AIM:The purpose of the present study was to describe how MI patients with diabetes mellitus (DM) differed from MI patients without DM with respect t...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(00)00117-3
更新日期：2001-01-01 00:00:00
abstract：AIMS:Structural abnormalities causing cardiac deterioration in hypertensive heart disease (HHD) are poorly understood. The aim of the study was to evaluate left ventricular (LV) myocardial changes in patients with HHD and cardiac failure. METHODS AND RESULTS:Among 1229 patients undergoing an LV or biventricular endomy...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfs169
更新日期：2013-03-01 00:00:00
abstract：:This article provides information and a commentary on key trials relevant to the pathophysiology, prevention, and treatment of heart failure (HF) presented at the annual meeting of the European Society of Cardiology held in Stockholm in 2010. Unpublished reports should be considered as preliminary, since analyses may ...
journal_title：European journal of heart failure
pub_type：
doi：10.1093/eurjhf/hfq186
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:It has been suggested that oxidative stress may play a role in the pathogenesis of heart failure, this may have potential implications for therapeutic strategies. However, measures of oxidative stress are subject to confounding inaccuracies. IgG antibodies to oxidized LDL reflect exposure to the lipoprotein ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2005.04.015
更新日期：2006-01-01 00:00:00
abstract：AIMS:Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF. METHODS AND RESULTS:The study included 279 participants from the PARAMOUNT study (57% women) with analysable b...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.67
更新日期：2014-05-01 00:00:00
abstract：AIMS:Post-discharge morbidity and mortality for acute heart failure (AHF) patients remains high. Although the adverse effects of neurohormonal activation are well known in chronic HF, the prognostic significance of serum aldosterone in patients hospitalized for AHF has not been well studied. METHODS AND RESULTS:A seco...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hft100
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION:Atrial fibrillation (AF) is common in patients with heart failure (HF) due to left ventricular systolic dysfunction (LVSD), with conflicting prognostic data. The aim of our study was to assess the prevalence and incidence of AF in patients with HF and to determine the prognostic impact of baseline AF and t...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejheart.2006.08.004
更新日期：2007-03-01 00:00:00
abstract：UNLABELLED:Aim Frequent ventricular premature contractions (VPCs) may cause haemodynamic deterioration and reversible left ventricular (LV) dysfunction. We aimed to clarify this mechanism. METHODS AND RESULTS:The haemodynamics, echocardiographic parameters, and plasma brain natriuretic peptide (BNP) level were assesse...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfs095
更新日期：2012-10-01 00:00:00
abstract：AIMS:The aim of this study was to investigate the prognostic impact of right ventricular (RV) size in patients with chronic heart failure. METHODS AND RESULTS:Normal volunteers (n = 80) and patients (n = 380) with left ventricular (LV) ejection fraction <45% on echocardiography and on optimal treatment for heart failu...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfq161
更新日期：2011-01-01 00:00:00
abstract：AIMS:Randomized trials have shown that beta-blockers (BBs) reduce mortality in chronic heart failure (HF). Less data are available on the role of BBs in patients with acute HF, specifically if BBs should be continued or temporarily withdrawn. The aim of this study was to evaluate the role of BBs on in-hospital outcomes...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfn008
更新日期：2009-01-01 00:00:00
